CH 1 The Basics: Types of Relationships Definition Unrelated Related, Proportional Inversely Related, Inversely Proportional Two items that are not associated Two items that are associated, or affiliated. Two items that are associated such that when one item increases, the other decreases. Two items that are associated such that when one item increases, the other increases A special form of Inverse Relationship. When two numbers with a reciprocal relationship are multiplied together, the result is 1. Directly Related, Directly Proportional Reciprocal Relationship Units Definition Length – Distance or Circumference Area Volume Hz “Increase by a factor” “Decrease by a factor” When converting from Large to Small Units When converting from Small to Large Units cm, ft cm2, ft2 cm3, ft3 per second Multiply by that number Divide by that number Multiply Divide Exponent Prefix Symbol Meaning Representation 109 giga mega kilo hecto deca deci centi milli micro nano G M k h da d c m u n billion million thousand hundred ten tenth hundredth thousandth millionth billionth 1,000,000,000 1,000,000 1,000 100 10 0.1 0.01 0.001 0.000001 0.000000001 106 103 102 101 10-1 10-2 10-3 10-6 10-9 Pairs Prefixes Abbreviations billions and billionths millions and millionths thousands and thousandths hundreds and hundredths tens and tenths giga & nano mega & micro kilo & milli hecto & centi deca & deci G&n M&u k&m h&c da & d CH 2 Sound: Acoustic Variable Pressure Density Distance Units Definition Formula pascals (Pa) kg/cm3 cm, mm Concentration of force in an area Concentration of mass in a volume Measure of particle motion = Force / Area = Mass / Volume Seven Acoustic Parameters • • • • • • • Period Frequency Amplitude Power Intensity Wavelength Propagation Speed Term Definition Acoustic Propagation Properties Biologic Effects The effects of the medium upon the sound wave The effects of the sound wave upon the biologic tissue through which it passes (ex: heat, pressure) particles move in a direction that is perpendicular to the direction that the wave propagates particles move in the same direction that the wave propagates when a pair of wave’s peaks occur at the same time and location when a pair of wave’s peaks occur at different times, and so do their troughs when two or more waves arrive at an identical location at exactly the same time, lose their individual characteristics at that moment and combine to form a single wave. the interference of a pair of in-phase waves results in the formation of a single wave of greater amplitude than either of its components the interference of a pair of out-of-phase waves results in the formation of a single wave of lesser amplitude than at least one of its components; outof-phase waves of equal amplitude may cancel each other out Transverse Waves Longitudinal Waves In-phase Out-of-phase/ Out-of-step Interference Constructive Interference Destructive Interference CH 3 Describing Sound Waves: Parameter Adjustable *period *frequency amplitude power intensity *wavelength speed no no yes yes yes no no Units Determined by Typical Value seconds, us, time per second, Hz pascals, cm, g/cm3, dB watts, dB watts/cm2, dB mm, distance m/s source source source source source both medium 0.06 – 0.5 us 2-15 MHz 1 - 3 MPa 4 – 90 mW 0.01 – 300 W/cm2 0.1 – 0.8 mm 1,500 – 1,600 m/s *most important to know Parameter Formula period frequency amplitude power intensity wavelength speed = 1/frequency = 1/period; = speed/wavelength EEKEE.EE inverse period /higher frequency lower frequency longer period / shorter (Amp)2 = Intensity/Area; directly related to = Power/Area; directly related to (Amp)2 = 1.54/frequency = frequency x wavelength; = distance/time t-requencytwavelengthhig.hrwavelength lower frequency /shorter frequency / longer wave lengt £edᵈEeEE= directly sound in slow medium /short sound in a fast medium/ wavelength long wavelength Parameter Definition period time from the start of one cycle to the start of the next cycle. (duration of one peak + one trough) the number of cycles that occur in 1 second the “bigness” of a wave; the difference between the maximum or minimum value and the average value of the acoustic variable; peak-to-peak amplitude: difference between the maximum and minimum values of an acoustic variable the rate of energy transfer or the rate at which work is performed the concentration of energy in a sound beam the distance or length of one complete cycle the rate at which a sound wave travels through a medium frequency amplitude power intensity wavelength propagation speed Sound Wave Frequency Tissue Type infrasound audible sound ultrasound less than 20 Hz 20 Hz – 20,000 Hz (20 kHz) greater than 20,000 Hz (20 kHz) Lung Fat Soft Tissue (avg) Liver Blood Muscle Tendon Bone Speed (m/s) 500 1,450 1,540 1,560 1,560 1,600 1,700 3,500 Material Speed (m/s) Air Water Metal 330 1,480 2,000 – 7,000 Definition Stiffness the ability of an object to resist compression Density the relative weight of a material Speed Increases Increases Increases Decreases CH 4 Describing Pulsed Waves: Parameter Definition Formula pulse duration (PD) the actual time from the start of a pulse to the end of that pulse; single on-time/transmit the time from the start of one pulse to the start of the next pulse the number of pulses that an u/s system transmits into the body each second the distance that a pulse occupies in space from the start to the end of a pulse the percentage or fraction of time that the system transmits a pulse = # cycles/freq; = # cycles x period talking time pulse repetition period (PRP) pulse repetition frequency (PRF) spatial pulse length (SPL) duty factor (DF) Parameter Adjustable pulse duration (PD)* pulse repetition period (PRP) pulse repetition frequency (PRF) spatial pulse length (SPL)* duty factor (DF)* *most important to know no yes; by DOV yes; by DOV no yes; by DOV Units PRI usec, time msec, time Hz, per sec mm, distance none i g • • • • Less listening Short PRP Higher DF Higher PRF (best image) as = # cycles x wavelength = PD/PRP x 100; = (PD x PRF) (100) source source source both source 0.5 – 3.0 us 0.1 – 1.0 ms 1 – 10 kHz 0.1 – 1.0 mm 0.2 – 0.5% Deep Imaging PRP increases , imaging decreases PRP as , = = 1/PRP Determined by Typical Value Shallow Imaging • • • • = PD + off-time; = 1/PRF depth imaging More listening Long PRP Lower DF Lower PRF increases depth decreases CH 5 Intensities: Intensity Measurement Methods SPTP SATP SPTA *most relevant with respect to tissue heating SATA SPPA SAPA spatial peak, temporal peak spatial average, temporal peak spatial peak, temporal average spatial average, temporal average spatial peak, pulse average spatial average, pulse average Temporal Intensities from Largest to Smallest Itp > Imax > Ipa > Ita Beam Uniformity Coefficient = SP/SA *the closer to 1 the more homogenous (equal in intensity) across the beam Rank of Intensities from Largest to Smallest SPTP > Im > SPPA > SPTA > SATA Intensity Considerations Definition Spatial Peak Intensity (Isp) Spatial Average Intensity (Isa) Temporal Peak Intensity (Itp) Imax (Im) Pulse Average Intensity (Ipa) Temporal Average Intensity (Ita) the beam’s intensity at the location where it is maximum the average intensity across the beam’s entire cross-sectional area the intensity of the beam at the instant in time of its maximal value the average intensity during the most intense half-cycle the average intensity during the pulse duration the average intensity of the entire pulse repetition period • The “Ten Commandments” of Intensity: see page 74 of textbook CH 6 Interaction of Sound and Media: Term Definition logarithm log decibel (dB) decibel notation a novel method of rating numbers represents the number of 10s that are multiplied to create the original number a common unit for measuring intensities • a relative measurement • a comparison • a ratio • logarithmic decrease in intensity, power, and amplitude as sound travels • total attenuation (dB) = AC x distance increase in intensity, power, and amplitude as sound travels when the boundary is smooth, the sound is reflected in only 1 direction in an organized manner when a wave reflects off an irregular surface, it radiates in more than one direction attenuation amplification specular reflection diffuse reflection/ backscatter scattering Rayleigh scattering absorption attenuation coefficient (AC) Half-value layer thickness (HVL) acoustic impedance normal incidence oblique incidence incident intensity reflected intensity the random redirection of sound in many directions a special form of scattering that occurs when the structure’s dimensions are much smaller than the beam’s wavelength; redirects the sound wave equally in all directions (ex: RBCs) *Rayleigh Scattering is directly related to frequency4 most sizeable component of attenuation; occurs when ultrasonic energy is converted into another energy form, such as heat; directly related to frequency the number of dBs of attenuation that occurs when sound travels 1cm; one half the frequency • = f/2 the distance sound travels in a tissue that reduces the intensity of sound to one-half its original value • 0.25 – 1.0 cm aka: penetration depth, depth of penetration, half-boundary layer the acoustic resistance to sound traveling in a medium • = density x speed • units: rayls • typical value: 1.25 -1.75 Mrayls (MZ) aka: characteristic impedance the incident sound beam strikes the boundary at exactly 90 degrees aka: perpendicular, orthogonal, right angle, 90 degrees the incident sound beam strikes the boundary at any angle other than 90 degrees; the physics of transmission and reflection are complex and may or may not occur aka: non-perpendicular, not at right angles • Acute: less than 90 degrees • Obtuse: greater than 90 degrees the sound wave’s intensity immediately before it strikes a boundary • = reflected intensity + transmitted intensity the intensity of the portion of the incident beam that, after striking a boundary, returns back where it came from transmitted intensity intensity reflection coefficient (IRC) intensity transmission coefficient (ITC) conservation of energy angle of incident refraction Snell’s Law Decibels 3 dB 10 dB -3 dB -10 dB the intensity of the portion of the incident beam that, after striking a boundary, continues forward in the same general direction that it was traveling the percentage of the intensity that bounces back when a sound beam strikes the boundary between 2 media • = (reflected intensity/ incident intensity) x 100 the percentage of intensity that passes in the forward direction when the beam strikes an interface between 2 media; most (99% or more) of a sound wave’s intensity is transmitted at a boundary between 2 soft tissues • = (transmitted intensity/ incident intensity) x 100 ITC + IRC = 100% = angle of reflection a change in direction of wave propagation when traveling from one medium to another; occurs only if 2 conditions are satisfied: • oblique incidence • different propagation speeds of the 2 media quantifies the physics of refraction • sin (transmission angle) = speed of Medium 2 sin (incident angle) speed of Medium 1 Meaning double ten times larger half one-tenth More Attenuation • • longer distances/ path length higher frequencies Less Attenuation • • shorter distances/ path length lower frequencies Attenuation Factors • • path length frequency of sound Sound Back to Txdcr Sound in all Directions Attenuation Processes • • • Organized Disorganized specular Rayleigh