NEONATE FROM BIRTH TO DISCHARGE (Group 1B) Objectives: ■ Describe the required setup at delivery room to take care of new born. ■ Recognise the common normal/abnormal findings on neonatal physical examination. ■ Understand normal neonatal physiological pattern such as voiding, defecating and feeding. ■ List vaccines that are routinely given to neonates after birth. ■ Know common neonatal screening tests. ■ Recognize and manage common health problems during infancy such as GERD, colic, and constipation. ■ To know about sudden infant death syndrome. THE REQUIRED SETUP AT DELIVERY ROOM TO TAKE CARE OF NEW BORN Zainab Al-Faraj After Delivery ■ Provide three major things: Dryness. Warmth. Suction. ■ Drying the baby and using warm blankets and heat lamps. After Delivery ■ Often a knitted hat is placed on the baby's head. ■ Placing a baby skin-to-skin on the mother's chest or abdomen also helps to keep the baby warm. ■ This early skin-to-skin contact also reduces crying, improves motherinfant interaction, and helps mothers to breastfeed successfully. ■ Stimulating the baby to cry by massage and stroking the skin can help bring the fluid up from the lungs where it can be suctioned from the nose and mouth Health Assessment Immediate resuscitation & life saving techniques Resuscitation measure and monitoring Physical Examination Temperature, Heart Rate and Respiratory Rate Weight, Length and Head Circumference Cord Care Bath Footprints and Identification Bracelets COMMON NORMAL /ABNORMAL FINDINGS ON NEONATAL PHYSICAL EXAMINATION Zainab Al-Faraj Before Examination ■ It is important to first take a good perinatal history which includes: The maternal background. The present pregnancy. Labour and delivery. Infant at delivery. Infant since delivery. Before Examination ■ Whenever possible the infant’s mother should be present. ■ A warm environment is essential to prevent hypothermia. ■ A good light source is important for the examiner to inspect the infant thoroughly. ■ Hand washing is important before any examination. ■ Full exposure of the infant is also essential. Order of Examination Measurements. General inspection. Regional examination. Neurological status. Examination of the hips. Examination of the placenta. Measurements Normal Abnormal Birth weight 2500g to 4000g Below 2500g or above 4000g Length 45 cm to 60 cm Below or above the gestational age Head circumference 32 cm to 38 cm Micro or macrocephaly Gestational age Physical and neurological features of term infants (37–42 weeks) Immature features in preterm infant (below 37 weeks). Postterm infants (42 weeks and above) have long nails. Skin temperature Abdominal wall (36–36.5 °C) or axilla (36.5–37 °C) Hypothermia (below 36 °C) General inspection Normal Abnormal Wellbeing Active, alert Lethargic, appears ill Appearance No abnormalities Dysmorphic features (e.g. Down Syndrome) Wasting Well nourished Soft tissue wasting Colour Pink tongue Cyanosis Pallor Jaundice Plethora Skin Smooth or mildly dry Vernix caseosa Erythema toxicum Dry, marked peeling Meconium staining Petechiae, bruising Regional examination Normal Abnormal Head Caput succedaneum and molding Cephalohematoma Subaponeurotic bleed Asymmetry Anencephaly Hydrocephaly Encephalocoele Eyes Mild edema on the lids Wide or closely spaced Cataracts Ptosis Palate Epstein's pearls High arched or cleft palate Teeth None at birth Extra or primary teeth Tongue Pink Cyanosed, pale, or large Neck Usually short Webbing, torticollis Heart Normal Abnormal Pulses Brachial and femoral pulses easily palpable. 