MBME 603 Biomaterials Science & Engineering Week 2 Processing of Biomaterials Cevat Erişken, PhD Department of Chemical and Materials Engineering 1 Processing of polymers • Polymer films: solution casting 2 Processing of polymers • Polymer films: solution casting 3 Processing of polymers • Polymer films: melt pressing 4 Processing of polymers • Polymer films: melt extrusion 5 Processing of polymers • Polymer fibers: wet spinning 6 Processing of polymers • Polymer fibers: wet spinning 7 Processing of polymers • Polymer fibers: electrospinning 8 Processing of polymers • Polymer fibers: dry spinning 9 Processing of polymers • Shaped polymer articles 10 Processing of polymers • Shaped polymer articles: blow molding 11 Processing of polymers • Shaped polymer articles: blow molding 12 Processing of polymers • Shaped polymer articles: calendaring 13 Polymer Scaffold The optimal chemical and physical configurations Permanent or biodegradable Naturally occurring, synthetic or hybrid materials Compatible with living systems or with living cells in vitro and in vivo Design characteristics are major challenges and should be considered at a molecular chemical level 14 Examples of polymer processing for scaffolds Salt leaching Gas foaming Phase separation (Kim et al., 2005) (Harris et al. 1998) (Sung& Park 1999) Freeze drying Fiber deposition Electrospinning (O’Brien et al., 2004) (Woodfield et al., 2004) (Erisken et al., 2008) 15 Salt leaching http://en.wikipedia.org/wiki/Bone#mediaviewer/File:Illu_compact_spongy_bone.jpg Ozkan + Biomaterials 2009 16 Salt leaching Ozkan + Biomaterials 2009 17 Gas foaming 18 Gas foaming 19 Phase separation He + 2014 J Maerials Chemistry B 20 3D Printing https://www.youtube.com/watch?v=L55EyKB1Lo4 21 Electrospinning 22 Electrospinning 23
