Adipose Tissue in fasting
Name : khidder essam khidder Ibrahim .
ID\N : 577
Supervisor : Doctor \ Mai
In principle , Fasting is generally considered as the
willful refrain from eating and sometimes drinking ,
Fasting is commonly observed around the world to lose
weight or religious practice .
Circulating factors regulating adipose tissue metabolism
during fasting :
The changes in adipose tissue metabolism during fasting
are largely driven by changes in the plasma levels of
various hormones .
Important metabolic hormones whose levels decrease
during fasting include insulin and leptin . Insulin has
enormous effects on adipose tissue metabolism .
Metabolic hormones whose levels increase during
fasting include cortisol, growth hormone, glucagon,
adrenaline, and noradrenaline .
noradrenaline acts as sympathetic-neuronal stimulation .
Adrenaline regulates metabolic pathways of the
hormonal pathway .
Hormonal regulation and major lipid fluxes in the
fasted state. Elevated plasma levels of cortisol,
catecholamines, and growth hormone, in
combination with low levels of insulin, promote
adipose tissue lipolysis by stimulating ATGL activity.
Purple lines represent metabolic routes. Green
lines represent hormonal routes .