120–160 beats per minute Pulses weak, collapsing, absent, fast or slow or irregular Capillary filling time Less than 4 seconds over chest and peripheries Prolonged filling time if infant cold or in shock Blood pressure Systolic 50 to 70 mm at term Hypertensive or hypotensive Precordium Mild pulsation felt over heart and epigastrium Hyperactive precordium Apex beat Heard maximally to left of sternum Heard best in right chest in dextrocardia Murmurs Soft, short systolic murmur common on day 1 Systolic or diastolic murmurs Heart failure Absent Oedema, hepatomegaly, tachypnea or excessive weight gain Lungs Normal Abnormal Respiratory rate 40-60 breaths per minute. Irregular in REM sleep. Periodic breathing with no change in heart rate or color Tachypnoea above 60 breaths per minute. Gasping. Apnoea with drop in heart rate, pallor or cyanosis Chest shape Symmetrical Hyperinflated or small chest Chest movement Symmetrical Asymmetrical in pneumothorax and diaphragmatic hernia Recession Mild recession in preterm infant Severe recession in respiratory distress Grunting Absent Expiratory grunt in respiratory distress Stridor Absent Inspiratory stridor a sign of upper airway obstruction Percussion Resonant bilaterally Dull with effusion or haemothorax. Hyperresonant with pneumothorax Adventitious sounds Transmitted sounds Crackles, wheeze or rhonchi Abdomen Normal Abnormal Umbilicus 2 arteries and 1 vein 1 artery, 1 vein. Infection. Bleeding or discharge. Hernia. Exomphalos. Liver Palpable 1 cm below coastal margin, soft Enlarged, firm, tender Spleen Not easily felt Enlarged, firm Kidneys Often felt but normal size Enlarged, firm Masses No other masses palpable. Full bladder can be percussed Palpable mass Bowel sounds Heard immediately on auscultation Few or absent Anus Patent Absent or covered Stools Meconium passed within 48 hours of Blood in stool. birth. Yellow stools by day 5. Breastfed White stools in obstructive stool may be green and mucoid jaundice. Offensive watery stools Spine Normal Abnormal Appearance Coccygeal dimple or sinus. Straight spine Sacral dimple or sinus. Scoliosis. Meningomyelocoele Genitalia Normal Abnormal Penis Urethral dimple at center of glans Hypospadias Testes Descended by 37 weeks Undescended Scrotum Well formed at term Inguinal hernia. Fluid hernia Vulva Skin tags, mucoid or bloody discharge Fusion of labia Clitoris Uncovered in preterm or wasted infants Enlarged in adrenal hyperplasia Urine Passed in first 12 hours Poor stream suggests posterior urethral valve Neurological status Normal Abnormal Behavior Alert, responsive Drowsy, irritable Position Flexion of all limbs at term Extended limbs or frog position Movement Active. Moves all limbs equally when awake. Stretches, yawns and twists Absent, decreased or asymmetrical movement. Jittery or convulsions Tone Normal Hyper or hypotonia Cry Good cry when awake Weak, high pitch or hoarse cry Vision Follows a face, bright light or red object Absent or poor following Hearing Responds to loud noise No response Sucking Good suck and rooting reflexes after 36 weeks gestation Weak suck at term Moro reflex Full extension then flexion of arms and hands. Symmetrical Absent, incomplete or asymmetrical response NORMAL NEONATAL PHYSIOLOGICAL PATTERN Afnan Al-Qarni Normal voiding pattern ■ Normal: 1 – 2ml/kg/hr ■ The infant's first urination nearly always occurs in the first 24 hours. ■ the appearance of newborn urine, which can initially be scant and darkly colored ■ Micturition, or urination, occurs involuntarily in infants and young children until the age of 3 to 5 years, after which it is regulated voluntarily. ■ Voiding in the healthy neonate is characterized by small, frequent micturition of varying volumes and interrupted voiding result in incomplete embtying of the bladder. ■ Interrupted voiding is clearly an immature phenomenon since it is seen in 60% of preterm neonates and disappears completely before the age of toilet training. ■ The reason for incomplete emptying in infancy is most likely a physiological form of dyscoordination between the sphincter and detrusor, which interrupts the urinary stream before the bladder is empty. ■ A decrease in voiding frequency, increase in bladder capacity and stepwise improvement in sphincter–detrusor coordination as infants grow helps them to achieve complete continence. ■ Bladder instability is rarely seen in healthy neonates and infants according to urodynamic studies but hyperactivity is suggested in the neonatal bladder with premature voiding contractions after only a few milliliters of filling and with leakage of urine. This latter phenomenon probably explains the low cystometric bladder capacity in this age group. High voiding pressure levels also accompany this