science: origins & limits can science eventually know everything? two senses of ‘everything’ : i. every true proposition can science eventually know everything? two senses of ‘everything’ : E = mc2 ii. all the fundamental laws of physics practical limits 1. we’re not smart enough List of unsolved problems in physics [Wikipedia] Why does time have a direction? Is the universe heading towards a Big Freeze, a Big Rip, a Big Crunch, or a Big Bounce? Or is it part of an infinitely recurring cyclic model? Does a multiverse exist? Why is there far more matter than antimatter in the observable universe? What is the identity of dark matter? What is the cause of the observed accelerated expansion (de Sitter phase) of the universe? Can quantum mechanics and general relativity be realized as a fully consistent theory? Does nature have more than four spacetime dimensions? Why is gravity such a weak force? Why is it that some cosmic rays appear to possess practical limits 2. the universe has bottomless levels I believe that scientific knowledge has fractal properties; that no matter how much we learn, whatever is left, however small it may seem, is just as infinitely complex as the whole was to start with. [Isaac Asimov] intrinsic limits 1. i. Gödel’s incompleteness theorems [1931] every mathematical system complex enough to include arithmetic contains theorems that cannot be proved true or false within the system. [Gardner, 354] ii. the system cannot demonstrate its own consistency. intrinsic limits like Tarski's undefinability theorem [1936] arithmetical truth cannot be defined in arithmetic. the theorem applies more generally to any sufficiently strong formal system, showing that truth in the standard model of the system cannot be defined within the system. [Wikipedia] intrinsic limits 2. any theory involves axioms, or “brute facts” Why does Earth go around the sun? Because it obeys the laws of gravity. Why are there laws of gravity? Because, Einstein revealed, large masses distort spacetime, causing objects to move along geodesic paths. Why do objects take geodesic paths? Because they are the shortest paths through space-time. Why do objects take the shortest paths? [Gardner, p 355] the endless regress a Theory of Everything: Superstring Theory The multitude of fundamental particles are in fact differing vibrations of one-dimensional “strings”. [google that, to see her is copyraawt ] - image Dalí Galatea of the Spheres, 1952 reductionism reductionism Dalí Galatea of the Spheres, 1952 reductionism Dalí Galatea of the Spheres, 1952 Even if quantum mechanics becomes “explained” as part of a deeper theory - call it X - as Einstein believed it eventually would be, then we can ask “Why X?” There is no escape from the superultimate questions: Why is there something rather than nothing, and why is that something structured the way it is? [Gardner, p. 355] sphere of knowledge “My Design in this Book is not to explain the Properties of Light by Hypotheses, but to propose and prove them by Reason and Experiments.” ] awe before the mystery dark matter filaments passing thru Jupiter [ illustration: Jet Propulsion Laboratory, CalTech ] awe before the mysterium: [Rudolph Otto, 1917] The Lord Reveals His Cosmic Form The Bhagavad Gita, Chapter 11 PHL110: Roland Puccetti’s problem [1963]: how would G know that it knows everything? the problem of unknown unknowns Yahweh PHL923: Jung’s Answer to Job [1952] science: origins & limits the first scientist? the first scientist? Natural Philosophy Philosophy Of Nature the first scientist? :coined by William Whewell in 1833 Hesiod Tell [750-650 B.C] me these things, Olympian Muses, from the beginning, and tell which of them came first. In the beginning there was only Chaos, the Abyss, but then Gaia, the Earth, came into being. Her broad bosom, the ever-firm foundation of all, and Tartaros, dim in the underground Depths, and Eros, loveliest of all the immortals. the One: unchanging & indivisible Parmenides [6th c B.C.] and the goddess greeted me kindly, and took my right hand in hers, and spake to me these words: nor let much-experienced habit force you along this path, to ply an aimless eye and resounding ear and tongue, but judge by logos Zeno’s paradoxes The Dichotomy That which is in locomotion must arrive at the half-way stage before it arrives at the goal. Aristotle, Physics VI:9, 239b10 Thales [624 – 546 B.C.] “All is Water” unity in diversity physical reductionism Anaximander [610 – 546 BC] Why doesn’t it fall? vs Why