MEDICAL BACKGROUND NECROTIZING FASCIITIS TABLE OF CONTENTS 01 Introduction/Definition 02 Etilogy 03 Epidemiology 04 APK 05 Pathophysiology 06 Diagnosis TABLE OF CONTENTS 07 Differential Diagnosis 08 Test and measures 09 Treatment/Management 10 PT Treatment 01 Introduction/Definition Necrotizing fasciitis (NF) is a life-threatening bacterial infection causing necrosis of the fascia, underlying skin, and vasculature. It is commonly known as a "flesh-eating disease" Group A Streptococci are thought to be the most common organisms causing necrotizing fasciitis Hallmarks: Friable superficial fascia Gray exudates pus Widespread tissue destruction Note: Infection is either pollumicrobial or monomicrobial Presentation: Severe pain Erythematous, blistering, and necrotic skin Systemically unwell, fever and tachycardia Presence of crepitus 02 Etiology Rare but rapidly progressive, life-threatening bacterial infections that can destroy the epidermis, dermis, subcutaneous tissue, fascia, and muscle. It can be caused by polymicrobial such as the group A Streptococcus (GAS) and Staphylococcus aureus Clostridium, Vibrio, and Klebsiella (other bacterias) Classification of NF: 1. Type 1: NF caused by both aerobic and anaerobic bacteria 2. Type 2: NF caused by group A beta-hemolytic Streptococcus and Staphylococcus aureus. 3. Type 3: NF caused by clostridium perfringens or less commonly clostridia septicum. It usually follows SignifIcant injury or surgery and results in gas under the skin (crackling). 03 Epidemiology The incidence of NF is estimated to be 0.3 to 15 cases per 100,000 population. 50% of cases occur in previously healthy individuals Risk Factors Abdominal surgery Medical comorbidities (e.g. diabetes, malignancy) More than 70% of cases are recorded in people with at least one of these clinical situations: immunosuppression, diabetes, alcoholism/drug abuse/smoking, malignancies, and chronic systemic diseases. For unclear reasons, it occasionally occurs in people with an apparently normal general condition. 04 APK The Skin 1. The body's largest and primary protective organ. 2. Functions as a temperature regulator and protection against ultraviolet (UV) light, trauma, pathogens, microorganisms, and toxins. 3. Immunologic surveillance, sensory perception, control of insensible fluid loss, and homeostasis in general. 1. Epidermis Stratum Corneum Stratum Lucidum Stratum Granulosum Stratum Spinosum Stratum Basale 2. Dermis Papillary Layers Reticular layer 3. Hypodermis (deeper subcutaneous tissue) Fascia made up of sheets of connective tissue that are found below the skin. These tissues attach, stabilize, impart strength, maintain vessel patency, separate muscles, and enclose different organs. Traditionally, the word fascia was used primarily by surgeons to describe the dissectible tissue seen in the body encasing other organs, muscles, and bones. Recently, the definition has been broadened to include all collagenous-based soft tissues in the body, including cells that create and maintain the extracellular matrix. Fascia Classification of Fascia: 1. Superficial fascia 2. Deep fascia 3. Visceral fascia 4. Parietal Fascia 05 Pathophysiology CLINICAL MANIFESTATION: Early features – pain, erythema, and edema Late features such as – pyrexial, tachycardia, hypotension, tachypnea, and altered mental status X-ray may show soft tissue gas 06 Diagnosis DIAGNOSIS: 1. Laboratory Risk Indicator for Necrotizing Fasciitis (LRINEC) DIAGNOSIS: 2. Plain Radiography 3. Computed tomography (CT Scan)/Magnetic Resonance Imaging (MRI) 07 Differential Diagnosis DIFFERENTIAL DIAGNOSIS: 1. Synergistic Necrotizing Cellulitis 2. Streptococcal Myonecrosis 3. Gas Gangrene 08 Test and measures Test and measures 1. Wound assessment 2. Integumentary Integrity 3. Observation and palpation assessment 4. Color assessment 5. Drainage assessment 6. Stage of current wound assessment 7. Wound healing tools 8. Sensory assessment 9. Range of motion assessment 09 Treatment/Management Treatment/Management 1. Antibiotic treatment 2. Hyperbaric oxygen therapy (HBOT) 3. Intravenous immunoglobulin (IVIG) 4. Wound closure and reconstructive surgeries are performed once bacteriologic, metabolic, and nutritional balances are obtained. 