I. Introduction. Mr Aiman has met a cardiologist at Hospital Seberang Jaya after suffering from shortness of breath and chest pain. After examination from a doctor, the blood pressure of Mr Aiman is higher compare than normal blood pressure. He was diagnosed with arteriosclerosis where the lumen part of his artery was accumulated with lipid and cholesterol. This caused the rate of changed of blood flow in Mr Aiman is slow. The study shows that the rate of changed of blood flow for normal artery is 100𝑐𝑚3 /𝑚𝑖𝑛. II. Objective. To measure the related rate of blood flow for arteriosclerosis patient with radius of lumen 0.05cm and length of artery 20cm. III. Problem statement. The rate of change of blood flow for normal artery is 100𝑐𝑚3 /𝑚𝑖𝑛 with radius of lumen 0.2cm and the length of artery is 20cm. What is the rate of change of blood flow for atherosclerosis patient with the radius of lumen 0.05cm. IV. Solution: dv dt = dv dr dr × dt Let r = 0.2 cm and l= 20 cm 𝑟 = 𝑙 𝑟 = 𝑙 0.2 20 1 100 𝚤 = 100𝑟 Let 𝑣 = 𝜋𝑟 2 𝑙 = 𝜋𝑟 2 (100𝑟) = 100𝜋𝑟 3 Where 𝑑𝑣 𝑑𝑟 = 300𝜋𝑟 2 𝑑𝑟 To find 𝑑𝑡 = ? for normal person. 𝑑𝑟 100𝑐𝑚3 /𝑚𝑖𝑛 = 300𝜋(0.2)2 × 𝑑𝑡 𝑑𝑟 𝑑𝑡 25 = 3𝜋 𝑐𝑚𝑚𝑖𝑛−1 Hence, the rate of change of blood flow for atherosclerosis is 𝑑𝑣 𝑑𝑡 = ? when radius 0.05cm let 𝑑𝑣 𝑑𝑡 = 𝑑𝑣 𝑑𝑟 × 𝑑𝑟 𝑑𝑡 25 = 300𝜋𝑟 2 × 3𝜋 25 = 300𝜋(0.05)2 × 3𝜋 = 6.25𝑐𝑚3 /𝑚𝑖𝑛 V. Conclusion. Hence, the rate of changed of blood flow on Mr Aiman who diagnosed arteriosclerosis is 6.25𝑐𝑚3 /𝑚𝑖𝑛.