PBL PRESENTATION GROUPS 300A & 300B Facilitators: Dr Jacob Setorglo & Dr Akwasi Anyanful GROUP A GROUP B 1. Kingsley 1. Sylvia 2. Wunfoonin 2. Richard 3. David 3. Louis 4. Emmanuella 4. Kofi 5. Austine 5. Entee 6. Bannerman 6. Adjoa 7. Christabel 7. Esther 8. Abraham 8. Branda 9. Harriet 9. Daniel 10. Shirley-Anne 10. Ato 11. Caesar 11. Adindaa 2 OUTLINE 1. PROBLEM STATEMENT 2. EFFECTS OF AGING ON BONE METABOLISM 3. EFFECT OF AGEING ON OESTROGEN, LH, FSH AND THEIR FEEDBACK MECHANISM 4. CORRELATION 5. REFERENCES 3 PROBLEM STATEMENT A 48-year old woman who has been having infrequent menses for the past 8 months reports to the hospital with complete cessation of her menses and complains of a racing heart, pain in her bones, painful sexual intercourse, insomnia and hot flashes. After investigations, she is given some calcium supplements. What is her predicament, and how can it be explained? 4 ANATOMY OF THE FEMALE REPRODUCTIVE SYSTEM (OVERVIEW) 5 HISTOLOGY OF THE OVARY • Various groups of cells can be found in the ovary. Examples of such cells include oocytes, theca cells and stromal cells. • However, the cells of hormonal relevance are the granulosa cells and the theca cells. • Granulosa cells are responsible for the production of oestrogen. 6 HYPOTHALAMIC PITUITARY OVARIAN (HPO) AXIS 7 EFFECTS OF AGEING ON OESTROGEN, LH, FSH 8 HISTOLOGY OF BONE (OVERVIEW) 9 EFFECTS OF AGING ON BONE METABOLISM 10 SOCIAL SUPPORT FOR THE AGED 11 CORRELATION 12 CONCLUSION •. 13 REFERENCES 1. How your vagina changes as you age. (n.d.). WebMD. https://www.webmd.com/women/ss/slideshow-waysyour-vagina-changes-as-you-age 2. Themes, U. (2016, June 22). Effects of aging on bone. Musculoskeletal Key. https://musculoskeletalkey.com/effects-of-aging-onbone/ 14