GRADE 12 CHEMISTRY PERFORMANCE TASK THE DARK SIDE OF CHEMISTRY Names of Members Member 1: Yuri Sy (Blue) Member 2: Raphael L. Uy (Online) Member 3: Nathan Yao (Blue) The Turn of Anabolic Steroids I. Introduction General Information (Yuri Sy) ● Introduce and describe the process/substance. ● Give the historical context. (inventor/discoverer, date of invention) Why was there a need to invent/discover this? ● Give an example of an industry that uses this today. Anabolic Steroids, mainly oxandrolone (C19H30O3) or more commonly known as Anavar have a very strong negative connotation these days. Oxandrolone is a substance that induces rapid weight gain for people who have medical conditions. According to WebMD, these conditions are patients who underwent surgery trauma, infections, etc. Oxandrolone is ingested orally compared to other anabolic steroids which are injected. The drug closely replicates male hormones created by the body, thus its effectiveness for weight gain. It was first used for medical purposes in the year 1964 but was created by researchers Raphael Pappo and Christopher J. Jung during the year 1962. Both researchers found the drug to have a lot of potential due to it having small side effects in terms of affecting male hormones while having a high anabolic or weight gain effect. With HIV and AIDS being a rising problem, Oxandrolone would help muscle growth and combat the rapid weight loss that comes with people who have these diseases. Although in 1989, with abuse of this substance in the bodybuilding industry and bad media, the company decided to discontinue selling this drug. It is only during 1995 that they rereleased it under a different name, now Oxandrin. Anavar once it was first produced gained a lot of traction in this industry due to the effortless process to get your hands on it. Without the need for prescriptions, anyone could buy Anavar in their local pharmacy. Even after being discontinued Anavar still remained popular due to its effectiveness in the medical industry as well as its optimality as a steroid for the bodybuilding industry to use. An industry that uses this today would of course still be the medical industry which uses it for combating rapid weight loss that patients deal with when they undergo some treatments. Other than this, the bodybuilding industry makes use of this drug greatly in order to overcome their genetic setpoint in terms of lean muscle mass to beat out the rest of the competition. This is “normal” in the industry as all top-tier bodybuilders abuse anabolic steroids which comes with a cost, as seen later as the paper continues. The Good Side (Raphael Uy) ● State and explain the inventor/discoverer’s intended good use of this substance/process. ● Explain the chemical reaction of the process/substance when it is used for the benefit of the society. ● Cite 2 other examples where this substance is used for the benefit of the society. Pappo and Jung created Anavar, which was mainly used as a treatment for catabolic disorders for people over 30 years. With its flexibility, it can be injected or taken by mouth. The primary use of Anavar is for frailty and loss of muscle mass due to aging. This is also used with other catabolic clinical disorders such as HIV. Anavar acts as an androgen receptor to influence and increase gene expression and cellular functioning. Primarily the substance induces protein synthesis in the body then regulates the androgen receptor in skeletal muscle and increases IGF-1 (insulin-like growth factor). Anavar is absorbed orally through the gastrointestinal tract, with effects occurring 1 hour after indigestion. 95% of Anavar is protein which contributes to the stability of the steroid and its resistance to the liver and its decomposition process. It is also used to treat burn injuries. Increases LBM (lean body mass) and enhances wound healing by binding to intracellular androgen receptors, forming a complex which binds to DNA and stimulates protein synthesis. Anavar is also seen being used in the aftermath of surgeries wherein the patient loses weight. This speeds up their recovery by letting them gain weight at a faster pace. The Dark Side (Nathan Yao) ● State and explain when (include date and context) the process/substance started to be used for the detriment of the society. ● Explain the chemical reaction of the process/substance when it is used for the detriment of the society. Is it different from when it was used for good? ● Cite 2 other examples where this substance is used for the detriment of the society. Now looking into the dark side of Anavar, the beginning of this substance misuse began in 1954. Professional athletes began consuming anabolic steroids during the 1954 Olympics when testosterone was given to Russian weightlifters. Eventually in the 1980s, this steroid was used by the general population, with the main purpose of enhancing athletic performance. Congress noticed the misuse of this substance and passed the Anabolic Steroid Act of 1990 which seeks to respond to the increased misuse of this steroid, categorizing it as a drug. In 2004, the congress prohibited over-the-counter steroid precursors and increased the penalties for the production, selling, and possession of these steroids. (National Institute of Drug Abuse, n.d.) Looking into the chemical composition of Anavar, the steroid is based on the dihydrotestosterone (DHT) hormone. It was slightly modified