Name of Test Purpose Normal Range High Results Mean Low Results Mean BUN (Blood Urea Nitrogen) Indirect measure kidney function 10 – 20 Low blood volume/ dehydration, shock, HF, kidney disease, drug toxicity Liver failure, cirrhosis, overhydration, nephrotic syndrome Creatinine (Cr) Diagnose impaired kidney function Male: 0.6 – 1.2 Female: 0.5–1.1 Kidney disease, heart failure, muscle disease Debilitation, decreased muscle mass Specific Gravity (Urinalysis) Measure urine particle concentration 1.010 – 1.030 Dehydration, pituitary tumor, hypotension, HF, liver failure Distal renal tubular disease, polycystic kidney disease, overhydration, diabetes insipidus Amylase (AMS) Detects & monitors pancreatitis 60 – 120 Pancreatitis Too much insulin production/overdose, hypothyroidism, Addison's, liver disease Glucose (serum) Blood sugar level 70 – 105 Diabetes, stress response, Cushing's, hyperthyroidism, acute/chronic pancreatitis Cholesterol (serum) Risk for CAD < 200 Family high cholesterol/lipid Malabsorption,malnutrition CBC RBC Evaluate anemia Male: 4.5 – 5.3 Female: 4.1–5.1 Illness, high altitude, congenital heart disease, COPD Anemia, hemorrhage, liver cirrhosis WBC Evaluates infection or immunosuppression 5,000 – 10,000 Infection, leukemic cancer, steroid usage, severe sepsis Drug toxicity, bone marrow failure, overwhelming infections, lupus Rapid indirect measurement of RBC count Indirect measurement of red blood cell number and volume Male: 13 – 18 Female: 12 – 16 Congenital heart disease, dehydration, COPD Anemia, cirrhosis, hemorrhage Male: 42 –52% Female36–46% Congenital heart disease, dehydration, COPD Anemia, cirrhosis, hemorrhage 150,000 – 400,000 Malignant disorders, rheumatoid arthritis, anemia Hemorrhage, infection, cancer therapy Hemoglobin (Hgb) Hematocrit (Hct) Platelet Blood ability to clot Coagulation Studies PT Tests extrinsic clotting 11 – 15 seconds Tests coagulation mechanisms 60 – 70 seconds (Activated PTT) More sensitive than PTT 30 – 45 seconds INR Test for coagulation (Prothrombin time) PTT (Partial thromboplastin time) APTT (International Normalized Ratio) D-Dimer > 1.5 – 2.0 *Higher for prosthetic valve Assess for breakdown of a venous clot (DVT, PE) < 0.5 Anticoagulation therapy, DIC, hepatic disease, malabsorption Deficiency factors, anticoagulation therapy Blood too thin, warfarin (Coumadin) therapy DIC, recent surgery, active or recent bleeding, TE, pregnancy, liver disease, inflammation, malignancy, hypercoagulable states Digitalis therapy, diuretic action, vitamin K therapy Extensive cancer, DIC Blood too thick Electrolytes Calcium (Ca) Parathyroid function & Ca2+ metabolism 8.6 – 10.2 Hyperparathyroidism, metastatic tumor to bone, Paget's disease Chloride (Cl) Acid-base status and hydration status 97 – 107 Dehydration, hyperventilation, DM Potassium (K) Fluid/Electrolyte status, heart function 3.5 – 5.0 Excessive intake, kidney disease/failure, Addison's, DKA Sodium (Na) Fluid/Electrolyte status 135 – 145 Increased intake, Cushing's, excessive sweating, diabetes insipidus Magnesium (Mg) Ca/Phosphorus balance 1.3 – 2.3 Renal failure, elderly, antacid overuse Hypoparathyroidism, renal failure, vitamin D defic. Overhydration, HF, pyloric obstruction, respiratory acidosis Deficient intake, diuretics (thiazide), Cushing's, hyperadlosteronism, steroid therapy, malignant HTN, cirrhosis with ascites, chronic diarrhea/vomiting Decreased dietary intake, Addison's, excessive water intake, vomiting/diarrhea, HF, burns, thoracentesis, ascites, SIADH Profound GI losses (suction, diarrhea), small bowel changes, alcoholics, loop diuretics, antibiotics Liver Function Tests (LFTs) 4 – 36 Hepatitis, hepatic necrosis, cirrhosis, hepatic tumor, obstructive jaundice 0 – 35 Heart diseases, liver diseases, skeletal muscle diseases, anemia, pancreatitis Acute renal disease, beriberi, pregnancy, diabetic ketoacidosis, chronic renal dialysis Detect & monitor diseases of the liver or bone 30 – 120 Primary cirrhosis, liver tumor, Paget’s disease, Rheumatoid arthritis, myocardial infarction Scurvy, pernicious anemia, malnutrition, hypophosphatemia, milkalkali syndrome Albumin Diagnose, evaluate, monitor cancer, immune dx, liver dx, nutrition, edema 3.5 – 5 Dehydration Malnutrition, liver disease, pregnancy, overhydration Bilirubin Evaluates liver function and patients with hemolytic anemias 0.3 – 1.0 Gallstones, extrahepatic duct obstruction, liver metastasis, cholestasis from drugs, Dubin-Johnson syndrome, anemias, cirrhosis Ammonia (serum) Supports diagnosis of liver disease 80 – 110 Liver disease, Reye's Syndrome ALT Identify diseases of the liver AST (Aspartate transaminase) Evaluate suspected coronary artery occlusive disease or hepatocellular disease ALP (Alkaline phosphatase) Essential or malignant hypertension