scattering diffuse or backscattering scattering Half Value Layer: Thin Half Value • • • High frequency sound media with high attenuation rate ex: lung or bone reflection scattering absorption Thick Half Value • • • Low frequency sound media with low attenuation rate ex: fluids Impedances b/t 2 Tissues Reflection identical slightly different substantially different none small large Attenuation of Ultrasound in Media: Medium Attenuation water blood, urine, biologic fluids fat soft tissue muscle bone and lung air extremely low low low intermediate higher even higher extremely high Speeds Angle of Transmission Speed 2 = Speed 1 Speed 2 > Speed 1 Speed 2 < Speed 1 no refraction; transmission angle = incident angle transmission angle > incident angle transmission angle < incident angle Event Requirement Reflection with Normal Incidence Reflection with Oblique Incidence Transmission Refraction different impedances required we cannot predict, it’s too complex! derived from reflection information; use law of conservation of energy oblique incidence and different speeds required CH 7 Range Equation: Term Definition go-return time; time-of-flight the elapsed time from pulse creation to pulse reception; directly related to depth of reflector (mm) = 1.54 mm/us x go-return time (us) 2 for every 13 usec of go-return time, the object creating the reflection is 1 cm deep in the body inversely • (Hz) = 77, 000 cm/s imaging depth (cm) directly • (us) = imaging depth (cm) x 13 us/cm depth of reflector (equation) 13-microsecond Rule PRF (as related to DOV) PRP (as related to DOV) Time of Flight Reflector Depth Total Distance Traveled 13 us 26 us 39 us 52 us 130 us 1 cm 2 cm 3 cm 4 cm 10 cm 2 cm 4 cm 6 cm 8 cm 20 cm Deep DOV Shallow DOV low long high short PRF PRP CH 8 Transducers: Transducer Converts from…. to….. ultrasound transmit ultrasound receive electrical acoustic acoustic electrical Effect Reverse Piezoelectric Piezoelectric Basic Ultrasound Transducer Construction: Transducer Component Description case electrical shield acoustic insulator PZT or active element wire matching layer backing layer or damping element Term transmission reception Piezoelectric Effect the outer most covering, constructed of metal or plastic, that protects the internal components of the txdcr from damage; insulates the patient from electrical shock thin metallic barrier lining the inside of the case; prevents electrical noise from contaminating the clinically important electrical signals used to create diagnostic images thin barrier of cork or rubber that isolates or “uncouples” the internal components of the txdcr from the case. Prevents vibrations in the case from inducing an electrical voltage in the PZT of the txdcr the piezoelectric crystal itself. ½ wavelength thick; impedance is 20x greater than that of the skin provides an electrical connection between the PZT and the u/s system; necessary for transmission and reception positioned in front of the PZT at the face of the txdcr. ¼ wavelength thick • increases the efficiency of sound energy transfer b/t the active element and the body • protects the active element bonded to the back of the PZT to reduce “ringing” and create pulses short in duration and length (improves Axial Resolution); commonly made of epoxy resin impregnated with tungsten filaments Definition electrical energy from the system is converted into sound the reflected sound pulse is converted into electricity describes the property of certain materials to create a voltage when they are mechanically deformed or when pressure is applied to them Reverse Piezoelectric Effect piezoelectric materials change shape when a voltage is applied to them Piezoelectric Materials materials with convert sound into electricity (and vice versa), commonly made of lead zirconate titanate (PZT) aka: ceramic, active element, or crystal decreased sensitivity during reception, txdcrs with damping material are less able to convert lowlevel sound reflections into meaningful electrical signals bandwidth the range of frequencies in the pulse • (Hz) = highest frequency – lowest frequency Quality factor a unitless number that is inversely related to bandwidth • Q-factor = main frequency / bandwidth Curie Temperature the temperature at which PZT is polarized; 300 – 400 degrees Celsius polarization depolarization sterilization disinfection the process by which piezoelectric materials are exposed to a strong electrical field while being heated to a substantial temperature (the Curie Temperature) the loss of piezoelectric properties due to exposure of temperatures exceeding the Curie point; thus, u/s txdcrs should only be disinfected with Cidex or other cold germicides the destruction of all microorganisms by exposure to extreme heat, chemical agents, or radiation the application of a chemical agent to reduce or eliminate infectious organisms on an object; attempts to significantly reduce the microbial load Component Thickness Active element (PZT) Matching Layer ½ wavelength thick ¼ wavelength thick Damping Material: Characteristics Consequences • • Imaging Transducers (PW) • • • • • • 1) decreased sensitivity 2) wide bandwidth (broadband) 3) low quality factor (QF) high degree of sound absorption acoustic impedance similar to PZT pulses with short duration and length (short “click) uses backing material to limit ringing reduced sensitivity wide bandwidth or broadband lower Q-factor improved axial resolution Continuous Wave Transducer electrical frequency = acoustic frequency Non-Imaging Transducers (CW/Therapeutic) • • • • • • pulses with long duration and length (continuous wave) no backing material increased sensitivity narrow bandwidth higher Q-factor (due to no off-time) cannot even create an image Pulsed Wave Transducer acoustic frequency determined by 2 characteristics: 1) speed of sound in the PZT (4 – 6mm/us) 2) thickness of the PZT (0.2 – 1 mm) f (MHz) = Sound’s Speed in PZT (mm/us) 2 x thickness of PZT (mm) Characteristics of a High Frequency PW Imaging Transducer • thinner PZT crystals • PZT crystals with higher speeds Characteristics of a Low Frequency PW Imaging Transducer • thicker PZT crystals • PZT crystals with slower speeds CH 9 Sound Beams: Term Definition Focus the location where the beam is the narrowest ( ½ its original diameter); the end of the near zone; the beginning of the far zone; the middle of the focal zone aka: focal point the region from the transducer to the focus; in the beginning the beam diameter, or width, is same as the transducer aka: near field, Fresnel zone the distance from the transducer to the focus aka: focal depth, near zone length the region that starts at the focus and extends deeper; where the beam diverges, or spreads out (beam diameter returns to same width as the txdcr at 2 focal lengths) aka: far field, Fraunhofer zone a region around the focus where the beam is relatively narrow; where best images are acquired; half the focal zone length is located in the near zone and the other half is in the far field narrowing of the sound beam widening or spreading out of the sound beam adjustable focus or multiple foci V-shaped waves created by tiny pieces of PZT or Huygen’s sources aka: diffraction patterns, Huygen’s wavelets, V-shaped waves states that a large active element may be thought of as millions of tiny, distinct sound sources that creates a Huygens’ wavelet with a V-shape; explains the shape of an imaging transducer’s emitted sound beam based upon constructive and destructive interference Near Zone Focal Length Far Zone Focal Zone Convergence Divergence Phased Array spherical waves Huygens’ Principle Location Beam Diameter at the transducer at the focus at 2 near zone lengths deeper than 2 near zone lengths beam diameter = transducer diameter beam diameter = ½ transducer diameter beam diameter = transducer diameter beam diameter > transducer diameter Shallow Focus • • Factors that Affect Focal Depth (for a fixed focus txdcr) Deep Focus smaller diameter PZT lower frequency (thick PZT) *focal depth is inversely related to wavelength Less Divergence • • larger diameter higher frequency (improves lateral resolution in the far field) *frequency is inversely related to beam divergence • • larger diameter PZT higher frequency (thin PZT) More Divergence • • smaller diameter lower frequency CH 10 Axial and Lateral Resolution: Term Definition Resolution Axial Resolution accuracy in imaging parallel to the sound beams main axis, the minimum distance that 2 structures, positioned front-to-back can be apart and still produce 2 distinct echos; not adjustable; 0.1 – 1.0 mm (lower the better; shorter pulses) • (mm) = SPL/2 (mm) = wavelength x # cycles 2 aka: Longitudinal, Range, Radial, or Depth resolution (LARRD) *improved with higher frequency txdcr because pulses are shorter perpendicular to the sound beams main axis, the minimum distance that 2 structures, positioned side-by-side can be apart and still produce 2 distinct echos • (mm) = beam width aka: Angular, Transverse, Azimuthal resolution (LATA) *improved in far field only with higher frequency txdcr because of less divergence the focal depth and the extent of focusing are determined when the transducer is made; cannot be changed aka: conventional or mechanical focusing, includes both external and internal techniques Lateral Resolution Fixed Focusing Better Axial Resolution is associated with the following • • • • • shorter spatial pulse length shorter pulse duration higher frequencies (shorter wavelength) fewer cycles per pulse (less ringing) lower numerical values Orientation Mnemonic Determined by Best with: Does it Change? In Near Field, best with In Far Field, best with Axial Lateral front-to-back; parallel to beam LARRD spatial pulse length shortest pulse highest frequency and fewest cycles No, same at all depths shortest pulse shortest pulse side-by-side; perpendicular to beam LATA beam width narrowest beam changes with depth, best at focus smallest diameter crystal largest diameter & highest frequency (least divergence) Focusing Techniques: Type Method Name Lens Curved active element Electronic external internal phased array fixed, conventional, or mechanical fixed, conventional, or mechanical adjustable 4 Effects of Focusing • • • • beam diameter in near field and focal length is reduced focal depth is shallower beam diameter in the far zone increases (more divergence) focal zone is smaller *only improves Lateral Resolution Characteristics Frequency – Continuous Wave Frequency – Pulsed Wave Focal Length Beam Divergence Lateral Resolution Axial Resolution Determinants of Sound Beams Determined by frequency of electrical signal from u/s system thickness and speed of sound of ceramic (PZT) diameter and frequency of sound of ceramic diameter and frequency of sound of ceramic beam width SPL & PD CH 11 Display Modes: Mode A-mode (Amplitude) Displayed as a single line with a series of upward spikes;* most accurate in determining depth of reflector B-mode or Ba line of dots of varying scan (Brightness) brightness; used to describe any form of gray scale image M-mode a group of horizontal wavy (Motion) lines that move up and down, indicating the reflector is moving closer to or away from the txdcr; straight horizontal line indicates a stationary reflector *has best temporal resolution; “sampling rate” is very high and equal to the system’s PRF X-axis Y-Axis Z-Axis depth amplitude - depth - brightness/amplitude/strength of reflector time depth - CH 12 Two-Dimensional Imaging: Term Definition Elevational Resolution aka: Slice Thickness, Volume Averaging answers: are the reflections on the image created from structures directly in the imaging plane or from structures that lie above or beneath the imaging plane? *Best with single, disc-shaped crystals found in Mechanical txdcrs because it is equal to Lateral resolution *Poorest with Linear arrays, due to rectangular shape of PZT overcomes poor Elevational Resolution from rectangular shaped PZTs by arranging multiple crystals in the up-and-down direction to focus the beam in the thickness plane.