General Principles of Virology Viral Replication ◦ A virus is not a cell ◦ A virus cannot replicate on its own ◦ It must attach to and enter a host cell ◦ It then uses the host cell’s energy to synthesize protein, DNA, and RNA ◦ Virus affected all living organisms 2 General Principles of Virology (cont’d) 3 Viral Illnesses 4 Viral Illnesses (con’t) 5 Viruses • Smallpox • Sore throat • Conjunctivitis • Warts • Influenzas • Covid 19 6 Opportunistic Infections 7 Herpes Simplex and Varicella Zoster Virus Infections 8 Antiviral Drugs 9 Antiviral Drugs 10 Antiviral Drugs - Key Characteristics 11 Antiviral Drugs - Key Characteristics (con’t) • Best responses to antiviral drugs are in patients with competent immune systems • A healthy immune system works synergistically with the drug to eliminate or suppress viral activity 12 Antiviral Drugs (non-HIV) 13 Antiviral Drugs (non-HIV) Adverse effects ◦ Vary with each drug 14 Antiviral Drugs (non-HIV) 15 Antiviral Drugs (non-HIV): 16 Antiviral Drugs (non-HIV) COPYRIGHT © 2014 BY MOSBY, AN IMPRINT OF ELSEVIER INC. 17 18 Antiviral Drugs (non-HIV) 19 Vaccination Information Sheet Also called a VIS Purpose Recipients Documentation 20 Nursing Implications ADPIE • Before beginning therapy, thoroughly assess underlying disease and medical history, including allergies • Assess baseline vital signs and nutritional status • Assess for contraindications, conditions that may indicate cautious use, and potential drug interactions 21 Nursing Implications ADPIE • Be sure to teach proper application technique for ointments, aerosol powders, and so on • Emphasize hand washing before and after administration of medications to prevent site contamination and spread of infection • Instruct patients to wear a glove or finger cot when applying ointments or solutions to affected areas 22 Nursing Implications ADPIE • Instruct patients to consult their prescriber before taking any other medication, including over-thecounter medications • Emphasize the importance of good hygiene • Inform patients that antiviral drugs are not cures but do help to manage symptoms 23 Nursing Implications ADPIE • Instruct patients on the importance of taking these medications exactly as prescribed and for the full course of treatment • Instruct patients to start therapy with antiviral drugs at the earliest sign of recurrent episodes of genital herpes or herpes zoster 24 Nursing Implications ADPIE Monitor for adverse effects ◦ Effects are varied and specific to each drug Monitor for therapeutic effects ◦ Effects will vary depending on the type of viral infection ◦ Effects range from delayed progression of AIDS and other viruses to decrease in flulike symptoms, decrease in frequency of herpes-like flare-ups, or crusting over of herpetic lesions 25 THINK LIKE A NURSE 26 THINK LIKE A NURSE 27