5. AB103: One study assessed the efficacy of a new type of treatment that affects the immune response, called AB103. 6. Supportive therapy Treatment/Management Urgent referral for extensive surgical debridement Aggressive wound debridement should be performed early with broadspectrum intravenous antibiotics unless a monomicrobial agent is identified, in which case more directed therapy would be appropriate. supportive care and resuscitation 10 PT Treatment Physiotherapy management Physiotherapy management will primarily occur after surgical debridement and mainly focus on the maintenance, prevention, and management of secondary complications. Physiotherapy does not play a role in the curative management of this pathology. Patients with necrotizing fasciitis have an increased risk of loss of endurance and strength. Prevention: Prophylactic chest physiotherapy to prevent atelectasis, as these patients often spend most of their time in bed Loss of muscle power and range of motion: By incorporating an exercise program Loss of function: Mobility program Pressure sores: Positioning and mobilization INITIAL EVALUATION GENERAL INFORMATION: Patients Name: MEP Age: 46 Sex: Female Address: Dulao, Aringao, La Union Civil Status: Married Handedness: Right Occupation: Housewife Religion: Roman Catholic GENERAL INFORMATION: Referring Department: Internal Medicine Referring Doctor: Brylle Domerson M. Turalba, MD Rehab Doctor: Date of Referral: April 11, 2023 Date of Consultation: April 11, 2023 Date of IE: April 11, 2023 Diagnosis: Necrotizing fasciitis lateral neck pulmonary infection 2° PTB 01 SUBJECTIVE SUBJECTIVE C/C: Pt’s husband complains of pt general weakness. Pt‘s Goal: Pt’s husband wants Pt to be able to regain normal strength and optimal function. HISTORY OF PRESENT ILLNESS Pt’s present condition started ~ 9 wks PTIE when pt noticed a small mass on the posterior part of the (R) ear. The mass is not visible but claims to be palpable. ~ 8 weeks PTIE, the mass becomes marble size, palpable and visible associated c tolerable pain and undocumented fever. Pt sought to consult at a private clinic and was prescribed unrecalled antibiotics. However, pt did not purchase the said medications and opted to consult a faith healer instead. Pt was instructed by the faith healer to apply coconut oil and pressure on the affected part. HISTORY OF PRESENT ILLNESS After several days, pt noticed the increasing size of the mass accompanied by worsening pain and more frequent episodes of fever. Mass is ruptured c purulent and blood discharge. Pt has been experiencing body weakness and DOB, hence pt opted to consult ITRMC. Pt was then admitted after. On April 11, 2023, pt was referred to the Department of Physical Therapy and rehabilitation medicine for further evaluation and management of the pt’s condition. PRESENT MEDICATIONS DRUG DOSES INDICATION SIDE EFFECTS Sultamicillin 750mg per tab b.i.d every 12 hours Respiratory tract, skin and soft tissues infections Diarrhea, nausea, vomiting, abdominal pain, sore mouth, fatigue, and itching. Relieve pain, tenderness, swelling, and stiffness Cough, fever, skin rash, sneezing, sore throat, swelling of the face, fingers, feet, or lower legs. To treat Gingivitis Hives, severe skin rash; wheezing, cold sweats, feeling light-headed; swelling of your face Celecoxib Chlorhexidine Gluconate Mouthwash 200mg per cab b.i.d 10ml