*May comprise of 700 total elements, 100 wide by 7 high. performed on a frozen image, called Post-processing; creates an image from 3D data acquired during the u/s exam; adding an element of realism (color, texture, etc) some of the sound beam energy that spills from the main axis in the Far field that creates undesirable reflections on the image (artifact) and degrades Lateral resolution; created by single element transducers. similar to side lobes, but are created by Phased array transducers, and occur all along the sound beam; reduce lateral resolution, degrade image quality, and create artifacts Most popular technique used to reduce side and grating lobes; stronger electrical signals are used to excite the inner crystals, and progressively weaker electrical spikes excite the outer crystals. a crystal is divided into a group of smaller crystals called sub-elements. These sub-elements are electrically joined, and act as if they are a single crystal, which reduces grating lobes. a technique used to make a sound beam narrow over a greater range of depths and thus optimizing lateral resolution; when an Array transducer is used, the u/s system may change the # of crystals used to transmit sound beams and receive reflected echos. Aperature may be thought of as “listening or transmit hole”. aka: variable aperature a machine that displays Doppler and 2D images 1 ½ D Array Rendering Side Lobes Grating Lobes Apodization Subdicing Dynamic Aperature Duplex Scanner Ch 12 cont.. Transducer Image Shape Steering Technique Mechanical Linear Sequential/Switched sector rectangular Linear Phased Array sector Focusing Technique mechanical electronic; fixed electronic PZTs fired in small groups; steering creates parallelogram shaped image *phased and dynamic receive electronic electronic *phased and dynamic receive Annular Phased sector mechanical electronic Crystals: # and Shape 1, disc-shaped 120-250, rectangular, 1 wavelength wide; up to 10cm wide footprint 100-300, rectangular, ¼ - ½ wavelength wide; compact footprint 1 x 1cm 4 +, ring-shaped *phased delays separated by microseconds Convex/Curvilinear/Curved blunted sector electronic electronic *phased and dynamic receive Vector/Virtual Sector trapezoidal electronic electronic *phased and dynamic receive 120-250, rectangular, 1 wavelength wide; ; up to 10cm wide footprint 120-250, rectangular, 1 wavelength wide; small footprint, only a few cms *time delays in the firing patterns of phased, linear sequential, curved, and vector arrays are separated by 10 nanoseconds Transducer Type Mechanical Linear and Convex Arrays Linear Phased Array Annular Phased Array Active Element Malfunction Effect on Image Loss of entire image Dropout of image information from the top to the bottom of the image. The location of the line corresponds to the broken crystal. Erratic steering and focusing. The extent to which the image is affected is variable. A horizontal or side-to-side band of dropout at a particular depth Electronic Pattern (created by the Beam Former) Sound Beam Slope Curvature Straight Line Slight Curvature Higher Curvature Left element is excited first, across to Right Last Right element is excited first, across to Left Last Steering Transmit Focusing Straight down/Unfocused Deeper focus Shallow focus Beam steered to the Right Beam steered to the Left CH 13 Real-Time Imaging (Temporal Resolution): Term Definition Frame Rate the system’s ability to create numerous frames each second (Hz); Directly related to Temporal Resolution and the system’s PRF. Inversely related to Tframe Temporal Resolution Tframe field of view line density Spatial Resolution “sampling rate” • PRF = # scan lines x frame rate Accuracy in time, describes the ability to precisely position moving structures from instant to instant. Excellent when a system produces many frames per second, and substandard when it produces few frames per second (Hz). Time it takes the system to create 1 frame. • = # pulses x PRP aka: sector size the spacing between sound beams • = # pulses / sector size image detail; combination of Lateral and Axial resolutions in M-mode, same as “frame rate”, is very high and equal to the system’s PRF Factor’s Affecting Frame Rate • System Settings Affecting Frame Rate Speed of Sound in the Medium (*fundamental • Imaging Depth • # of Pulses per frame limitation) • Imaging Depth *inversely related to both Shallow Imaging • • • • • Deep Imaging • • • • • short go-return time shorter Tframe higher frame rate Superior Temporal Resolution higher frequency txdcr long go-return time longer Tframe lower frame rate Inferior Temporal Resolution lower frequency txdcr Factors Determining Number of Pulses per Frame • • • number of focal points sector size line density Single Focus • • • • • • one pulse per scan line shorter Tframe higher frame rate better Temporal resolution poorer Lateral resolution good for moving structure imaging Multi-Focus • • • • • • many pulses per scan line longer Tframe lower frame rate diminished Temporal resolution improved Lateral resolution (*main advantage) good for static structure imaging Narrow Sector • • • • fewer pulses per frame shorter Tframe higher frame rate superior Temporal resolution Low Line Density • • • • • • widely spaced lines fewer pulses per frame shorter Tframe higher frame rate high Temporal resolution poor Spatial resolution Wide Sector • • • • more pulses per frame longer Tframe lower frame rate inferior Temporal resolution High Line Density • • • • • • tightly packed lines more pulses per frame longer Tframe lower frame rate low Temporal resolution excellent Spatial (detail) resolution (*main advantage) Better Temporal Res- higher Frame Rate • • • • shallower imaging (high freq) single focus narrow sector size low line density Worse Temporal Res- lower Frame Rate • • • • deeper imaging (low freq) multiple foci (improved lateral res) wide sector size high line density (improved spatial res) CH 14 Pulsed Echo Instrumentation: U/S System 2 Major Functions 1) Preparation and Transmission of electrical signals to the transducer, which creates a sound beam 2) Reception of electrical signals from the transducer, with subsequent processing into clinically meaningful images and sounds 6 Major Components of U/S Systems Transducer Pulser and Beam Former Receiver Display Storage Master Synchronizer Term Pulser Voltage Pulse Repetition Period Noise Signal-to-Noise ratio (S/N) during transmission, it transforms electrical energy into acoustic energy. during reception, it converts returning acoustic energy into electrical energy creates and controls the electrical signals sent to the transducer that generate sound pulses. • Pulser determines the amplitude (power output), PRP, & PRF • Beam Former determines the firing delay patterns for phased arrays transforms the electrical signals from the transducer into a form suitable for display presents processed data. May be a flat screen monitor, a transparency, a spectral plot, or a variety of other formats archives the ultrasound studies maintains and organizes the proper timing and interaction of the system’s components Definition • Effect on Image: the brightness of the entire image changes • Adjustable by user • Concerns BioEffects: Thermal Index and Mechanical Index. • range: 0 – 100% • directly related to S/N ratio • determines PRP & PRF aka: Output Gain, Output Power, Acoustic Power, Transducer Output, Acoustic Output, Pulser Power, Energy Output, Transmitter Output, Power, or Gain Determined by Pulser voltage; the time between one voltage spike and the next Determines Imaging Depth a random and persistent disturbance that obscures or reduce’s a signal’s clarity; contaminates images with low-level undesirable information a comparision of the meaningful information (signal) in an image, compared to the amount of contamination (noise). *most commonly improved by increasing Output Power Beam Former “transmit-receive” Switch Channel Receiver Amplification Preamplification Compensation Compression Demodulation Reject A sophisticated electronic device that receive’s the pulser’s single electrical spike and distributes it to the numerous active elements of an array transducer. * During reception, it establishes the correct time delays used for dynamic receive focusing. * Also adjusts electrical spike voltages to reduce lobe artifacts via apodization * in modern txdcrs, it is called a digital beam former 1) protects the delicate receiver components from the from the powerful signals that are created for pulse transmission 2) directs the electrical signals from the transducer to the appropriate electronic and processing components within the ultrasound system made up of a single PZT element in the txdcr, the electronics in the beam former/pulser, and the wire that connects them prepares the information contained in the miniscule reflection signals for eventual display on the system’s monitor *see 5 Receiver Functions table* Each electronic signal returning from the transducer is made larger; (dB) The process of improving the quality of a signal before it is amplified; occurs as close to the active elements as is practical Corrects for attenuation with regards to path length/depth to create an image of uniform brightness; (dB) Performed twice: 1) keeps electrical signal levels within the accuracy range of the system’s electronics 2) keeps an image’s gray scale content within the range of detection by the human eye (20 shades) Only affects weak signals; User-controlled compression modifies the gray scale mapping of ultrasound images; (dB) 2 part process that changes the electrical signals within the receiver into a form more suitable for display on a monitor 1) Rectification: converts all negative voltages into positive voltages 2) Smoothing/Enveloping: places a smooth line around the “bumps” and evens them out Allows the sonographer to control whether low-level gray scale information within the data will appear on the displayed image Dynamic Frequency Tuning U/S system takes higher frequency signals to create shallow part of the image & lower frequency signals to create deeper part of the image As Low As Reasonably Achievable; States that when modifications to either output power or receiver gain can improve the image’s diagnostic quality, the first and best choice is the one that will minimize the patient’s ultrasound exposure. ALARA Shallow Imaging • • • shorter listening time shorter PRP higher PRF Deep Imaging • • • longer listening time longer PRP lower PRF 3 Advantages of Digital Beam Formers • • • software programming extremely stable versatile 3 Brightness Controls • • • Power Output/ Acoustic Output Time Gain Compensation Receiver’s Gain Anatomy of a TGC Curve Near gain Delay Slope Knee Far Gain First part of a TGC curve; At superficial depths, reflections undergo a small, constant amount of compensation Second part of a TGC