Biopsychology The Endocrine System The endocrine system is what controls the release of hormones into our blood stream. The endocrine system communicates information from the brain to the body. Hormones are released, and they have an effect on target organs such as the heart, liver or lungs. Hormones are produced in large quantities, and have an immediate effect (although it’s much slower than the nervous system). markbatchelor@ada.ac.uk 1 Biopsychology Activity: fill in the table to highlight the hormones and their functions Hormone gland function markbatchelor@ada.ac.uk 2 Effect on Psychology Biopsychology Exam Practice: Outline the function of the endocrine system (6 marks) markbatchelor@ada.ac.uk 3 Biopsychology Give two examples of the effects of hormones released by glands of the endocrine system. (4 marks) 1 2 markbatchelor@ada.ac.uk 4 Biopsychology Matching task Endocrine System Gland Chemical substances that regulate the activity of cells or organs in the body. They circulate in the bloodstream and are carried to target sites throughout the body. An important part of the fight-or-flight response as it facilitates the release of adrenaline. Situated above the kidneys. Hormones Produces cortisol – a stress hormone. If cortisol levels are low, the individual has low blood pressure, poor immune function and inability to deal with stress. Also produces aldosterone, which is responsible for maintaining blood volume and blood pressure. Pituitary Gland A network of glands throughout the body that manufacture and secrete chemical messengers known as hormones. Adrenal Gland Structure that releases hormones directly into the bloodstream via blood vessels. Testes The release of a hormone by a gland Ovaries Releases adrenaline and noradrenaline – hormones that prepare the body for flight or flight. Adrenaline helps the body response to a stressful situation e.g. increasing heart rate and blood flow to the muscles and brain. Noradrenaline constricts the blood vessels, causing blood pressure to increase. Secretion A gland in the brain (just underneath the hypothalamus) often called the “master gland.” Produces hormones whose primary function is to influence the release of hormones from other glands, and in so doing regulate many of the body’s functions. Adrenal Cortex Adrenal Medulla They facilitate the release of oestrogen and progesterone (female hormones). They facilitate the release of testosterone (male hormone). Testosterone causes the development of male characteristics such as growth of facial hair, deepening of the voice and growth spurts. markbatchelor@ada.ac.uk 5 Biopsychology 19 Quick Questions 1. What is the endocrine system? 2. What does the endocrine system use to deliver hormones to their targets? 3. What are hormones? 4. Where is the pituitary gland? 5. What controls the pituitary gland? 6. What is the pituitary gland also known as? 7. What are the two parts of the pituitary gland? 8. Which part of the pituitary gland releases ACTH as a response to stress? 9. ACTH stimulates which glands to produce what hormone? 10.What does the posterior pituitary release which is important in childbirth? 11.Where are the adrenal glands? 12.What is the outer part of the adrenal gland called? 13.What is the inner part of the adrenal gland called? 14.What hormone does the adrenal cortex produce and what is its purpose? 15.What does a low level of cortisol lead to? 16.What two hormones does the adrenal medulla produce and what does each of those hormones do in a stressful situation? 17.What do ovaries produce? 18.What hormone is produced by the testes? 19.What does that hormone do? markbatchelor@ada.ac.uk 6 Biopsychology The Sympathetic Stress Response Write down what happens to the different parts of the body during times of stress Eyes Saliva Bronchial tubes Stomach Digestive system Kidneys/adrenal glands Reproductive organs markbatchelor@ada.ac.uk 7 Biopsychology It is important to know the difference here about chronic and acute stress. Write this down in your own words below: Chronic stress is: Acute stress is: For example: For example: Activity: Which form of stress do you think is worse for you? Take a look at the following examples and decide whether they are acute or chronic stressors – don’t forget to justify your answers. 1. Exams 2. Being late for a lesson 3. Watching a scary film 4. Trying to meet a coursework deadline 5. Meeting someone who is attractive 6. Trying to decide what to wear for a night out 7. Being shouted at 8. Trying to lose weight 9. Reading a threatening text message 10. Watching your team lose on penalties markbatchelor@ada.ac.uk 8 Biopsychology Activity: Use the words from the list below to complete the diagram which shows the two processes involved in the response to stress. ACTH Adrenaline Blood pressure Cortex Cortisol Energy Heart & Pulse rate Hypothalamus Immune System Medulla perceived Pituitary Sweat production Sympathetic Stressors Stressors perceived markbatchelor@ada.ac.uk 9 Biopsychology Exam Practice (June 2017): Outline the fight or flight response [3 marks] Exam Practice (June 2018) The fight or flight response enabled our ancestors to survive but can be less helpful in response to more modern stressors . Explain how the body responds during fight or flight and why this could be unhelpful in a driving test situation (4 marks) markbatchelor@ada.ac.uk 10 Biopsychology Biological Rhythms Bio-rhythms refer to the body’s natural physical cycle. The most commonly thought of is our sleep-wake cycle that runs throughout the day and night. Scientists term this the circadian rhythm. Another cycle is the menstrual cycle, which is an infradian rhythm. There are even rhythms that run over the course of a year known as circannual rhythms. There are several issues which you need to understand. 