][
DRUG STUDY
COURSE
Pharmacology
PRESENTED TO Mr. Ronald Jayson E. Torres, RN
NAME
Deluvio, Donne Louis Raphael D.
SECTION BSN 2B
Name of Drug
Generic Name
Salbutamol
Brand Name
Actimed Salbutamol
Drug Class
short-acting beta-2
adrenergic agonist
Route of Administration
Salbutamol can be
administered through
various routes such as
inhalation, oral,
intravenous,
subcutaneous, and
intramuscular injection.
Dosage
The dosage of salbutamol
varies depending on the
age and condition of the
patient. For adults, the
usual dose is 2-4 mg 3-4
times daily. For children
aged 6-12 years, the
recommended dose is 2
CONCEPT
SUBMITTED ON
Respiratory System
October 05, 2023
Mechanism of Action
Indication
Contraindication
Side Effects
Adverse Effects
Salbutamol is a short-acting
beta-2 adrenoceptor agonist
that is used to treat
bronchospasm in conditions
such as asthma and chronic
obstructive pulmonary disease
(COPD). Salbutamol works by
stimulating beta2-adrenergic
receptors, which are
predominantly found in
bronchial smooth muscle.
Activation of these receptors
leads to the activation of adenyl
cyclase and an increase in the
intracellular concentration of
cyclic-3′,5′-adenosine
monophosphate (cyclic AMP).
This increase in cyclic AMP
leads to the activation of
protein kinase A, which inhibits
the phosphorylation of myosin
and lowers intracellular ionic
calcium concentrations,
resulting in relaxation of the
smooth muscles of all airways,
from the trachea to the
terminal bronchioles.
Salbutamol is only weakly
Salbutamol is a medication
used to relax and open up
airways, and is commonly
used to relieve symptoms
of asthma and chronic
obstructive pulmonary
disease (COPD). It is also
used to prevent asthma
symptoms which occur
with exercise or on
exposure to an allergen,
such as cat or dog fur,
pollen or house dust.
Salbutamol injection is also
used for the management
of uncomplicated
premature labour between
22 and 37 weeks of
pregnancy.
Salbutamol is a medication
used to relax and open up
airways, and is commonly
used to relieve symptoms
of asthma and chronic
obstructive pulmonary
disease (COPD).
Healthcare providers
should exercise caution
when administering
salbutamol to patients
with a history of heart
problems, high blood
pressure, diabetes, low
levels of potassium in the
blood, seizure, overactive
thyroid, or any allergy.
Salbutamol should also be
used with caution in
pregnant and
breastfeeding women.
Salbutamol is a medication
used to relax and open up
airways, and is commonly
used to relieve symptoms
of asthma and chronic
obstructive pulmonary
disease (COPD). Some
common side effects of
salbutamol include feeling
shaky, headache, muscle
cramps, and nervous
tension. Other side effects
may include dry mouth,
irritated throat, dizziness,
lightheadedness,
heartburn, loss of
appetite, altered taste
sensation, restlessness,
anxiety, trembling,
sweating, and palpitations.
Serious side effects are
rare but may include
worsening bronchospasm,
irregular heartbeat, and
low blood potassium
levels. If you experience
any of these serious side
effects or if your breathing
Per Organ System Adverse
Effects.
Salbutamol is a fast-acting
bronchodilator and
reliever medication that
works by stimulating the
beta-2 adrenoceptors in
your bronchial muscles,
which are the smooth
muscles lining the two
Salbutamol may interact
with other medications
such as beta-blockers,
digoxin, diuretics, tricyclic
antidepressants,
monoamine oxidase
Cardiovascular
Palpitations, tachycardia,
chest pain, arrhythmias
Central nervous system
Tremors, headache,
nervousness, restlessness
Gastrointestinal
Nausea, vomiting
Respiratory
Paradoxical bronchospasm
Skin
Rash.
Nursing Responsibilities
Salbutamol is a medication used
to treat bronchospasm in
conditions such as asthma and
chronic obstructive pulmonary
disease (COPD). Here are some
nursing responsibilities relevant
to the care and management of
patients taking salbutamol:
Assessment
- Check the patient's medical
history, including allergies, and
assess the patient's respiratory
status before administering
salbutamol.
- Monitor the patient's vital signs,
including blood pressure, heart
rate, respiratory rate, and oxygen
saturation before and after
administering salbutamol ⁷.
- Assess the patient's lung sounds
before and after administering
salbutamol.
- Monitor the patient for adverse
reactions such as rapid heartbeat,
chest pain, and allergic reactions
such as rash, itching, and
swelling.
1
DRUG STUDY
GENERIC NAME
Name of Drug
Mechanism of Action
mg 3 or 4 times daily; for
children aged 2-6 years,
the recommended dose is
1-2 mg 3 or 4 times daily.
Elderly patients should be
given the lower dose
initially.
Salbutamol
bound to plasma proteins and
is not metabolized in the lung
but is converted in the liver to
the 4'-o-sulphate (salbutamol
4'-O-sulfate) ester, which has
negligible pharmacologic
activity. It may also be
metabolized by oxidative
deamination and/or
conjugation with glucuronide.