curve; The depth at which variable compensation begins Third part of a TGC curve; compensation corrects for the effects of increasing attenuation that result from increasing path length Fourth part of a TGC curve; reflections are maximally compensated by the system Fifth part of a TGC curve; indicates the maximum amount of compensation that the receiver can provide Ch 14 cont.. Receiver Functions Function (in order) Adjustable Signals Processed Effect on Image Synonyms All signals treated identically Signals treated differently based on reflector depth Entire image gets brighter or darker Image will be uniformly bright from top to bottom Amplification Yes Compensation Yes Compression Yes Signals treated differently depending on strength Changes gray scale mapping Demodulation No None Reject Yes Prepares electrical signals to be suitable for display via Rectification and Enveloping/Smoothing Only weak signals affected; strong signals remain unchanged Output Power • • • • • Changes brightness of entire image Alters signal-to-noise ratio Alters patient exposure Bioeffect concerns Decrease this first if image is too bright vs Weak echoes appear or are eliminated from image Receiver gain Time Gain Compensation (TGC), Depth Gain Compensation (DGC), Swept Gain Log compression, dynamic range Threshold, suppression, priority control Receiver Gain • • • • • Changes brightness of entire image Does not affect signal-to-noise ratio Does not change patient exposure No bioeffect concerns Increase this first if image is too dark CH 15 Displays and Image Processing: Bistable • • Grayscale Images are composed of only 2 shades: black and white High contrast Term Contrast Brightness Scan Converter • • • • Present multiple levels of brightness: white, light gray, medium gray, etc. Assigns different gray shades to different echo amplitudes Differentiates biologic tissues of different reflectivity Low contrast Definition Determines the range of brilliancies (shades of gray) within the displayed image Determines the brilliance of the displayed image Translates the information from the spoke (pulse) format into the video format; modern technology uses digital scan converters • Storage of image data = “writing” • image data is displayed = “reading” Analog Numbers unlimited and continuous range of “real world” numbers that are found in everyday life Digital Numbers Associated with computer devices and have only discrete values Electrons Charged particles within an analog scan converter that contain the image information and are shot out of the gun to the silicon wafer Dielectric matrix Contained in the larger end of the tube of an analog scan converter which receive and or Silicon wafer store the electrons; may be thought of as picture divided into millions of tiny dots, each containing an electron bucket which are read to retrieve the image information. Spatial resolution Image detail Pixel Picture element, the smallest building block of a digital picture; a single shade of gray at any instant in time Pixel Density The number of picture elements per inch Bit Binary digit, the smallest amount of computer memory; bistable, having a value of either 0 or 1 Binary number A group of bits and is simply a series of zeroes and ones Byte A group of eight bits of computer memory (i.e.: 10011111) Word Consists of 2 bytes, or 16 bits Analog Real World Digital Computer World Analog-to-digital Converts electrical signals from the transducers during reception into digital form: a (A-to-D) string containing only 0s and 1s. converter Preprocessing Any process of the reflected signals before storage; controlled by the sonographer; cannot be reversed or undone Postprocessing Any process after storage in the digital scan converter; controlled by the sonographer; can be reversed Digital-to-analog Translates digital signals back into analog form to be displayed on analog video display (D-to-A) converter Magnification Zoom, enlargement of a portion of the image to fill the entire screen ROI Region of Interest, the selected part of the image Read Magnification Write Magnification Coded Excitation Spatial Compounding Frequency compounding Edge Enhancement Temporal Compounding Fill-in Interpolation Elastography PACS DICOM Occurs after the image data is stored (postprocessing); system scans the anatomy, image data is converted from A-to-D and stored in the scan converter, sonographer identifies the ROI and the system reads and displays only the original data that pertains to the ROI; nothing is rescanned, # of pixels remains the same, but are enlarged Applied during data acquisition, but before storage (preprocessing); system scans the anatomy, image data is converted from A-to-D and stored in the scan converter, ROI is identified and the system discards existing info in the scan converter, ROI is rescanned and new data is written into the scan converter; # of pixels is increased, improving spatial resolution, pixels are the same size. A sophisticated method, developed within the context of Bioeffects, of improving image quality. Creates very long sound pulses containing a wide range of frequencies, keeping the peak intensity below the FDA’s limit. Special mathematical techniques shortens the long reflected pulses improving resolution and providing high imaging quality. *Occurs in the pulser. Image is obtained by acquiring multiple frames from different angles and then combined to create a single real-time image; electronic beam steering is required, thus this is only available with phased array txdcrs; the more frames acquired in the compound sequence, the better the image quality; reduces speckle and shadowing artifacts; limitations: reduced frame rate and temporal resolution Image is created using the entire reflection with all reflected frequencies from a single pulse down a scan line; reduces speckle artifact and reduces noise. An image processing method that makes pictures look sharper; increases the image contrast in the area immediately around the edge; creates subtle bright and dark highlights on either side of these boundaries to make them appear more defined. Aka: Persistence, temporal averaging. Image processing technique that continues to display the same view with a “history” from earlier frames creating a smoother image with reduced noise, higher S/N ratio, and improved image quality. Limitation reduction in frame rate, reducing temporal resolution. With sector shaped images, the distance between scan lines increases as depth increases; this method of image processing (preprocessing) fills in the gaps of missing data by predicting the gray scale levels from known levels of neighboring pixels; increases line density, improving spatial resolution; *improves the ability to precisely visualize the borders of round structures. Reduces temporal resolution Emerging technique that relates images to the mechanical properties of tissue; tissues will deform differently following the application of a force, estimates of tissue stiffness/elasticity are obtained and combined with ultrasound reflections to create an elastogram; potential as a complimentary tool for the diagnosis of cancer as it can be applied to differentiate malignant from benign lesions Picture Archiving and Communications System; physical computer network/laboratory in which images and additional medical information are digitized and stored on. 3 Advantages: 1) Instant access 2) No degradation of data 3) Ability to electronically transmit images an reports to remote sites Digital Imaging and Computers in Medicine; a set of rules that allows imaging systems on the network to communicate Analog Numbers • • • Digital Numbers • • • • Real world, 0-9 Unlimited # of choices Continuous values Computer world, 0 & 1 Limited choices Discrete values Binary numbers Analog Scan Converter • • • • Digital Scan Converter 1st type of scan converter, making gray scale imaging possible Funnel-shaped vacuum tube with an electron gun located in its smaller end and a dielectric matrix in the larger end Excellent Spatial Resolution because of the large number of storage elements within the matrix Obsolete due to the following limitations: 1) Image Fade- stored charges on the silicon wafer dissipate over time 2) Image Flicker- caused by switching between read and write modes 3) Instability- picture quality depends on many factors including length of use, room temperature, and humidity 4) Deterioration- image degrades as device ages Low Pixel Density • • • • # of bits 1 2 3 4 5 10 n Used in modern ultrasound machines • Uses a process called digitizing by computer technology to convert images into numbers; 2 important elements are: pixel and bit Image is stored as series of ones and zeros and then processed and re-translated into an image displayed on a monitor Advantages include: 1) Uniformity- consistent gray scale quality throughout the image 2) Stability- does not fade or drift 3) Durability- not affected by age or heavy use 4) Speed- nearly instant processing 5) Accuracy- error-free • • High Pixel Density • • • • Few pixels per inch Larger pixels Less detailed image Lower spatial resolution Bits and Shades of Gray Exponent (Max) Number of Shades 21 22 23 24 25 210 2n • 2 4 8 16 32 1024 Many pixels per inch Smaller pixels More detailed image Higher spatial resolution Digital Images Pixels • • • Image element Image detail Spatial Res Bits • • • Computer memory Gray shades Contrast Res Fewer Bits per Pixel • • Fewer shades of gray Degraded contrast resolution More Bits per Pixel • • More shades of gray Improved contrast resolution Translating Analog and Digital Information 1) Voltage is always analog and must be converted to digital form (a string of 0s and 1s) by the analogto-digital (A-to-D) converter. 2) Digital information is stored, or “written”, in the scan converter’s computer memory. *Any processing before storage in the scan converter is preprocessing 3) Image information, in digital form, continues to be processed by the u/s system’s computer. *Any processing after storage in the digital scan converter is postprocessing 4) If the display unit is analog (TV monitor), then the image information must be translated from digital form back to analog by a digital-to-analog (D-to-A) converter. If the display is a digital unit (flat screen) then there is no need for a D-to-A converter. 