1. There is general debate regarding what animal behaviour can tell us about ourselves. When studying biological rhythms much of the research is on non human animals. What can we extrapolate to human biological rhythms? 2. Studies have shown that we and other animals have strong internal mechanisms that govern our rhythmic states. But how much can external factors alter our internal biological clock? If you were kept in a constant environment (e.g. a room with no windows, clocks, radios…) would your sleep pattern remain unaffected? 3. If you have ever been to a different time zone, you may have experienced severe disruption to your daily rhythm. Why do people suffer from ‘jet lag’, and why is it worse if you fly back from America than when you fly out to America? 4. Is it possible to synchronise our rhythms with other people? Why would a female’s menstrual cycle match another female? 5. Why are there individual differences in peoples’ sleep patterns? Could these be learned? markbatchelor@ada.ac.uk 11 Biopsychology Activity: On the clock faces below highlight the times in the day that you , sleep, eat, exercise. AM PM markbatchelor@ada.ac.uk 12 Biopsychology Internal v External factors Endogenous pacemakers Exogenous zeitgebers Description: Description: Example: Example: Study that relates to this: Study that relates to this: markbatchelor@ada.ac.uk 13 Biopsychology Circadian Rhythms in Humans Event (high ; Low ) 00:00 02:00 Sleep propensity 02:00 04:00 04:00 06:00 06:00 08:00 08:00 10:00 14:00 16:00 16:00 18:00 18:00 20:00 20:00 22:00 22:00 00:00 Birth Ovulation Libido Conception Death Body Temperature Concentration Alertness Pain intensity Hayfever Heart attack Tooth ache (Adapted from Rhythms of Life; Foster & Kreitzman (2005)) markbatchelor@ada.ac.uk 12:00 14:00 Tissue Repair Growth hormone 10:00 12:00 14 Biopsychology Problems with disruption of Circadian Rhythms On the previous page there is a chart detailing some key performances that are know to be sensitive to the 24 hour clock. You job is to advise the following people who are experiencing problems in their lives. 1. John often wakes in the middle of the night to switch the heating on. Why might this be? 2. Yoko has broken her leg, and spends the day sleeping and watching TV, she doesn’t know why would her doctor advises her to sleep well at night. 3. Paul suffers from hay fever and takes his antihistamine tablet when it gets intolerable around 9am. He thinks the pills work, but hates suffering on his way to work. 4. George and Patti are trying for a baby. They work from home and will often try mid afternoon and again in the early evening. They haven’t conceived yet. 5. Ringo has had a heart attack recently, but is planning on returning to work. Although he loves his job, his journey to work is stressful. His boss has said that he can work flexi-time. What would you suggest he does? 6. Eric hates going to the dentist. The most painful experience one afternoon when he had a filling. He is wondering if there is a particular time he should book. 7. Billy is in training for the London marathon next year. He goes for a 5 mile run every day at lunchtime but wonders if this is the best time? 8. Linda is expecting her second child in two months. She is hopeful that she will give birth at a reasonable time in the day and was wondering how she can prepare. 9. Brian keeps his asthma inhaler in his bag so he won’t forget it when he leaves for school. But his mum says he needs to keep it by his bed at night; who’s right? markbatchelor@ada.ac.uk 15 Biopsychology Activity: Fill in the following information Look up the famous experiment that Siffre conducted (use your text books and/or Internet.) Type of research method used? Procedure (including time spent) Main findings Conclusions Now use you knowledge of this event to assess the problems that the Chilean Miners would have had to face and suggest a plan for them to follow during their ordeal and any after care they should receive. Think also about the social effects of being underground for such a period. (information over the page… Circadian Rhythms Psychological health issues Social problems markbatchelor@ada.ac.uk 16 Biopsychology Chilean miners report After 69 days underground, what will it be like for them to return to their normal lives when the excitement dies down? Right now their neurotransmitters are working overtime due to stress. They will have very high levels of adrenaline, which can make them startle easily, and even become more aggressive than usual. They will also have high levels of serotonin and dopamine. But this won’t last forever and when their lives become normal those hormone levels will decrease and they may suffer from feelings of depression. Selective serotonin reuptake inhibitors such as Prozac can help replace lost serotonin and the miners have been offered six months of counseling. However they may suffer from long term psychological problems such as PTSD which doesn’t show up for at least six months. The miners individual personalities should help moderate the stress. They all choose to be miners so should already be known to deal with difficult conditions. Chili is a Catholic country so the men would also have had their faith which would have helped them, as would the mutual support of each other. In the first days of the disaster, the