Sonication Stages 65°C 60°C 60°C 55°C 55°C 50°C 50°C 45 °C Verify 42°C 40 °C Align First three (or more as needed) sonications 35 °C One or two sonications to make sure we see tremor relief and no side effects Physiological Physiologic Verification Verification Anatomical Localization Fully reversible Making sure spot is aligned in all three planes and not spreading Transition zone Checking for tremor relief, side effects to ensure target location is effective Treat Low Treat High See next slide for lesioning info. Treatment Ablative Treatment Lesion Creating a permanent lesion At 43°c – 240 minutes To create a lesion At 54°c – 3 seconds At 57°c – 1 second