Journal of American College Health ISSN: (Print) (Online) Journal homepage: https://www.tandfonline.com/loi/vach20 Depressive and anxiety symptoms in first generation college students Jonathan K. Noel, Haleigh A. Lakhan, Cara J. Sammartino & Samantha R. Rosenthal To cite this article: Jonathan K. Noel, Haleigh A. Lakhan, Cara J. Sammartino & Samantha R. Rosenthal (2021): Depressive and anxiety symptoms in first generation college students, Journal of American College Health, DOI: 10.1080/07448481.2021.1950727 To link to this article: https://doi.org/10.1080/07448481.2021.1950727 Published online: 27 Jul 2021. Submit your article to this journal Article views: 1063 View related articles View Crossmark data Citing articles: 1 View citing articles Full Terms & Conditions of access and use can be found at https://www.tandfonline.com/action/journalInformation?journalCode=vach20 JOURNAL OF AMERICAN COLLEGE HEALTH https://doi.org/10.1080/07448481.2021.1950727 MAJOR ARTICLE Depressive and anxiety symptoms in first generation college students Jonathan K. Noel, PhD, MPHa, Haleigh A. Lakhan, BSa, Cara J. Sammartino, PhD, MSPHa and Samantha R. Rosenthal, PhD, MPHa,b a Department of Health Science, College of Health & Wellness, Johnson & Wales University, Providence, Rhode Island, USA; Department of Epidemiology, Brown School of Public Health, Providence, Rhode Island, USA b ARTICLE HISTORY ABSTRACT Objectives: Depression and anxiety contribute to the burden of disease among college students. The current study determined if depressive and anxiety symptoms were more prevalent in first generation students and if social and emotional support moderated this relationship. Methods: Depressive and anxiety symptoms were measured in 432 U.S. college students via an online survey. Single items determined student generation status and available social support. The CES-D10 and GAD-7 measured depression and anxiety, respectively. Structural equation modeling was used to identify significant effects. Results: First generation status was associated with increased cognitive-emotional (p = 0.036) and somatic (p = 0.013) anxiety symptoms, but not depression. High social and emotional support appeared to suppress somatic anxiety symptoms experienced by first generation students (p = 0.004). Conclusions: Greater anxiety symptoms in first generation students may be due to increased general and acculturative stress, although more research is needed. Large national surveys of college students should consider adding a question about first generation status. Introduction There were 258 million cases of depression worldwide in 2017, a 50% increase since 1990.1 Currently, depression is a leading cause of disability, as measured by years lived with disability, and is the fourth leading contributor to the global burden of disease.2 Characterized as having low energy, loss of interest, sadness, poor concentration, and low self-worth, depression affects 16 million American adults each year and is more likely to affect women than men.3–5 Worldwide, the lifetime prevalence of depression ranges from ten to fifteen percent. 1 Co-morbid depression and anxiety have been well documented,3 and past-year anxiety prevalence among U.S. adults has been estimated at approximately 21%.6 Undergraduate and graduate students often report symptoms of a mental illness. Results from the American College Health Association (ACHA)-National College Health Assessment (American College Health Association (ACHA)-NCHA) suggest that approximately 20% and 28% of college students report that depression and anxiety, respectively, has interfered in their academic performance over the past 12 months. 7 Over 85% self-reported that they felt overwhelmed by all they had to do over the past year; nearly two-thirds felt very lonely or overwhelming anxiety; and 45% felt so depressed that it was difficult for them to function. A recent systematic review, compiling data across 24 CONTACT Jonathan K. Noel Rhode Island 02903, USA © 2021 Taylor & Francis Group, LLC jknoel@hotmail.com Received 13 November 2019 Revised 10 March 2021 Accepted 25 June 2021 KEYWORDS Depression; anxiety; first generation; students; college articles, suggests that the prevalence of depression in undergraduate students is approximately 31%.8 A study using the Counseling Center Assessment for Psychological Symptoms (CCAPS) survey and a sample of n = 1,056 students from the Midwest United States (U.S.) reported similar results.9 Evidence suggests that there may be disparities in the prevalence of depression and anxiety symptoms between population sub-groups. Disproportionately underrepresented groups are more likely to be exposed to psychological, environmental, systematic, and interpersonal risk factors that may lead to anxiety, and generalized anxiety disorder (GAD) may be more prevalent among lower socioeconomic groups.10 For example, Hispanic patients seeking primary care services may have higher rates of mental illness, which may be moderated by