r Academy of Management Journal 2022, Vol. 65, No. 5, 1747–1769. https://doi.org/10.5465/amj.2018.1181 A TROJAN HORSE INSIDE THE GATES? KNOWLEDGE SPILLOVERS DURING PATENT LITIGATION KIRAN S. AWATE Virginia Polytechnic Institute and State University MONA MAKHIJA The Ohio State University While patent litigation is an important appropriability mechanism for protecting firms’ proprietary knowledge, through the litigation process, valuable knowledge may unintentionally spill over from firms defending their patents to those they accuse of patent infringement. We examine whether such spillover subsequently enhances the innovation of accused firms by analyzing over 3,000 patent litigation cases from 1998 through 2015 in the U.S. pharmaceutical industry. We find that firms accused of infringement have higher levels of innovation following litigation relative to other similar firms. Furthermore, litigation of patents that build on recent and heterogeneous knowledge and are characterized by greater scope more strongly enhance the accused firms’ subsequent innovation. These findings support the argument that patent litigation can facilitate knowledge spillovers. document—insights into its proprietary knowhow related to the patented technology. In disclosing this knowledge to the court, it is also made available to the firm accused of infringement (hereafter, for purposes of brevity, the accused firm). Through such revelations, patent litigation may result in the transfer of proprietary knowledge to the accused firms, offering them a unique opportunity to learn. That is, while firms undertakes litigation in order to protect and capture value from their innovation, it may also result in proprietary knowledge unintentionally spilling over to accused firms that can subsequently be used in their own innovation activities. In this way, patent litigation may be a double-edged sword. We examine whether knowledge spillovers that occur during patent litigation enhance subsequent innovation outcomes of accused firms. Firms undertake litigation for patents they consider to be highly valuable (Lanjouw & Lerner, 2001). Assuming that litigation creates a breeding ground for spillovers, accused firms should benefit more as the value of the spillovers increases. Since the firm accused of patent violation will likely operate in the same technological space as the patent-holding firm, it will have both the intent and the capacity to learn (Bettis & Prahalad, 1995; Hamel, 1991; Makhija & Ganesh, 1997). Irrespective of which firm ultimately wins the case, we expect that the accused firm can use insights gained during litigation to optimize its subsequent innovation efforts (Pisano, 1994). In order to For firms to engage in the uncertain activity of innovation, they must be able to extract adequate value from their efforts. Appropriability regimes create barriers to imitation and protect firms’ knowledge from spilling over to their rivals (Cohen, Nelson, & Walsh, 2000; Pisano, 1994; Teece, 1986). Strong appropriability regimes include patents, which ensure intellectual property rights for a certain duration of time (Mahoney & Pandian, 1992), and their enforcement through litigation (Lanjouw & Schankerman, 2001; Somaya, 2003). In industries where patents are effective intellectual property protection mechanisms, it is the ability to litigate them that defines their efficacy. An intriguing consequence of patent litigation that has gone unnoticed is its potential to facilitate knowledge spilling over from firms defending their patents against infringement to those they accuse of patent infringement. During the process of patent infringement litigation, the patent-holding firm may need to reveal—above and beyond what is in the patent We thank our colleagues, Michael Leiblein, Benjamin Campbell, Oded Shenkar, Charles Stevens, and Rafael Corredoira, for reading various drafts and providing important feedback. We also thank Daniel Chow and Bryan Choi from the Moritz College of Law for their very valuable insights on patent litigation. We are particularly grateful to Editor Kevin Steensma and three anonymous reviewers for their extremely helpful advice and thoughtful suggestions to improve this research. 1747 Copyright of the Academy of Management, all rights reserved. Contents may not be copied, emailed, posted to a listserv, or otherwise transmitted without the copyright holder's express written permission. Users may print, download, or email articles for individual use only. 1748 Academy of Management Journal understand this phenomenon and ground our theory development, we interviewed patent litigation lawyers, scientists and managers who had served as witnesses in patent litigation, and academics who specialize in intellectual property laws. To examine the effects of spillovers during litigation, we developed a database with over 3,000 patent infringement lawsuits from 1998 to 2015 in the pharmaceutical industry. The pharmaceutical industry’s reliance on patents makes it an ideal context for this research. The database includes detailed information on pharmaceutical firms that were involved and not involved in litigation, the nature of the litigated patents, and attributes of the litigation cases. Consistent with prior research that has assessed learning through subsequent performance outcomes (Baum, Li, & Usher, 2000; Madsen & Desai, 2010), we measure the accused firm’s novel innovation outcomes subsequent to patent litigation. Our findings support the argument that knowledge spillovers during litigation enhance accused firms’ subsequent novel innovations relative to those of other firms. Furthermore, this relationship strengthens with increases in the recency, heterogeneity, and scope of the knowledge on which the litigated patent is built. These findings highlight the limitations of a key appropriability mechanism for curtailing spillovers in an otherwise strong appropriability regime. LITIGATION AS AN APPROPRIABILITY MECHANISM When knowledge unintentionally spills over from originating firms, recipient firms can improve their products or processes at little or no cost (Jaffe, Trajtenberg, & Fogarty, 2000; Mansfield, 1985; Shaver & Flyer, 2000). Because others benefit from their innovation activities, the rewards to the originating firm are greatly reduced, diminishing its incentive to engage in such costly activities in the first place. Appropriability regimes assist firms in capturing value from the innovations they create, by preventing knowledge spillovers (Cohen, Nelson, & Walsh, 2000). An appropriability regime consists of environmental factors that govern the ability to capture rents generated by an innovation (Teece, 1986), and include intellectual property rights and legal mechanisms for protecting these rights (Teece, Pisano, & Shuen, 1997). A strong appropriability regime confers ownership rights over an innovation created by a firm through a patent and excludes others from using the innovation for a certain duration of time to ensure that the patent owner is the primary beneficiary October of its efforts (Somaya, 2012; Pisano, 2006). The stronger the regime, the greater the protection of intellectual property through durable patents and their enforcement (Gulati & Singh, 1998). Evidence suggests that litigation does play a role in preventing firms from infringing patents (Lanjouw & Schankerman, 2001; Linden & Somaya, 2003; Teece, 2000). The threat of litigation alone can be a credible deterrent to potential infringers (Clarkson & Toh, 2010; Nerkar, Parachuri, & Khaire, 2007; Reitzig, Henkel, & Heath, 2007; Reitzig & Wagner, 2010), due to its high direct and indirect costs (Lanjouw & Lerner, 2001; Somaya, 2012; Tan, 2016). This may explain why firms with greater resources are also more likely to initiate lawsuits (Agarwal, Ganco, & Ziedonis, 2009; Waldfogel, 1995). Even then, firms do not undertake litigation for just any potentially infringed patent. They litigate only those patents most valuable to their competitive position (Allison, Lemley, Moore, & Trunkey, 2003; Simcoe, Graham, & Feldman, 2009). Because patent litigation is such a key element of a strong appropriability regime, scholars have implicitly assumed that litigation, once undertaken, gives rise to the outcome for which it is designed—ensuring that patented knowledge is correctly assigned to the firm that originated it and limiting the unwarranted use of spillovers by others. However, a closer consideration of litigation processes highlights an unforeseen consequence of litigation—the necessity of sharing information to demonstrate infringement can itself give rise to spillovers. The problem stems from the intangible nature of information—it is in part a public good and therefore difficult to contain (Arrow, 1962; Mansfield, 1985). Litigation by a patent-holding firm to enforce its intellectual property rights can be a mechanism that increases knowledge spillovers to a competitor, the very problem it was meant to address. This is due to a number of intrinsic characteristics of the patent litigation process. The first stems from the particularly close interface between the plaintiff and defendant firms during litigation.1 The more geographically proximate firms are, the more likely it is that there will be spillover of complex and intricate knowledge (Appleyard, 1996; Chung & Alcacer, 2002; Rosenkopf & 1 In this research, the patent-holding firm is the plaintiff in litigation that is accusing another firm of patent infringement. The firm accused of infringing the patent is the defendant. The terms “patent-holding firm” and “plaintiff” are therefore used interchangeably here, as are the terms “accused firm” and “defendant.” 