would it fall? Socratic wisdom: knowing you don’t the temple at Delphi Reality vs appearance R a p h a e l, T h e S c h o o l o f A t h e n Plato [428-424 BC] Reality vs Plato’s Cave appearance Aristotle: [384-322 BC] the specialization of knowledge Physics On the Heavens On Generation and Corruption Meteorology On the Universe On the Soul On Memory On Sleep On Dreams Politics Rhetoric On Divination in Sleep History of Animals Movement of Animals Categories Poetics Physiognomics On Plants On Marvellous Things Heard Mechanics On Indivisible Lines Parts of Animals On Colors Economics On Interpretation A conceptual and historico-linguistic analysis of a definition like mass is the quantity of matter would show us that whatever was and is understood by these words owes much to the fact that the concepts of quantity and of matter were for two millennia inculcated into the minds of men and into their languages, more than in any other way, through the agency of Aristotle's Categories, Physics, and Metaphysics. If energy means something when we read it in the formula e = mc2 we may forget that this "linguistic" tool is the creation of Aristotle . . . . And if potential has assumed so many uses - from social and military contexts to electricity, dynamics, and what not - is it not because we have been trained to handle this term as an indispensable instrument to describe an infinite variety of situations that have something in common, as Aristotle repeated ad nauseam, when making "potency" one of the basic concepts for the understanding of the structure of the world? We have used, misused, abused, eliminated, and reinstated the concepts of substance and essence. Relation and analogy, form, cause, alteration of qualities, and development from potentiality to actuality are all terms that have not yet stopped serving their purpose. [from the Gillespie Dictionary of Scientific Biography, 1970-1980] science: origins & limits 99 : free animal 1 free animal : 1 human : 99 : human + livestock ‘the City’ Tuttle, “Reductionist Science and Religion” pasadosafehaven.org herding culture: :based on control & commodification of animals :its religion & science both reductionist reductionism “analysis” from PIE root *leu- "to loosen, divide, cut apart" reductionism “vivisection” an estimate: 115 million animals per year, worldwide The Peter Gilgan Centre, Sick Kids Hospital Maternal-pup interaction disturbances induce longlasting changes in the newborn rat pulmonary vasculature. Jaques Belik et al. Am J Physiol Lung Cell Mol Physiol, 2015 from a study on cardiac injury in neonatal mice: Briefly, P1 or P7 pups were randomized and anaesthetized by hypothermia for 5 min prior to thoracotomy. To induce MI, the left anterior descending (LAD) coronary artery was ligated with a 6–0 non-absorbable polypropylene suture (Medtronic, Minneapolis, MN, USA). For apical resection, the apex of the heart was resected using fine scissors. [1 the mice "were allowed to recover under a heat lamp before being returned to their mother." they "were sacrificed 1 or 3 weeks after surgery by decapitation according to approved protocols and hearts were collected for analysis.“ 1 1 Ezh2 is not required for cardiac regeneration in neonatal mice. PLoS One. 2018 Feb 21. Ronald Cohn et al. Maintaining skeletal muscle mass: lessons learned from hibernation. Exp Physiol, 2014 "We analysed the molecular pathways upregulated during hibernation in an obligate hibernator, the 13lined ground squirrel . . . . We extended our observations to non-hibernating animals and demonstrated that SGK1-null mice developed muscle atrophy. These mice displayed an exaggerated response to immobilization and starvation." from a study on fear and the mammal brain: Mice were trained with a single foot shock (0.4 mA, Training), and 24hrs later tested (Test 1). Twenty-four hrs after the Test 1, the mice received systemic injections of MEM (50 mg/kg body weight (bw)) or vehicle (VEH) once a week for four weeks (MEM-4 or VEH group). Another group received an injection of MEM only 24hr after Test 1 (MEM-1 group). Contextual fear memory was assessed again four weeks after initial training (Test 2). All groups displayed comparable and high freezing response levels during Test 1. In contrast, the MEM-1 and -4 groups showed reduced freezing compared to the VEH group in Test 2 (Figure 1A), although this reduction was only statistically significant in the MEM-4 group. These observations were consistent with previous findings (Akers et al., 2014), and indicated that post-training MEM treatment enhanced forgetting in a dose-dependent manner.1 1 Hippocampal neurogenesis enhancers promote forgetting of remote fear memory after hippocampal reactivation by retrieval. Elife. 