social status or social standing within the community.11 Importantly, first generation college students, defined as the first persons in their immediate family to attend college, may be at increased risk for symptoms of mental illness, although research is limited. For many first generation (first gen) students, post-secondary education comes with added stressors that those whose parents received a college degree are less likely to endure.12 In a survey of 58,000 students, first gen students were more likely to have competing job responsibilities, competing familial responsibilities, weaker math and English skills, and worse study skills.12 Department of Health Science, Johnson & Wales University, 8 Abbott Park Place, Providence, 2 J. K. NOEL ET AL. Lacking these advantages, first gen students may be negatively impacted. First gen students were more likely to feel depressed, stressed, or upset,12 and academic performance may suffer.13 Using data from approximately 36,000 students who participated in the Community College Survey of Student Engagement, grade-point averages (GPA) were significantly lower among first gen students, compared to non-first gen students, regardless of gender, ethnicity, or race,13 and in a sample of 1,864 undergraduates from a large, public research university in the U.S., first gen students were less academically engaged and less likely to graduate. 14 Moreover, the results from 948 freshman and sophomores enrolled in science, technology, engineering, and math (STEM) courses suggest that first gen students are more likely to experience imposter feelings, which occur when an individual feels like they will be exposed as incompetent or unfit.15 Receiving social support, whether emotional, informational or companionate, may moderate the development and severity of depression and anxiety symptoms.16 Positive effects of social support on psychological well-being have been documented,17 and in a systematic review of 34 studies, poor perceived social support was associated with worse depression and anxiety symptoms, lower probability of recovery, and poorer social functioning.18 Among those from ethnic and racial minority groups, low social support has been documented as a predictive factor for the diagnosis of depression.16 In a review of 797 longitudinal studies, poorer perceived social support was associated with worse depressive symptoms and poorer physical functioning.18 A systematic review of 63 articles also documented an association between social support and mental health symptoms.19 Among 45 cross-sectional studies, 33 (73%) found a significant positive association between social support and mental health. The remaining cross-sectional studies either found no significant associations or did not test for the association in the study. Among seven longitudinal studies that assessed the association between social support and depression, two concluded that less social support at earlier time points was associated with depression symptoms later in life. Although health disparities in depressive and anxiety symptoms have been documented across several population groups, the existing literature is sparse regarding symptoms of mental illness in first generation college students. To address this gap, the current study sought to determine if there was an association between first gen student status and depressive and anxiety symptoms in a sample of U.S. college students. Additionally, the study tested whether the relationship between student generation status and depression and anxiety symptoms was moderated by perceived social support. It was hypothesized that depressive and anxiety symptoms would be greater among first gen students but the effect would be limited to those with lower perceived social support. Methods Data The data for the present analysis originates from the Mobile Screen Time Project, which was a cross-sectional Web-based survey that was conducted to determine if mobile screen time was associated with mental health outcomes. Data collection occurred from March to May 2019. Sample and sample recruitment Individuals were eligible to participate if they were 18 years old or older, spoke English and were enrolled in a U.S.-based institution of higher education at the time of survey administration. There were no exclusion criteria. A convenience sample was recruited through several different digital and traditional modalities, including: craigslist.org, Amazon’s Mechanical Turk, Facebook, and Twitter. An invitation to participate was also distributed via email listservs from two colleges and universities located in the northeast U.S. As an incentive, six participants were randomly selected to receive a $25 electronic gift card. A total of 565 individuals initiated the survey by clicking on the link in the study advertisement. Of those, 432 (76.5%) met study eligibility requirements and are included in the current analysis. The remaining 133 individuals were either less than 18 years old or not currently