2022 Awate and Makhija Almeida, 2003). Litigation creates even closer colocation than many previously considered contexts for spillovers, as well as deeper interaction among participating firms over a particular technological innovation. The rules and procedures of litigation require litigating parties to share highly firm-specific information and respond directly to very pointed questioning about the patented innovation. In doing so, the litigation process itself can give rise to highly proprietary and valuable spillovers to the accused firm, which is often also a competitor. A second issue arises from the codified nature of the litigated patent that often limits the extent to which the knowledge contained within it is easily understood (Lanjouw & Schankerman, 2001; Somaya, 2003). The patent may even be intentionally obscure in an effort to hamper imitability (James, Leiblein, & Lu, 2013). Since patents do not disclose complete information on the inner workings of a new technology or its underlying science (Devlin, 2010; Ouellette, 2012), additional disclosures by the patent-holding firm become necessary during litigation. In particular, the firm may need to offer new information not documented in the patent to defend its arguments of infringement. In the process of elaborating this knowledge, it may provide detailed insight into its more complex aspects that are not readily apparent. These spillovers can help the accused firm gain a broader and deeper comprehension of the knowledge than would otherwise be possible. Third, since the patents selected for litigation typically involve knowledge considered to be particularly important for a firm’s competitive position (Allison et al., 2003; Lanjouw & Schankerman, 2001), additional proprietary information not part of the patent can unintentionally be revealed. That is, while explaining the nature of its patented knowledge during litigation, a firm can inadvertently shed light on firm-specific concepts, approaches, and procedures that are above and beyond the litigated patent. Such procedural knowledge is typically not protected by patents (Arora, 1997; Cohen & Klepper, 1996). For example, information about hypotheses that were considered and then rejected can reveal to the accused firm approaches that should not be pursued in the future, thus helping to preserve its resources. The accused firm can also use insights into best practices and superior investment approaches for innovation. Given the uncertainties of the innovation process, learning about another firm’s innovation-related choices, processes, and outcomes can inform the accused firm’s subsequent efforts in a related domain. In this way, spillovers of knowledge complementary 1749 to the patent can also be valuable to the recipient firm. KNOWLEDGE SPILLOVERS DURING THE LITIGATION PROCESS In the United States, patent litigation begins when a firm files an infringement complaint against another firm in one of 94 U.S. federal district courts. At this point, the accused firm can also present counterclaims (Nard & Wagner, 2008), such as noninfringement (its activities are outside the domain of the patent), invalidity (the patented art is not novel or is nonobvious) and unenforceability (the patent is misrepresented or misconstrued). The presiding judge then schedules a meeting or a pre-trial conference with the plaintiff and defendant firms to lay out the framework that will govern how the case will go forward. The parties agree to a case schedule—the process by which the parties will exchange data, provide copies of relevant documents, respond to written questions called “interrogatories,” and give sworn testimony in depositions (Roper, Cooper, Gutman, & Pappas, 2016). The pre-trial conference is followed by large-scale exchange of information known as “discovery,” in which each party can obtain evidence and information relevant to the case from the opposing party or third parties. This phase offers an important opportunity for each party to provide information that supports its case and learn about the positions and supporting evidence of the opposing party. Parties can request research notebooks and electronically stored information about procedures or experiments related to the patent, and inspect equipment and physical locations (Jarvis, Frelinghuysen, Rader, & Christoff, 2018; Manzo, 2012). It is common for hundreds of thousands, or even millions, of pages of documentation to be exchanged (Moore, Holbrook, & Murphy, 2018). Discovery also includes deposition (sworn oral testimony) of the parties’ employees and third-party expert witnesses to explain the facts of the case to the judge or jury and provide expert opinions concerning the issues of infringement. Any information obtained during discovery can be highlighted and discussed in the courtroom (Manzo, 2012). In the final phase, the parties can request trial by jury or judge alone. Given that neither the judge nor the jurors will have expertise with the patented technology, much of a patent trial involves educating them about the relevant technology, the patented invention, the nature of infringement, and any prior art that allegedly invalidates the patent. Each side 1750 Academy of Management Journal presents its arguments about the evidence through testimony and exhibits presented during trial. Infringement is proven when “each and every element” in a claim of the patent is shown to be employed by the accused firm (Jarvis et al., 2018: 297). At the end of the trial, a verdict is returned. The entire litigation process can take up to two and a half years.2 As the above description of the litigation process indicates, a necessary component of the litigation process is the sharing, explication, and discussion of firms’ proprietary information. Thus, even though litigation is undertaken for the protection of a firm’s intellectual property rights, this process will unavoidably give rise to spillovers. While exact patented knowledge may in fact be prohibited for use by other parties, limited roadblocks appear to exist in the transfer of other highly related types of knowledge provided during courtroom proceedings. For example, despite pervasive use of confidentiality agreements for protecting sensitive disclosures (Chisum, 2019), several intellectual property rights attorneys we interviewed indicated difficulties in enforcing them. To understand the nature and implications of the knowledge being discussed in the courtroom and pursue a particular litigation strategy, attorneys have little choice but to interface heavily with the scientists and managers of the firm they are representing. This makes it difficult to curtail transfers of any proprietary knowledge to their client firm. One attorney noted, Both patent attorneys and expert witnesses are usually in-house. There is no way that an attorney has the knowledge to conduct the case by himself. The attorney discusses everything with people in the firm, everything. Otherwise they would not know how to conduct the case. In addition, the stakes of litigation are so high that obtaining a favorable ruling often overshadows concern over knowledge spillovers. As a professor specializing in IP law explained, People know that leakages happen. But I have found that it is really hard to prove—confidential information may or may not be [related to] the patent. Two scientists who served as witnesses in patent lawsuits discussed with us the highly detailed testimony they provided in court that elaborated 2 According to some studies (e.g., Ansell, Holzwarth, O’Brien, & Scally, 2017), patent holders’ litigation success rate is about 33%. Assessment of success may be complicated by court decisions that uphold some but not all patent claims. In addition, three quarters of cases are appealed after trial, which can also lead to decision reversals. October the exact steps of the experimental process undertaken to come up with the patented technology. Both noted that questioning was often so detailed that they were unable to withhold proprietary information. They agreed that such information could provide useful insights for another firm’s subsequent innovation efforts in similar domains. Insights gained through knowledge spillovers can help a firm go down the learning curve faster than if it had to replicate the entire innovation process on its own. HYPOTHESES Effect of Knowledge Spillovers During Litigation on Novel Innovation Outcomes An innovation comes about through recombining knowledge components (Ethiraj & Levinthal, 2004; Fleming, 2001; Katila & Ahuja, 2002). The search for useful recombinations is, however, difficult due to the inability to forecast exactly how to achieve a desired result (Fleming & Sorenson, 2004). Thus, the innovation process involves not only successes but also significant failures from which firms learn to make decisions about next steps. In this way, the search for an innovation is not only complex but also path-dependent and reiterative. The issuance of a patent represents a successful outcome of this process. Differences in firms’ knowledge bases lead to variations in their ability to create novel innovations (Yayavaram & Ahuja, 2008; Yayavaram & Chen, 2015). A firm will likely have limited depth of understanding or experience with at least some of the knowledge components that make up another firm’s innovation (Katila & Ahuja, 2002; Kaplan & Vakili, 2015; Stuart & Podolny, 1996), or have little grasp of how the components are integrated so that they work in the correct way (Henderson & Clark, 1990). The innumerable ways in which knowledge components can potentially be recombined reflects a “rugged landscape” that makes the more superior options difficult to identify (Fleming & Sorenson, 2004). Even if a patent-holding firm is able to successfully overcome these difficulties, information about how it managed to do so is not contained in the patent and is essentially invisible to other firms. The processes by which the coveted knowledge is created remains mostly within the firm. When patent-holding firms undertake litigation to defend their patents, they have the burden of both demonstrating infringement and defending themselves against counterclaims of invalidity or unenforceability of the patent. There are several ways in which this process can expose its proprietary 2022 Awate and Makhija firm-specific information to the accused firm. To show that a patented technology has been infringed, the patent-holding firm will have to explain the nature of the technology in detail, often with supporting new information that is not explicitly in the patent. Evidence for this can be seen in a case brought by Purdue against Amneal in 2015 regarding its patent covering the controlled release oral dosage containing oxycodone (Purdue Pharma L.P. v. Amneal Pharms., LLC, 2015). The court heard testimony from multiple expert witnesses and admitted hundreds of exhibits that revealed detailed information about the nature of the patent claims. According to the court docket, Purdue disclosed important information regarding the invention not documented in the patent to clarify the nature of the intellectual property covered in the patent. For example, it indicated the sources of key