miners, organised the underground space into sleep, work, and recreation areas. Work rotas were also organised and they used the headlights of mine trucks to create lighted areas to help them maintain their circadian rhythms. This idea was suggested by NASA as it was crucial to keep the men all on the same circadian rhythm and at sync with the outside world. Experiments have shown that, when placed in 24-hour light or 24-hour dark situations, people naturally wake a half-hour hour later every day, which adds up to a 3.5-hour time displacement by the end of a week. If the miners’ sleep/wake cycle had not been adjusted with the truck lights, people from the surface trying to contact them would have disrupted their biological rhythms and caused an experience similar to jet lag. While the truck lights were enough to maintain the men’s biological clocks, they may not have been adequate to stave off light-deficit depression. However if the men manifest this kind of depression, which is similar to seasonal affective disorder, exposure to normal Chilean daylight will cure them. markbatchelor@ada.ac.uk 17 Biopsychology Read the article A study from Stanford University's Sleep Disorders Clinic looked at the National Football League's (NFL's ) Monday Night Football results for possible advantages of West Coast versus East Coast teams by a circadian rhythm effect. The fascinating results, which reviewed the past 25 years of Monday Nite (sic) Football games (which always begin at 9:00 p.m. Eastern Standard Time), were published in the journal Sleep (1997;20[5]:362-365). Dr. Roger S. Smith and colleagues at Stanford found that West Coast teams win substantially more often and by significantly more points per game than East Coast teams. West Coast teams won 63.5% of games, while East Coast teams won only 36.5% of games. West Coast teams won by an average of 14.7 points per game, whereas East Coast teams won by an average of 9.0 points per game. West Coast teams won 59.3% of the home games through the years, while winning 71.0% of Monday Nite (sic) Football games. East Coast teams won 56.5% of their home games, but only 43.8% of Monday Nite Football home games! Overall, West Coast team records are 4.4 percentage points better than East Coast team records since 1970. However, when West Coast teams play East Coast teams for Monday Nite Football, West Coast team records are 27.0 percentage points better than East Coast team records! Furthermore, West Coast teams performed significantly better than East Coast even when taking into account the statistical predicted point spread by Las Vegas odds makers! These results, the authors feel, are not a result of jet lag, since this effect should be virtually equal or to the advantage of an East Coast team traveling westward. The authors concluded that the power of circadian rhythms produces an advantage for the West Coast NFL teams during Monday Nite Football. This advantage they suspect may relate to the fact that West Coast teams are competing closer to the time that they typically train each day. This effect not only enhances home-field advantage for the West Coast teams, but also eliminates the beneficial effects of home-field advantage for East Coast teams! The findings of this study seem to indicate that athletic performance is enhanced at certain times of day, likely a result of an effect of the body's circadian rhythm. It also implies that "it may be more advantageous to perform closer to one's peak performance time of day rather than try to acclimate to an opponent’s time zone markbatchelor@ada.ac.uk 18 Biopsychology Extension Activity: The Role of the Suprachiasmatic Nucleus (SCN) in the Sleep-Wake Cycle. In humans and mammals, the biological clock is not under the direct control of the pineal gland. This is because it lies too deep within the skull to directly receive light. The SCN is located in the hypothalamus just above the optic chiasm, which is where the optic nerves receiving information from each eye cross over. The SCN is linked by a neural pathway to each eye allowing it to receive information about how much light is falling on the retina. This occurs even when our eyes are shut as light can still penetrate the eyelids. Stephan and Zucker (1972) found that cycles of sleep, feeding and activity are disrupted if the SCN is removed or damaged as light is no longer able to reset the clock each day. Another neural pathway, known as the retinohypothalamic tract, links the SCN to the pineal gland. As dusk falls, the SCN triggers the pineal gland to release melatonin. When circulating blood levels of melatonin reach a critical point, we feel the need to sleep. In the absence of light cues, melatonin is still released in a cyclical manner, but if the SCN is destroyed, the circadian cycle disappears. Melatonin plays a role in controlling other hormones and in influencing physiological processes and seasonal behaviours. As the hours of daylight fall, more melatonin is produced encouraging animals to enter their hibernation phase. Infradian rhythms are thought to be affected by damage to the SCN because they are reliant upon light levels, which determine the season, being measured against the 24-hour clock. Rusak and Zucker (1975) found that SCNmarkbatchelor@ada.ac.uk 19 Biopsychology lesioned male hamsters began to secret testosterone all year round rather than just during their normal breeding season. Yamazaki et al (2000) reported that circadian rhythms persist in culture-grown tissues in the laboratory implying that body cells seem to follow circadian