Fig. 1. (a) Structure of the proposed bio-FET showing its floating-gate, control- gate, and sensing area. (b) Equivalent capacitive model for the device. B. Chen, A. Parashar and S. Pandey, "Folded Floating-Gate CMOS Biosensor for the Detection of Charged Biochemical Molecules," in IEEE Sensors Journal, vol. 11, no. 11, pp. 2906-2910, Nov. 2011, doi: 10.1109/JSEN.2011.2149514. https://ieeexplore.ieee.org/document/5762313 Fig. 2. (a) Three-dimensional device structure created using Sentaurus Struc- ture Device Editor. (b) A graph of the floating-gate voltage versus the applied control-gate voltage at three fixed charge densities on the sensing area (SA). The inset shows the variation of the floating-gate voltage with charge density on the sensing area (SA) at three fixed control-gate voltages. B. Chen, A. Parashar and S. Pandey, "Folded Floating-Gate CMOS Biosensor for the Detection of Charged Biochemical Molecules," in IEEE Sensors Journal, vol. 11, no. 11, pp. 2906-2910, Nov. 2011, doi: 10.1109/JSEN.2011.2149514. https://ieeexplore.ieee.org/document/5762313 Fig. 3. Transconductance versus control-gate voltage are plotted for poly amino acids and compared with the DI water reference curve. B. Chen, A. Parashar and S. Pandey, "Folded Floating-Gate CMOS Biosensor for the Detection of Charged Biochemical Molecules," in IEEE Sensors Journal, vol. 11, no. 11, pp. 2906-2910, Nov. 2011, doi: 10.1109/JSEN.2011.2149514. https://ieeexplore.ieee.org/document/5762313 Fig. 4. Subthreshold current versus drain voltage is plotted for different PAA concentrations and compared with the DI water reference curve. B. Chen, A. Parashar and S. Pandey, "Folded Floating-Gate CMOS Biosensor for the Detection of Charged Biochemical Molecules," in IEEE Sensors Journal, vol. 11, no. 11, pp. 2906-2910, Nov. 2011, doi: 10.1109/JSEN.2011.2149514. https://ieeexplore.ieee.org/document/5762313 Fig. 5. Relative shift in the logarithmic drain current (difference in a device’s drain current with poly amino acid and with DI water) versus percentage con- centration of four poly amino acids (PAA, PDDAC, PSASS). B. Chen, A. Parashar and S. Pandey, "Folded Floating-Gate CMOS Biosensor for the Detection of Charged Biochemical Molecules," in IEEE Sensors Journal, vol. 11, no. 11, pp. 2906-2910, Nov. 2011, doi: 10.1109/JSEN.2011.2149514. https://ieeexplore.ieee.org/document/5762313 Fig. 6. Snapshot of the fabricated chip showing single and an array of biosensor devices. Cell lines placed on the chip adhered to the surface and are growing into neurons (translucent globules). B. Chen, A. Parashar and S. Pandey, "Folded Floating-Gate CMOS Biosensor for the Detection of Charged Biochemical Molecules," in IEEE Sensors Journal, vol. 11, no. 11, pp. 2906-2910, Nov. 2011, doi: 10.1109/JSEN.2011.2149514. https://ieeexplore.ieee.org/document/5762313