SpecAWKTM Plus
Chinese Herbal Extration
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Index
SpecAWKTM Plus
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Background
Skin aging---Intrinsic & Extrinsic
ROS
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Background
ROS
Inflmamation
MAPK
pathway
Lipid
peroxidation
DNA
Translation
MMPS
Amino
crosslinking
Melanin
Collagen
break down
Collagen
denaturationBrown yellow
rubbish
Skin ageing, skin is dark yellow without gloss
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Background
Principles of Traditional Chinese Medicine
Traditional Chinese Medicine (TCM) prescriptions usually contain several herbs called a
“fufang”. This formulation is based on the principle of “Jun-Chen-Zuo-Shi(君-臣-佐-使)”.
Jun(emperor) treats the main cause of the disease.
Chen(minister) enhances the actions of “Jun” or treats accompanying symptoms.
Zuo(adjuvant) reduces or eliminates possible toxic effects of the Jun or Chen herbs but also
treats accompanying symptoms.
Shi(courier) helps to deliver or guide the other herbs to the target organs.
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Background
The advantage of Multi-target
Water exchange channel
+
+ ...
Channel of ions exchange, Na , K ,
Channel of sugar entrying
Channel of amino acids movement
..
.
. .
Channel f or e g uric acid, excretion
Channel f or other organic compounds, like medicines, metablization
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Background
The advantage of Multi-target
M1
M2
Three compounds connect diff erent position targets
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M3
Background
The advantage of Multi-target
The shortage of single-target drugs
At the beginning, the antibacterial effect of Penicillinis very good. Thousands of soldiers were saved by
Penicillinis during the World War II.
Dr. Fleming's discovery of penicillin occurred in 1928.
In 1940, Howward Walter Florey from Australia and Boris Ernst Chain from England succeeded in separating the pure
products.
Penicillin was used to treat infections in 1943.
The three men won the Nobel Prize.
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Background
The advantage of Multi-target
Why is the antibacterial effect not as good as it used to be?
A single compound acts on a single target.
Bacterias have evolved to become resistant, they can produce an enzyme which can
hydrolyzes the active structures of penicillin.
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Background
The advantage of Multi-target
Radix isatidis——A representative TCM
It has not been reported to be resistant to antiviral or antimicrobial
action for hundreds of years.
The reason is the multimolecular interaction in Chinese medicine.
Multi-targets attack and inhibit on bacteria.
So it is difficult for bacteria or viruses to establish resistance to multimolecule, multi-target drugs.
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Background
The advantage of TCM
Traditional Chinese Medicine from Tu’s winning of Nobel Prize.
Traditional Chinese Medicine is very scientific, safe and effective.
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Key Ingredients
Scutellaria baicalensis Georgi
（黄芩）
Gastrodia
（天麻）
Panax Ginseng
（人参）
Glycyrrhiza uralensis Licorice
（甘草）
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Poria cocos extract
（茯苓）
Salvia Miltiorrhiza
(丹参）
Lycium Chinese
（枸杞）
Paeonia Suffruticosa Root Bark
（丹皮）
Panax notoginseng
（三七）
Carthamus Tinctorius Flower
（红花）
Key Ingredients
Study 200 TCM
Screening for
10 years
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Best ratio of
10 TCM
Extract by
Ethanol
Patented
technology
Effective
product
Identification
TLC
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HPLC fingerprint
Identification
Triterpenoid saponin：Ginsenoside, notoginsenoside etc
Flavonoids：
Licoflavone
Functions:
Strengthening circulation of blood
Anti-inflammation
Anti-oxidation
Whitening
Promote the production of collagen
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Identification
INCI Name：
Panax Ginseng root extract(rensheng）—— Strengthening circulation of blood, Anti-oxidation
Poria cocos sclerotium extract (fuling)—— Anti-inflammation, Astringent
Salvia Miltiorrhiza extract(dansheng）—— Anti-inflammation, Anti-oxidation, Moisture
Paeonia suffruticosa root extract（danpi）—— Anti-inflammation, Strengthening circulation of blood
Panax Notoginseng root extract(sanqi）—— Strengthening circulation of blood, Anti-oxidation
Gastrodia Elata Root Extract(tianma）—— Anti-oxidation, Conditioning
Glycyrrhiza uralensis(Licorice) root extract（gancao）—— Anti-inflammation, Anti-oxidation
Carthamus Tinctorius flower extract(honghua）—— Strengthening circulation of blood, Anti-oxidation
Scutellaria Baicalensis root extract（huangqin）—— Anti-inflammation, Anti-oxidation
Lycium Chinese root extract（gouqi）—— Anti-oxidation
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Efficacy
In-Vitro tests---Promoting collagen synthesis
Result:
Collagen secretion rate increased linearly with increasing concentration, 80.5 ug/mL SpecAWK TM Plus
can promote 50% collagen secretion.