activity even when they are not under the direct control of the SCN. However, the SCN is known to play a key role as the circadian pacemaker and although the mechanisms are as yet unclear, it probably coordinates the behaviour of other body cells either by sending neural signals or by releasing neurohormones (Gross and Rolls, 2008). The Tale of the Mutant Hamsters There is strong evidence for the importance of the SCN in maintaining the circadian rhythm. When SCN cells are removed from the brain and kept in the laboratory, they follow a cycle of neural activity lasting approximately 24.5 hours. Ralph et al (1990) bred mutant hamsters with a 20hour rhythm. They then transplanted SCN cells from mutant adult hamsters into normal hamster foetuses who were born displaying the mutant 20-hour cycle. They also transplanted normal SCN tissue into the mutant hamsters who started to show a 24-hour cycle within a week. Notes: markbatchelor@ada.ac.uk 20 Biopsychology Activity: (Bet you cannot fill in the gaps) The Role of The Suprachiasmatic Nucleus in Sleep Light enters the ________ even when they are______ Information sent via neural pathway to _______ Information sent via _______ is located in the hypothalamus another ____ pathway to _____ gland ___________ gland is located deep within the brain Low light information from ______ triggers pineal to release ________ Levels of _________ rise Sleep Melatonin is released by the pineal gland in the a ___________ of _______ cues, but the circadian cycle d___________ if the _______ is destroyed markbatchelor@ada.ac.uk 21 ______ levels of _______ reach critical level Biopsychology Studies on Bio Rhythms: Name of researchers What they basically did, found out and concluded Useful for what argument? markbatchelor@ada.ac.uk 22 Criticisms? Biopsychology Exam Practice: June 2018 Julia complains that her baby is sleeping all day and keeping her awake all night Using your knowledge of research into exogenous zeitgebers, discuss what Julia could do to encourage her baby to sleep more at night. (8 marks) markbatchelor@ada.ac.uk 23 Biopsychology Turn over page markbatchelor@ada.ac.uk 24 Biopsychology Julia decided to record how many hours her baby slept for in the day and in the night for one week. Table 1 The number of hours slept in the day and the number of hours slept in the night over one week. Mon Tues Weds Thurs Fri Sat Sun Number of hours slept in the day 8.5 9.0 7.0 9.5 10.5 6.5 8.5 Number of hours slept in the night 9.0 8.0 8.5 7.0 7.5 10.5 8.0 Calculate the mean number of hours slept in the night. Show your workings Give your answer to two significant figures (3 marks) Explain one reason why the mean is the most appropriate measure of central tendency for this set of data (2 marks) markbatchelor@ada.ac.uk 25 Biopsychology Example answer for the 8 mark question exogenous zeitgebers in biological rhythms. An exogenous zeitgeber indicates external stimuli, such as alarm clocks or sunlight, which help to synchronize personal biological rhythms to the outside world. Zeitgeber means time giver. An endogenous pacemaker is an internal biological clock in the brain controlling biological rhythms. An example is the suprachiasmatic nucleus (SCN); this is a small cluster of cells in the hypothalamus. The SCN causes the pineal gland to release melatonin – a hormone that causes the body to feel sleepy. However, it is hard to distinguish between cause and effect; does melatonin alone cause the body to feel sleepy? Siffre (1972) spent 179 days in a cave with the absence of all time givers e.g. clocks and daylight, in order to find the effect of daylight on circadian cycles. His circadian cycle extended to approximately 27 hours, which caused him to think he spent 151 days instead of 179 days in the cave. This study shows that our internal body clock is not accurate enough and we need external cues to inform our bodies when it is time to sleep and time to wake up. Although external cues are important, boredom could lead to sleeping more, which leads to not being tired at the end of the day, so we end up going to sleep later. In babies this is markbatchelor@ada.ac.uk 26 Biopsychology important as they need routine to their day in order to regulate their sleep cycle. DeCoursey et al (2000) displayed the importance of the SCN in their study. They destroyed the SCN in some chipmunks. They found that these chipmunks were much more active at night than normal chipmunks, This might indicate that babies have an underdeveloped SCN response to day light. It is important therefore to regulate daylight as a constant for a neonate to adapt. External zeitgebers are important as well, as they allow people/ animals to adapt or adjust their biological rhythms to changes in the environment. This study also proves that with the absence of the SCN in the brain, exogenous zeitgebers have little or no effect on our body, thus disrupting our biological rhythms and sleeping patterns. This shows the importance of endogenous pacemakers in relation to our biological rhythms. Although this study is high in ecological validity, it cannot be generalised to the human race and it doesn’t say whether or not the chipmunks were male or female. Over to you: • How many marks would you give this answer? • Have another look and count how many evaluative points you spot. • How many studies are mentioned in total? • How many key technical terms can you count? Write them down below and give a definition . . . markbatchelor@ada.ac.uk 27 Biopsychology • Summary of studies on Circadian Rhythms Name & Study What they found