In 2016, Anwar and Chaudhry(2016) found that the depletion of the ozone layers is due to chlorofluorocarbons (CFSc. Chlorofluorocarbons are group of gases that is harmful to the ozone layer. It is a chemical compound that is composed of chlorine (Cl), Flourine (FL), and Carbon (C). The CFCs are used for refrigents, rocket launcher and other products such as plastic foam insulation. When the ozone layer becomes thin, the UV-radiation will enter the earth’s surface. UV-radiation is damaging to health. Too much exposure to UV rays can lead to skin cancer and eye cancer. It has also an adverse effect to the environment. Its impact outspreads to the destruction of aquatic life and quality of air. Consequently, this contribute to global warming. According to Emberson and Pandey (2018), ozone is a good gas that composed the ozone layer. It is a good gas when it is in the stratosphere, but when it is positioned at the troposphere, the ozone gas becomes a threat to human and plants. The agricultural areas that are near from industrial site is prone to harmful effects of ozone. Some of the areas are in the Midwestern United States of America (USA), coast of China, and in Indo-Gangetic plains in the South Asia. The congregation of ozone in these agricultural areas affects the growth of plants that results to reduction of yields. Plants that are damaged by ozone pollution manifests a yellowish color of the leaves. The emissions of substances that contributes to ozone gases do not only affect the area of its origin, but rather it can spread to other continents through hemispheric transport. These areas that has increasing level of ozone is vulnerable to food production and security. Emberson and Pandey (2018) also reported that India's crop production is already affected by high concentration of ozone, suggesting an estimated 14 to 16 percent reduction in harvest of wheat and rice. Adam and Dowe (1988) reported the effects of stratospheric ozone depletion in the agricultural sector of the United States (US). The depletion of the ozone layer is one of the many environmental issues that affects not only the human health, but also the productivity of plants and agricultural crops. In this case, Adam and Dowe (1988) found out that the depletion of the ozone layer negatively affects the agricultural productivity due to the increasing harmful effects of the ultra-violet radiation (UV-B). The variations on the yields of crop contributes to an estimated 0.9 billion dollars of economic losses in US. Meanwhile, the result also suggested that around 1.3 to 2.5 billion dollars is loss from the effects of both the ultra-violet radiation and stratospheric ozone depletion. Ozone layer is vital to all living things on earth as it protects them from the harmful effects of UV-rays. Fahey and Hegglin (2011) presented 20 questions and answers on the depletion of the ozone layer. According to Fahey and Heggler (2011), there is a rigorous thinning of the ozone layer in Antarctica, which is also called the "ozone hole". It was in the 1980s that the ozone hole was first recorded and it has increased in the 20 th century. Meanwhile, in 1989, the Montreal Protocol was formulated and established. It is intended to stop the production and consumption of the substances that cause the depletion of the ozone layer. Fortunately, the protocols were successful in controlling the massive creation and consumption of these substances. If nations will continue to follow and observe the conditions under this international agreement, this will largely help in reducing the gases. The thinning of the stratospheric ozone layer due to the adverse effect of atmospheric pollution has resulted to an increased UV-years at the earth’s surface. According to Normal (2010), the depletion of the ozone layer has an adverse impact on health, particularly on the eyes and the skin. The harmful effects of ultra-violet radiation can cause genetic mutation and the threat of melanoma and non-melanoma cancer of the skin. It is not only dangerous to the eyes and skin, but as well as to the immune system of the body. UV-rays can block the immune responses, specifically the adaptive immune system. Too much exposure to UV radiation can also lead to sun allergy such as Polymorphic Light Eruption (PLE), which happens to estimated 5 to 20 percent of the population. The PLE is manifested by red, itchy, and erupted skin. The harmful effects of the thinning of the ozone layer to human health is one of the major issues that is widespread today. However, to reduce the effect of too much exposure to UV radiation, the use of personal protection is highly encouraged. Emberson, L., & Pandey, D. (2018, April 13). Why ozone levels pose a challenge to food securityHi. Google. Retrieved November 7, 2021, from https://www.google.com/amp/s/www.downtoearth.org.in/news/agriculture/amp/why-ozonelevels-pose-a-challenge-to-food-security-60170. Fahey, W. D., & Hegglin, M. I. (n.d.). 20 questions and answers. Ozone Secretariat. Retrieved November 6, 2021, from https://ozone.unep.org/20-questions-and-answers. Adams, R. M., & Dowe, R. D. (2004, December 17). The economic effects of stratospheric ozone depletion on U.S. agriculture: a preliminary assessment . Journal of Environmental Management. Retrieved November 4, 2021, from https://www.google.com/url?sa=t&source=web&rct=j&url=https://www.scienc edirect.com/science/article/pii/030147979090026S&ved=2ahUKEwjSjv6Tnf7zAhVVL6YKHf kKAlIQFnoECAUQAQ&usg=AOvVaw33FbMsOOdcZVcRwXoL2urg. Anwar, F., & Chaudhry, F. (2016, January). Causes of ozone layer depletion and its effects on human ... Research Gate. Retrieved November 6, 2021, from https://www.researchgate.net/publication/292071680_Causes_of_Ozone_Layer_Depletion_an d_Its_Effects_on_Human_Review. Norval, M. (n.d.). The human health effects of ozone depletion and interactions with climate change. Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology. Retrieved November 4, 2021, from https://pubmed.ncbi.nlm.nih.gov/21253670/.