low bladder capacity. ■ The normal infant voids approximately 20 times per day. ■ Bladder capacity – Newborn up to 1 week of age BC: 25 ± 10 mL per day – 1 week to 3 months of age BC: 53 ± 13 mL per day ■ During the first 3 years of life the number of voiding episodes, including interrupted voiding, post-void residual urine and voiding during sleep, decreased while bladder capacity increased. A- Sphincter relaxation is present but less complete. B- the start of sphincter relaxation, which precedes the bladder contraction by a few seconds, is indicated (‘start’). Note that a voluntary cessation of voiding (‘stop’) is associated with an initial increase in sphincter EMG and detrusor pressure. A resumption of voiding is associated with sphincter relaxation and a decrease in detrusor pressure that continues as the bladder empties and relaxes. Micturition reflex • When the bladder is full, stretch receptors in the wall of bladder send nerve impulses to the sacral region to the spinal cord. Parasympathetic response by sending signals to the bladder and stimulate contraction of Detrusor muscle and relaxation of the internal urethral sphincter. • This part of the reflex is involuntary and is predominant in infant and young children. Micturition reflex • As the central nervous mature, it acquires voluntary control over the external urethral sphincter. • Urination is controlled by the micturition centre in the pons. This centre receive sensory signals from the bladder and communicates with the cortex about the appropriateness of urination at the moment. At times when it not convenient to urinate, the centre sends back an inhibitory signal to keep sphincter closed and prevent voiding. When decide to urinate this inhibition is removed. The spinal cord instructs the Detrusor muscle to contract and sphincter to open. Normal stooling pattern ■ The infant typically passes a first meconium stool shortly after birth, often within the first hours and typically before 24 to 48 hours. ■ These black, tarry, and sticky stools transition as the mother's human milk production increases. ■ This transition typically occurs in a pattern, often from green/brown to a seedy, loose, mustard yellow appearance. ■ During the first week of life, infants pass a mean of four stools per day, although this is variable depending upon whether infants are breastfed or bottle. ■ It is not rare for an infant to pass stool with nearly every breastfeeding when the mother's milk is in because of the gastrocolic reflex signaling the colon to empty. Normal oral feeding pattern ■ From birth throughout the first 6 months of life, infants will obtain their primary food (milk) through nutritive sucking. ■ Nutritive Sucking Process: The process that allows an infant to obtain food, either maternal milk or infant formula. ■ Sucking is a process integrated by three highly correlated phases: a) expressionsuction, b) swallow and c) breathing. a) expression-suction: ■ Suction component: negative intra-oral pressure to draw milk in the mouth. ■ Expression component: compression of nipple to eject milk into mouth. b) Swallow ■ Oral phase: voluntary part of swallowing. Food bolus is formed and push it to the back of the throat. ■ Pharyngeal phase: starts with the stimulation of tactile receptors in the oral phyranx by the food bolus, the swallow reflex is initiated and is under involuntary control. The tongue blocks the oral cavity to prevent food going back to the mouth, the soft palate blocks entry to the nasal cavity and the vocal cords close to protect the airway to the lungs. The larynx pulled up with epiglottis flipping over covering entry to the trachea. UES opens to allow the passage of food bolus ■ Oesophageal phase: the food bolus is propelled down the oesophagus by peristalsis, the larynx moves down back to the original position. c) breathing ■ During sucking and breathing air does not enter the digestive system. Relaxation of the soft palate and vocal cords allow air entering the nose to move towards the lungs. Contraction of the cricopharyngeus prevents air entering the oesophagus. Infants must cease breathing for approximately