GI/Hepatic DRUG LIST- Reuben 2022
1. Peptic Ulcer Disease
H2 antagonists
cimetidine (gen, TAGAMET)*
ranitidine(gen, ZANTAC)
nizatidine (gen, AXID)
famotidine (gen, PEPCID)
Proton Pump Inhibitors (PPIs)
omeprazole (PRILOSEC)*
esomeprazole (NEXIUM)
lansoprazole (PREVACID)
dexlansoprazole (DEXILANT)
pantoprazole (PROTONIX)
rabeprazole (ACIPHEX)
omeprazole/sodium bicarbonate (ZEGERID)
Surface Protectants
sucralfate (CARAFATE)
bismuth subsalicylate (PEPTO-BISMOL, KAOPEPTATE)
Antacids
calcium carbonate (TUMS, others)
sodium bicarbonate (gen, ALKA SELTZER)
aluminum hydroxide (gen, ALTERNAGEL)
magnesium hydroxide (MILK OF MAGNESIA)
Prostaglandin analog
misoprostol (CYTOTEC)
H. pylori
Proton pump inhibitors
clarithromycin (BIAXIN)
metronidazole (FLAGYL)
amoxicillin (AMOXIL, TRIMOX)
tetracycline (gen, SUMYCIN)*
levofloxacin (LEVAQUIN)
bismuth subsalicylate/metronidazole/tetracycline
(HELIDAC)
bismuth subcitrate/metronidazole/tetracycline
(PYLERA)
2. ANTIEMETICS
5-HT3R Antagonists
ondansetron (ZOFRAN)*
granisetron (KYTRIL)
palonosetron (ALOXI)
dolasetron (ANZEMET)
NK1 Receptor Antagonists
aprepitant (gen, EMEND*)
fosaprepitant dimeglumine (EMEND IV) prodrug
Dopamine Receptor Antagonists
prochlorperazine (COMPAZINE)
promethazine (gen, PHENERGAN, others)
droperidol (INAPSINE)
haloperidol (HALDOL)
metoclopramide (REGLAN)
trimethobenzamide (gen, TIGAN)
Antihistamines
diphenhydramine (gen, BENEDRYL) OTC
dimenhydrinate (DRAMAMINE)
Anticholinergics
hyoscine (SCOPOLAMINE)
scopolamine (gen, TRANSDERM SCOP)
meclizine (gen, ANTIVERT, BONINE)
cyclizine (CYCLIVERT) OTC
Glucocorticoids
dexamethasone (DECADRON)
methylprednisolone (gen, MEDROL)
BZDs
lorazepam (ATIVAN)
alprazolam (XANAX)
diazepam (VALIUM)
Cannabinoids
dronabinol (MARINOL)
nabilone (CESAMET)
3. Inflammatory Bowel disease (IBD)
5-ASA derivatives
sulfasalazine (gen, AZULFIDINE)
olsalazine (DIPENTUM)
balsalazide disodium (gen, GIAZO, COLAZAL)
mesalamine (gen, PENTAZA, ASACOL, others)*
Steroids (Glucocorticoids)
prednisone (gen)
methylprednisolone (gen)
hydrocortisone (gen)
budesonide (gen, ENTOCORT, SYMBICORT, others)
Immunosuppressive agents
azathioprine (gen, AZASAN, IMURAN)
6-mercaptopurine (gen, PURINETHOL)
tacrolimus (gen, PROGRAF)
cyclosporine (gen, SANDIMMUNE, GENGRAF, others)
methotrexate (gen, TREXALL, OTREXUP)
Biologics
infliximab (REMICADE)*
adalimumab (HUMIRA)
certolizumab (CIMZIA)
golimumab (SIMPONI)
natalizumab (TYSABRI)*
vedolizumab (ENTYVIO)
ustekinumab (STELARA)
Antidiarrheal medications (adjunctive)
diphenoxylate + atropine (gen, LOMOTIL)
loperamide (gen, IMODIUM)
4.Irritable bowel syndrome (IBS)
IBS-C
Fiber/bulk forming laxatives
Osmotic laxatives
bisacodyl (gen, CORRECTOL, DUCOLAX)
lubiprostone (AMITIZA)*
linaclotide (LINZESS)*
IBS-D
alosetron (LOTRONEX)*
loperamide*
rifaximin (XIFAXAN)
Atropine* (included as prototype drug)
dicyclomine (gen, BENTYL)
hyoscyamine (ANASPAZ)
Antidepressants (TCAs, SSRIs) used for pain
Idiopathic/Opioid-induced Constipation
lubiprostone (AMITIZA)*
linaclotide (LINZESS)*
VARICEAL HEMORRHAGE
somatostatin
octreotide (gen, SANDOSTATIN)
vasopressin (gen)
propranolol (gen, INDERAL)
nadolol (CORGARD)
Other medications
pancrelipase (PANCREAZE, others )
Ursodiol (gen, URSO 250/FORTE, ACTIGALL)
5. OBESITY and APPETITE
Anorexigenics
Amphetamines
phentermine/topiramate (QSYMIA)
orlistat (XENICAL), Alli OTC
liraglutide (SAXENDA) also a diabetic drug
semaglutide (OZEMPIC, WEGOVY)
topiramate (TOPAMAX) anticonvulsant
phentermine (gen, ADIPEX-P, SUPRENZA)
bupropion (WELLBUTRIN) antidepressant
bupropion-naltrexone (CONTRAVE)
metformin (GLUCOPHAGE)
Appetite enhancers
dronabinol (gen, MARINOL)
megestrol (gen, MEGACE)
corticosteroids
6. Herbal Supplements and Nutraceuticals
Echinacea
Garlic
Ginkgo
Ginseng
St. John’s wort
Glucosamine
Grapefruit juice
7. Overactive Bladder
*Darifenacin (ENABLEX) anticholinergic -dry mouth
Beta-3 receptor agonists
*Mirabegron (MYRBETRIQ)
Vibegron (GEMTESA)
Bolded drugs are some of the more commonly
used. *Drug Class prototype
NOTE: A drug with multiple indications may only
be listed once; however, you are still required to
know those common indications that pertain to that
drug.