information used for the invention and elucidated the exact science underlying the patent, both of which were previously unknown to Amneal, the firm accused of infringement. Amneal was able to hear Purdue explain exactly how to achieve the desired level of gel viscosity for a proprietary use. While the exact technology as patented may not be utilized, insights can still be gained into ways to improve or extend this technology in new directions, or develop alternative gel-based technologies that are similar but not exactly the same. Since neither the patent nor court rulings include this information, the accused firm has significant leeway for making use of these insights. In the process of demonstrating that the patented technology is valid (i.e., novel and nonobvious), the patent-holding firm may need to provide detailed information about the procedures that led to the innovation, including assumptions and choices made, allocation of resources for particular activities, insights from mistakes, and an unforeseen trajectory of decision-making that yielded the successful innovation. In this respect, the plaintiff firm may unintentionally divulge information that can be extremely useful to the defendant firm for improving its own decision choices to create innovations in a related technological space. It can avoid the mistakes made by the patent-holding firm while learning from its successes. Consider the case of Amgen Inc. and Genetics Institute Inc. (GenI) filed in 1989 (Amgen, Inc. v. Chugai Pharm. Co., 1989). Amgen cloned a gene called the human hormone erythropoietin (EPO), which helps to treat chronic anemia associated with end-stage renal disease, and received a patent for the procedure in 1987. GenI utilized a similar technique for cloning the gene, leading Amgen to file a patent infringement 1751 lawsuit against GenI. During the discovery phase of litigation, Amgen provided handwritten notes on detailed discussions between two of its leading scientists that revealed a sequential plan to systematically probe and screen genomic libraries. Amgen also shared memos documenting key decisions undertaken by the team, outcomes of the experiments conducted, and detailed consideration of their implications. In their testimonies, scientists discussed some of their assumptions proven wrong and the insights they gained from their mistakes. In the end, Amgen explained virtually every step for bringing about a complex and highly innovative outcome— the cloning of a gene. Given the relatively new science involved, the accused firm had the opportunity to learn at length from experts in the patent-holding firm about best practices in cloning genes. Even if GenI did not go on to use the exact knowledge for the cloning of the EPO gene, it could leverage new insights to improve its own cloning techniques. The fact that accused firms will likely operate in similar technological spaces as the patent-holding firms plays a key role in their ability to learn from spillovers and come up with novel discoveries in a related domain. Learning through such means assists the firm in making better choices among alternative courses of action that not only increase the likelihood of successful innovation outcomes but also make the process of innovation more efficient (Posen & Chen, 2013). The case of Endo Pharms v. Actavis Inc., in which Mallinckrodt LLC was also a plaintiff, exemplifies such a situation (Endo Pharms. Inc. v. Actavis Inc., 2017). Although a suit was brought against Actavis and Teva for violating Mallinckrodt’s patent for reducing the ABUK content of oxymorphone to 5 ppm, these firms brought a countersuit based on patent unenforceability, arguing that the plaintiffs did not actually have a workable invention when they received the patent. In the process of addressing this countersuit, Mallinckrodt not only pointed out errors in the defendants’ approach but also explained in detail the process by which ABUK can be reduced from 400 ppm (which the level defendants had knowledge about) to 5 ppm. Actavis and Teva had already displayed an intent to compete in this space by introducing their own versions of the drug, but they lacked the ability to reduce ABUK to acceptable levels. Since the procedural aspects of the knowledge introduced into court by Mallinckrodt were outside the scope of the patent, the accused firms were now in a better position to use this knowledge in subsequent innovations. Note that the knowledge spillovers that occur during litigation are of a more exact and detailed nature 1752 Academy of Management Journal than are those that occur in many other contexts. The discovery stage alone gives the accused firm access to extensive and even proprietary information about the patent-holding firm’s innovation process. Court proceedings can result in considerable explanation and clarification of these processes. In this way, new information to which it otherwise would not have had access can flow to the accused firm. Given the difficulties in coming up with novel innovations (Fleming & Sorenson, 2004), insights gained through knowledge spillovers during litigation can bolster the accused firm’s ability to subsequently develop its own novel innovations in a related technological domain. Firms that do not undergo litigation will not have access to such spillovers. The ability to draw from spillovers that occur during litigation will assist accused firms toward higher subsequent novel innovation output than firms without litigation events. Hypothesis 1. Accused firms will have higher subsequent novel innovation output than firms not accused of patent infringement. Spillovers of More Recent Knowledge During Litigation Litigation-related spillovers are not uniform in their value to the recipient firm; some types will be more beneficial than others. Spillovers pertaining to more recent or newer knowledge will be more valuable to the accused firm than those related to older knowledge. More recent knowledge may reflect an underlying technology or science that is still evolving (Ahuja & Lampert, 2001; Heeley & Jacobson, 2008), and is plagued with a higher degree of causal ambiguity and uncertainty (Arend, Patel, & Park, 2014; Johannessen, Olsen, & Lumpkin, 2001). The opportunity to receive first-hand information from a firm that originated or utilized a new technology successfully will therefore be very instructive. During litigation, the patentholding firm can shed light on how it identified, tested, and utilized the newer knowledge elements to create the new invention. In addition, the firm can provide insights into other knowledge components with which this knowledge recombines well and the procedures that best correspond with its effective application. In this way, spillovers during litigation of a patent containing more recent knowledge can provide important learning opportunities for the accused firm that can eventually help it to develop its own novel innovations in a similar technological domain. October Patent litigation involving knowledge that is older and already known in the industry is likely to offer comparatively less useful learning opportunities to the accused firm. Older knowledge may be already on the road to obsolescence (Darr, Argote, & Epple, 1995). The longer such knowledge has been around, the more opportunities other firms in the industry will have had to learn about it (Fleming, 2001; Hargadon & Sutton, 1997). For example, the patent-holding firm might have licensed that technology or process, resulting in greater knowledge diffusion. Older knowledge may have already resulted in rival firms finding ways to “design around” it. Since technologies continue to evolve over time, spillovers associated with older knowledge may not be adequately informative for subsequently bringing about novel outcomes. We therefore expect litigation involving more recent knowledge to create better learning opportunities than older knowledge, enhancing accused firms’ subsequent novel innovations in the same technological domain. Hypothesis 2. The more recent the knowledge in the litigated patent, the higher an accused firm’s subsequent novel innovation output over firms not accused of patent infringement. Spillovers Involving Heterogeneous Knowledge During Litigation The heterogeneity of the knowledge in the litigated patent also influences the value of spillovers to the accused firm. Homogeneous knowledge involves components with important similarities and overlap in their function that jointly create deep understanding or fine-grained intuition about that function (Kaplan & Vakili, 2015). Because they emanate from a single discipline or domain and possess obvious interconnections, a combination of similar knowledge components in an innovation can reduce the potential for unexpected and unusual insights (Taylor & Greve, 2006). On the other hand, heterogeneous knowledge components that differ considerably in their underlying attributes and involve scientific principles from different disciplines can give rise to unique and path-breaking innovations (Carnabuci & Operti, 2013; Phene, Fladmoe-Lindquist, & Marsh, 2006). It is for this reason that more heterogeneous knowledge is often considered to be particularly valuable for bringing about more novel innovations (Hargadon & Sutton, 1997; Rodan & Galunic, 2004). The innovation process to effectively bring heterogeneous knowledge components together and successfully create an innovation will, however, have 2022 Awate and Makhija ex ante uncertainty due to unknown causal associations among them (Rosenkopf & Almeida, 2003). Because of their underlying dissimilarities, recombination of heterogeneous knowledge components is not easily accomplished. Even after the firm has figured out which elements to use, it will still have imprecise knowledge about how to actually combine them in a way that leads to the desired outcome (Fleming & Sorenson, 2004). Initially, it will understandably operate with incorrect assumptions that result in suboptimal outcomes. Ongoing experimentation that rectifies these assumptions is thus required to improve outcomes. The ability the firm eventually develops for successfully utilizing heterogeneous knowledge in its innovation and the understanding it now has about how such knowledge elements interact with one other constitute a competitive advantage that other firms will have difficulty emulating. When litigation involves a patent that has recombined such interdisciplinary