What we can conclude Sifre (1972) Klietman Recht (1995) Takahasi (2002) Decoursey (2000) Morgan (1995) Stopa (1999) markbatchelor@ada.ac.uk 28 Biopsychology Describe and evaluate research on circadian rhythms, with reference to endogenous pacemakers and exogenous zeitgebers (16 marks) Circadian rhythms are those rhythms that last about 24 hours. The two best-known circadian rhythms are the sleep wake cycle and the body temperature cycle. People may think the reason they go to sleep and wake up at fairly regular times is because of changes in daylight – you feel sleepy when it gets dark and are roused by streaming sunlight; or perhaps a person’s sleep wake cycle is governed by knowing what time of day it is. These are external cues from the environment called exogenous zeitgebers. Psychologists have investigated what happens when a person is free of such exogenous zeitgebers (external cues). One of the most memorable studies was conducted by the French cave explorer, Michel Siffre who is a specialist in the study of the human internal clock. He spent long periods of time living underground in order to study his own biological rhythms. Underground, in a cave, he had no external cues to guide his rhythms – no daylight, no clocks, no radio. He simply woke, ate and slept when he felt like it. The only influence on his behaviour was his internal ‘clock’ or ‘free running rhythm’. Siffre’s experiences showed that the free-running cycle settles down to a regular rhythm which is a little more than 24 hours. However, there is an issue of validity relating to Siffre’s study. The study of Michel Siffre may be described as a case study as it is the study of one individual and therefore has unique features. His body’s behaviour may not be typical of all people and, in addition, living in a cave may have particular effects due to, for example, the fact that it is cold. However, subsequent markbatchelor@ada.ac.uk 29 Biopsychology studies above ground have confirmed the findings of research in cave environments. Siffre’s study was also an experiment. He controlled key variables (exogenous zeitgebers) to observe there effects on the sleep wake cycle. The experiment approach is important because it allows us to demonstrate casual relationships. Despite the above criticism, there is support by other studies for Siffre’s case study. For example, Aschoff and Wever (1976) placed participants in an underground World War II bunker in the absence of social and environmental cues. They found that most people displayed circadian rhythms between 24 and 25 hours, though some rhythms were as long as 29 hours. These studies show that circadian rhythms persist despite isolation from natural light, which demonstrates the existence of an endogenous ‘clock’. However, this research also shows that external cues are important because the clock was not perfectly accurate: it varied from day to day. When looking at studies involving the sleep wake cycle, research methodology needs to be accounted for. In all studies, participants were isolated from variables that might affect their circadian rhythms such as clocks, radios and daylight, in. However, they were not isolated from artificial light because it was thought that dim light, in contrast to daylight, would not affect the circadian rhythm. Recent research by Czeisler et al (1999) suggests that this may not be true as they altered participants’ circadian rhythms down to 22 hours and up to 28 hours just using dim lighting. Folkard et al (1985) conducted an experiment to see if external cues could be used to override the internal clock. A group of 12 people lived in a cave for three weeks, isolated markbatchelor@ada.ac.uk 30 Biopsychology from natural light and other time cues. These volunteers agreed to go to bed at 11.45 pm and to get up when it indicated 7.45 am. Initially the clock ran normally, but gradually they quickened the clock until it was indicating the passing of 24 hours when actually only 22 hours had passed. At the beginning, the volunteers circadian rhythms matched the clock, but, as it quickened, their rhythm no longer matched the clock and continued to follow a 24-hour cycle rather than the 22-hour cycle imposed by the experiment (except for one participant who did adapt to the 22-hour cycle). Overall, this suggests that the circadian rhythm can only be guided to a limited extent by external cues. However, there are exceptions as individual differences need to be taken into account. One important type of individual difference is the cycle length: research has found that circadian cycles in different people can vary from 13 to 65 hours (Czeisler et al, 1999). The second type of individual difference relates to cycle onset – individuals appear to be innately different in terms of when their circadian rhythms reach their peak. For example, Duffy et al (2000) found that morning people prefer to rise early and go to bed early (about 6am and 10pm), whereas evening people prefer to wake and go to bed later (10am and 1am). Hormone production also follows a circadian rhythm. Cortisol is at it’s lowest around midnight and peaks around 6am. Cortisol is a hormone produced when we are stressed but is also related to making us alert when we wake up, and can explain why, if we awaken at 4am, it is hard to think clearly. This is because cortisol levels are not sufficiently high for alertness. Melatonin (which induces sleep) and growth hormone are two other hormones that have a clear markbatchelor@ada.ac.uk 31 Biopsychology circadian rhythm, both peaking at around midnight. The