The following drugs will not be on the
final exam unless we have already
covered them but I want you to see their
names
ANTIDIARRHEALS
WHO Oral rehydration solution
difenoxin+ atropine (MOTOFEN)
diphenoxylate + atropine (gen, LOMOTIL)
loperamide (gen, IMODIUM)
alosetron (LOTRONEX)* for IBS-D
aluminum hydroxide (ALTERNAGEL)
BILE-SALT-BINDING RESINS
cholestyramine (gen, PREVALITE)
colestipol HCl (gen, COLESTID)
colesevelam (WELCHOL)
bismuth subsalicylate (PEPTO-BISMOL)
octreotide (gen, SANDOSTATIN)*
7. Drugs that Stimulate GI MOTILITY
Cholinergic
bethanechol (gen, DUVOID, URECHOLINE)
neostigmine (BLOXOVERZ) urinary retention
Dopamine receptor antagonists
metoclopramide (REGLAN)
domperidone (investigational new drug program)
erythromycin (gen, ERY-TAB, others) motilin agonist
LAXATIVES
Bulk-forming
methylcellulose (CITROCEL)
psyllium (METAMUCIL)
polycarbophil (FIBERCON, FIBERLAX, others)
Stool softening/Coating
docusate (COLACE, CORRECTOL, DULCOLAX)
glycerin suppositories (FLEET, COLACE, others)
Mineral oil (coating agent)
Osmotic
magnesium citrate (CITROMA)
magnesium hydroxide (MILK OF MAGNESIA)
polyethylene glycol (MIRILAX, MOVIPREP, others)
lactulose (CONSTULOSE, ENULOSE, GENERLAC)
sorbitol (Ora-Sweet SF)[OTC]
sodium phosphate (Fleets Phospho-soda, OsmoPrep,
Visicol)
Stimulant laxatives
bisacodyl (gen, CORRECTOL, DUCOLAX)
Athraquinone derivatives
Aloe
senna (EX LAX, SENOKOT)
cascara
Opioid Receptor antagonists
methylnaltrexone bromide (RELISTOR)
alvimopan (ENTEREG)
Hepatitis and Hepatic Pharmacology
Hepatitis B
Pegylated interferon alfa-2a(Pegasys)
Pegylated interferon alfa-2b (PEG-INTRON)
NRTIs
Adefovir dipivoxil (HEPSERA)
Lamivudine (EPIVIR)
Telbivudine (TYZEKA)
Tenofovir (VIREAD)
Entecavir (BARACLUDE)
Emtricitabine (EMTRIVA)
Hepatitis C
Ribavirin* (VIRAZOLE, REBETOL)
NS5B inhibitors (-buvir)
Sofosbuvir* (SOVALDI) HCV
Dasabuvir (used in combo)
HCV Protease NS3/4A inhibitors (-previr)
Simeprevir* (OLYSIO) HCV
Paritaprevir (used in combo)
Grazoprevir (used in combo)
Telaprevir (INCIVEK)
Boceprevir (VICTRELIS)
NS5A inhibitors (-asvir)
Ledipasvir (in combo)
Daclatasvir (DAKINZA)
Ombitasvir (in combo)
Elbasvir (in combo)
Velpatasvir (in combo)
Fixed Combinations
Elbasvir-grazoprevir (ZEPATIER)
Sofosbuvir-velpatasvir (EPCLUSA)
Ombitasvir, paritaprevir, and ritonavir (TECHNIVIE)
Ombitasvir, paritaprevir, ritonavir, dasabuvir (VIEKIRA)
Ledipasvir-sofosbuvir (HARVONI)