knowledge, spillovers can provide intricate and multifaceted insights to the accused firm about the recombination process that it would otherwise not have. For example, the patent-holding firm might disclose pertinent information about how it went about creating connections among knowledge components that come from disparate disciplines and draw on different technological principles. Such spillovers offer the accused firm an opportunity to understand and unravel complex causal linkages that underlie the patented technology (Henderson & Clark, 1990; Yayavaram & Ahuja, 2008). These insights can provide the accused firm with a much better understanding of how it too can successfully integrate such heterogeneous knowledge. Merged with its own knowledge, this new understanding can improve the accused firm’s ability to create novel innovations in a similar technological space. In contrast, when patent litigation involves less heterogeneous knowledge, spillovers during litigation will tend to have comparatively less value for the accused firm. Whereas spillovers related to knowledge spanning dissimilar technological domains can help a firm broaden its horizons and utilize more creative combinations of knowledge (Hargadon & Sutton, 1997), those pertaining to less heterogeneous knowledge may result in deeper understanding but fewer insights of a cutting-edge nature (Fleming, 2001). We therefore expect that spillovers during patent litigation involving more heterogeneous knowledge will enhance the accused firm’s ability to 1753 subsequently create novel innovations in the same technological space. Hypothesis 3. The more heterogeneous the litigated patent knowledge, the higher the subsequent novel innovation output of accused firms over firms not accused of patent infringement. Spillovers Pertaining to Knowledge Scope During Litigation Above and beyond the recency and heterogeneity of a litigated patent’s knowledge components, the scope of the patent and the knowledge contained within it also affects the value of spillovers to the accused firm. The overall patent reflects a unique contribution to the state of knowledge or “art” in a particular sphere of technology. It embodies distinct scientific or technical insights and relationships that are new, and referred to as new art (Mueller, 2018). Patents can vary, however, in the extent of new scientific relationships that comprise this art (Jaffe et al., 2000; Manzo, 2012). While a successfully granted patent must articulate or claim at least one new technical relationship (uspto.gov), patents can claim multiple such relationships for characterizing their innovation (Nard & Wagner, 2008). The number of claims in a patent, reflecting distinct technical relationships underlying the innovation, reflects the scope of knowledge in the patent. Litigated patents with a larger number of claims create more opportunities for spillovers of unique knowledge during litigation. To demonstrate infringement, the patent-holding firm will need to explain both how each claim in its patent differs from prior art and in what way it has been infringed by the accused firm. The more claims there are in the patent, the more elucidation will be required by the patent-holding firm. Since any particular claim is unlikely to be completely self-explanatory or unambiguous in how it relates to the new art (Roper et al., 2016), the patent-holding firm will need to explain in detail to the court the essential role each claim has in creating the new art and the manner in which they operate jointly to give rise to the innovation (Nard & Wagner, 2008). In this way, a patent characterized by greater scope can result in more extensive explanation and elaboration during the litigation process. After absorbing this information presented during litigation, the accused firm can gain a much better understanding of the patented technology than it possessed prior to litigation. Since the number of claims is directly tied to the scope of the patent, 1754 Academy of Management Journal litigation of a patent with more claims will give rise to a deeper and more enriching debate over the underlying features of the new art. Only by defending the uniqueness of all the claims encompassed within the patent will the patent-holding firm be in a position to demonstrate how these insights have been infringed by the accused firm. Litigation of a patent characterized by more claims thus increases the magnitude of proprietary knowledge spillovers, in turn enhancing the accused firm’s subsequent novel innovations within the same technological domain. Hypothesis 4. The greater the scope of the litigated patent, the higher the accused firm’s subsequent innovation output over firms not accused of patent infringement. METHODS Industry Context and Sample To test the hypotheses, we utilize the context of the U.S. pharmaceutical industry, in which firms expend significant resources for innovation activities (Sorensen & Stuart, 2000). The well-functioning appropriability regime for intellectual property in the United States incentivizes firms in this industry to seek patents to protect their proprietary knowledge and undertake litigation when they believe their patents are infringed. The U.S. pharmaceutical industry thus offers a rich context to examine how patent litigation might affect organizational learning and innovation. The sample was constructed from the domestic and foreign pharmaceutical firms operating in the U.S. market and covered in Pharmaprojects, a comprehensive database on the activities of pharmaceutical firms that has also been used in prior studies (Adegbesan & Higgins, 2011; Hess & Rothaermel, 2011; Kapoor & Klueter, 2015). Financial data for firms were obtained from COMPUSTAT via Wharton Research Data Services. Patent data were taken from the United States Patent and Trademark Office, and alliance-related information from Recombinant Capital, a proprietary database tracking the life sciences industry. Data on patent litigation were obtained from Westlaw, a database by Thompson Reuter that tracks litigation cases in the United States. Finally, drug approval data were collected from U.S. Food and Drug Administration (FDA). After combining all these sources, a unique dataset was created that includes firms that have and have not undergone litigation (i.e., have not initiated lawsuits nor been sued). Inclusion of nonlitigated October firms ensures that counterfactuals are accounted for in our estimations. In the pharmaceutical industry, drugs and their patents span 14 different therapeutic classes (Pharmaprojects, 2015; WHO, 2018). Each therapeutic class refers to a distinct medical condition, such as oncology, central nervous system, cardiovascular, etc., and treatments specific to that condition. Drug development projects within a given therapeutic class have strong complementary relationships and spillover effects. Hence, we utilize a firm-therapeutic class-year panel dataset, with independent and dependent variables measured at the therapeutic class level. A particular firm-therapeutic class combination is included when a firm is active in that class. In the original sample drawn from Pharmaprojects, consisting of 444 public and private firms, we identified 132 firms that had undergone a litigation event and 312 firms that had not. Firms were dropped from this set when financial and other data were not available for the entire sample period. After accounting for missing data, the sample for our main analysis consisted of 22,486 firm-therapeutic-year class observations for 169 firms (60 with a litigation event and 109 without such an event) for the period 1998 to 2015, constituting an unbalanced panel dataset. Dependent Variables Firm’s novel innovation output. The dependent variable (DV) for our hypotheses is assessed by the number of a firm’s novel drugs in a given therapeutic class approved by the FDA subsequent to the litigation event.3 For every firm i, we count the number of drugs in therapeutic class j in year t. This measure has also been used in prior research to measure a firm’s novel innovation output (Hoang & Rothaermel, 2005; Rothaermel & Deeds, 2004). While the FDA gives approval for both novel and generic drugs, our measure accounts only for novel drugs. Drugs considered novel by the FDA include those utilizing new molecular entities, as well as those containing new combinations of existing molecular entities that offer significantly better treatment or 3 The approach used here is consistent with that typically used in the learning literature (Argote & Epple, 1990; Desai, 2008; Haunschild & Sullivan, 2002; Lieberman, 1984), in which learning outcomes are measured through the following sequence: a prior state, a treatment through which learning can occur, and an outcome state. The change in behavior between the prior state and subsequent state is attributed to learning (holding other influences constant). 2022 Awate and Makhija much lower side effects than existing drugs (Hunt, 2002; Sorescu, Chandy, & Prabhu, 2003). To test the sensitivity of our dependent variable, we utilize an additional measure to assess spillovers subsequently utilized by the accused firm: citations of the litigated patent in the accused firm’s subsequent patents. This robustness test is discussed in the results section. Independent Variables Litigation event. To distinguish between accused firms and those not involved in litigation, we utilize a dummy variable. If a focal firm i is accused of infringing a patent in therapeutic class j in year t 2 5, this observation is coded as 1, and 0 otherwise. We utilize a rolling window approach (one to eight years) to identify the optimal lag between the litigation event and the firm’s novel innovation output. A five-year lag is identified as yielding the strongest coefficient for the litigation event dummy (findings available upon request). As expected, spillovers greatly reduce the overall time for coming up with innovations, which is typically eight to 10 years (Buzzell, 1988; Zemmel & Sheikh, 2010). Knowledge recency. The measure for knowledge recency is applied to all patents in therapeutic class j that are litigated against firm i in year t 2 5. This builds on prior work suggesting that recency of knowledge of a patent is reflected in a smaller difference between the grant dates of a focal patent and the patents it cites (Heeley & Jacobson, 2008; Katila, 2002; Nerkar, 2003). We utilize the formula in Heeley and Jacobson (2008) for calculating knowledge recency, as follows: N X Knowledge Recency5 j50 jt 2 f jt P pjt S:D: where fjt is the average age of patents cited by the litigated patent in a technology class j in year t, with jt is the average age of citations by all patents j 2 N; P in technology class j in year t; S.D. is the standard jt ; and, pjt is the proportion of the focal deviation of P firm i’s patents in class j in year t. To temper the effect of very old citations, we include only those cited patents whose recency is in the top 10th percentile of all cited patents. Because we subtract the firm score from the average technology class score, litigated patents using relatively newer technological inputs will have more positive scores, while those with relatively older inputs will have more negative scores. 