studies mentioned above are typical of the biological approach to understanding behaviour: they propose that human behaviour can be explained in terms of structures in the brain and in terms of hormonal activity. However, human behaviour is often more complex than this because people can override biologically determined behaviours by making choices about what they do which relates to the debate of freewill against determinism. On the other hand, sometimes it may not be possible to override biological factors and biological rhythms may be a case in point. Core body temperature is one of the best indicators of the circadian rhythm. It is lowest at about 4.30am (about 36˚) and highest at around 6pm (about 38˚). There is a slight trough just after lunch which is not just due to the effects of having had lunch as the dip occurs even when people have not eaten. The circadian variation in core body temperature has been linked to cognitive abilities. For example, Folkard et al (1977) looked at the learning ability of 12-13 year old children who had stories read to them at either 9am or 3pm. After one week, the afternoon group (higher core body temperature) showed both superior recall and comprehension, retaining about 8% more meaningful material. This suggests that long-term recall is best when body temperature is highest. There is evidence that temperature changes do actually cause the changes in cognitive performance. Giesbrecht et al (1993) lowered body temperature (by placing participants in cold water) and found that cognitive performance was worse on some tasks. However, other research has found that the link is spurious. For example, Hord and Thompson (1983) tested cognitive markbatchelor@ada.ac.uk 32 Biopsychology performance in a field rather than lab situation and didn’t find any correlation between core temperature and cognitive performance. It may be that the higher core body temperature leads to increase physiological arousal and this leads to improved cognitive performance (Wright et al, 2002) Circadian rhythms are part of the daily lives of humans. They cue our levels of alertness, our need for sleep, and our time of waking. Research shows that light, hormones, food, and a variety of other factors are important in determining circadian rhythms. Our fairly consistent sleep pattern suggests they are innate and not learnt meaning there is an internal or endogenous mechanism – the biological clock. However, this can be overridden by psychological factors, such as anxiety Your notes: markbatchelor@ada.ac.uk 33 Biopsychology Ultradian Rhythm This links well to sleep and characterises the dream cycle. There are many issues related to sleep and its importance to our well-being. How long could you stay awake and would it affect your performance the next day? Why is the brain active during REM sleep? What is the significance of the different stages during sleep? Why is it necessary to move through each stage several times throughout the night? What about evidence from research involving animals? markbatchelor@ada.ac.uk 34 Biopsychology Ultradian Cycle In the box, draw the stages of sleep typically gone through during a night’s sleep (human). Stages of sleep during one night 1 Put the following labels on the graph: REM (inc times), SWS (inc times), Delta waves, Theta waves. 0 You should be able to describe this in words for say, 6 marks, and take up half a page of any essay on this area (only half a page). Try this, and include some of the technical terms: Stage -1 -2 -3 Ultradian rhythm; EEG; stages 1-4; REM; non REM; hyponogogic state. -4 1 2 3 4 5 Hours of sleep markbatchelor@ada.ac.uk 35 6 7 8 9 Biopsychology What happens physiologically when we are asleep. Using the information you have learnt so far describe the ultradian cycle below (AO1)) markbatchelor@ada.ac.uk 36 Biopsychology Infradian Rhythm Describe what an Infradian Rhythm is below and how research has shown the effect of internal and external mechanisms that can change this cycle. markbatchelor@ada.ac.uk 37 Biopsychology markbatchelor@ada.ac.uk 38 Biopsychology Shopping sprees linked to periods Women may be able to blame impulse buys and extravagant shopping on their time of the month, research suggests. In the 10 days before their periods began women were more likely to go on a spending spree, a study found. Psychologists believe shopping could be a way for premenstrual women to deal with the negative emotions created by their hormonal changes. Professor Karen Pine will present her work to a British Psychological Society meeting in Brighton later this week. She asked 443 women aged 18 to 50 about their spending habits. Almost two-thirds of the 153 women studied who were in the later stages of their menstrual cycle - known as the luteal phase - admitted they had bought something on an impulse and more than half said they had overspent by more than £25. A handful of the women said they had overspent by more than £250. And many felt remorse later. Professor Pine, of the University of Hertfordshire, said: "Spending was less controlled, more impulsive and more excessive for women in the luteal phase. "The spending behaviour tends to be a reaction to intense emotions. They are feeling stressed or depressed and are more likely to go shopping to cheer themselves up and using it to regulate their emotions." She said much of this could be explained by hormonal changes during the menstrual cycle. And the findings were exaggerated in the women with severe PMT. "We are getting surges and fluctuations in hormones which affect the part of the