enrolled in a 2-year or 4-year higher education program. Sample recruitment and study protocols were approved by two university Institutional Review Boards. Measures The independent variable was first generation student status, which was measured using the following question: “Are you a first generation college student?” The response options were “Yes” and “No,” which were contrast coded with “No” as the reference group. There were two dependent variables: depressive symptoms and anxiety symptoms. Depressive symptoms were measured using the Center for Epidemiological Study Short Depression Scale (CES-D10).20 The CES-D10 contains 10 items regarding past week experiences of symptoms related to the development of depression (α = 0.83). For example, items include “I felt hopeful about the future” and “I felt lonely.” The response options ranged from “rarely or none of the time,” which was coded as 0, to “all of the time,” coded as 3. Reverse scoring was implemented for two of the items. The CES-D10 has shown strong test/re-test reliability and convergent validity in youth and adult populations.21–23 Anxiety symptoms were measured using the Generalized Anxiety Disorder 7-item scale (GAD-7).24 The GAD-7 measures the experience of nervousness, anxiousness, worrying, difficulty JOURNAL OF AMERICAN COLLEGE HEALTH relaxing, restlessness, annoyance, irritability, and fear over the past two weeks on a 4-point Likert scale that ranges from “not at all” to “nearly every day.” Responses were scored from 0 to 3 for all items. GAD-7 validity and reliability has been demonstrated in adolescents and the general adult population.25,26 Perceived social and emotional support was used as a moderating variable. It was measured using the following question: “How often do you get the social and emotional support you need?” Responses were measured on a 5-point Likert scale ranging from “Never” to “Always,” and responses were coded from 0 to 4. Several covariates were measured. Age was measured as an ordinal variable, and participants were able to indicate if they were ≤ 18, 19, 20, 21, 22, 23, or ≥ 24 years old. Gender was categorized as male, female, or transgender, although persons who were transgender were excluded from the analysis due to low counts (n = 5). Race was measured as Asian, Black/African American, Caucasian, Multiple or Other, and ethnicity was categorized as Hispanic or non-Hispanic. Relative socioeconomic status (SES) was measured using the Macarthur Scale of Subjective Social Status (Macarthur SSS),27 which assesses a person’s perceived rank relative to others in their community, where 1 indicates being the “worst off ” and 10 indicates being the “best off.” Statistical analysis Prior to analysis, the distribution of continuous variables were examined for significant skewness and kurtosis. All were considered normally distributed. Because prior literature suggests that the factor structure of the CESD1028–30 and GAD-731,32 may vary between populations, an exploratory factor analysis (EFA) was conducted. Given the low number of items in each scale, possible solutions were limited to one and two factors because it was determined that a greater number of factors would not be substantively meaningful. Model fit was assessed using the Root Mean Square Error of Approximation (RMSEA, < 0.08), Comparative Fit Index (CFI, > 0.90), Tucker Lewis Index (TLI, > 0.90), and Standardized Root Mean Square Residual (SRMR, < 0.08). Significant differences in model fit between the one and two factor solutions were determined using the chi-square difference test. The factor structure identified by the EFA was used in the remaining analyses. Structural equation modeling (SEM) was used to determine if first gen status was associated with depressive and anxiety symptoms. The CES-D10 and GAD-7 factor structure, as determined by the EFA, were specified as latent constructs and regressed on first gen status, which was specified as a manifest independent variable. To determine if social and emotional support moderated the relationship between first gen status and depressive and anxiety symptoms, the social and emotional support variable was centered prior to the first 3 gen by social emotional support interaction term being specified. Additionally, the models were adjusted for age, gender, race, ethnicity, and relative SES. Model fit was assessed using the RMSEA, CFI, TLI, and SRMR. Plots and simple slope tests were used to further investigate significant interaction terms. Descriptive statistics were generated using SPSS for Windows Version 25.0 (Armonk, NY: IBM Corp.). EFA and SEM models were generated using Mplus version 8.3 (Los Angeles, CA: Muthén & Muthén). Models were estimated using maximum likelihood, and statistical significance was set at α = 0.05. Results Sample Approximately 43% of the sample were first generation students (Table 1). A majority of participants (50.7%) were 19 to 21 years old while 26.4% indicated they were 24 years old or older. Nearly two-thirds