per gargle t.i.d PAST MEDICAL HISTORY PAST MEDICAL HISTORY: (+) DM II (2012) (+) Previous Surgery (-) Hypertension (-) CVD (-) Pulmonary Tuberculosis (-) Allergies FAMILY HISTORY PERSONAL HISTORY Px is a non-smoker Px is a non-alcoholic Px drinks coffee occasionally Px does household chores SOCIAL HISTORY Px has (1) son Px’s family is financially unstable Px’s husband is a fisherman ENVIRONMENTAL HISTORY Px lives in a bungalow house with her husband and son Px approximately has: 10 steps from Bedroom to Bathroom 8 steps from Bedroom to Livingroom 8 steps from Bedroom to Kitchen 12 steps from the Bedroom to the Main door Px needs to go up 3 flights of stairs to proceed to the main road Px commutes with a tricycle and jeepney whenever she goes to the town proper or to buy groceries 02 OBJECTIVE VITAL SIGNS VS: Ⓝ ā p̄ BP (mmHg) <120/80 130/80 130/80 SPO2 (%) 95-100 92% 94% OCULAR INSPECTION Mesomorph Bedridden Not in apparent pain/distress (+) NGT (+) IV line on (L) dorsal hand and (R) dorsal oot (+) IFC (+) Swelling on (L) UE (+) Dry wound on (L) lateral wrist (+) General dry scaling of the skin (-) Deformities PALPATION Normothermic on all assessed body parts. (+) Grade 1 edema on (L) UE (-) Tenderness RANGE OF MOTION All major jts of (B) UE/LE are found to be WNL and were assessed actively and passively done, with normal end feel except: Findings: LOM on (B) SH flexion, abduction, and hip flexion. Significance: pt’s LOM is d/t prolonged immobilization and hospitalization GROSS MANUAL MUSCLE TEST All major muscles of (B) UE are graded 2-/5 to 2+/5, while (B) LE are grossly graded 1/5. Findings: This indicates muscle weakness on (B) UE/LE Significance: pt is 2° probable nerve damage and general body deconditioning. SENSORY ASSESSMENT Superficial Sensation: (3 trials were done grossly for both light touch and pain sensations. For Light Touch, the dull end of the neuro hammer and a brush is used, for Pain, the pointy end of the neuro hammer, ) SENSORY ASSESSMENT Findings: Pt has intact sensation on all assessed segments. However, pt’s sensation is decreased in all assessed segments specifically on LE. Significance: Pt has no sensory deficit that could affect the tx. The intact sensation was crucial to identify any stimulus that could cause pain and any possible accident. Also, good sensory input was manifested thus, pt will able to have smooth and coordinated movements. A fair superficial sensation will serve as a precaution for the application of modalities. DEEP TENDON REFLEX DEEP TENDON REFLEX Significance: Pt has normoreflexia on (B) brachialis which indicates the reflex arc is intact. On (B) biceps and triceps reflex, pt presents a slight but definitely present response. On (B) LE, pt has hyporeflexia, indicating that the reflex arc has been damaged or severed. PATHOLOGICAL REFLEXES (-) Babinski on (B) foot (-) Clonus on (B) foot Significance: There were no pathological reflexes present that could be a hindrance to pt.’s treatment course and there would be no unwanted, involuntary movements of the foot even c the slightest of stimuli. CHEST AUSCULTATION Anterior Normal areas ↓ breath sound in all assessed Significance: pt’s diagnosis. Posterior N/A ↓ breath sound is d/t secondary complication of pt’s SPUTUM ASSESSMENT Findings: Color: Clear Odor: Odorless Amount: > 2 tbsp Texture: Smooth/non-viscous Significance: Clear sputum indicates that there is no significant presence of infection or inflammation in the respiratory tract. Odorless sputum suggests that there is no significant bacterial or fungal infection present. Non-viscous sputum is also a positive sign, as overly thick or sticky sputum can indicate that the body is having difficulty clearing mucus from the lungs. WOUND ASSESSMENT Findings: Size: 2 inches in length. Covering the posterior