half a second to swallow. ■ Respiratory rates during breastfeeding range from 40 to 65 breaths/minute7 and reduce due to increased swallowing during NS. References ■ Wen, J. G., Lu, Y. T., Cui, L. G., Bower, W. F., Rittig, S., & Djurhuus, J. C. (2015). Bladder function development and its urodynamic evaluation in neonates and infants less than 2 years old. Neurourology and urodynamics, 34(6), 554-560. ■ Fowler, C. J., Griffiths, D., & de Groat, W. C. (2008). The neural control of micturition. Nature reviews. Neuroscience, 9(6), 453-66. ■ SillÉn, U. (2001). Bladder function in healthy neonates and its development during infancy. The Journal of urology, 166(6), 23762381. ■ Warren, J. B., & Phillipi, C. A. (2012). Care of the well newborn. Pediatrics in Review, 33(1), 4-18. doi:10.1542/pir.33-1-4 ■ Duong, T. H., Jansson, U. B., Holmdahl, G., Sillén, U., & Hellstrom, A. L. (2010). Development of bladder control in the first year of life in children who are potty trained early. Journal of pediatric urology, 6(5), 501-505. ■ den Hertog, J., van Leengoed, E., Kolk, F., van den Broek, L., Kramer, E., Bakker, E. J., ... & Benninga, M. A. (2012). The defecation pattern of healthy term infants up to the age of 3 months. Archives of Disease in Childhood-Fetal and Neonatal Edition, 97(6), F465-F470. ■ Geddes, D. T., & Sakalidis, V. S. (2016). Breastfeeding: how do they do it? Infant sucking, swallowing and breathing. Midirs Midwifery Digest, 26(1), 95. ■ Rendón Macías, M. E., & Meneses, G. J. S. (2011). Physiology of nutritive sucking in newborns and infants. Boletín Médico del Hospital Infantil de Mexico, 68(4), 319-327. Vaccine and drugs that are routinely given after birth shaikha alsayel Newborn screening ■ Hearing loss ■ Metabolic and genetic disorders ■ Critical congenital heart disease ■ Eyes Hearing loss ■ Automated Auditory Brainstem Response (AABR) ■ Otoacoustic Emissions (OAE) Metabolic and genetic disorders ■ Blood spot" testing, the screen is obtained by analyzing drops of blood placed on special paper. ■ Blood is collected for an initial screen between 24 and 48 hours of life Critical congenital heart disease ■ Using pulse oximetry Eyes ■ Response to light. ■ Pupil response. ■ Ability to follow a target. ■ Visually evoked response testing. ■ Red reflex test References ■ Www-uptodate-com.library.iau.edu.sa. (2018). Login e-Resources Portal | IAU. [online] Available at: https://www-uptodate-com.library.iau.edu.sa/contents/overview-of-theroutine-management-of-the-healthy-newborninfant?search=overview%20of%20rotation%20management%20of%20healthy%20newb orn%20Infants&source=search_result&selectedTitle=1~150&usage_type=default&displ ay_rank=1 [Accessed 12 Nov. 2018]. ■ Chop.edu. (2018). Types of Visual Screening Tests for Infants and Children | Children's Hospital of Philadelphia. [online] Available at: https://www.chop.edu/conditionsdiseases/types-visual-screening-tests-infants-and-children [Accessed 12 Nov. 2018]. ■ HealthyChildren.org. (2018). Purpose of Newborn Hearing Screening. [online] Available at: https://www.healthychildren.org/English/ages-stages/baby/Pages/Purpose-ofNewborn-Hearing-Screening.aspx [Accessed 12 Nov. 2018]. COMMON HEALTH PROBLEMS IN INFANCY Norah jamal alromaih 2150007912 What are we going to cover? GERD Colic constipation Colic ■ Definition and difference between colic and normal crying ■ Epidemiology ■ risk factors ■ Etiology ■ Evaluating the patient and diagnosis ■ Complications Colic ■ Persistent or excessive crying Criteria is Crying for no apparent reason for 3 or more hours in 3 or more days in an apparently healhty infant less than 3 months old Difference between colic and normal crying ■ Paroxysms ■ Qualitative differences ■ Hypertonia ■ Difficulty consoling Epidemiology ■ Prevalence is between 8-40% Risk factors ■ Dissatisfaction in the marital relationship ■ parental perception of stress ■ lack of parental self-confidence during the pregnancy ■ dissatisfaction with the delivery ■ family stress Etiology Unknown – Gastrointestinal disturbance ■ Faulty feeding techniques ■ Cow's milk protein intolerance ■ Lactose intolerance – Biological factors ■ Immature