of the sample were female (65.3%) and a majority (54.5%) identified as Caucasian. The sample was predominantly non-Hispanic (83.8%), and the mean SES score was greater than 5, suggesting that participants thought, on average, that they were better off than others in the community. The majority (53.3%) of participants reported usually or always receiving the social and emotional support they needed. No participants indicated they never receive social and emotional support. CES-D10 One and two factor solutions of the CES-D10 were explored. Based on the chi-square difference test, model fit for the two factor solution was significantly greater than the one factor solution (χ2(1) = 144.32, p < 0.001), and the fit indices suggested good model fit (RMSEA [90%CI] = 0.07 [0.05, 0.08]; CFI = 0.95; TLI = 0.94; SRMR = 0.05). Therefore, the two factor solution for the CESD10 was accepted and used in subsequent analyses. Factor 1 consisted of the positive affect items: hopeful about the future and happy (Table 2). Factor 2 consisted of the negative affect items: bothered, trouble concentrating, depressed, everything was an effort, fearful, restless sleep, lonely, and could not get going. GAD-7 One and two factor solutions to the GAD-7 were explored. Based on the chi-square difference test, model fit for the two factor solution was significantly greater than the one factor solution (χ2(1) = 61.71, p < 0.001), and the fit indices suggested good model fit (RMSEA [90%CI] = 0.06 [0.04, 0.09]; CFI = 0.99; TLI = 0.98; SRMR = 0.02). Therefore, the two factor solution for the GAD-7 was accepted and used in subsequent analyses. Factor 1 consisted of cognitive-emotional symptoms 4 J. K. NOEL ET AL. Table 1. Descriptive statistics (n = 432). Variable Relative SES Depression scale 1 Depression scale 2 Anxiety scale 1 Anxiety scale 2 Age (yrs) ≤18 19 20 21 22 23 ≥24 First generation student Yes No Receive social/emotional support Always Usually Sometimes Rarely Never Gender Female Male Race Asian Black/African American Caucasian Multiple Other Ethnicity Hispanic Non-Hispanic Mean (SD) 6.3 (1.8) 2.5 (1.7) 8.7 (5.0) 4.8 (3.8) 2.7 (2.5) Count (%) 38 (8.8) 67 (15.5) 85 (19.7) 67 (15.5) 39 (9.0) 22 (5.1) 114 (26.4) 185 (42.8) 247 (57.2) 73 (16.9) 170 (39.4) 131 (30.3) 58 (13.4) 0 (0) Figure 1. Final structural equation model for the effect of first generation student status on depressive and anxiety symptoms, moderated by emotional/social support. Standardized values. Bold indicates statistical significance (p < .05). Model fit: RMSEA (90%CI) =.04 (.03, .05); CFI = .96; TLI = .95; SRMR = .04. 282 (65.3) 150 (34.7) 63 (14.6) 61 (14.1) 235 (54.5) 26 (6.0) 47 (10.9) 70 (16.2) 362 (83.8) Table 2. Exploratory factor analysis – factor loadings. Variable CES-D10* Hopeful about the future Happy Bothered Trouble concentrating Depressed Everything was an effort Fearful Restless sleep Lonely Could not get going GAD-7** Nervous Worry Worrying about different things Trouble relaxing Annoyed Afraid Restless * Factor 1 .692 .826 .860 .901 .880 .835 Factor 2 .502 .672 .811 .642 .604 .562 .597 .582 .678 .769 .731 Model fit: RMSEA (90%CI) = .07 (.05, .08); CFI = .95; TLI = .94; SRMR = .05. Model fit: RMSEA (90%CI) = .06 (.04, .09); CFI = .99; TLI = .98; SRMR = .02. ** of anxiety: nervous, worry, worrying about difference things, and trouble relaxing (Table 2). Factor 2 consisted of the somatic symptoms of anxiety: annoyed, afraid, and restless. Structural equation modeling The proposed SEM model demonstrated good model fit (RMSEA [90%CI] = 0.04 [0.03, 0.05]; CFI = 0.96; TLI = 0.95; SRMR = 0.04), and no model modifications were pursued. First gen status was not a significant predictor of either CES-D10 factor (p > 0.05) (Figure 1; Table 3). However, first gen status was significantly associated with both GAD-7 factors. There was a positive association with the cognitive-emotional factor (b = 0.22, p = 0.036) and the somatic factor (b = 0.30, p = 0.013). Further, social and emotional support was a statistically significant moderator of the relationship between first gen status and the somatic factor (b = −0.27, p = 0.028). A simple slopes analysis suggests that first gen students who rarely receive social and emotional support have greater somatic anxiety symptoms compared to non-first gen students (p = 0.004), while there was no significant difference in somatic anxiety symptoms in students reporting sometimes (p = 0.602), usually (p = 0.182), or always (p = 0.853) receiving social and emotional support (Figure 2). There were several other interesting findings. There was a negative association between relative SES and depressive and anxiety symptoms (p’s < 0.001) (Table 3). Age was positively associated with the positive affect factor of the CES-D10 (p = 0.007), and males reported fewer cognitive-emotional anxiety symptoms (p < 0.001). Additionally, relative to Caucasians, participants who identified as Asian reported higher negative affect depressive symptoms (p = 0.006) and somatic