nape. Color: Yellowish and black Odor: Foul Significance: Pt’s wound extends to the nape. Pt’s wound has a yellowish color which may indicate the presence of pus or dead tissue in the wound. This could be a sign of infection or a non-healing wound. Pt also presents black or dark brown skin surrounding a wound could indicate dead tissue or necrosis. This can be a sign of a serious wound that requires medical attention. ACTIVITIES OF DAILY LIVING ASSESSMENT Barthel Index for Activities of Daily Living (ADL) Findings: Pt garnered a score of 0 points which indicates pt totally dependent on all ADLs. Feeding —> 0 = Unable Bathing —> 0 = Unable Grooming —> 0 = Unable Dressing —> 0 = Unable Bowel control —> 0 = Incontinent (or needs to be given enemas) Bladder control —> 0 = Incontinent (catheterized, unable to manage alone) ACTIVITIES OF DAILY LIVING ASSESSMENT Toilet use —> 0 = Unable Transfers (bed to chair and back) —> 0 = Unable Mobility on level surfaces —> 0 = Immobile or <50 yards Stairs —> 0 = Unable Significance: Pt being totally dependent in ADLs may be at increased risk of developing physical health problems, such as pressure ulcers, infections, and falls. Caregiver education should be emphasized to assist pt in ADLs. 03 ASSESSMENT PT DIAGNOSIS Pt is medically diagnosed with Necrotizing fasciitis on lateral neck pulmonary infection 2° PTB as manifested by a wound 2 inches in length, covering the posterior nape with a yellowish and black color and a foul smell. Muscle weakness on (B) UE (2-/5 to 2/5) LE (1/5), LOM on (B) SH flexor, abd, and Hip flexors, total dependence in ADLs, decreased sensation on UE/LE, grade 1+ of bicep and tricep reflex and grade 0 on the knee and Achilles reflex. PT DIAGNOSIS Based on the aforementioned signs and symptoms above, the pt presents, sudden body weakness followed by DTR on (B) LE. This may be a suggestive diagnosis of GBS. However, it is possible that necrotizing fasciitis can cause body weakness in rare cases but it is not always present. The body's immune response to this infection can lead to systemic symptoms such as fever, chills, and body aches, which can contribute to weakness and fatigue. ↓ PROBLEM LIST 1. Muscle weakness on (B) UE (2-/5 to 2/5) LE (1/5) 2. LOM on (B) SH flexor, abd, and Hip flexors 3. Total dependence on ADLs. 4. Decreased sensation on UE/LE. LONG-TERM GOALS 1. Pt will be able to achieve optimal muscle strength on (B) UE/LE s interference to ADLs. 2. Pt will be able to achieve optimal ROM in (B) UE/LE 3. Pt will be able to attain an optimal level of independence in ADLs, c or s signs of difficulty. 4. Pt will be able to prevent 2° complications, such as jt. contractures and pressure sores. SHORT-TERM GOALS 1. Pt will present an increase in muscle strength by 1 muscle grade increment on (B) UE/LE p PT for 6 wks. 2. Pt will present increased ROM on (B) UE/LE by 10-15° of increments in joint motion p PT for 3 wks. 3. Pt will be able to do ADLs with maximal dependence on the pt’s husband and other caregivers. 04 PLAN OF CARE PHYSICAL THERAPY MANAGEMENT 1. AAROMEs on (L) UE x AP x 10 reps x 1 set 2. PROMEs to AAROMEs on (B) LE x AP x 10 reps x 1 set 3. FES on (B) elbow and wrist flexor/extensor 4. ES on (B) knee and ankle flexor/extensor x 5 mins 5. DBE HOME INSTRUCTION PROGRAM 1. AAROMEs on (L) UE x AP x 10 reps x 1 set 2. PROMEs to AAROMEs on (B) LE x AP x 10 reps x 1 set 3. Proper bed positioning every hour 4. DPE 5. ES (B)UE/LE RECOMMENDATIONS 1. Respectfully recommend pt to a neurologist. 2. Respectfully recommend the next PT intern to assess the following: Tactile fremitus Chest expansion measurement Chest breathing symmetry PREPARED BY Anab M. Alnow LC PT INTERN 23’ Peter Gabriel Jacinto UB PT INTERN 23’ Princess Shakira M. Cajigal MMSU PT INTERN 23’ Jiggy Allen C. Vives MMSU PT INTERN 23’