5) The signal is presented on the display for interpretation. Preprocessing • • • • • • • Time gain compensation (TGC) Log compression/ Dynamic Range Write magnification Persistence/ Temporal compounding Spatial compounding Edge enhancement Fill-in interpretation (phased array txdcrs only) Read Magnification Postprocessing • • • • • Write Magnification • • • 3 steps Uses old data Postprocessing • • • • • • • Larger pixel size Same # of pixels as in the original ROI Unchanged spatial resolution Unchanged temporal resolution • • • • Coded Excitation provides… • • • • • Higher S/N ratio Improved axial resolution Improved spatial resolution Improved contrast resolution Deeper penetration Any change after freeze frame Black/white inversion Read magnification Contrast variation 3-D rendering 4 steps Acquires new data Preprocessing (cannot be used on a frozen image) Identical pixel size More pixels than the original ROI Improved spatial resolution May improve temporal resolution, if the bottom of the ROI is shallower than the Original image’s DOV Types of Data Storage: Type of Medium Paper Media Examples • Charts from pen writers Advantages • • Portability Does not require a device to read Disadvantages • • • Magnetic Media • • • • Chemically Mediated Photographs Optical Media • • • • • “Floppy” Computer Discs Computer memory Magnetic Tape Video Tape Photographs Flat films Multiformat camera film Laser discs Compact discs (CDs) • • • • • • • • • Able to store large amounts of information efficiently Can store and play dynamic (moving) images Can record color High resolution Accepted in the medical community Can produce color images • Store huge amounts of data Inexpensive Not erased by exposure to magnetic fields • • • • • Bulky, hard to store Difficult to make copies Cannot display dynamic images Can be erased by strong magnetic fields Bulky, difficult to store and retrieve Requires chemical processing Artifacts can arise from dirt or chemical contamination Requires a display system No standardized format for image display and storage CH 16 Dynamic Range: Term Definition Dynamic Range # of choices; a method of reporting the extent to which signals vary and can still produce accurate images - Units: dB - A comparison, a relative measure, or a ratio, between the largest and smallest signals that are measured accurately Smallest signals that are accurately measured; min. intensity which should be exceeded to get a certain change - Signals below the threshold are too weak and will not be recognized by the system and is tossed out Largest signals (max. intensity) that are accurately measured - Signals above the saturation point are too strong and are read as the max. intensity value (ex: if a signal is 7dB and the sat. point is 6.5dB then the signal is read as 6.5dB) = (threshold) to (saturation point) Ability to distinguish the different/ adjacent reflector and still produce similar echoes Limited choices; bistable (black and white) - High contrast - Low contrast resolution Threshold Saturation Point Range of accurate measurement Contrast Resolution Narrow Dynamic Range Wide Dynamic Range Many choices; gray scale imaging (possible due to digital scan converter) Compression Low contrast High contrast resolution Performed by the u/s machine so it can display the image; signal ranking remains the same, but the range is changed: smallest signal remains smallest value and largest signal remains largest value - Adjustable by Sonographer via Gray Scale Mapping *General Rule: the dynamic range of information decreases the more it is processed* U/S System Component Dynamic Range Transducer Receiver Amplifier Scan Converter Display Archive Human Eye 120 dB 100 - 120 dB 60 – 100 dB 40 – 50 dB 20 - 30 dB 10 – 30 dB 10 – 20 dB * always less than display Mathematics of Compression: decibels add or subtract • Uncompressed signal – amount of compression = dynamic range of compressed signal • Compressed signal + amount of compression = dynamic range of original signal Images and their Dynamic Ranges Fewer Shades • • • • • Few choices Black and white (bistable) Narrow dynamic range High contrast Low contrast resolution More Shades • • • • • Many choices Gray scale Wide dynamic range Low contrast High contrast resolution CH 17 Harmonics and Contrast Agents: Term Definition Fundamental Frequency Frequency of sound transmitted into the body by the transducer; main frequency (or) fixed frequency of the transducer - 1st Harmonic Twice the fundamental frequency; resonant frequency - 2nd Harmonic - Sound waves arise from nonlinear behavior Image created by main frequency - Creates superficial image - More distortion, lobe artifacts The creation of an image from sound reflections at twice the frequency of the transmitted sound. - Improves the image quality because harmonic frequencies undergo less distortion (do not create lobe artifacts) than fundamental frequency - 2 Forms: Tissue & Contrast Means irregular or disproportionate, asymmetrical; Difference of speed between compression (fast) and rarefaction (slow); creates a “spilling” of energy, or harmonics Means proportional or symmetrical; responds in an even manner Resonance of tissue: Created by the conversion of a miniscule amount of energy from the fundamental frequency to the harmonic frequency of a sound wave as it travels through the body during transmission (nonlinear behavior) - Do not develop in very superficial layers - Develop in deeper/intermediate layers - Disappear in deepest layers - Increases S/N ratio - Distortion free - No grating lobes - Arise from main axis, strongest part of the sound beam Most commonly used technique that separates fundamental freq. from harmonic freq.: 2 inverted/opposite consecutive pulses are transmitted down each scan line. 1) Fundamental signals exhibit linear behavior, thus destructively interfere and completely cancel each other out, leaving only the harmonic portion of the reflections Harmonic Frequency Fundamental Image Harmonic imaging Nonlinear behavior Linear behavior Tissue Harmonics Pulse Inversion Harmonics Power Modulation Contrast Agents 2) Harmonic signals exhibit nonlinear behavior, they interfere constructively and produce echoes of higher quality Disadvantage: - Temporal Resolution is reduced Another technique used to augment harmonic reflections, while eliminating distorted fundamental reflections: 2 consecutive pulses are sent down each scan line, the second pulse is 2x the strength of the first one. The first, weaker pulse contains no harmonics. - During reception, reflections from the first pulse (fundamental only) are amplified to DOUBLE which then cancels out the fundamental frequency of the second pulse’s reflections, leaving only the harmonic frequency portion of the reflection to create an echo of higher quality Disadvantage: - Temporal Resolution is reduced Microbubbles; gas bubbles encapsulated in a shell, that are either ingested or injected in the circulation, designed to create strong reflections that actually “light up” blood chambers, vessels, or other anatomic regions • 5 requirements: 1) safe 2) metabolically inert (inactive) 3) long lasting 4) strong reflector of u/s 5) small enough to pass through capillaries - Microbubbles are strong scatterers of sound because they are the same size as RBCs and resonate when exposed to freq. of 2-4MHz • 2 Characteristics: 1) The nature of the outer shell should be flexible 2) The gas molecule that fills the microbubble; Larger gas molecules find the shell less permeable and remain trapped within the bubble Contrast Harmonics Mechanical Index Much stronger than tissue harmonics; Created during reflection as energy is converted from the fundamental freq. to the harmonic freq. Nonlinear changes in size of microbubbles when struck by sound waves, or resonance: bubbles expand to a greater extent than they shrink. - Peak rarefaction pressure, which expands the bubble, is most important with regard to contrast harmonics Advantages: - Increased spatial resolution - Increased contrast resolution - Reduces artifact A number that estimates the amount of contrast harmonics produced; depends on the frequency (inversely related) of the transmitted sound and peak rarefaction pressure (directly related) of the sound wave. MI = peak rarefaction pressure √frequency Other Non-linear Behavior of Tissue Harmonics that minimizes distortion: Beam Strength Amount of Tissue Harmonics created Weak Intermediate Strong none Tiny amount Significant amount Summary of Tissue Harmonics • • • • • Not present as sound leaves the transducer Created deeper in the tissues Created in the tissues during transmission Created by nonlinear behavior in the speed of sound: Sound in compressions travels faster than sound in rarefactions Primarily created along the beam’s main axis; beams that are more likely to create harmonics are least likely to create artifacts Lower MI • • • Small pressure variation Higher frequency Less Bioeffects Higher MI • • • Large pressure variation Lower frequency More bioeffects Low MI: < 0.1 • • • • • • No harmonics Backscatter Linear behavior Higher frequency sound Low beam strength Bubble expands very little Higher MI: 0.1 to 1.0 • • • • • • Some harmonics Resonance Nonlinear behavior Lower frequency sound Higher beam strength Bubble expands moderately Tissue Harmonics • • • • • • Strongest harmonics Bubble disruption Extreme nonlinear behavior Lowest frequency sound Highest beam strength Bubble expands greatly Contrast Harmonics • • Created during transmission in tissue Occurs as sound propagates in tissue • • • Results from nonlinear behavior of transmitted sound beam Weaker harmonic signal • • Highest MI: > 1.0 • • Created during reflection off of microbubble Occurs only when contrast agents are present and with MIs > 0.1 Results from nonlinear behavior of microbubble Stronger harmonic signal Affected by the microbubble’s shell and the gas within it CH 18 Hemodynamics: Term Definition Hemodynamics Flow Study of blood moving/circulating through the circulatory system Aka: Volume flow rate; indicates the volume of blood moving during a particular time. Flow measurements answer the question “how much?” - Units: L/min (volume/time) - 3 Types: Pulsatile, Phasic, Steady Indicates the speed or swiftness of a fluid moving from one location to another. Velocity answers the question “how fast?” - Units: cm/s (distance/time) Occurs when blood moves with a variable velocity. Blood accelerates and decelerates as a result of cardiac contraction; therefore, pulsatile flow commonly appears in the arterial circulation. Aka: Spontaneous flow; Also occurs when blood moves with a variable velocity. Blood accelerates and decelerates as a result of respiration; therefore, phasic flow often appears in the venous circulation Occurs when a fluid moves at a constant speed or velocity. Present in the venous circulation when individuals stop breathing for a brief moment. Normal physiological flow; flow streamlines are aligned and parallel; characterized by layers of blood that travel at individual speeds. Silent flow - 2 Types: Plug flow, Parabolic flow - Reynolds number of < 1,500 All layers and blood cells travel at the same velocity Bullet shaped profile; velocity is highest in the middle (center of the lumen), and then gradually decreases to its minimum at the vessel wall. Predicts whether flow is laminar or turbulent; ratio between viscosity and inertia Abnormal flow characterized by chaotic flow patterns in many different directions and at many speeds; streamlines are often obliterated; associated with cardiovascular pathology and elevated blood velocities seen downstream from a significant stenosis in a vessel. Converts flow energy into other forms such as sound and vibration. - Eddy current/swirling: small, hurricane-like, swirling, rotational patterns appear in turbulent flow - Reynolds number of > 2,000 Sound associated with turbulent flow Tissue vibration associated with turbulent flow; aka: palpable murmur, which is one you can feel with your fingertips Difference of energy; blood moves from regions of high energy to low energy by contraction of the heart during systole. Associated with all moving objects; determined by: 1) an object’s mass 2) the speed at which it moves KE = ½ MV2 Velocity Pulsatile Flow Phasic Flow Steady Flow Laminar Flow Plug Flow Parabolic Flow Reynolds Number Turbulent Flow Murmur, Bruit Thrill Energy Gradient Kinetic Energy Pressure/ Potential Energy Gravitational Energy Viscosity Viscous Energy Loss Hematocrit Frictional Energy Loss Inertial Energy Loss Inertia Stenosis Post-stenotic