anxiety symptoms (p = 0.023), while Black/African Americans reported fewer cognitive-emotional anxiety symptoms (p = 0.048). Discussion The findings suggest that first generation college students are at an increased risk for experiencing cognitive-emotional and somatic symptoms of anxiety. However, moderate to high levels of social and JOURNAL OF AMERICAN COLLEGE HEALTH 5 Table 3. Structural equation model standardized coefficients. Variable First generation Yes No Emotional/social support First generation* emotional/social support Age Relative SES Gender Male Female Race Asian Black/African American Multiple Other Caucasian Ethnicity Hispanic Non-Hispanic * CESD-10: Factor 1 Estimate p CESD-10: Factor 2 Estimate p GAD-7: Factor 1 Estimate p GAD-7: Factor 2 Estimate p −.03 . −.38 −.03 .14 −.25 .610 . <.001 .496 .007 <.001 .15 . −.25 −.13 .02 −.21 .185 . <.001 .269 .414 <.001 .22 . −.14 −.16 −.02 −.17 .036 . .012 .156 .464 <.001 .30 . −.16 −.27 .03 −.17 .013 . .014 .028 .267 <.001 .20 . .120 . −.11 . .364 . −.45 . <.001 . −.16 . .181 . .01 .10 .04 .06 . .943 .562 .864 .841 . .44 .20 .27 −.30 . .006 .231 .259 .248 . .14 −.30 −.20 −.11 . .356 .048 .375 .650 . .38 −.05 .23 −.21 . .023 .757 .357 .455 . .30 . .218 . .35 . .113 . .16 . .439 . .23 . .324 . Statistically significant effects (p < 0.05). Figure 2. GAD-2: Factor 2 symptoms by first generation status and emotional/social support. emotional support appear to act as a protective factor against somatic anxiety symptoms among this population. Interestingly, there were no signification relationships between student generation status and depressive symptoms, although there were several other significant relationships that may merit further investigation. Specifically, higher relative SES was associated with lower depressive and anxiety symptoms; females reported experiencing greater cognitive-emotional anxiety symptoms; and Asian Americans reported experiencing greater negative affect depressive symptoms and somatic anxiety symptoms. Anxiety in first generation students Anxiety symptoms in first generation students may be pronounced due to increased stress. The Cognitive Activation Theory of Stress (CATS) posits that a stress response occurs whenever there is a discrepancy between the expectations of an experience and what occurs in reality.33 When expectancies are not met, the stress response manifests as a general increase in arousal that can affect numerous body systems. Short-term experiences of stress in response to expectancy discrepancies often have positive benefits that serve to protect the individuals from a threatening or negative experience, but sustained stress may produce negative psychological and physiological consequences due to allostatic load. Within the context of the present study, we propose that first generation students may be experiencing chronic increased stress, which manifests in some as anxiety symptoms, due to a discrepancy between what the college experience was expected to be and the reality of college life. Using CATS as a model, the findings are consistent with previous research. For example, psychological distress (ie, anxiety, stress, and depression) rose steadily through the first semester of college and remains elevated through the second semester in a sample of undergraduates.34 Anxiety symptoms were previously strongly correlated with perceived stress,35 and additional findings from the American College Health Association (ACHA)NCHA survey suggest that stress increases the likelihood of being diagnosed with a mental illness, including anxiety.36 Here, the effects were seen after experiencing as few as one stressful event. Moreover, perceived stress mediated the relationship between sleep quality and anxiety symptoms in a sample of undergraduate nurses.37 First generation students may experience high levels of acculturative stress, which reflects the stress experienced during the cultural adaptation process and has been previously identified as a significant risk factor for anxiety.38 Among Latinx college students, acculturative stress mediated the relationship between acculturation and depression, with the effects stronger among men, 39 and acculturative stress may increase symptoms of anxiety and depression due to a lack of access to emotional regulation strategies.40 Moreover, in a three-year longitudinal study 6 J. K. NOEL ET AL. of immigrant-origin adolescents, exposure to acculturative stress was predictive of greater experiences of anxiety-related symptoms.41 Consequently, interventions that target stress have been shown to decrease anxiety symptoms. A meta-analysis of 24 intervention studies that included over 1,400 university students concluded that mindfulness programs on college campuses significantly decrease symptoms of stress and anxiety.42 Mindfulness programs that are designed to reduce stress in order to decrease anxiety may be more effective at reducing anxiety symptoms than those that focus on physical activity levels,43 and in a