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Efficacy
In-Vitro tests-----Anti-oxidation
Anti-Oxidation of SpecAWK TM Plus
Anti-oxidation
120.00%
100.00%
80.00%
66.95%
60.00%
53.90%
40.00%
20.00%
34.39%
17.59%
96.00%
95.46%
95.00%
93.15%
94.00%
93.00%
92.00% 91.48%
91.00%
90.00%
89.00%
95.46%
93.15%
0.07mg/ml 0.09mg/mL
AWK Plus AWK100umVE
Plus
0.00%
0.01mg/Ml
0.02mg/Ml
0.03mg/Ml
0.04mg/Ml 0.07mg/ML 0.09mg/Ml
Result:
The best clearance rate of SpecAWKTM Plus is 95.46% at 0.09 mg/mL, it's better than VE（0.043mg/ml）.
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Efficacy
In-Vitro test--Inhibit formulation of melanin
Tyrosinase inhibition
0.1
0.09
0.08
0.07
0.06
0.05
0.04
0.03
0.02
0.01
0
Vitamin C
SpecAWKTM Plus
Melanin inhibition—cell test
20.00%
18.00%
16.00%
14.00%
12.00%
10.00%
8.00%
6.00%
4.00%
2.00%
0.00%
17.94%
13.00%
20ug/ML
Result:
Result:
Vc≈SpecAWKTMPlus, SpecAWK
almost close to VC.
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200ug/Ml
TMPlus
tyrosinase inhibition is
Melanin Inhibition rate is 13% at the 20 ug/mL ,17.94%
at the 200ug/mL.
Efficacy
In-Vitro test-----Anti-Inflammation
Quantitative analysis of proinflammatory cytokines—— NO, TNF-α and IL-6
Conclusion: The report shows that SpecAWKTM Plus has a significant anti-inflammatory effect.
References: The anti-inflammatory activity of SpecAWKTM plus
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Efficacy
In-ViVo test---Skin Elasticity& Skin Firmness
Product:
5% SpecAWK TM Plus cream
Device:
Detection with Cutometer MPA580
Subjects：
20 females
Age range:
35+ years old
Test Site：
Face
Period:
8 weeks
Test Parameters：
Skin Elasticity& Skin Firmness
Volunteers’ evaluation
Temperature:
20℃- 25℃;
Humidity:
40% - 60%
Application Frequency：
Twice a day after cleaning face in the morning & evening
References：
5% SPECAWK PLUS elasity and firmness improved test report(5% solution SGS)
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Efficacy
In-ViVo test---Skin Elasticity& Skin Firmness
Skin Firmness
Skin Elasticity
0.8
0.71
0.7
0.6
10
0.63
9
8.03
8
0.55
6.65
7
0.5
F3/F4
8.92
F4
0.4
6
5
0.3
4
0.2
3
2
0.1
1
0
0
Baseline
4 weeks
8 weeks
F3/F4 is closer to 1, the skin elasticity is better.
Baseline
4 weeks
8 weeks
The lower the F4, the better the skin firmness.
Result:
Result:
Elasticity of skin improved obviously 15% at 4 weeks,
Firmness of skin improved obviously 10% at 4 weeks,improved
30% at 8weeks.
25% at 8weeks compared with 0 days.
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Efficacy
In-ViVo test---Skin Smoothness&Wrinkle
Product:
5% SpecAWK TM Plus cream
Device:
Detection with Visioscan VC98
Subjects：
20 females
Age range:
35+ years old
Test Site：
Face
Period:
8 weeks
Test Parameters：
Skin Smoothness&Wrinkle
Volunteers’ evaluation
Temperature:
20℃- 25℃;
Humidity:
40% - 60%
Application Frequency：
Twice a day after cleaning face in the morning & evening
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Efficacy
In-ViVo test---Skin Smoothness&Wrinkle
Skin Smoothness
45.5
Sesm
42.4
45.4
42.3
45.3
42.2
SEw
45.2
Skin Wrinkle
42.1
45.1
42
45
41.9
44.9
41.8
44.8
Baseline
4weeks
8weeks
The lower the Sesm is, the smoother the skin.