Salbutamol is ultimately
excreted in the urine as free
drug and as the metabolite.
Onset:
The onset of action for
salbutamol is usually within 5
minutes after inhalation
Peak Action:
peak effects occurring within
30-60 minutes and lasting for 35 hours
Duration:
The onset of action for oral
salbutamol is usually within 30
minutes, with peak effects
occurring within 2 hours and
lasting for 4-6 hours.
Pharmacokinetics (ADME)
Salbutamol is readily absorbed
from the gastrointestinal tract
and is subject to first-pass
metabolism in the liver and
NAME
Torres, Ronald Jayson E.
BRAND NAME
Indication
Actimed Salbutamol
Contraindication
large tubes (bronchi) that
carry air from your
windpipe (trachea) to your
lungs. This causes your
bronchi to relax and dilate,
widening your airway for a
short period of about 4 to
6 hours and making it
easier for you to breathe.
Salbutamol can be used to
treat or prevent
bronchospasm in patients
with asthma, bronchitis,
emphysema, and other
lung diseases. It can also
be used to treat acute
episodes of bronchospasm
caused by bronchial
asthma, chronic bronchitis,
and other chronic
bronchopulmonary
disorders such as chronic
obstructive pulmonary
disorder (COPD).
Salbutamol can also be
used as a bronchodilator in
patients with cystic
fibrosis.
inhibitors (MAOIs), and
other sympathomimetic
drugs. The use of
salbutamol with these
medications may increase
the risk of side effects such
as heart palpitations,
tremors, and nervousness.
Therefore, it is important
to inform your healthcare
provider about all the
medications you are taking
before using salbutamol.
Side Effects
DRUG CLASS
Adverse Effects
suddenly becomes more
difficult after using
salbutamol, contact your
healthcare provider
immediately.
Nursing Responsibilities
Diagnosis
- Identify the patient's need for
bronchodilator therapy based on
their medical history and physical
examination.
Planning
- Develop a care plan that
includes the frequency of
administration of salbutamol
based on the patient's condition
and response to treatment.
- Educate the patient on how to
use the inhaler or nebulizer
correctly.
Intervention
- Administer salbutamol as
prescribed by the physician.
- Monitor the patient for adverse
reactions to salbutamol.
- Educate the patient on how to
recognize and manage adverse
reactions to salbutamol.
Evaluation
- Evaluate the effectiveness of
salbutamol in relieving
bronchospasm by assessing the
patient's respiratory status before
and after administration of the
medication.
- Monitor the patient for adverse
reactions to salbutamol and
It is important to note that
salbutamol should only be
used as directed by your
healthcare provider. If you
experience any side effects
or if you're breathing
COURSE
short-acting beta-2 adrenergic agonist
Pharmacology
CONCEPT
Reproductive System
2
DRUG STUDY
GENERIC NAME
Salbutamol
Name of Drug
Mechanism of Action
possibly in the gut wall ¹. The
main metabolite of salbutamol
is an inactive sulfate conjugate.
Salbutamol is ultimately
excreted in the urine as free
drug and as the metabolite.
After oral administration, 5878% of the dose is excreted in
the urine in 24 hours,
approximately 60% as
metabolites. A small fraction is
excreted in the feces.
BRAND NAME
Indication
Actimed Salbutamol
Contraindication
Side Effects
DRUG CLASS
Adverse Effects
suddenly becomes more
difficult after using
salbutamol, contact your
healthcare provider
immediately.
short-acting beta-2 adrenergic agonist
Nursing Responsibilities
report any adverse reactions to
the physician immediately.
Assessment Findings to Watch
Out For
- Rapid heartbeat
- Chest pain
- Allergic reactions such as rash,
itching, and swelling
- Feeling shaky
- Headache
- Muscle cramps
Salbutamol is a direct-acting
sympathomimetic that acts on
beta-2 receptors to relax
bronchial smooth muscle with
less prominent effect on the
heart. It activates adenyl
cyclase, the enzyme that
stimulates the production of
cyclic adenosine-3', 5'monophosphate (cAMP).
Increased cAMP leads to
activation of protein kinase A,
which inhibits phosphorylation
of myosin and lowers
intracellular ionic Ca
concentrations, resulting in
muscle relaxation.
Reference: ACTIMED SALBUTAMOL Watsons Health Hub.
https://watsonshealth.com.ph/actimedsalbutamol/.
NAME
Torres, Ronald Jayson E.
COURSE
Pharmacology
CONCEPT
Reproductive System
3
DRUG STUDY
GENERIC NAME
Name of Drug
Mechanism of Action
NAME
Torres, Ronald Jayson E.
Salbutamol
BRAND NAME
Indication
Actimed Salbutamol
Contraindication
COURSE
Pharmacology
Side Effects
DRUG CLASS
Adverse Effects
CONCEPT
short-acting beta-2 adrenergic agonist
Nursing Responsibilities
Reproductive System
4