Research title: Thyroid hormone is required
for hypothalamic neurons regulating
cardiovascular functions
MCB 136
Discussion Section
10: Research paper
discussion
Check-in question
If arterial pressure is elevated, baroreceptors trigger which of the following
responses:
A. Rise in vasopressin secretion
B. Decrease in sympathetic flow to the heart, arterioles, and veins
C. Increase activity in sympathetic vasoconstrictor nerves
D. Increased in epinephrine secretion
Overview
• Abstract
• Introduction
• Results
• Figure 1 and cardiovascular regulation
Read up until here
Question 1. This paper is an excellent example of which
fundamental physiological principle below? Select one.
A. Homeostasis is essential for health and survival.
B. The functions of organ systems are coordinated with each other.
C. Most physiological functions are controlled by multiple regulatory
systems, often working in opposition
D. Information flow between cells, tissues and organs is an essential
feature of homeostasis and allows for integration of physiological
processes.
Question 2. Justify your choice in question 1
in one or two sentences.
Question 3. Figure 1 in the previous slide shows that mice heterozygous for a
mutation in thyroid hormone receptor α1 (Thra1+/m) have significant changes
in which of the following measures of cardiovascular function (select all that
apply):
A. Systolic blood pressure
B. Diastolic blood pressure
C. Ace expression
D. Systolic blood pressure after T3 treatment
E. Diastolic blood pressure after T3 treatment
F. Angiotensin II expression after T3 treatment
G. Heart rate after T3 treatment
Question 4: Which statement below represents the strongest conclusion
from the results in Fig 1, and why? Select one.
a.
b.
c.
d.
Blood pressure homeostasis does not involve Thra1+ signaling, because
blood pressure is similar in wildtype (WT) and mutant (Thra1+/m) mice.
The effects of mutant Thra1+ on cardiovascular function is similar in mice
and humans.
Impaired T3 signaling in Thra1+/m mice disrupts developmental but not
adult pathways that regulate cardiovascular function, because T3
treatment does NOT restore cardiovascular measures.
Impaired T3 signaling in Thra1+/m mice disrupts both developmental and
adult pathways that regulate cardiovascular function, because T3
treatment restores SOME cardiovascular measures but not others.
Question 5: What happens during diastole?
A.
B.
C.
D.
E.
F.
G.
H.
Ventricles relax
Ventricles contract
Atria relax
Atria contract
Blood pressure decreases
Blood pressure increases
Heart fills with blood
Heart ejects blood
Which of the following can cause a
decrease in mean arterial pressure?
A.
B.
C.
D.
A drop in total peripheral resistance
An increase in a stroke volume of the left ventricle
An increase in heart rate
An increase in venous return