brain linked to emotions and inhibitory control. So the behaviour we found is not surprising." Another explanation might be that women are buying items to make themselves feel more attractive coinciding with the time of ovulation when they are most fertile, typically around 14 days before the start of a period. Most of the purchases made by the women were for adornment, including jewellery, make-up and high heels. Professor Pine said: "Other researchers have found there is an ornamental effect around the time of ovulation." Researchers have found women tend to dress to impress during their fertile days. Professor Pine, author of the book Sheconomics, said if women were worried about their spending behaviour they might avoid going shopping in the week before their period was due. markbatchelor@ada.ac.uk 39 A Level Psychology Approaches Handout Estrous Cycle Phase Influences Cocaine Craving in Rats Mar 06, 2019 | Original Press Release from Elsevier Menstrual cycle may influence addiction risk in women, according to a new study in Biological Psychiatry by researchers at the National Institute on Drug Abuse and University of Maryland School of Medicine. In female rats, craving for cocaine during abstinence from the drug was stronger during estrus—the phase in which ovulation occurs— than non-estrus, and female rats were more prone to relapse of cocaine use than male rats. This new link between menstrual cycle and drug craving may help explain differences between men and women in cocaine seeking and vulnerability to relapse after quitting. “Sex differences are extremely important in addiction. This new study suggests that the period around ovulation is the most vulnerable period for promoting addiction. This knowledge has implications for both prevention and treatment,” said John Krystal, MD, Editor of Biological Psychiatry. “To the degree that results from animal models generalize to humans, our findings implicate the phase of the menstrual cycle as a risk factor for relapse in women and, therefore, should be taken into consideration in the development of relapse prevention treatments,” said senior author Satoshi Ikemoto, PhD, NIDA. To assess the influence of the menstrual cycle on addiction, first author Céline Nicolas, PhD, NIDA, and colleagues used a model of cocaine use in rats that mimics the intermittent binge-like pattern of human cocaine use. They compared this model with the standard rat model of cocaine use that provides continuous access to the drug. Although both access models led to progressively increased cocaine seeking during abstinence, referred to as incubation of cocaine craving, cocaine seeking was higher after intermittent access. Regardless of the type of access provided to the rats, cocaine seeking was higher in female rats than male rats. “In female rats, the magnitude of cocaine craving was critically dependent on the phase of the estrous cycle, demonstrating a novel role of ovarian hormones in incubation of cocaine craving,” said Dr. Ikemoto. Previous studies in humans suggest that women relapse faster after quitting cocaine and have stronger craving than men. The new findings reveal that the estrous cycle may contribute to these differences between women and men and highlight a potential target to help prevent relapse in wome This article has been republished from materials provided by Elsevier. Note: material may have been edited for length and content. For further information, please contact the cited source. Reference: Nicolas, C., Russell, T. I., Pierce, A. F., Maldera, S., Holley, A., You, Z.-B., … Ikemoto, S. (2019). Incubation of Cocaine Craving After Intermittent Access Self-administration: Sex Differences and Estrous Cycle. Biological Psychiatry, 0(0). https://doi.org/10.1016/j.biopsych.2019.01.015 markbatchelor@ada.ac.uk 40 A Level Psychology Approaches Handout Example essay Infradian Cycles are those lasting longer than 24 hours. Of which menstruation, a 27-29 day cycle is the most widely studied. Research has shown that menstruation can become synchronised after exposure to other females. This suggests that this particular infradian rhythm can be modified by exogenous zeitgebers. Russell et al (1980) conducted a study using sweat samples from donor women, which were rubbed onto the lips of the recipient participants. He found that eventually the cycles of the recipient women synchronised with those of the donor women. It is thought that pheromones found in sweat saliva and urine in both males and females, can/do influence a menstrual cycle. Empson (1977) studied 21 males, measuring their moods and temperatures over 102 days. Evidence of a 20-day cycle was found, where the men had peaks and troughs in both their temperatures and morning alertness. However Russell’s study doesn’t take into account the fact psychological effects of menstruation, such as PMS occur up to 5 days before menstruation. PMS itself is also found in all cultures, which suggests it is controlled by endogenous pacemakers. Also the role of the pituitary gland is what tends to internally regulate the cycle. A study of 600 girls in Germany found that menarche (first menstrual cycle) was more likely in the winter months. This suggests that melatonin may affect the cycle. Furthermore, it has also been found that blind girls reach menarche earlier than sighted girls. Light is the main exogenous zeitgeber in humans. Wever (1983) found that exposure to bright light suppresses the production of melatonin, creating a markbatchelor@ada.ac.uk 41 A Level Psychology Approaches Handout disruption in