turbulence Bernoulli’s Principle Ohm’s fluid Law Veins Hydrostatic Pressure A form of stored energy; has the ability to perform work; a major form of energy for circulating blood and creates flow by overcoming resistance PE = Mass x Gravity x Height A form of stored or potential energy associated with any elevated object Describes the thickness of a fluid - Units: Poise More energy is lost with movement of high viscosity fluids; viscous loss is associated with blood overcoming its internal stickiness; determined by Hematocrit The percentage of blood made up of RBCs; normal value = 45% Occurs when flow energy is converted to heat as one object rubs across another, i.e: blood rubbing/sliding against vessel walls Energy is lost when the speed of a fluid changes, regardless of whether the fluid speeds up or slows down; occurs during 3 events: 1) Pulsatile flow (arterial) 2) Phasic flow (venous) 3) Velocity changes at a stenosis Relates to the tendency of a fluid to resist changes in its velocity A narrowing in the lumen of a vessel Turbulent flow downstream from the stenosis A modified law of conservation of energy; describes the relationship between velocity (kinetic energy) and pressure in a moving fluid (blood) - When velocity is high, pressure is low - When velocity is low, pressure is high Pressure gradient = flow x resistance; Resistance to flow increases whenever there is a stenosis; in the circulatory system, the resistance vessels are called arterioles thin-walled, collapsible, low-resistance vessels; allows for large volume increases with very small pressure increases by changing shape from an hourglass, to oval, to round as inflow increases. Pressure related to the weight of blood pressing on a vessel measured at a height above or below heart level; units: mmHG - Hydrostatic pressure is 0mmHG everywhere in a supine patient, or at heart level in an upright patient - Hydrostatic pressure is negative at locations above the heart in an upright patient, creating erroneously low measured pressures - Hydrostatic pressure is positive at locations below the heart in an upright patient, creating erroneously high measured pressures: Measured pressure = circulatory press. + hydrostatic pressure Effects of a Stenosis • • • • • Change in flow direction Increased velocity as vessel narrows Turbulence downstream from the stenosis Pressure gradient across the stenosis Loss of pulsatility A- “Upstream”, flow reversal seen during diastole; pressure reduces, velocity increases B- Area of stenosis, velocity is maximum, pressure is lowest C- “Downstream”, Pressure is higher than B, but less than A; flow reversal seen during systole; post-stenotic turbulence Ohm’s Law – Fluid • • • Ohm’s Law- Electricity • • • Pressure Flow Resistance Voltage Current Resistance Measurement Site Blood Pressure (example) Level Hydrostatic Pressure Measured Pressure Ankle knee Waist Mid chest Top of head 140 mmHg 140 mmHg 140 mmHg 140 mmHg 140 mmHg Far below heart level Somewhat below heart Slightly below heart Heart level Above heart 100 mmHg 75 mmHg 50 mmHg 0 mmHg -30 mmHg 240 mmHg 215 mmHg 190 mmHg 140 mmHg 110 mmHg Breathing and Venous Flow Inspiration Expiration • • • • • Diaphragm moves downward toward the abdomen Thoracic pressure decreases Abdominal pressure increases Venous return to the heart increases Venous flow in legs decreases • Diaphragm moves upward into thorax • • • • Thoracic pressure increases Abdominal pressure decreases Venous return to the heart decreases Venous flow in legs increases CH 19 Doppler: Term Definition Doppler principle Physical principle used to measure the velocity of blood in the circulation; (velocities sampled every second) Produced by relative motion of sound source (transducer) and receiver (RBCs); relative motion of RBCs towards or away from the txdcr that causes a change in the main frequency is called Doppler frequency; The Doppler shift is a low frequency that “rides” on top of the much higher txdcr frequency Doppler shift (Hz) = reflected freq. – transmitted freq. The process of extracting the low Doppler frequency from the txdcr’s carrier frequency When blood cells move toward the txdcr, the reflected frequency is higher than the transmitted frequency; When blood cells move away from the transducer, the reflected frequency is lower than the transmitted frequency Purely a magnitude, indicates the distance that a RBC moves in 1 sec Defined by a magnitude and a direction Doppler shift = 2 x velocity of blood x txdcr freq. x cosine Propagation speed Cosine: angle between sound and vessels 2: represents the fact that there are actually 2 doppler shifts 1st shift = reception of sound wave by moving RBC 2nd shift = transducer’s reception of the sound wave from the moving RBC Doppler shift/ Doppler frequency Demodulation Positive Doppler Shifts Negative Doppler Shifts Speed Velocity The Doppler Equation Measured velocity Bidirectional Doppler Phase quadrature/ Quadrature detection Continuous Wave (CW) Doppler Range ambiguity Duplex imaging/scanning = true velocity x cosine Distinguishes the direction of flow toward or away from the transducer with spectral tracing, and/or audio: spectrum below the baseline indicates a negative shift, or flow away from the txdcr; spectrum above the baseline indicates a positive shift, or flow toward the txdcr A commonly used signal processing technique for bidirectional Doppler Requires 2 crystals in the txdcr, one always transmitting, the other always receiving. (+) ability to accurately measure very high velocities (+) very small doppler shifts can be detected (highly sensitive) (+) artifact free (-) cannot determine exact location of the moving blood cells (range ambiguity) due to overlap of transmit and receive beams (-) lack of TGC (-) anatomic imaging cannot be performed with CW txdcr A disadvantage of CW doppler; Depth of reflections cannot be determined because reflections are being measured from entire overlap area of transmit and receive beams Simultaneous anatomic imaging and Doppler Fusion: 2D US + MRI/CT Pulsed Wave (PW) Doppler Range resolution Aliasing Nyquist limit Gray Shades of a Spectrum Color Flow Doppler Color Map Velocity Mode 1 PZT alternates between transmit and receive; velocities are sampled many times per second; sampling rate = system’s PRF (+) range resolution (-) inaccurate measurement of high velocity signals, aliasing (-) cannot pick up very low doppler shifts Greatest advantage of PW Doppler; the ability to select the exact location where velocities are measured by placing a small marker, called the gate, or sample volume, on a 2D image. The US system then calculates the ToF for a sound pulse traveling to and from the gate. (aka: range specificity, freedom from range ambiguity artifact) Most common error associated with Doppler ultrasound: High velocity flow in one direction is incorrectly displayed as traveling in the opposite direction; a false identity • Never occurs with CW Doppler • Occurs when scanning deeper and Doppler sampling rate (PRF) is too low in comparison to the measured blood velocities The highest Doppler frequency or velocity that can be measured without the appearance of aliasing; The very top of the spectral graph display when blood flow is toward the txdcr, and the very bottom of the display when flow is away from the txcdr Nyquist limit (Hz) = PRF 2 Related to amplitude of the reflected signal (# of blood cells creating the reflection) A form of 2D Doppler, where velocity information is coded into colors and superimposed on a 2D gray scale, anatomic image. Reports average or mean velocities. - Is a pulsed u/s technique - Has range resolution (or range specificity) - Is subject to aliasing - Is considered semi-quantitive - Provides info regarding direction of flow - Uses a Color map - Knowledge of angle between directions of sound and flow is less important than compared to CW or PW Doppler A “dictionary” or lookup table, used by color flow Doppler to convert measured velocities into colors that appear on the image. Displayed as a vertical bar of various colors, with a black bar in the center which indicates “no Doppler shift”. 2 most common dictionaries: - Velocity mode - Variance mode The color provides information on flow direction and velocity. Colors above the black stripe indicate flow towards the txdcr, or positive Doppler shifts. Colors below the black stripe indicate flow away from the txdcr, or negative Doppler shifts. - Velocity maps with multiple colors above and below the black stripe indicate slower velocities closer to the black, and faster Variance Mode Doppler Packets Power Doppler Spectral Analysis Fast Fourier Transform (FFT) Spectral Window Spectral Broadening Autocorrelation velocities farthest from the black, either towards or away from the txdcr (above or below the black stripe) - Color change is always up and down, never side to side Same information provided as velocity mode, but also distinguishes laminar flow from turbulent flow - Color change is side-to-side, as well as up and down: • L:L - Left is Laminar • R:T – Right is Turbulent With color Doppler, multiple u/s pulses per scan line are used to accurately determine blood velocities (aka: ensemble); with larger packets or longer ensemble lengths are composed of larger number of pulses per scan line: (+) More accurate velocity measurement (+) Increased sensitivity to low flow (-) more time needed to acquire data (-) reduced frame rate (-) decreased temporal resolution (-) subject to aliasing (mixing of colors) * Packet size should be selected to balance 2 competing interests: accurate velocity measurements and adequate temporal resolution (aka: energy mode or color angio) Non-directional color Doppler; no velocity or direction information, only detects flow: the amplitude of the reflection is directly related to the number of moving blood cells. (+) not angle dependent (+) no aliasing (+) sensitive to low flow or velocity (such as venous flow) (-) no measurement of velocity or direction (-) lower frame rates than conv. color flow (reduced temp. reso.) (-) prone to “flash artifact” with slight motion of txdcr, patient, or soft tissues A tool that breaks the complex signals into its basic “building blocks” and identifies velocities that make up the reflected Doppler signal 2 Methods: - Fast Fourier Transform (FFT) - Autocorrelation A digital technique used to process both PW and CW Doppler signals (+) exceedingly accurate (+) displays all individual velocity components that make up the complex reflected signal; distinguishes laminar from turbulent flow The region of a (FFT) spectral trace between the baseline and the spectrum; when clear = laminar flow, spectral broadening = turbulent flow With turbulent flow, the pulsed Doppler spectral window is filled in; a wider range of velocities and Doppler shifts within the sample volume (aka: correlation function) the digital technique used to analyze color flow Doppler because of the enormous amount of data that is processed. (+) substantially faster than FFT (-) less accurate than FFT Doppler Shift measured in Hertz • • • Directly related to velocity Directly related to transducer frequency Directly related to the cosine of the angle between the direction of the flow and the direction of sound Angle (degrees) Cosine Percent of True Velocity 0 1.0 30 0.87 60 0.5 90 0 120 -0.5 150 -0.87 180 -1.0 *at angles other than 0 and 180, only a portion of the true velocity is measured Factors that