1755 Knowledge heterogeneity. Our measure of knowledge heterogeneity is applied to all patents in therapeutic class j that are litigated against firm i in year t – 5. While a patent is assigned to one primary therapeutic class, it can also have connections to other secondary therapeutic classes (indicated in the Pharmaprojects database).4 Litigated patents incorporating more secondary therapeutic classes are expected to yield more heterogeneous knowledge. Heterogeneity is thus assessed through the distribution of secondary therapeutic classes in litigated patents using an entropy index (Desai, 2008; Haunschild & Sullivan, 2002). For every focal firm i that is active in a focal therapeutic class j, we assess the knowledge heterogeneity of the patents litigated in year t 2 5 as follows: Knowledge X heterogeneity5 2 ½Pk ðln Pk Þ for k51, . . . , 13 where P is the proportion of secondary therapeutic classes (with k representing the 13 possible therapeutic classes). This measure takes higher values when more therapeutic classes are associated with litigated patents, and lower values when fewer therapeutic classes are involved. Knowledge scope. The number of patent claims, each of which identifies fundamental and distinct features of the new art, reflects the scope of the patent (Merges & Nelson, 1990; Novelli, 2015). We therefore measure knowledge scope by taking the log of the number of claims in the litigated patents for firm i in therapeutic class j and year t 2 5. Control Variables We control for a number of alternative explanations for a firm’s innovation outcomes utilizing a range of additional variables for firm i in year t. To isolate the effects of learning from spillovers, we control for the innovation capabilities of the firm prior to the litigation event through the accused firm’s prior novel drug approvals in a particular therapeutic class in the prior five-year period. This controls for a firm’s experience with prior successes that can also influence subsequent innovations. We include the number of a firm’s patents as well as its research and development (R&D) intensity as additional measures of the firm’s prior innovation 4 For example, Pharmaprojects can assign a cancerrelated patented drug to a primary therapeutic class of oncology, while also indicating relevant secondary therapeutic classes, such as musculoskeletal or pulmonary. 1756 Academy of Management Journal capabilities and knowledge stock (Baum, Calabrese, & Silverman, 2000). Firm revenue (logged) serves as a proxy for firm size (Henderson & Cockburn, 1994; Yang et al., 2010), since larger firms may have more resources, complementary assets, and product lines that can be employed for innovation (Freeman & Soete, 1997). To address a firm’s accumulation of knowledge over time, we control for firm age in years (logged). Since pharmaceutical firms operating in multiple primary therapeutic classes may be better able to recombine knowledge from different classes, improving their innovation outcomes, we control for the active technology areas of a firm by assigning 1 to a firm that operates in more than one primary therapeutic class (Gambardella & McGahan, 2010). To control for a firm’s access to diverse knowledge and resources that might also influence learning in the innovation process (Powell, Koput, & Smith-Doerr, 1996), we include the firm’s R&D in foreign countries. Since learning can also occur through alliances (Makhija & Ganesh, 1997; Steensma & Corley, 2001), we control for total numbers of codevelopment and licensing alliances in the last five years. The effects of mergers and acquisitions the firm undertakes are also accounted for, as acquisitions are common in the pharmaceutical industry and can influence knowledge acquisition. Since firms from developed countries may have better access to resources than those from developing countries, we control for this through the number of patents filed in the firm’s country of origin. Due to additional opportunities they afford for spillovers, we also control for co-occurring litigation, or any instance in which an accused firm is a defendant in more than one litigation in a year, as well as when the accused firm is a plaintiff in other litigation, both through dummy variables. Estimation Method Our dependent variable is a count variable, making a Poisson fixed-effects model well-suited for conducting the analysis (Hausman, Hall, & Griliches, 1984). Our data include therapeutic classes nested within firms. It is possible that errors for firm observations across therapeutic classes are correlated, violating the assumption of nonindependence of observations. According to scholars (Cameron, Gelbach, & Miller, 2011; Pepper, 2002), standard errors should be clustered at the highest level of aggregation, which in our case is the firm. We further test our models using two-way clustered errors at the firm and therapeutic class levels, and find similar results. To control for October time-invariant heterogeneity across classes, we include firm fixed effects as well as 14 dummies for therapeutic class. We also add year dummies to account for sources of heterogeneity stemming from factors that vary over time but are generally unvarying among firms, such as changes in economic or regulatory conditions. We conduct our estimation using two models. The first model examines the effect of the litigation event variable on number of novel drugs. The second model assesses the effects of knowledge recency, heterogeneity, and scope on number of novel drugs. RESULTS The descriptive statistics and correlations among all variables used in the analysis are displayed in Table 1. To confirm that our analysis is not unduly affected by multicollinearity, we estimate variance inflation factors (VIF) for all variables. VIFs for all models in the main analysis are below 2, which is well within the acceptable range. Although VIFs are neither a necessary nor sufficient indicator of multicollinearity, a large sample such as ours mitigates the loss of power associated with multicollinearity (Echambadi, Campbell, & Agarwal, 2006). In order to understand the value of litigation for an accused firm’s innovation outcomes, we begin our analysis by comparing firms with and without litigation events in a given technological class. If the two sets of firms differ systematically in their underlying characteristics, it may mean that these characteristics are driving their innovation outcomes, rather than whether a litigation event occurred. To assess such possible selection bias among firms that underwent litigation and those that did not, we employ a coarsened exact matching (CEM) technique (Blackwell, Iacus, King, & Porro, 2009). CEM improves the estimation of causal effects by reducing imbalance between “treatment” (firms with a litigation event) and “control” (firms without a litigation event) groups. Compared to other matching techniques, CEM better aligns the distributional characteristics of these groups to help reduce concerns of statistical bias and model dependence (Iacus, King, & Porro, 2012), as well as endogeneity concerns. For our purposes, eliminating systematic differences that relate specifically to the innovation capabilities of the two sets of firms will improve their comparability. To create a matched sample, we therefore utilize four firm-level variables that can affect novel innovation output—revenue, R&D intensity, patent output, and age. 21 19 20 17 18 16 15 14 12 13 11 9 10 8 2 3 4 5 6 7 1 Mean SD 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 a Correlations calculated with logged variables. Mean and SD reported as normal; n 5 22,486. No. of novel drugs 0.05 0.3 1.00 approved 4187 10084 0.15 1.00 Firm sizea R&D intensity 994.2 4764.8 20.03 20.31 1.00 Firm agea 41.2 42.2 0.11 0.57 20.16 1.00 Prior drug approvals 0.3 1.0 0.30 0.29 20.06 0.27 1.00 Patents 25.2 80.2 0.11 0.33 20.06 0.35 0.23 1.00 Research in 2.0 2.7 0.13 0.36 20.09 0.31 0.28 0.41 1.00 different a geography Codevelopment 8.1 21.6 0.17 0.55 20.14 0.46 0.36 0.43 0.45 1.00 alliancesa 1.8 3.6 0.19 0.50 20.10 0.46 0.39 0.40 0.51 0.73 1.00 Licensing alliancesa Merger and 0.03 0.2 0.08 0.16 20.04 0.16 0.12 0.11 0.17 0.15 0.16 1.00 acquisition flag Active technology 1.0 0.2 0.00 0.00 0.03 0.02 0.01 0.02 0.01 20.02 0.03 0.03 1.00 areas Litigation event 0.07 0.3 0.12 0.27 20.07 0.20 0.24 0.16 0.06 0.24 0.17 0.12 20.00 1.00 Other litigation as 0.03 0.2 0.10 0.21 20.04 0.18 0.27 0.20 0.04 0.26 0.20 0.06 0.01 0.30 1.00 plaintiff Cooccurring 0.01 0.1 0.02 0.11 20.02 0.06 0.03 0.02 20.04 0.02 20.00 0.06 0.00 0.33 0.08 1.00 litigation Citations to litigated 1.4 21.6 0.03 0.07 20.01 0.04 0.05 0.10 0.02 0.05 0.03 0.00 20.01 0.17 0.02 0.10 1.00 patent Prior citation to 1.0 0.2 20.04 20.17 0.05 20.11 20.07 20.02 20.04 20.05 20.04 20.07 20.01 20.46 20.07 20.28 20.05 1.00 litigated patent Technology overlap 0.05 0.2 0.06 0.16 20.05 0.17 0.14 0.11 0.12 0.19 0.18 0.10 20.00 0.10 0.07 20.00 0.01 20.08 1.00 No. of technology 1.5 2.8 0.04 0.16 20.04 0.15 0.09 0.14 0.09 0.12 0.12 0.11 0.02 0.14 0.05 0.05 0.12 20.19 0.33 1.00 subclasses Knowledge recency 20.01 0.01 20.02 20.04 0.01 0.01 20.08 20.00 20.07 20.04 20.05 20.06 0.00 0.00 20.02 20.01 0.04 0.04 20.04 20.02 1.00 Knowledge 0.2 0.6 0.08 0.31 20.08 0.20 0.13 0.13 0.04 0.23 0.17 0.09 0.02 0.60 0.20 0.39 0.18 20.45 0.08 0.13 20.04 1.00 heterogeneity a Knowledge scope 122 638 0.05 0.20 20.04 0.10 0.10 0.08 20.00 0.11 0.06 0.09 20.02 0.56 0.14 0.62 0.32 20.40 0.01 0.08 0.03 0.58 1.00 Variables TABLE 1 Summary Statistics 2022 Awate and Makhija 1757 1758 Academy of Management Journal The “Pre-CEM” and “Post-CEM” columns in Table 