Liaquat College of Medicine & Dentistry
Department of Examination
Pharmacology
First Semester Examination (1)
First Professional MBBS
BLOOD Module
OSPE For JSMU
OSERVED STATION 01
INSTRUCTIONS AND TASK FOR THE CANDIDATES
On the table there is laminated picture. Observe it carefully and interpret it
Task No. 1: Identify the type of adverse effect in above shown clinical picture.
Task No. 2: Examiner will ask you a few questions regarding the above shown clinical picture.
On the table there is laminated picture. Observe it carefully and interpret it.
Task No. 1: Identify the type of adverse effect in above shown clinical picture.
Task No. 2: Name the drug that causes the above shown adverse effect.
Task No.3: What are major uses of this drug?
Task No.4: What are the two major contraindication of this drug?
Task No.5: How resistance to this drug develops?
Answer No.1: Tetracycline staining
Answer No.2: tetracycline
Answer No.3:
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Legionella infection
Rocky mounted spotted fever
Mycoplasma infection
Answer No.4:
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Pregnancy
Children below 8 years
Answer No.5:
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Efflux pump
Enzymatic inactivation of tetracycline
Liaquat College of Medicine & Dentistry
Department of Examination
Pharmacology
First Semester Examination (1)
First Professional MBBS
BLOOD Module
OSPE For JSMU
OSERVED STATION 02
INSTRUCTIONS AND TASK FOR THE CANDIDATES
On the table there is laminated picture. Observe it carefully and interpret it
Task No. 1: Identify the class of drug in the above shown diagram.
Task No. 2: Examiner will ask you a few questions regarding the above shown diagram.
On the table there is laminated picture. Observe it carefully and interpret it.
Task No. 1: Identify the class of drug in the above shown diagram.
Task No. 2: What is the mechanism of action of this drug?
Task No. 3: Name two beta lactam antibiotics.
Task No. 4: Name any two beta lactamase inhibitor.
Task No.5: What are the two mechanism of resistance developed against this drug?
Answer No.1: Penicillin
Answer No.2: It inhibit the cell wall synthesis by inhibiting the transpeptidation of the
chain
Answer No.3:
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Cephalosporin
Monobactam
Answer No.4:
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Clavunic acid
Sulbactum
Answer No.5:
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Efflux pump
Alteration of penicillin binding protein
peptidoglycan
Liaquat College of Medicine & Dentistry
Department of Examination
Pharmacology
First Semester Examination (1)
First Professional MBBS
BLOOD Module
OSPE For JSMU
OSERVED STATION 03
INSTRUCTIONS AND TASK FOR THE CANDIDATES
On the table there is laminated picture. Observe it carefully and interpret it
Task No. 1: Identify the class of drug in the above shown diagram.
Task No. 2: Examiner will ask you a few questions regarding the above shown diagram.
On the table there is laminated picture. Observe it carefully and interpret it
Task No. 1: Identify the class of drug in the above shown diagram.
Task No. 2: What are the adverse effects of this drug?
Task No. 3: Name three drugs with once daily dosing of this class.
Task No. 4: Why this drug is contraindicated in children less than 18 years?
Task No. 5: What is the bioavailability of this drug?
Answer No.1: Fluoroquinolones
Answer No.2:
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Nausea
Vomiting
Diarrhea
Dizziness
Insomnia
Answer No.3:
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Gatifloxacin
Gemifloxacin
Levofloxacin
Answer No. 4: Because it might damage the growing cartilage.
Answer No. 5: 85% to 90%
Liaquat College of Medicine & Dentistry
Department of Examination
Pharmacology
First Semester Examination (1)
First Professional MBBS
BLOOD Module
OSPE For JSMU
OSERVED STATION 04
INSTRUCTIONS AND TASK FOR THE CANDIDATES
On the table there is laminated clinical picture. Observe it carefully and interpret it.
Task No. 1: In the above shown diagram red man syndrome developed in a patient due to rapid I/V
injection of which antibiotic?
Task No. 2: Examiner will ask you a few questions regarding the above shown clinical picture.
On the table there is laminated clinical picture. Observe it carefully and interpret it.
Task No. 1: In the above shown diagram red man syndrome developed in a patient due to rapid I/V
injection of which antibiotic?
Task No. 2: Write mode of action of above used drug?
Task No. 3: What does MRSA stands for?
Task No. 4: Name 2 non beta lactam cell wall synthesis inhibitor
Task No. 5: Name 2 mechanism by which resistance can develop against this drug?
Answer 1.Vancomycin
Answer 2. It inhibits cell wall synthesis by inhibiting polymerization of peptidoglycan
Answer 3. Methicillin resistant staphylococcus aureus.
Answer 4.
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Fosfomycin
Daptomycin
Answer 5.
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Decrease permeability for Drug
Decrease binding of vancomycin to receptor molecules.
Liaquat College of Medicine & Dentistry
Department of Examination
Pharmacology
First Semester Examination (1)
First Professional MBBS
BLOOD Module
OSPE For JSMU
OSERVED STATION 05
On the table there is laminated picture. Observe it carefully and interpret it
Task No. 1: Name the drug which causes cyanosis (Gray Baby Syndrome) if used in neonates?
Task No. 2: Examiner will ask you a few questions regarding the above shown picture.
On the table there is laminated picture. Observe it carefully and interpret it
Task No. 1: Name the drug which causes cyanosis (Gray Baby Syndrome) if used in neonates?
Task No. 2: Write mode of action of above mentioned drug?
Task No. 3: Name two protein synthesis inhibitors which act on 30S subunit of ribosome?
Task No. 4: Write 2 major adverse effect of the drug?
Task No. 5: Write its antimicrobial spectrum?
Answer 1.Chloramphenicol
Answer 2. It inhibits protein Synthesis by bindings to 50S subunit of ribosome.
Answer 3.
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Tetracycline
Amikacin
Answer 4.
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Aplastic anemia
Depressed breathing
Cardiovascular collapse
Answer 5.
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Rickettsia
Anaerobes