motor regulation ■ Increased serotonin ■ Tobacco smoke exposure – Psychosocial phenomena Evaluation and diagnosis Colic is suspected from history but confirmed retrospectively as it runs the characteristic course History ■ When does the crying occur? – Typically during the evening ■ How long does the crying last? ■ What do you do when the baby cries? – Elicit information about soothing techniques ■ How and what do you feed the baby? – Underfeeding, over feeding and inappropriate feeding ■ How do you feel when your baby cries? ■ How has the colic affected you family? History ■ Feeding, stooling, urination and sleeping patterns ■ Vomiting ■ Prenatal and perinatal history ■ Psychosocial hitory – Parent infant interactions Examination ■ Observe the infant and parent interaction during a bout of crying ■ Assessment of temperament and responsiveness to stimuli ■ Plot growth parameters Examination ■ Assess identifiable causes of prolonged crying in infants – Assess hydration and subcutaneous fat – Assessment of tongue tie – Eye examination – Ear examination – Oropharyngeal examination – Cardiovascular evaluation – Abdominal evaluation – Perineal evaluation – Evaluation of skin and musculoskeletal system – Evaluation of the nervous system Management goals help the parents cope with the child's symptoms prevent longterm sequelae in the parent-child relationship Management ■ Mainstay management is parental support and education ■ Fist line interventions – Address feeding problems and suggest techniques to sooth the infant – Decrease environmental stimuli Complications ■ Child abuse ■ Post partum depression ■ Early cessation of breast feeding What are we going to cover? GERD Colic constipation GER and GERD outline ■ Definitions and basic concepts ■ Clinical manifestations of GERD ■ Clinical approach ■ Treatment What is the difference between regurgitation and vomiting? ■ Regurgitation is effortless reflux ■ Vomiting is forceful expulsion with involvement of abdominal and respiratory muscles Physiological infantile gastroesophageal reflux ■ Effortless retrograde movement of gastric contents upward into the esophagus or oropharynx ■ Common under 12 months up to 30 regurgitations, but declines as age approaches 12 months Factors playing part in GER ■ ■ ■ ■ ■ ■ Liquid diet Horizontal body position Short narrow esophagus Small non compliant stomach Frequent large volume feedings Immature lower esophageal sphincter How to differentiate between GER and GERD? Esophagitis Respiratory complications Poor weight gain and failure to thrive Clinical manifestations of GERD GI related Respiratory related ■ Heartburn ■ Cough ■ Epigastric abdominal pain ■ Wheezing ■ Dysphagia ■ Aspiration pneumonia ■ Failure to thrive ■ Hoarse voice ■ Recurrent hiccups and belching MOTHER COMING TO YOU WORRIED ABOUT HER CHILD WITH FREQUENT REGURGITATION WHAT WILL YOU DO? Uncomplicated GER ■ No warning signals ■ No complications {good weight gain, good feeding, not irritable} ■ History and physical examination is enough, laboratory testing is not required ■ Educate and reassure parents, symptom usually resolve by one year ■ Periodically re-evaluate the patient for new symptoms or warning signals ■ If no improvement by 18-24 months, re-evaluation is required Treatment ■ Mainly lifestyle management, pharmacotherapy is NOT indicated Treatment: lifestyle changes ■ Avoid tobacco smoke exposure ■ Smaller feeding size ■ Empiric trial of milk free diet ■ Thickening feeds ■ Keeping an infant upright for 20 to 30 minutes What are we going to cover? GERD Colic constipation Constipation ■ Definition ■ Differential diagnosis ■ Clinical evaluation: history and physical examination ■ Investigations ■ Treatment Definition of constipation ■ two or fewer stools per week Or ■ Passage of hard pellet like stools for at least 2 weeks Constipation in infants Mostly due to dietary changes However, most important organic causes will be Hirschsprung disease and cystic fibrosis. Differential diagnosis ■ Hirschsprung’s disease ■ Congenital anorectal malformations ■ Neurologic disorders ■ Encephalopathy ■ Spinal cord abnormalities: myelomeningocele, spina