Baseline
4 weeks
8 weeks
The lower the SEw is, the less the skin winkles
Result:
Result:
The skin smoothness is improved after 4weeks and
The skin wrinkle is improved after 4 weeks,wrinkle
improved 1% at 8 weeks.
reduce depend on the time.
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Efficacy
In-ViVo test---Skin gloss& Skin color
Product:
5% SpecAWK TM Plus cream
Device:
Skin Color
Detection with Colorimeter CL400
Skin Gloss
Detection with Glossymeter GL200
Subjects：
20 females
Age range:
35+ years old
Test Site：
Face
Period:
8 weeks
Test Parameters：
Skin gloss& Skin color
Volunteers’ evaluation
Temperature:
20℃- 25℃;
Humidity:
40% - 60%
Application Frequency：
Twice a day after cleaning face in the morning & evening
References：
5% SpecAWK plus whitening test(SGS)
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Efficacy
In-ViVo test---Skin gloss& Skin color
Skin gloss
Skin gloss
9
8
7
6
5
4
3
2
1
0
Skin Color
8.4 8.2
6.9 6.8
7.5 7.4
left
right
Baseline
4weeks
8weeks
42
41
40
39
ITA° 38
37
36
35
34
33
40.7
39
38.18
37.29
37
left
right
36
Baseline
4weeks
8weeks
Result:
Result:
Comparing with pre-treated, Both left and right side improved
Comparing with pre-treated,The face both left-right sides
10% at 4 weeks, improved about 20% at 8 weeks.
improved 3% at 4 weeks, improved 10 at 8weeks.
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Efficacy
In-ViVo test---Skin lightening
Product:
5% SpecAWK TM Plus cream
Device:
Skin Color
Detection with Colorimeter CL400
Skin Gloss
Detection with Glossymeter GL200
Subjects：
20 females
Age range:
35+ years old
Test Site：
Face
Period:
8 weeks
Test Parameters：
Skin lightening
Volunteers’ evaluation
Temperature:
20℃- 25℃;
Humidity:
40% - 60%
Application Frequency：
Twice a day after cleaning face in the morning & evening
References：
Spec AWK Plus 0.5%.2.5% lightening Test report(SPEC CHEM)
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Efficacy
In-ViVo test---Skin lightening
Skin lightening
L1
L2
L3
69 69
△L (skin lightness)
66
63
62
63
62 62
60
Baseline
64
62
60
2 weeks
4 weeks
8 weeks
0.5% SpecAWK™ Plus
Result:
Skin lightness increased after 4 weeks, improved about 10% after 8 weeks with 0.5% SpecAWK™ Plus treatment.
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Efficacy
In-ViVo test---Skin lightening
80
△L (skin lightness)
70
61
64 65
60
72
69 71
59
71 73 73
63 63
L1
50
L2
40
L3
30
20
10
0
Baeline
2 weeks
4 weeks
8 weeks
2.5% SpecAWK™ Plus
Result:
Skin lightness improved after 4 weeks and 8 weeks, respectively, skin lightness improved 11.3% at 4
weeks, skin lightness improved 14 % after 8 weeks with 2.5% SpecAWK™ Plus treatment.
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Efficacy
In-ViVo test---Skin lightening
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Efficacy
In-ViVo test --- Volunteers’ self-assessment
Skin gloss
Skin brightness
Skin smoothness
Skin moisture
Skin brightening comprehensive
assessment
After 4 weeks treatment（%）（%）
Left cheek
Right cheek
94
94
82
82
88
88
100
100
After 8 weeks treatment（%）（%）
Left cheek
Right cheek
100
100
88
88
100
100
100
100
100
100
After 8 weeks of treatment, the satisfaction of the skin brightening evaluation was 100%.
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Summary
Elastin+
Inflmamation--
Collagen+
Melanin -
Yellowing-Gloss++
Skin
Whitening++
Antidullness++
Skin tone
up++
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Roughness-
Smoothness+
Wrinkle--
Skin Healthy
+++
SpecAWKTM Plus
Firmness++
Safety
Free from pesticide residue
Heavy metal and microbiology——Pass
No Phototoxicity
References：
AWK pesticide residue test 农药残留检测（无农残）En
Heavy metal and microbiology
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Stability
pH(Acid)
Experimental procedure:
Sample dissolved in mixture of
water-ethanol (1/1, V/V), HCl was
added to adjust its pH values
pH=6.5, HPLC analysis, room
temperature
pH=2.0, temperature: 50 ℃
Lasted 2 months.