pilot study of 33 pre-healthcare undergraduate students, positive benefits were seen in as little as 5 minutes of meditation daily.44 Social support and anxiety The findings suggest that the experience of somatic anxiety symptoms, such as being annoyed, afraid or restless, may be moderated by increased social and emotional support, whereby decreased social support resulted in greater levels of somatic anxiety symptoms. Research conducted on other populations is supportive. Among student veterans, social support moderated the relationship between coping mechanisms and anxiety symptoms 45 and predicted academic adjustment among returning veterans.46 Peer social support moderated the relationship between distress and self-stigma among college students with a previous mental health diagnoses47 and may predict later anxiety symptoms.48 Importantly, the relationship between social support and anxiety symptoms in students may be universal, with consistent effects found in numerous countries.49 SES and mental illness Higher relative SES was associated with lower depressive and anxiety symptoms, which is consistent with existing research. For example, individuals from lower SES classes are more likely to suffer depressive symptoms,50 and college students with greater financial burdens are more likely to suffer from depressive and anxiety symptoms.51 Moreover, the relationship between objective measures of social class and depressive symptoms may be mediated by subjective measures of SES,52 which were used in the current study, while others have demonstrated that the effect is stronger among women relative to men.53 Additionally, a systematic review concluded that the relationship between economic stress and symptoms of mental illness in adolescents is mediated via parental conflict, parental depression, parenting practices, and resiliency.54 Moreover, the relationship between SES and mental illness has been tentatively extended to treatment outcomes, with evidence suggesting that SES deprivation is associated with poorer psychological therapy outcomes.55 Females and anxiety The findings suggest that female college students experience more cognitive-emotional symptoms of anxiety, which is consistent with previous research. Anxiety disorders are the most common psychological condition among female adolescents and young adults,56 and in the present context, greater anxiety symptoms may be due to greater anxiety sensitivity, which is a fear of anxiety-related situations or the consequences of anxiety. Other studies have reported that female college students had significantly greater anxiety sensitivity scores than their male counterparts,35 and such gender disparities likely begin in childhood and continue through adolescence and into adulthood.57,58 Moreover, anxiety sensitivity mediated the relationship between gender and cognitive symptoms of anxiety in a sample of adults,59 and anxiety mediated the relationship between anxiety sensitivity and functional impairment.60 Asian americans and mental illness Relative to Caucasians, self-identified Asian Americans reported greater negative affect depressive symptoms and somatic symptoms of anxiety, which adds to a mixed body of literature. Greater depressive symptoms, using the CES-D, among Korean American adolescents compared to Caucasians have been previously reported,61 and elevated depression symptoms were identified in Asian American undergraduate students compared to Caucasian students.62 However, others have reported that the prevalence of mental illness is lower in Asian Americans, although differences in rates may be due to cultural perceptions of the disease, access to linguistically appropriate care, and disease presentation.63 Moreover, a study of non-institutionalized Asian and European Americans reported that Asian Americans were less likely to express specific somatic and psychological symptoms of depression, even if the overall symptomology is equivalent across groups.64 Implications and next steps There are research and programmatic implication to the findings. First, additional research studies are needed on the relationship between first generation student status and symptoms and diagnoses of mental illness. As noted previously, the literature is relatively sparse on this topic. Initially, cross-sectional research using representative samples are needed to confirm the present findings and expand upon them. Interestingly, there are several existing, high quality studies that could add a question to classify students based on generation status. For example, the Behavioral Risk Factor Surveillance System (BRFSS) currently collects employment data that allows participants to identify themselves as students and questions about poor mental health and previous diagnosis of JOURNAL OF AMERICAN COLLEGE HEALTH depressive disorder are included in recent years of data collection.65 Although students are a minority of BRFSS respondents, the number of respondents is likely to be greater than 10,000 