bifida, tethered cord ■ Cystic fibrosis ■ Metabolic causes: hypothyroidism, hypercalcemia, hypokalemia, diabetes insipidus ■ Heavy-metal poisoning Clinical evaluation: history The alarming signs Alarming signs Acute signs Chronic signs ■ Delayed passage of meconium ■ Constipation since birth ■ Fever, vomiting and diarrhea ■ Ribbon stools ■ Urinary incontinence or bladder disease ■ Weight loss or poor weight gain ■ Delayed growth ■ Congenital anomalies ■ Family history of hirschsprung disease ■ Rectal bleeding ■ Severe abdominal distension Clinical evaluation: physical examination ■ General ■ Neurological ■ Digital rectal examination Investigations ■ Laboratory – Celiac screening – Urine analysis and culture – TSH – Electrolyte and calcium – Blood lead level ■ Imagine – Abdominal x ray – Barium enema – Spine radiographs ■ Anorectal manometry Treatment of acute constipation ■ Infants who did not start solid food – sorbitol-containing juices (eg, apple, prune, or pear) can be added to formula ■ Infants who did start solid food – sorbitol-containing fruit purees Treatment of chronic constipation ■ Glycerin suppositories or rectal stimulation with a lubricated rectal thermometer. ■ Osmotic laxatives (ex. PEG) for those older than 6 months References ■ Nelson’s essentials of pediatrics ■ Up to date Case ■ A 3-month-old boy is discovered not breathing in his crib this morning. Cardiopulmonary resuscitation was begun by the parents and was continued by paramedics en route to the hospital. You continue to try to revive the child in the emergency center, but pronounce him dead after 20 minutes of resuscitation. You review the history with the family and examine the child, but you are unable to detect a cause of death. How should you manage this situation in the emergency department? What is the most likely diagnosis? What is the next step in the evaluation? DO NOT FORGET THE PARENTS! SUDDEN INFANT DEATH SYNDROME SIDS Sara Abdullah Al Arhain 2150007225 Definition The unexpected death of an infant younger than 1 year of age in which the cause remains unexplained after an autopsy, death scene investigation, and review of clinical history. SIDS is diagnosed by exclusion. Risk factors ■ Premature. ■ Low birth weight. •Winter •It is common between 2 and 4 ■ Smoking mothers months. ■ Drug addict mothers - ■ African American & Native American ■ Infants that have siblings who have died of SIDS Rarely before 4 weeks or after 6 months of age. Causes Divided into two: ✤ Congenital ‣ Cardiac anomalies (arrhythmia, congenital heart disease). ‣ Metabolic disorders ‣ CNS etiologies ✤ Acquired conditions. ‣ infection ‣ accidental trauma ‣ intentional trauma. Mechanism of SIDS ( It is still not very clear) ■ Prone position during sleep, especially on soft bedding. CO rebreathing from sleeping face down 2 ■ Brainstem abnormalities. ■ Maturational delay related to neural or cardiorespiratory control. ■ Prolongation of the Q-T interval ■ Abnormal CNS control of respiration DDX of SIDS Prevention ■ Prenatal measures - Avoid smoking and other substances Mothers should avoid use of tobacco, alcohol, and illicit drugs during pregnancy, as well as after birth. - Regular and continues Prenatal care z Prevention ■ Sleep position and environment - Supine sleep position - Firm sleep surface - Room-sharing without bed-sharing - Avoid soft objects and bumper pads in the bed - Avoid overheating - Pacifier use Prevention ■ Hospital setting - Perinatal care and precautions Immediately after birth, the infant should be given to the mother for skin-to-skin contact. Professional staff should instruct and observe closely during skin-to-skin contact and breastfeeding, to ensure that the infant's face is clear and that the airway is not obstructed, and that the mother remains alert. Appropriate position in the nursery Prevention ■ Other - Breast feeding. - “ Tummy time” when the infant is awake and observed to facilitate the development of shoulder girdle strength and avoidance of occipital plagiocephaly. ■ References Nelson’s essentials of pediatric, 7th edition Pediatric case file, 3rd edition Up To Date THANK YOU ANY QUESTIONS?