our biological rhythms. Daylight, in effect will re-set our biological clock, however artificial light is not as effective. Light is detected in the SCN and does not just affect the SCN. Hall (2000) found that certain proteins found in the body, known as chryptochromes, detect changes in light. This could explain why Campbell and Murphy (1988) found that by shining a light on the back of the knee caused a shift in the circadian rhythm. Miles et al (1977) showed the importance of light as a time giver through the difficulties observed in blind people. Due to the lack of light information being received by blind people their sleep patterns are messed up. One young man who was blind from birth had a circadian rhythm of 24.9 hours. After being exposed to various exogenous zeitgebers such as clocks and other social cues, still found great difficulty in reducing his internal pace, causing him difficulty in functioning, which resulted in him having to take stimulants in the morning and sedatives in the evening in order to adjust his biological rhythms in time with the rest of the world. This study cannot be generalised to the wider population as it is based on one person. So, in conclusion, both endogenous pacemakers and exogenous zeitgebers play an important role in biological rhythms. With the absence of both exogenous zeitgebers and endogenous pacemakers our biological rhythms are extended. However both are needed in order for our biological rhythms to function and adjust properly. markbatchelor@ada.ac.uk 42 A Level Psychology Approaches Handout Matching task Circadian Rhythm The hormone that builds up during daylight hours and helps the brain recognise tiredness Ultradian Rhythm Biological mechanisms that help regulate sleep wake cycles Adrenaline The daily rhythm found in most creatures on earth Melatonin Environmental stimuli that helps people recognise the passing of time during the day Suprachiasmic nucleus The hormone that prepares the body for fight or flight Pineal Gland Where melatonin is secreted from Acute stress A shock or alarm reaction to an external stimuli Exogenous zeitgebers The ninety minute cycle that characterises sleep Endogenous pacemakers The tendency of the daily rhythm to extend beyond 24 hours as illustrated by Sifre (1972) Circadian shift The small cluster of light sensitive cells in the brain markbatchelor@ada.ac.uk 43 A Level Psychology Approaches Handout markbatchelor@ada.ac.uk 44 A Level Psychology Approaches Handout Twitter term challenge: you have 280 characters to explain a term (without using the term in your explanation) Term: markbatchelor@ada.ac.uk 45 A Level Psychology Approaches Handout Glossary of terms: Biological Determinism Neurochemistry Evolution Genotype Phenotype Natural Selection Endocrinology Synapse Action Potential ANS CNS PNS markbatchelor@ada.ac.uk 46 A Level Psychology Approaches Handout Neuroplasticity Sympathetic/parasympathetic arousal Motor neurons Sensory Neurons Relay Neurons Synaptic transmission Pituitary gland Adrenal glands HPA axis Amygdala ACTH markbatchelor@ada.ac.uk 47 A Level Psychology Approaches Handout Infradian Ultradian Circadian Melatonin Pineal Gland SCN Oestrogen Testosterone Adenosine markbatchelor@ada.ac.uk 48 A Level Psychology Approaches Handout The LADDER of Learning A checklist for understanding Listed below are the key topics on this section. I have created a ladder or steps up to success. The further up you go the harder the task, the harder the task the more deep your learning. Your job is to cover at least one of the faces by doing the task below that relates to your personal goals and ability: Ask you self the question and then look at the choice of activity – complete the harder tasks to get a happier face. You will be laughing all the way to the exam! Key: Climb along the ladder I really have no idea about this – was I away? Ok – I have heard of this and remember something I did ok on this in the assessment and I am able to talk about it I am confident if this came up in the exam I would ace it – give me the exam now! REMEBERING & UNDERSTANDING APPLICATION ANALYSIS EVALUATE & CREATE Write down all the key words for the topic and define them in your own words (glossary) Illustrate the point with a real life example and explain how it fits in. Find a contrasting or comparable idea that fits with this one Create a table of strengths and weaknesses for a theory Produce summary mindmaps of the subtopic that you can remember Research and find a piece of evidence or study that illustrates the topic Reproduce key terms on revision cards Look up a past exam question you have done on this and improve it. Re read a key study and de construct it by writing in your own words the Aims, Methods, Results and Conclusions Create true or false cards on the key terms Condense notes into 3 key bullet points and write a paragraph on how they link together Complete any missing activity in the Psychology booklet Mark gives out markbatchelor@ada.ac.uk Explain how a psychologist might use the information to improve the lives of others Summarise key idea in 100 words Create a mindmap or flow diagram of a topic showing all the links and connections Explain how a piece of evidence supports or goes against this idea. Create a useful mnemonic the use in the exam that includes evaluative points. Choose a key theory and use a study to explain how it refutes or supports it. Create a cartoon strip/storyboard of the study Produce a revision guide that other students might use. Create a song or poem that helps you remember the key issues. 49