2016 Sep 26. Temple Grandin slaughterhouse 1. 2. 3. 4. 5. The command of Allah is coming, so be not impatient for it. Exalted is He and high above what they associate with Him He sends down the angels, with the inspiration of His command, upon whom He wills of His servants, [telling them], "Warn that there is no deity except Me; so fear Me.“ He created the heavens and earth in truth. High is He above what they associate with Him. He created man from a sperm-drop; then at once, he is a clear adversary. And the grazing livestock He has created for you; in them is warmth and [numerous] benefits, and from them you eat. [An-Nahl, 1-5] S a u l t a k e s p ri s o n e r s a n d c a tt l e [ M o r g And they were helped against them, and the Hagarites were delivered into their hand, and all that were with them: for they cried to God in the battle, and he was intreated of them; because they put their trust in him. And they took away their cattle; of their camels fifty thousand, and of sheep two hundred and fifty thousand, and of asses two thousand, and of men an hundred thousand. [1 Chronicles 5:20-21] img sources / links / permissions s2 commons.wikimedia.org/wiki/File:Bloch-SermonOnTheMount.jpg s9 commons.wikimedia.org/wiki/File:Infinite_regress_en.svg s11 commons.wikimedia.org/wiki/File:Open_and_closed_strings.svg s 13 en.wikipedia.org/wiki/File:Periodic_Table_Of_Elements.svg s14 commons.wikimedia.org/wiki/File:Standard_Model_of_Elementary_Particles.svg s16 commons.wikimedia.org/wiki/File:Sphere_-_monochrome_simple.svg s17 single page-scan of PD text [e.g. gutenberg.org] s18 www.jpl.nasa.gov/spaceimages/details.php?id=PIA20178 s19 commons.wikimedia.org/wiki/File:Krishna_shows_Arjuna_his_universal_form_(bazaar_art_by_C._Konddiah_Raja ,_c.1950%27s.jpg s20 en.wikipedia.org/wiki/Yahweh#/media/File:Zeus_Yahweh.jpg s21 en.wikipedia.org/wiki/Job_(biblical_figure)#/media/File:Job_and_his_friends.jpg s19 commons.Wikimedia.org/wiki/File:Krishna_shows_Arjuna_his_universal_form_(bazaar_art_by_C._Konddiah_Raj a,_c.1950%27s.jpg s23 commons.wikimedia.org/wiki/File:GodfreyKneller-IsaacNewton-1689.jpg s24 single page-scan of PD text e.g. gutenberg.org s26 commons.wikimedia.org/wiki/File:Hesiod_and_the_Muse.jpg s27 commons.wikimedia.org/wiki/File:Parmenides.jpg s28 commons.wikimedia.org/wiki/File:14.25_Sophia_(Wisdom)_in_the_Celsus_Library_in_Ephesus.JPG s29 commons.wikimedia.org/wiki/File:Zeno_Dichotomy_Paradox_alt.png s30 upload.wikimedia.org/wikipedia/commons/e/e0/Clouds_over_the_Atlantic_Ocean.jpg s31 commons.wikimedia.org/wiki/File:PSM_V10_D563_Anaximander_cylindrical_earth.jpg s32 en.wikipedia.org/wiki/File:Socrates_Louvre.jpg s33 commons.wikimedia.org/wiki/File:Temple_of_Apollo_in_Delphi_01.jpg commons.wikimedia.org/wiki/File:John_Collier_-_Priestess_of_Delphi.jpg s34 commons.wikimedia.org/wiki/File:Sanzio_01_Plato_Aristotle.jpg s35 commons.wikimedia.org/wiki/File:Allegory_of_the_Cave._Plato,_The_republic,_Book_VII.jp s36 / s37 commons.wikimedia.org/wiki/File:Sanzio_01_Plato_Aristotle.jpg s39 xkcd.com/1338/ s41 google maps detail s42 pasadosafehaven.org s43 en.wikipedia.org/wiki/File:Bison_skull_pile_edit.jpg commons.wikimedia.org/wiki/File:Battery_hens_-Bastos,_Sao_Paulo,_Brazil-31March2007.jpg commons.wikimedia.org/wiki/File:Shooting_Buffalo_BAH-p242.png commons.wikimedia.org/wiki/File:Livestock_chicago_1947.jpg s45 commons.wikimedia.org/wiki/File:Lascaux-IV_26.jpg commons.wikimedia.org/wiki/File:Polish_beef_cuts.PNG commons.wikimedia.org/wiki/File:Beef_cuts_Brazil.svg s47 commons.wikimedia.org/wiki/File:Lab_mouse_mg_3263.jpg s48 commons.wikimedia.org/wiki/File:The_Peter_Gilgan_Centre_for_Research_and_Learning.jpg s50 commons.wikimedia.org/wiki/File:GMAP210neonatesc.jpg s53 Grandin, Temple. (2009). How does visual thinking work in the mind of a person with autism? A personal account. Philosophical transactions of the Royal Society of London. Series B, Biological sciences. 364. 1437-42. 10.1098/rstb.2008.0297. s54 commons.wikimedia.org/wiki/File:High_Priest_Offering_Sacrifice_of_a_Goat.jpg commons.wikimedia.org/wiki/File:Nepal-animal-cruelty-2.jpg commons.wikimedia.org/wiki/File:Animal_sacrifice_at_Eid_at_Adha_11.jpg en.wikipedia.org/wiki/File:Solomon%27s_Temple_Jerusalem.jpg s56 themorgan.org/collection/crusader-bible/48