due to the large sample recruited for each year’s survey. In 2018, approximately 2.7% (n = 11,688) of respondents were students. Additionally, the American College Health Association (ACHA)’s National College Health Assessment (NCHA) should include a question to determine first generation status. The NCHA currently contains several items assessing the mental health of respondents, and its large sample size (n = 54,497 in Spring 2019) makes it ideal for further investigating the relationships identified here.66 If the current findings are confirmed in larger cross-sectional surveys, prospective longitudinal research may be warranted to determine if symptoms of mental illness among first generation students develop during or prior to the college experience; if first generation students are more or less likely to access institutional healthcare resources; the effectiveness of available healthcare resources; and protective and risk factors for the development of symptoms of mental illness. A representative sample of the U.S. college student population would be ideal, but given the logistical difficulties, well designed cohorts of students recruited from a representative sample of colleges and universities may be an effective and pragmatic alternative. Programmatically, the findings extend previous research suggesting that first generation students may be at risk for experiencing symptoms of mental illness, and while some of those symptoms may be moderated by student social networks, such a focus is not a cureall. If the current findings are confirmed, colleges and universities should consider developing and implementing programs that can specifically address the mental health concerns of first generation students. Such programs may include resources to assist these students in acclimating to the college and university environment; developing a healthy work-life-family balance; and providing early intervention treatment programs. Moreover, while the use of university resources is an individual choice, developed programs should proactively identify first generation students upon enrollment and routinely provide relevant information via email or other appropriate media. Limitations There are several limitations to the study. It was a cross-sectional survey that recruited a convenience sample. It is unlikely that the sample was representative of all college students, particularly since the prevalence of first generation students was greater than 40%, and the results may not be generalizable to other populations. According to the U.S. Department of Education, 23.9% 7 of college students in the 2015–2016 academic year were first generation.67 The study is also limited be the restrictive nature of the response options for age, which ended at ≥ 24 years old. Further research using representative samples are required to confirm the results. Due to the anonymous nature of the survey, it was not possible to confirm student generation status, and it is possible that misclassification occurred. Moreover, a definition of “first generation student” was not provided to participants, and different interpretations between participants may lead to skewed results. The study relied on self-report, which is subject to recall bias, and since self-reporting depressive and anxiety symptoms may be a sensitive topic for participants, social desirability bias may have occurred, which could have led to participants indicating that they experience fewer symptoms than what occurs in reality. Social support may have been under or over-estimated since it was measured with a single item, and unique sources of social support may be better captured using a multi-item scale. Finally, the study was not powered by first generation student status, and while the sample size was moderately large, it is possible that the study was underpowered to detect differences in depressive symptoms by student generation status and the potential interactive effects of social and emotional support. Conclusions First generation undergraduate students may be at an increased risk of experience cognitive-emotional and somatic symptoms of anxiety, although the somatic symptoms of anxiety may be moderated by receiving adequate social and emotional support. The relationship may be due to increased stress felt by first generation students, although more research is needed. Existing surveillance studies that include college students should consider asking a question about generation status, and universities and colleges should consider developing programs that can specifically address college-related stress in this population. Conflict of interest disclosure The authors have no conflicts of interest to report. The authors confirm that the research presented in this article met the ethical guidelines, including adherence to the legal requirements, of the United States and received approval from the Johnson & Wales University Institutional Review Board. 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