affect Aliasing Less Aliasing • • • Slower blood velocity Lower frequency transducer Shallow gate (high PRF) 100% 87% 50% 0% 50% 87% 100% More Aliasing • • • Faster blood velocity Higher frequency transducer Deep gate (low PRF) 5 Techniques that Eliminate Aliasing (use in order): Method Strategy/ (-) disadvantage 1) Adjust the scale (PRF) to its maximum 2) New, Shallower view (sample volume) 3) Lower transducer frequency Increases Nyquist limit (-) less sensitive to very small Doppler shifts/low velocities Increases Nyquist limit (PRF) (-) None Decreases Doppler shift/ reduces height of doppler spectrum (-) resolution degrades/ lower quality anatomic image 4) Use baseline shift (down/zero) Aliasing remains, but display is more appealing (-) ineffective if Doppler shift wraps around itself completely 5) Use CW Doppler Never aliases, but (-) range ambiguity *Eliminating aliasing “improves the ability to measure the maximum velocity with Doppler” PW Doppler • • • • Range resolution Sample volume Limited maximum velocity – Nyquist Aliasing CW Doppler • • • • Range ambiguity Region of overlap Unlimited maximum velocity No aliasing Pulsed Doppler Transducer • • • • • CW Doppler Transducer At least one crystal Dampened PZT (backing material) Low Q-factor Wide bandwidth Lower sensitivity • • • • • At least 2 crystals Undampened PZT (no backing material) High Q-factor Narrow bandwidth Higher sensitivity Imaging Doppler • • • • • • • • Normal incidence – 90 deg Higher frequency – improves resolution Pulsed wave only Minimum of 1 crystal 0 or 180 deg Lower frequency – avoids aliasing Pulsed or CW Min. of 1 (pulsed) or 2 (CW) crystals Doppler Artifact Doppler modality/ Appearance How to eliminate Ghosting Clutter CF- spilling of color outside vessel PW – low doppler shifts appear below spectral baseline CF- “mirror image” appears as second vessel color flow below anatomic ROI PW- “mirror image” appears as identical Doppler spectrum both above and below baseline Increase Wall Filter (reject) Increase Wall Filter (aka: high pass filters) Decrease Gain Check angle between txdcr and vessel Crosstalk Summary of Doppler Modalities Continuous Wave Pulsed Wave • Identifies highest velocity jets anywhere along the length of the u/s beam (-) range ambiguity • Most sensitive • Accurately identifies the location of flow (+) range resolution • Moderately sensitive (+) Very good temporal resolution (+) Very good temporal resolution (+) no aliasing (-) subject to aliasing • Peak velocity measurements • Peak velocity measurements Color Flow • Provides 2D flow information directly on anatomic image (+) range resolution • Moderately sensitive • Size of color jet is most affected by Doppler gain settings (+/-) Reduced temporal resolution due to multiple packets (-) based on pulsed u/s, subject to aliasing • Mean velocity measurements Power Mode • Used with low velocity or small volume blood flow (+) range resolution • Greater sensitivity than color flow (-) lowest temporal resolution (-) subject to flash artifact, not to aliasing • NO velocity measurements CH 20 Optimizing Doppler Imaging: System Setting Importance How it affects Doppler image Steering of Color Box -Normal incidence, or 90deg angle, between the direction of flow and the direction of the sound beam will result in NO Doppler shift. The cosine of 90 is 0. -NO color appears on image with Normal Incidence. -The Color Box should always be steered at any angle other than 90 -Too high of color gain can cause color to appear throughout the color box -Color is created in the lumen of the blood vessels -Color confetti appears throughout color box -Too low of color gain -No color is present Color Doppler Gain Spectral Doppler Gain *Be sure to check angle of color box to vessel before adjusting gain -Too high pulsed Doppler gain -Too low pulsed Doppler gain Wall Filter -increasing Wall Filter rejects low Doppler shifts -does not affect appearance of higher velocity flows Velocity Scale (PRF) -Increasing the PRF, or velocity scale, will make the transducer less sensitive to low Doppler shifts • Refer to CH 20 in the text for image comparisons -gray scale noise appears throughout the spectrum -ALL gray scale will disappear in the image: noise and meaningful Doppler spectrum -Ghosting of color doppler is eliminated -with pulsed Doppler, eliminates low velocity flows near the baseline -Aliasing still appears -Aliasing will be eliminated; low velocity flow vessels will be absent color with color doppler CH 21 Artifacts: Term Definition Artifact Hyperechoic an error in imaging Portions of an image that are brighter than surrounding tissues, or tissues that appear brighter than normal Portions of an image that are not as bright as surrounding tissues, or tissues that appear less bright than normal. An extreme form of hypoechoic, meaning entirely without echoes (echo-free). Describes structures with equal echo brightness A portion of tissue or an image that has similar echo characteristics throughout A portion of tissue or an image that has differing echo characteristics throughout Six assumptions are incorporated into the design of every ultrasound machine (see table below). Artifacts arise when these assumptions are not true. Reduces an image’s noise content. Increases the signal-to-noise ratio (2x the fundamental freq) Hypoechoic Anechoic Isoechoic Homogenous Heterogenous Assumptions Harmonic imaging Types of Artifacts • • • • Not real Not seen on the image Incorrect shape or size Incorrect brightness Causes of Artifacts • • • • Violation of assumptions Equipment malfunction or poor design The physics of ultrasound Operator error Six Assumptions of Imaging Systems 1) 2) 3) 4) 5) 6) Sound travels in a straight line Sound travels directly to a reflector and back. Sound travels in soft tissue at exactly 1,540 m/s Reflections arise only from structures positioned in the beam’s main axis The imaging plane is very thin The strength of a reflection is related to the characteristics of the tissue creating the reflection Appearance Possible Cause Anatomic reflectors absent on image/ less # of reflectors Anatomic reflector appears multiple times on image. Artifact positioned deeper than the true anatomy/ vertical misregistration Anatomic reflector appears multiple times on image. Artifact displaced to the side of the true anatomy/ horizontal misregistration Anatomic reflectors appear with abnormal brightness Anatomic structures appear at incorrect depth Anatomic structures appear in the incorrect imaging planes Anatomic structures do not correspond to echoes on the image • • • • • • • • • • • • • • • • • • • • Shadowing Shadowing by refraction/ Edge Shadowing Lateral Resolution Axial Resolution Comet tail Ring down Reverberation Mirror image Refraction Side lobe Grating lobe Enhancement (hyperechoic) Focal Banding (hyperechoic) Shadowing (hypoechoic) Shadowing by refraction/ Edge Shadow (hypoechoic) Speed errors Range ambiguity artifact Slice or section thickness/ Elevational Resolution artifact Acoustic speckle Multipath ** See “Artifacts Table” Document** CH 22 Quality Assurance: Term Definition Quality Assurance the routine, periodic evaluation of an ultrasound system to guarantee optimal image quality. Medical and legal necessity for every laboratory. The sonographer is responsible for implementing a QA action plan that is based on objective standards. Completely unbiased. Is factual, repeatable, and able to be counted. Is the same, even when obtained from different people. Not affected by an individual’s previous experience, preference, or taste. One that is influenced by an individual’s experience or beliefs. Often, it cannot be verified using concrete facts and figures. Is affected by opinion, belief, or assumption and frequently varies from person to person. Composed of TMM (tissue mimicking material) embedded with nylon strings to produce reflections at strategic locations, structures that mimic hollow cysts, and solid masses. Are similar to soft tissue in the following ways: - Speed of sound (1540 m/s) - Attenuation - Scattering characteristics - Echogenicity Evaluates: - Gray scale, TGC, A.O., Foci, Calipers, Axial and Lateral Resolutions Evaluate all modalities of Doppler. 3 Types: - Flow phantoms (most common) - Vibrating string - Moving belt Determines beam profile/ elevational resolution. Contains a diffuse scattering plane that is at an angle to the incident sound beam (linear phantom). When u/s beam is overly thick, cystic structures may appear filled in. Refers to the ability of a system to display low-level echoes. Is assessed when the sonographer adjusts the system controls to change echo brightness from barely visible to full brightness (saturation). Evaluated in 2 ways: Normal and Maximum Normal sensitivity settings should not vary from one routine evaluation to the next. All pins, solid masses, and cystic structures in the test phantom are accurately displayed. Output Power, TGC, and amplification (gain) are adjusted to establish normal sensitivity. Evaluated with Amplification (gain) and Output Power of the system set to maximum practical levels. Depth of tissue-like texture on the display is measured. Maximum visualization depth is used to assess sensitivity and should not differ from one routine evaluation to the next. Objective Standard/Statement Subjective Standard/Statement Tissue Equivalent Phantom Doppler Phantom Slice Thickness Phantom Sensitivity Normal Sensitivity Maximum Sensitivity Dead Zone Registration Accuracy Range Accuracy/Vertical depth calibration Depth calibration Horizontal Calibration Digital Calipers Axial Resolution Lateral Resolution Uniformity/ Compensation Operation Display, Hardcopy Output (printout), and Gray Scale Dynamic Range The region close to the txcdr where images are inaccurate. It extends from the txdcr to the shallowest depth from which meaningful reflections appear. Results from txdcr ringing and the time it takes the system to switch from transmit to receive mode. - Higher frequency = thinner dead zone - Lower frequency = thicker dead zone • An acoustic standoff, or gel pad, or 50cc IV bag positioned b/t the txdcr and the patient allows accurate imaging of important superficial structures. • An increasingly deeper dead zone = cracked PZT, detached backing material, or a longer PD. The ability of the system to place reflections in proper positions while imaging from different orientations The system’s accuracy in placing reflectors at correct depths located parallel to the sound beam. If differences appear, error may be caused by: - System malfunction - Speed of sound in tissue phantom is different than 1540m/s The accuracy of reflector depth positioning in A-mode, M-mode, Bmode, and 2D imaging The system’s ability to place echoes in their correct position when the reflectors are perpendicular to the sound beam Used to measure distances of structures during exams. Should be evaluated in both vertical and horizontal directions. Evaluated by scanning sets of successively closer spaced pins within the phantom Evaluated by measuring the width of reflections on the display that are created by point targets in the phantom. The system’s ability to display similar reflectors in the phantom with echoes of equal brightness. With proper TGC, identical reflectors should have the same appearance on the monitor, regardless of their depth. Adjusting the system’s output power and amplification of the system should alter the appearance of the