2a show the difference in means of the selected variables before and after the CEM balancing process. It is evident that, prior to CEM balancing, the treatment and control groups differ in key characteristics, whereas post-balancing, the lack of statistically significant differences in the means of the matching variables suggests that the groups are more comparable. Building on previous research using matched sampling (e.g., Sorenson & Stuart, 2008; Zhang & Guler, 2020), we use a conditional fixed effects Poisson model to control for unobserved attributes of firms with and without litigation events, producing unbiased and efficient estimates (Armstrong, Gasparrini, & Tobias, 2014). Together, the CEM sampling approach and conditional Poisson method enable a direct comparison between the two sets of firms, and allow us to assess whether a litigation event has an impact on a firm’s subsequent innovation outcomes. Table 2b contains results for the conditional fixed effects Poisson model using the balanced sample in which firm-class-year observations with a litigation event are matched with firm-class-year observations without such an event. In this way, firms without a litigation event are active in the same therapeutic class as those with a litigation event. We also control for a variety of other factors to reduce any further potential imbalance between the two sets of firms. The crosssectional nature of this analysis allows us to utilize a larger sample of firms (359) than our main analysis and match more firms with litigation events (66 firms with 2,318 observations) to those without litigation events (293 firms with 2,387 observations), for a total of 4,705 observations. As Table 2b reports, TABLE 2A Pre- and Post-Balancing Using CEM October TABLE 2B CEM Analysis of Matched Firms With and Without Litigation Events DV 5 No. of novel drugs approved Firm size R&D intensity Firm age Prior drug approvals Patents Research in different geography Codevelopment alliances Licensing alliances Merger and acquisition flag Active technology areas Litigation event Observations Number of firms Firm dummies Year dummies Therapeutic class dummies Adj. R-squared Model 20.00† (0.00) 20.66† (0.40) 0.00 (0.00) 0.18 (0.05) 20.00 (0.00) 20.05 (0.06) 0.34 (0.13) 0.75 (0.18) 0.52 (0.33) 0.49 (0.23) 0.36* (0.18) 4,705 359 Yes Yes Yes 0.27 Note: Included: firms’ country of origin; robust standard errors in parentheses. The cross-sectional approach used for CEM estimations allowed us to match more firms with and without litigation events. The matched set of firms includes 66 with litigation events and 293 without such events. † p , 0.1 p , 0.05 p , 0.01 p , 0.001 Comparison of Firms With and Without Litigation Event Pre-CEM Firm size R&D intensity Patent output Firm age 3666.7 (170.0) 908.2 (13.95) 9.95 (0.37) 26.49 (0.54) Note: Robust standard errors in parentheses. † p , 0.1 p , 0.05 p , 0.01 p , 0.001 Post-CEM 162.6 (267.4) 0.03 (0.02) 0.14 (0.49) 1.02 (0.81) after using the matched sample, the treatment variable litigation event has a positive and significant effect on novel innovation outcomes for accused firms (b 5 0.369, p , 0.05). The significance of the treatment variable gives us initial confidence that a litigation event plays an important role in influencing a firm’s innovation outcomes. Table 3 contains the analysis for all hypotheses for all firms. Model 1 contains only control variables, with subsequent models adding in the explanatory variables. Model 6 is the full model. We first discuss the findings for the hypotheses, and then the findings for controls. 2022 Awate and Makhija According to our baseline hypothesis (Hypothesis 1), a patent litigation event will improve accused firms’ subsequent novel innovation output over those without such an event. The rationale for this relationship stemmed from the notion that knowledge spillovers from the patent-holding firm during litigation will assist accused firms with their own subsequent innovations in the same technological class as the litigated patent. Results for Hypothesis 1 for all firms are seen in model 2 of Table 3. We find that accused firms’ litigation event is positive and highly significant 1759 (b 5 0.461, p , 0.001), consistent with the logic that spillovers during litigation assist accused firms’ subsequent novel innovations. The magnitude of the coefficient suggests that litigation increases the odds of an accused firm’s novel drug discovery by 18%. The findings from both the CEM and the main analyses strongly confirm Hypothesis 1. Hypothesis 2 suggested that when litigation pertains to patents involving more recent knowledge, the accused firm’s subsequent novel innovation outcomes will be enhanced relative to nonlitigation TABLE 3 Effect of Litigation on Accused Firms’ Novel Innovation Output DV: No. of Novel Drugs Approved Firm size R&D intensity Firm age Prior drug approvals Patents Research in different geography Cooccurring litigation Other litigation as plaintiff Codevelopment alliances Licensing alliances Merger and acquisition flag Active technology areas 1 2 3 4 5 6 0.05 (0.05) 20.00† (0.00) 20.18 (0.36) 0.12 (0.04) 0.00 (0.00) 0.05 (0.08) 0.06 (0.34) 20.07 (0.18) 0.23 (0.14) 0.27 (0.17) 0.18 (0.20) 20.40 (0.14) 0.06 (0.04) 20.00† (0.00) 20.15 (0.38) 0.11 (0.03) 0.00 (0.00) 0.07 (0.08) 0.02 (0.34) 20.14 (0.18) 0.21 (0.14) 0.31† (0.17) 0.18 (0.20) 20.41 (0.13) 0.46 (0.13) 0.05 (0.04) 20.00† (0.00) 20.17 (0.36) 0.13 (0.04) 0.00 (0.00) 0.06 (0.08) 0.05 (0.34) 20.07 (0.18) 0.23† (0.14) 0.28 (0.17) 0.19 (0.21) 20.40 (0.14) 0.05 (0.04) 20.00† (0.00) 20.08 (0.34) 0.12 (0.04) 0.00 (0.00) 0.06 (0.08) 20.01 (0.35) 20.10 (0.18) 0.23 (0.14) 0.37 (0.18) 0.24 (0.22) 20.44 (0.14) 0.06 (0.04) 20.00† (0.00) 20.09 (0.39) 0.12 (0.03) 0.00 (0.00) 0.06 (0.08) 20.03 (0.35) 20.16 (0.18) 0.20 (0.13) 0.30† (0.17) 0.17 (0.20) 20.41 (0.13) 0.07 (0.04) 20.00† (0.00) 20.02 (0.37) 0.12 (0.03) 0.00 (0.00) 0.08 (0.08) 20.08 (0.37) 20.18 (0.18) 0.21 (0.14) 0.38 (0.18) 0.23 (0.21) 20.44 (0.142) Litigation event Knowledge recency 2.61 (1.15) Knowledge heterogeneity 0.29 (0.10) Knowledge scope Observations Number of firms Country of origin Firm fixed effects Therapeutic class dummies Year dummies 22,486 169 Yes Yes Yes Yes Note: Robust standard errors in parentheses. † p , 0.1 p , 0.05 p , 0.01 p , 0.001 22,486 169 Yes Yes Yes Yes 22,486 169 Yes Yes Yes Yes 22,486 169 Yes Yes Yes Yes 0.09 (0.02) 22,486 169 Yes Yes Yes Yes 2.00 (0.99) 0.22 (0.09) 0.08 (0.02) 22,486 169 Yes Yes Yes Yes 1760 Academy of Management Journal firms. Given that more recent knowledge will likely be more unfamiliar to the accused firm, such spillovers can generate new insights that can be valuable for its subsequent innovations. As can be seen in models 3 and 6 in Table 3, the coefficient is positive and significant in both cases (b 5 2.610, p , 0.05; b 5 2.002, p , 0.05). The magnitude of the coefficient indicates that a one standard deviation increase in knowledge recency of a litigated patent increases the odds of the accused firm’s novel drug discovery by 7%. Hypothesis 2 is thus supported. Hypothesis 3 predicted that patent litigation involving greater knowledge heterogeneity will enhance accused firms’ subsequent novel innovation outcomes over those of accused firms. This causal association was based on the expectation that such spillovers shed light on more intricate interrelationships among diverse knowledge elements. It also offers the accused firm an opportunity to understand the strategic rationale for combining such heterogeneous knowledge elements. The coefficients for this variable are significant in both models 4 (b 5 0.291, p , 0.05) and 6 (b 5 0.223, p , 0.05). The magnitude of the coefficient indicates that a one standard deviation increase in a litigated patent’s knowledge heterogeneity increases the odds of accused firms’ novel drug discovery by 14%. These findings are consistent with the argument that litigation involving more heterogeneous knowledge elements offer richer insights on complex underlying causal mechanisms, allowing the firm to improve its own ability to subsequently create novel innovations. Hypothesis 3 is thus supported. Hypothesis 4 predicted that litigated patents associated with greater scope will enhance the accused firm’s subsequent novel innovation output. This argument was based on the logic that greater patent scope results in a wider range of knowledge spillovers. The coefficient for knowledge scope is positive and significant in both models 5 (b 5 0.091, p , 0.001) and 6 (b 5 0.080, p , 0.001). The magnitude of the coefficient indicates that a one standard deviation increase in the scope of a litigated patent increases the odds of accused firms’ novel drug discovery by 17%. Hypothesis 4 is thus supported. Among the control variables, three are seen to be statistically significant across the models. Prior drug approvals significantly affect subsequent innovation outcomes, supporting the role of experiential learning in innovation. Licensing alliances are also seen to play a crucial role in enhancing innovation outcomes, as predicted. Interestingly, more technology areas in which the firm is active negatively affects October innovation outcomes, suggesting that specialization is important for the ability to learn from spillovers. Other control variables are not found to be statistically significant, possibly due to some being highly correlated with other control variables. Robustness Checks To ensure the robustness of our results, we conducted a number of additional tests, with results in Tables 4 to 6. First, we account for the possibility that the accused firm’s citations of the litigated patent are a more direct reflection of it benefiting from spillovers. We therefore rerun the analyses using number of citations of the litigated patent in the accused firms’ subsequent patents as an alternate dependent variable. Results are shown in Table 4. Even with additional controls becoming significant when using this dependent variable, findings for the explanatory variables remain consistent with those in the main analysis, confirming all hypotheses. Another possible issue for our analysis is endogeneity biasing our estimates (Certo, Busenbark, Woo, & Semadeni, 2016). For example, the accused firm may have been targeted for litigation rather than some other firm due to the former’s prior work in the same domain as the litigated patent. Evidence for nonrandom targeting of the accused firm