1.Pneumonoultramicroscopicsilicovolcanoconiosis (45 letters) (45 letters) Inhalation of very fine silicate or quartz dust causes pneumoconiosis. 2. Pseudopseudohypoparathyroidism (30 letters) (30 letters) A mild form of pseudohypoparathyroidism characterized by normal calcium and phosphorus levels in the blood. 3. Floccinaucinihilipilification (29 letters) (29 letters) The longest unchallenged nontechnical word that is not recognized by all directories, including Merriam-Webster. Floccinaucinihilipilification, according to other sources, is the act or habit of describing or regarding something as unimportant, having no value, or being worthless. It is frequently used in a humorous context. 4. Honorificabilitudinitatibus (27 letters) (27 letters) Shakespeare's longest word in his works. Honorificabilitudinitatibus is the longest word in the English language, with consonants and vowels alternated. 5. Thyroparathyroidectomized (25 letters) (25 letters) A medical term that refers to the removal of both the