image on the system’s display and all output devices. Adjusting brightness or contrast of a monitor should only alter the image on the display. QA Requirements QA Goals Assessment of system components Guarantee proper operation of the system Repairs Detect gradual changes Preventative maintenance Minimize downtime Record keeping Reduce the number of non-diagnostic exams Reduce number of repeat scans QA Devices (TMM) 1) Tissue equivalent phantom Measures: - Gray scale - TGC (normal and Max) - A.O. - Foci - Calipers - Axial and Lateral Res. 2) Doppler phantom (measures all doppler modalities) Types: - Vibrating string - Moving belt - Flow phantom 3) Beam profile/ slice thickness phantom (measures Elevational Res.) QA Methods test under known, defined conditions Use constant instrument settings Use a phantom with measurable characteristics Image in an identical environment CH 23: Sonographers in the Clinical Setting Term Definition Major Principles of Medical Ethics 1) Respect for autonomy 2) Nonmaleficence 3) Beneficence 4) Justice The patient has the capacity to act intentionally, with understanding, and with free will. The basis of informed consent. In making voluntary, knowledgeable decisions, the patient is assumed to be of sound mind. Avoid needless harm or injury to the patient, whether by action or inaction. Requires medical competence. The actions of health care providers should benefit the patient. Fairness. People who are equals should qualify for equal treatment, regardless of age, gender, educational background, and other factors. The process by which patients are educated about the essentials of a medical procedure which includes: - The nature of the procedure - Reasonable alternatives - The risks, benefits, and uncertainties related to each alternative - Assessment of the patient’s understanding - The patient’s acceptance When to question a patient’s ability to participate in decision making: - Underage (<18) - Patient is incapacitated or incapable - Patient does not speak English. A translator is required, but only the patient can provide consent. Revocation of consent by the patient can occur at any time. The sonographer must end the exam as soon as it is safe to do so. Upon meeting a patient: - Treat the patient respectfully. Introduce yourself, and describe your role and the procedure. - Identify the patient before starting an exam NEVER provide a clinical interpretation of the exam to the patient! Respect for autonomy Nonmaleficence Beneficence Justice Informed Consent Patient-Sonographer Interaction Interpretation of the Exam Dignity Ergonomics Causes of Injury Standard Precautions SOPs (Standard Operating Procedures) the quality of being worthy, honored, or esteemed; includes a patient’s perception of being in control and having self-worth. Every patient has the right to be treated in a dignified manner, one that is respectful and ethical. Factors of loss of dignity: - Advanced age - Infirmity - Lack of privacy Studies the interaction between the sonographer, patient, and equipment in order to optimize the well-being of sonographers in their professional environment. More than 3 out of 4 sonos experience WRMSIs and nearly 20% end their careers as a result of these injuries. Repetitive motions, forceful or awkward movements, poor posture, improper positioning, strain, and pressure on joints for extended periods. A set of guidelines to minimize the exposure and risk of health care workers when in contact with a patient. Based on the idea that all patients should be treated as potentially infectious. A detailed work practice program that helps prevent WRIs. Sonographer should know the location of SOPs. Supervisor is responsible to make sure all employees are following SOPs. CH 24: Bioeffects Term Definition Bioeffects Hydrophone/Microprobe Effects of sound on living tissue created by intense sound beam Similar to a small hypodermic needle with a tiny piece of PZT attached to its end; connected by a wire to an oscilloscope. Measures the characteristics of a sound beam at specific locations. A voltage from the hydrophone relates to the pressure and is displayed on the oscilloscope. Also measures: Period, PRP, PRF, PD, Amplitude, and DF. Provides known relationship b/t the acoustic pressure signal and the voltage created by the PZT. Intensities and other output measures can be derived from the signals of a calibrated hydrophone. - Output Power is highest = Pulsed Doppler - Output power is lowest= gray scale imaging - Output power is intermediate= CF Doppler and M-mode Constructed from a very thin membrane of PZT plastic. A very small area, located at the center of the membrane, is pressure sensitive: Only detects intensity Force exerted on tissue by the sound beam. If the target is a balance or a float, the measured force relates to the power in the beam. Sheer stresses and streaming of fluids can distort or disturb biologic structures. Based on the interaction of sound and light. A shadowing system that allows us to visualize the shape of a sound beam in a medium Process of conversion of energy to heat 1) Calorimeter 2) Thermocouple 3) Liquid crystal Measures total power/ entire intensity in a sound beam through absorption A tiny electronic thermometer. Can measure intensity at a particular location Change color based on their temperature A primary mandate regarding clinical ultrasound is that the benefits to the patient must outweigh the risks of the exam. - Diagnostic ultrasound has no known harmful bioeffects - Under controlled circumstances, bioeffects are beneficial. For example: therapeutic u/s is widely used to treat musculoskeletal injuries The science of identifying and measuring the characteristics of an u/s beam that are relevant to its potential for producing biological effects. Within the living body Calibrated hydrophone Membrane hydrophone Radiation Force/ Feedback Microbalance Acousto-Optics Schlieren 3 Devices that measure Output of txdcr by Absorption: Calorimeter Thermocouple Liquid Crystal Risk-Benefit Relationship Dosimetry In vivo In vitro “in glass”; outside the living body - Research indicates that very high intensities can cause genetic damage and cell death - Important in the research of bioeffects - Bioeffects are real even though they may not apply to clinical setting - Bioeffect research that claims direct clinical significance (w/o in vivo validation) should be viewed with caution Mechanistic Approach 1 of 2 techniques used to study bioeffects. Searches for a relationship b/t cause & effect Empirical Approach 1 of 2 techniques used to study bioeffects. Searches for a relationship b/t exposure & response • The strongest conclusions are made when the mechanistic and empirical conclusions are in agreement. Mechanistic Empirical • Broad exposure range can be evaluated (+) • No need to understand mechanism (+ and -) • Uncertainty about assumptions (-) • Biological significance is obvious (+) • Are other mechanisms involved? (-) • Species differences may alter results (-) • Is the bioeffect clinically significant? (-) Thermal Mechanism/ Index (TI) A useful predictor of maximum temperature increase under most clinically relevant conditions. Any rise in temperature from 37֯C, by 2-4C,֯ or exposure time is more than 50 hours, harmful bioeffects will occur. Temp. of 41֯C + during a testicular exam can cause infertility. Fetal tissues are less tolerant than adult tissue, but no harmful bioeffects have been observed below 39֯C - FDA has set SPTA regulatory limit to 720 mW/cm² - TIS: soft tissue - TIB: bone - TIC: cranial bone Nonthermal Mechanism Consist of cavitation (implosion of gaseous nuclei, bubbles, or contrast agents) and radiation force (microstreaming of fluids). Cavitation Interaction of sound waves with microscopic, stabilized, gas bubbles (gaseous nuclei) in the tissues. Describes the creation of gaseous nuclei from dissolved gases in a fluid. Stable cavitation Occurs at lower MI levels. Gaseous nuclei expand and contract, or oscillate, but do not burst Transient/Normal/Inertial cavitation Occurs at higher MI levels. Bubble-bursting! Produces highly localized, violent effects such as colossal temps & shock waves (enormous pressures). • The pressure threshold for transient cavitation is only 10% higher than that required for stable Stable • • • Oscillating bubbles microstreaming and shear stresses lower MI Transient • • • • also called normal or inertial bursting bubbles higher MI Shock waves and very high temperatures Mechanical Index (MI) Lower MI • • • Less cavitation Less pressure Higher frequency Epidemiology Limitations of Epidemiologic Studies A calculated number related to the likelihood of harmful bioeffects from cavitation. Related to 2 sound wave characteristics: 1) Peak rarefaction pressure 2) Lower frequency MI = Peak Rarefaction Pressure √frequency Higher MI • • • More cavitation More pressure Lower frequency A branch of medicine associated with population studies and the prevalence of disease. It is Empirical (exposure & response) retrograde – uses clinical surveys. Most deal with in utero fetal exposures to u/s because: - Large percentage of pregnant women are scanned - u/s is routinely used during normal pregnancies - harmful effects, if present, have the potential to affect the fetus for life Evaluates: - fetal weight - Abd. Circumference - Head circumference - Femur length - Congenital abnormality - APGAR scores - Hearing - Infection Data indicates that u/s exposure is not associated with adverse fetal outcome. 1) Studies are often retrograde. *Antegrade studies are always better. 2) Ambiguities may exist in the data (ie: justification for the exam, gestational age, number of scans, technique, and exposure time) 3) Risk factors other than exposure to u/s may precipitate a bad outcome in the fetus. Including: environmental factors, poor nutrition, smoking, or alcohol and drug abuse. Best Epidemiologic Studies are Clinical Safety and Prudent Use Conclusions of the AIUM: Training and Research Conclusions of the AIUM: Electrical Safety Overall Safety Considerations Prospective and Randomized 1) The advantage of a prospective study is that a complete and accurate compilation of meaningful information is obtained 2) Randomized studies create 2 groups of patients. The advantage of randomized study is that other risk factors that could negatively affect fetal outcome are present in both groups and can be accounted for. • No confirmed harmful bioeffects from exposure to diagnostic u/s have ever been reported • It is possible that bioeffects may be identified in the future • The benefits to the patient outweighs the risks • It is appropriate to diagnostic u/s prudently to provide benefit to the patient • It is inappropriate to use diagnostic u/s in a non-medical setting for entertainment • No confirmed bioeffects on patients or sonos have been found with the use of diag u/s • Experience with diag u/s may differ from research and training, due in part to longer research exams and greater exposure • When used w/o direct medical benefit to the patient, the subject should be informed of how the research study differs from standard diag procedures. The greatest risk arises form electrical shock from a cracked transducer housing. In addition, image quality may be compromised when using damaged transducers • Only perform studies with valid medical justification • ALARA: do not prolong studies • Minimize patient exposure BE: • Prudent • Careful • Judicious