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Stability
Temperature
Experimental procedure:
Room temperatures.
Lasted two months
50℃
Lasted 2 months
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Formulation
Multi-target natural whitening cream
Product Name
Dosage(%)
Supplier
3.5
SC
1.5
SC
SpecKareTMGTCC
CC
INCI Name
Cetearyl Glucoside (and)Cetearyl
Alcohol
POTASSSIUM CATYL
PHOSPHATE
Caprylic/Capric Triglyceride
Carbonicacid,dioctylester
1
3
SC
Shea Butter
Shea Butter
1
SC
DC200
SpecThemTM C1618
Dimethicone
Cetostearyl Alcohol
2
2
SC
SpecThemTM GMS
Glyceryl Monostearate
1
SC
SpecKareTM3GF
Glyceryl linoleate,Glyceryl
oleate,Glyceryl linolenate
3
SC
1
1
4
2
0.15
To 100
3
0.2
0.1
1
1
SC
SpecSufcTM
M68
SpecSufcTM P1601
A
SpecKareTM
B
VEA
Glycerin
SpecKareTM NMF50
SpecKareTM TRHL
SpecThemTM XTG200
Water
SpecAWKTM Plus
SpecKareTM ALLA
EDTA-2Na
SpecWhiteTM VB3
SpecKareTM HAL
C
SIMULGEL EG
SpecKareTM NK2
D
ParbFree® PCG
Frangace
Tocopheryl Acetate
Glycerin
Betaine
Trehalose
Xanthan Gum
Aqua
Allantion
Disodium EDTA
Nicotinamide
Sodium Hyaluronate
Sodium Acrylate / Sodium
Acryloyldimethyl Taurate
Copolymer & Isohexadecane&
Polysorbate 80
Dipotassium Glycyrrhizinate
Caprylyl Glycol（and）
Phenoxyethanol
SC
SC
SC
SC
SC
SC
0.5
0.05
SC
0.5
SC
0.1
References： Multi-target natural whitening cream（3%SpecAWK PLUS）
SpecAWKTM Plus
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Formulation
SpecAWKTM Plus Cream color
SpecAWKTM Plus：0.2%
Color:White
SpecAWKTM Plus：1.5%
Color:off-White
SpecAWKTM Plus
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SpecAWKTMPlus ：0.5%
Color:White
SpecAWKTM Plus：1.0%
Color:White
SpecAWKTM Plus：2.0%
Color:off-White
SpecAWKTMPlus：5.0%
Color:Slight yellow White
Market products
资生堂悦薇珀翡紧颜亮肤乳
SHISEIDO VITAL-PERFECTION
WHITE REVITALIZING EMULSION
——Panax Ginseng root extract
雅诗兰黛肌透修护眼部精华霜
Estee Lauder Advanced Night Repair Eye
Synchronized Complex II
——Poria cocos sclerotium extract
资生堂百优优效修护精华液
SHISEIDO BIO-PERFORMANCE
SUPER CORRECTIVE SERUM——
Carthamus Tinctorius flower extract
SpecAWK
TM Plus
科颜氏新集焕白均衡亮肤淡斑精
华液
KIEHL‘S DERMATOLOGIST
SOLUTIONS CLEARLY
CORRECTIVE DARK SPOT
S O L U T I O N ——Paeonia
suffruticosa root extract
雅诗兰黛肌透修护眼部密集精华露
Estee Lauder Advanced Night Repair Eye
Serum Synchronized Complex II——
Scutellaria Baicalensis root extract
SpecAWKTM Plus
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Product information
Product Name：
SpecAWKTM Plus
INCI Name：
References PPT page 16
Dosage：
Daily care(anti-aging) products:0.5%.
Repair products (fade lines, wrinkles):1.0%.
Lifting,whitening products:2.5%.
Freckle and anti-wrinkle products:5%.
Usage:
It's very stable, it can be added before or after
emulsion.
Package:
1KG/5KG/25KG
Storage：
Keep in dark and cool palce
Shelf life：
3 years
Application：
Lotion/Emulsion/Serum/Cream
Preservative Free：
SpecAWKTM Plus
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Qualified Materials
Thank you !
In need of samples and technical data,please do not hesitate to contact us.
CONTACT
Email: sc@specchemind.com
Tel:
86 25 84523390, 84523391
Fax:
86 25 84520790, 84520791
No.10 Wanshou Rd, Nanjing P.R. China
Zipcode: 211800