for litigation may be indicated by overlap in the subclasses of the litigated patent and the accused firm’s prior patents. Such overlap suggests that the accused firm is already active in a domain related to the litigated patent and possesses innovation capabilities in this domain. To address possible endogeneity, we employ a two-stage Heckman (1979) model, with the first stage accounting for whether the accused firm had a patent in the past five years with at least one subclass in common with the litigated patent. Next, we select an exclusion restriction that influences the first-stage selection equation but not the second-stage dependent variable and error term (Shaver, 1998; Wolfolds & Siegel, 2019). The exclusion restriction selected is the total number of subclasses in the accused firm’s patents. Its correlation of 0.36 with the firststage outcome variable, and 0.02 and 0.01 with the second-stage dependent variable and error term, respectively, fulfills the exclusion restriction criteria. To correct for selection bias, the inverse Mills ratio (IMR) obtained from the first-stage Probit equation is inserted into the second-stage equation. Tables 5 and 6 contain the two-stage Heckman results for both the main and the alternate 2022 Awate and Makhija 1761 TABLE 4 Robustness Check—Effect of Litigation on Accused Firms’ Citations of the Litigated Patent DV: No. citations of litigated patent Firm size R&D intensity Firm age Prior drug approvals Patents Research in different geography Cooccurring litigation Other litigation as plaintiff Citation before litigation Codevelopment alliances Licensing alliances Merger and acquisition flag Active technology areas 1 2 3 4 5 6 0.30 (0.07) 28.46 0.26 (0.09) 28.01 0.32 (0.07) 28.77 0.32 (0.12) 24.85 0.16 (0.13) 24.92 0.22† (0.12) 24.48 (1.43) 20.25 (0.26) 0.22 (2.16) 20.43 (0.31) 0.07 (0.05) 0.00 (1.47) 20.31 (0.26) 0.21 (1.52) 20.31 (0.35) 0.19 (1.71) 20.30 (0.38) 0.10 (0.06) 0.00 (0.05) 0.00 (1.70) 20.24 (0.39) 0.05 (0.04) 0.00 (0.00) 0.28 (0.34) 1.92 (0.30) 20.52 (0.21) 0.29 (0.66) 0.85 (0.24) 21.58 (0.31) 20.85 (0.66) 20.65 (0.24) 3.75 (0.65) (0.00) 0.17 (0.28) 2.78 (0.34) 20.24 (0.21) 20.52 (0.79) 0.79 (0.24) 21.03 (0.29) 20.91 (0.74) 21.11 (0.25) (0.00) 0.45 (0.44) 1.17 (0.35) 20.48 (0.30) 20.10 (0.45) 1.53 (0.44) 22.72 (0.63) 20.75 (0.62) 20.18 (0.16) (0.00) 0.40 (0.37) 1.20 (0.52) 20.69 (0.30) 20.03 (0.43) 1.07 (0.42) 22.07 (0.36) 20.60 (0.45) 20.31 (0.21) (0.00) 0.40 (0.36) 1.05 (0.50) 20.64† (0.35) 20.07 (0.40) 1.33 (0.42) 22.29 (0.38) 20.65 (0.44) 20.09 (0.20) 0.88 (0.35) 22,486 169 Yes Yes Yes Yes 10.66 (3.09) 0.87 (0.34) 0.60 (0.29) 22,486 169 Yes Yes Yes Yes (0.08) 0.00 (0.00) 0.09 (0.26) 2.89 (0.45) 20.07 (0.21) 20.42 (0.94) 0.80 (0.23) 21.00 (0.29) 20.96 (0.79) 21.19 (0.27) Litigation event Knowledge recency 34.55 (7.18) Knowledge heterogeneity 2.69 (0.75) Knowledge scope Observations Number of firms Country of origin Firm fixed effects Therapeutic class dummies Year dummies 22,486 169 Yes Yes Yes Yes 22,486 169 Yes Yes Yes Yes 22,486 169 Yes Yes Yes Yes 22,486 169 Yes Yes Yes Yes (0.04) 0.00 Note: Robust standard errors in parentheses. † p , 0.1 p , 0.05 p , 0.01 p , 0.001 dependent variables. As expected, the exclusion restriction variable number of subclasses is significantly associated with the first-stage outcome variable subclass overlap (p , 0.001). The significant and negative IMR in the second-stage models in Table 6 indicates the possibility of endogeneity. Even so, results for the explanatory variables remain similar to those of our main analysis, providing additional support for the four hypotheses. DISCUSSION Extant research has highlighted patent litigation as a key part of a strong appropriability regime that ensures a firm’s ability to derive value from its own innovations. Since the overarching purpose of patent litigation is to prevent knowledge spillovers, all else being equal we should expect that undergoing litigation will have no real value to accused firms. This would be particularly true if nondisclosure 1762 Academy of Management Journal October TABLE 5 Robustness Check Using Heckman 2-Stage Models: Effect of Litigation on Accused Firms’ Novel Innovation Output DV: No. of Novel Drugs Approved Firm size R&D intensity Firm age Prior drug approvals Patents Research in different geography Cooccurring litigation Other litigation as plaintiff Codevelopment alliances Licensing alliances Merger and acquisition flag Active technology areas No. of technology subclasses First- Stage Model 0.00 (0.02) 20.00 (0.00) 0.10 (0.07) 0.05 (0.01) 20.00 (0.00) 0.12 (0.08) 20.61 (0.24) 20.05 (0.11) 0.08 (0.07) 0.17† (0.09) 0.29 (0.28) 20.16 (0.22) 0.09 (0.02) IMR 1 2 3 4 5 6 0.05 (0.05) 20.00 (0.00) 20.18 (0.36) 0.12 0.06 (0.04) 20.00 (0.00) 20.14 (0.38) 0.12 0.05 (0.04) 20.00 (0.00) 20.16 (0.36) 0.13 0.05 (0.04) 20.00 (0.00) 20.09 (0.35) 0.12 0.06 (0.04) 20.00 (0.00) 20.07 (0.39) 0.12 0.07 (0.04) 20.00 (0.00) 20.01 (0.38) 0.12 (0.04) 0.00 (0.00) 0.05 (0.08) 0.04 (0.36) 20.07 (0.18) 0.23 (0.14) 0.28 (0.18) 0.18 (0.22) 20.40 (0.14) (0.04) 0.00 (0.00) 0.08 (0.08) 20.01 (0.37) 20.15 (0.18) 0.21 (0.14) 0.32† (0.17) 0.19 (0.21) 20.42 (0.14) (0.04) 0.00 (0.00) 0.06 (0.08) 0.03 (0.37) 20.07 (0.18) 0.23† (0.14) 0.28 (0.18) 0.20 (0.22) 20.40 (0.14) (0.04) 0.00 (0.00) 0.06 (0.08) 0.01 (0.38) 20.10 (0.18) 0.23 (0.14) 0.37 (0.18) 0.24 (0.24) 20.43 (0.14) (0.03) 0.00 (0.00) 0.07 (0.08) 20.07 (0.39) 20.17 (0.18) 0.20 (0.13) 0.31† (0.17) 0.19 (0.21) 20.42 (0.14) (0.03) 0.00 (0.00) 0.08 (0.08) 20.09 (0.40) 20.18 (0.18) 0.21 (0.14) 0.38 (0.18) 0.24 (0.22) 20.44 (0.14) 0.08 (0.21) 0.02 (0.20) 0.09 (0.02) 22,486 169 Yes Yes Yes Yes 1.99 (0.99) 0.22 (0.09) 0.08 (0.01) 22,486 169 Yes Yes Yes Yes 0.03 (0.20) Litigation event 0.06 (0.20) 0.46 (0.13) Knowledge recency 0.02 (0.20) 2.60 (1.15) Knowledge heterogeneity 20.02 (0.20) 0.29 (0.10) Knowledge scope Observations Number of firms Country of origin Firm fixed effects Therapeutic class dummies Year dummies 22,486 169 Yes n/a Yes Yes 22,486 169 Yes Yes Yes Yes 22,486 169 Yes Yes Yes Yes 22,486 169 Yes Yes Yes Yes 22,486 169 Yes Yes Yes Yes Note: DV of Heckman first-stage model: Technology overlap between accused and plaintiff firms. Robust standard errors in parentheses. † p , 0.1 p , 0.05 p , 0.01 p , 0.001 agreements effectively limit meaningful spillovers. Our findings show, however, that litigation can actually enhance accused firms’ subsequent novel innovation output relative to firms that have not undergone litigation, even after controlling for innovation-related capabilities. This suggests not only that knowledge spillovers occur during the litigation process, but that they occur in ways that help accused firms bring about their own novel innovations in a related domain. This is surprising given the role played by patent litigation in strong appropriability regimes for limiting spillovers. An alternative measure to directly assess the use of spillovers (citations of the litigated patent) lends further credence to this overall finding. 2022 Awate and Makhija 1763 TABLE 6 Robustness Check Using Heckman 2-Stage Models: Effect of Litigation on Accused Firms’ Citations of the Litigated Patent DV: No. Citations Of Litigated Patent Firm size R&D intensity Firm age Prior drug approvals Patents Research in different geography Cooccurring litigation Other litigation as plaintiff Citation before litigation Codevelopment alliances Licensing alliances Merger and acquisition flag Active technology areas IMR 1 2 3 4 5 6 0.26 (0.07) 28.19 (1.49) 20.27 (0.26) 0.19 (0.09) 0.00 (0.00) 0.17 (0.18) 3.18 (0.43) 0.01 (0.18) 20.35 (0.87) 0.79 (0.23) 21.05 (0.28) 21.12 (0.73) 21.18 (0.26) 20.45 (0.39) 0.20 (0.09) 27.91 (2.41) 20.46 (0.34) 0.01 (0.04) 0.00 (0.00) 0.38 (0.24) 2.51 (0.40) 20.42 (0.17) 0.40 (0.60) 0.83 (0.24) 21.70 (0.31) 21.37 (0.70) 20.67 (0.19) 20.97 (0.33) 4.10 (0.59) 0.29 (0.08) 28.59 (1.51) 20.33 (0.26) 0.18 (0.07) 0.00 (0.00) 0.27 (0.19) 3.09 (0.38) 20.15 (0.20) 20.45 (0.72) 0.76 (0.23) 21.08 (0.28) 21.07 (0.70) 21.10 (0.24) 20.50 (0.39) 0.26 (0.10) 23.58 (1.43) 20.54 (0.39) 0.12† (0.06) 0.00 (0.00) 0.76 (0.29) 1.95 (0.38) 20.11 (0.23) 20.09 (0.45) 1.43 (0.60) 22.97 (0.84) 22.00 (0.95) 20.08 (0.32) 22.06 (0.68) 0.06 (0.13) 24.41 (1.47) 20.44 (0.44) 20.05 (0.04 0.00 (0.00) 0.64† (0.38) 2.10 (0.55) 20.50 (0.22) 20.03 (0.39) 1.15 (0.38) 22.51 (0.52) 21.80† (1.00) 20.20 (0.16) 21.93 (0.63) 0.15 (0.10) 23.37 (1.56) 20.62 (0.49) 20.00 (0.04) 0.00 (0.00) 0.70 (0.36) 2.02 (0.47) 20.31 (0.30) 20.05 (0.40) 1.33 (0.49) 22.68 (0.62) 22.02† (1.14) 0.11 (0.23) 22.41 (0.80) 1.08 (0.21) 22,486 169 Yes Yes Yes Yes 15.52 (3.61) 1.36 (0.58) 0.71 (0.17) 22,486 169 Yes Yes Yes Yes Litigation event Knowledge recency 35.08 (6.65) Knowledge heterogeneity 3.41 (1.02) Knowledge scope Observations Number of firms Country of origin Firm fixed effects Therapeutic class dummies Year dummies 22,486 169 Yes Yes Yes Yes 22,486 169 Yes Yes Yes Yes 22,486 169 Yes Yes Yes Yes 22,486 169 Yes Yes Yes Yes Note: DV of Heckman first-stage model: Technology overlap between accused and plaintiff firms. First-stage results are in Table 5. Robust standard errors in parentheses. † p , 0.1 p , 0.05 p , 0.01 p , 0.001 We also observed that some types of spillovers are more useful than others for enhancing the accused firm’s subsequent novel innovation output. Spillovers that help to reduce the ambiguity of causal relationships underpinning another firm’s innovation are most useful to the accused firm. The relative unfamiliarity of newer and more recently created knowledge components in the litigated patent renders spillovers more valuable by shedding additional light on this new knowledge and how it can be effectively used. Similarly, spillovers that clarify how heterogeneous components in the litigated 1764 Academy of Management Journal patent are successfully integrated provide insights to the accused firm about how to use similarly heterogeneous or disparate components for an innovation. Litigation of patents with greater scope likewise creates spillovers that unravel the patent’s complex and multidimensional nature, leading to a better understanding of its underlying science. In all, findings support our argument that learning through knowledge spillovers does operate during courtroom proceedings, an issue not previously considered in the literature. This study highlights how, even in an appropriability regime that confers strong ownership rights over innovations, spillovers are difficult to contain. In particular, it points to a key trade-off in the patent litigation process for protecting a firm’s proprietary knowledge. While litigation helps to protect the knowledge covered in the patent itself, it also requires the firm to give up additional proprietary knowledge in the process, above and beyond the patent. Given that a patent-holding firm is likely to defend some of its most valuable knowledge through litigation—that which underpins its competitive advantage (Somaya, 2003)—the risk of unintended knowledge spillovers to other firms will have serious ramifications for its competitive position. Through spillovers during litigation, the firm may have strengthened a competitor (Hamel, 1991; Makhija & Ganesh, 1997). This research thus demonstrates how an institution whose primary purpose is to protect intellectual property rights also has the effect of enabling broader diffusion of this knowledge. These dual effects underscore the double-edged sword of patent litigation. Knowledge spillovers are known to occur through various means, including employee mobility (Agarwal, Ganco, & Ziedonis, 2009; Corredoira & Rosenkopf, 2010; Rosenkopf & Almeida, 2003), network ties (Liebeskind, Oliver, Zucker, & Brewer, 1996; Powell, Koput, & Smith-Doerr, 1996), and alliances (Mowery, Oxley, & Silverman, 1996; Steensma & Corley, 2001). While studies have highlighted informal means of knowledge transmission, the very specific rules and procedures that litigating parties must follow generate the spillovers that occur during litigation. It is the requirement for disclosures at various stages of litigation that make spillovers more or less inevitable during the process. This unusual element may also make spillovers more systematic than in other contexts, as they relate more directly to a particular patented innovation. This study also adds important contributions to our understanding of patent litigation, which has October thus far explained firms’ decisions to initiate litigation rather than what happens once they undertake litigation. This research hones in on the latter, and underscores the vital importance of spillovers during this process. Since the litigating parties are often competing in a similar space, their desire to learn from one another is particularly acute. Spillovers can facilitate particularly valuable learning, including about better technologies, superior processes, and more viable innovation strategies. Griliches (1992) and Jaffe, Trajtenberg, and Fogarty (2000) noted that the most interesting aspect of spillovers is the impact of the discovered ideas or compounds on the research endeavors of others. Our research is particularly helpful in shedding light on this relationship. A litigated patent represents a successful invention, one that has likely undergone prior failures and engendered a valuable learning process for the patent-holding firm, giving rise to previously unknown but important new insights. For this reason, any new information about the processes by which the firm came up with the new knowledge, the paths that lead to failure and should be avoided, and new directions to take the knowledge, will be valuable to other firms. Innovation involves a particularly difficult process, and insights from other firms can not only save resources and time but also improve their ability to develop their own novel innovations. This research demonstrates that spillovers during litigation can actually provide learning opportunities that can enhance the innovativeness of other firms. This is important in that innovation represents a capability that is not easily developed or transferred. Since patent litigation can present a unique opportunity for the accused firm to learn from knowledge spillovers during the proceedings and enhance its own innovation capabilities, a key question arises— should a firm actively solicit being targeted for litigation as a strategy? Some may suggest that the opportunities to learn may be worth involvement in litigation, although the evidence does not automatically support such a conclusion. Litigation is not only accompanied by significant costs in terms of expenditures and time, it also carries the risk of an unfavorable ruling that can result in loss of a strategic market, revenues, and reputation. There is also the possibility of leakage of the accused firm’s own proprietary knowledge—spillovers can operate as a two-way street during litigation. Nonetheless, the findings of this study suggest that the accused firm’s ability to benefit from knowledge spillovers may help to balance the costs of litigation. 2022 Awate and Makhija Future Research Directions This research can be extended in a number of directions. Although our focus was on how the accused firm gains insights from the patent-holding firm, future research might consider litigation that involves contested patents of both firms, as this may reflect conditions under which innovation-related knowledge spillovers also accrue to the patentholding firm. Such a context may also assist in developing greater understanding about how litigation dynamics influence spillovers to each party. Similarly, while this research examined effects of spillovers while holding technological class constant, it may be that specific disease areas or baseline technologies have stronger effects on the hypothesized relationships. We believe that a deeper examination of such factors can provide more insights into the micro-mechanisms at play in this setting. Another issue worth examining is the use of patent litigation in industries characterized by weaker appropriability regimes than that of the pharmaceutical industry. While we expect that our arguments here are largely generalizable to other industries, those with comparatively weaker regimes will likely exacerbate spillovers to competitors, potentially reducing incentives for innovation. It may be that in such industries, firms adopt alternative isolating mechanisms and complementary assets to thwart spillovers and maintain their proprietary knowledge (Teece, 1986). On the other hand, industries in which technologies evolve at a slower pace may be less hampered by weaker appropriability regimes, given lower innovation-based competition. We argued that, irrespective of the outcome of litigation—that is, whether a firm wins or loses—the important phenomenon of unintended knowledge spillovers during courtroom discussion will still occur and create conditions for learning. Future research can, however, consider whether and how litigation outcomes matter for learning. For example, it may be that learning from spillovers is even more impactful when the other firm wins the case, as this win reflects the proprietary nature of the knowledge spillovers. On the other hand, the outcome of the case may have a psychological effect on the use of spillovers, in that the winning firm chooses to ignore spillovers due to its belief that its own knowledge is superior. It may also be useful to examine the trajectory of subsequent innovations for litigated and nonlitigated patents. For example, given the potential for knowledge spillovers through litigation, subsequent innovations in a litigated technological domain may 1765 occur more rapidly than for those patents not subjected to litigation. Even though this research highlighted how knowledge spillovers are generated during litigation, it remains unclear whether patent-holding firms appreciate the effect of such spillovers. It may be that the implications of spillovers escape the notice of firms that initiate patent litigation only sporadically or infrequently. On the other hand, firms that more regularly undertake patent litigation may have learned about their spillover effects. This may be reflected in a reduction in the use of patent litigation over time, or through specific strategies by which such spillovers are reduced. To assess whether patent-holding firms learn over time about the beneficial effects of knowledge spillovers to their competitors, and, if so, how they respond, it would be helpful for researchers to take a more longitudinal perspective of firms’ litigation strategies. We assumed in this research that the patentholding firm unintentionally spills knowledge during litigation. Given the value of this proprietary knowledge to the firm’s competitive advantage, it seems unlikely that the firm reveals this knowledge intentionally. However, subsequent research may reexamine this assumption. It may be that firms actually make an effort to provide information sparingly and only as necessary. For example, if a firm believes it has a strong case, it may try to withhold information. On the other hand, if the firm thinks it might lose the case, it may choose to introduce more supporting evidence. Providing information may be recognized as a necessary evil in the litigation process, without which the patent becomes worthless to the firm. CONCLUSION Scholars have highlighted the importance of strong appropriability regimes that provide patents, and have emphasized that patent litigation protect firms’ proprietary knowledge and reduce spillovers (James, Leiblein, & Lu, 2013; Mahoney & Pandian, 1992; Somaya, 2003). Past research has paid little attention, however, to how patent litigation actually affects spillovers of firms’ proprietary knowledge. This study demonstrated that litigation can actually enhance knowledge spillovers from a patent-holding firm to an accused firm. Proving infringement of a patent often requires presentation of considerable information during litigation that had previously remained secret, including the proprietary processes that led to the patented innovation, disproved 1766 Academy of Management Journal assumptions and alternative hypotheses tested, and deeper appreciation of the nature of the new scientific insight and its further application. With the intent and capacity to learn (Hamel, 1991; Makhija & Ganesh, 1997), the accused firm is uniquely positioned to acquire valuable insights about the innovation process that can help it to subsequently create its own novel innovations in the same technological arena. This study is the first to demonstrate how knowledge spillovers during litigation benefit the accused firm’s subsequent novel innovations, shedding insight into the micro-mechanisms through which such learning occurs. REFERENCES Adegbesan, J. A., & Higgins, M. J. 2011. 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