to make a huge difference to the effects. By replacing two carbon atoms with an oxygen atom, it provides Anavar an at least three times increase in anabolic strength as compared to the DHT. Below is a chemical equation that exhibits the entire process of how the substance is modified: C19H30O2 + O2 → C19H30O3 To give a definition to anabolic and androgenic rating, these ratings provide insight on how potent an anabolic steroid is from both the anabolic and androgenic standpoint. (Hodnik, 2016) However, the score does not always define its strength and potency. This rating is used in almost, if not all kinds of anabolic steroids. In the case of Anavar, its androgenic rating is 24, which is rather low. But despite that, it has great anabolic properties. It's androgenic and anabolic properties are the reasons behind its potency when bodybuilding or when competing in athletic competitions. One example where the Anavar steroid is misused would be the improvement of personal appearance. Some effects Anavar has on the human body are the burning of fat and a preserver of existing muscle tissue. These are what cause the muscular looks on the human body. Another example where it is misused would be the enhancement of athletic performance. Anavar enhances one’s strength, endurance, stamina, and recovery. Because of this, there would be a noticeable change in one's performance when working out. II. Chemistry Application and Context (Group) ● State which Chemistry concept can be related to the process/substance in order to control it. ● Give at least one chemical equation that represents the process/substance. (synthesis of oxandrolone) C19H30O3 ● Should the chemical reaction speed up or slow down? State and explain at least 3 factors (temperature, concentration, catalyst, pressure, nature of substance, etc) that must disrupt the system in order to control the process/substance. Include at least 3 references to back up this information. Chemical Equation (decomposition): C19H30O3 → C19H30O3 Isomer 4CH3 + 4H3C +O3 The chemistry concept that we have decided to use for the control of the process of production of oxandrolone would be chemical kinetics. This is because chemical kinetics is the branch of chemistry that deals with the extent and rate of a chemical reaction/equation. They measure the efficiency and economy of the chemical reaction itself. By increasing or decreasing of the activation energy, we will be able to speed up or slow down the rate of chemical reactions. One of the factors that we can use would be temperature. The temperature has a directly proportional relationship with the rate of reaction. With this, if you want to speed up the reaction, you must increase the temperature and vice versa. This is brought about by the increase in the kinetic energy of the particles, as temperature increases, the rate of bumping particles creates more kinetic energy (Key, n.d.). By gaining more energy the activation energy barrier of the reaction will be achieved more quickly. According to ScienceReady, “temperature affects rate of collision as well as the energy of molecules during collisions”. With this, more effective collisions will be achieved once the temperature is increased. Lastly, the impact of temperature on the rate of reaction is greatly affected even by a 10-degree celsius increase which would double the reaction rate. (Beck, 2020). Another factor would be the nature of the substance, this plays a big factor in the medical field. Proper chemical equations need to be made in order to properly produce the drug. In order to increase or decrease the reactions, we’ll have to make chemical changes. According to an article written by S.J. Enna, David B. Bylund, “Use of the anabolic steroid oxandrolone (60) 〈62TL365〉 results in increased growth velocity in young men who have a delay in reaching adolescence. In combination with recombinant human growth hormone, the drug is effective in the treatment of short stature in young women with Turner syndrome, a form of mental retardation.” The improper elements used will cause negative side effects as seen here. In order to increase the rate of reaction we’ll have to change the chemical structure. Apart from these two factors, one more factor would be the surface area. The reaction is sped up when the surface area is smaller and is slowed down when larger. Given that Anavar is taken in tablets, the speed of the reaction is faster when its taken by tiny bits and is slower when it is taken as a tablet. According to an article made by Urban, M. (2017), there are different versions of Anavar. There are three versions mentioned in the article: powdered oxandrolone, Anavar capsule size, and an oral solution. The raw powdered Anavar is best when consuming the right dose. This is a method in speeding up the reaction as powdered Anavar has less surface area when compared to a capsule. Synthesis of Anavar: III. Plan of Action (Group) ● State your objective in uncovering information about the substance/process. ● Determine and explain your plan of action in order to uncover how these processes/substances can be controlled. (You may choose to do an experiment, extensive research, interview, or industry analysis) ● Give a step by step procedure of your chosen plan of action. Our objective in uncovering and further extending our research on information regarding Anavar would be to find out if it is something that needs to be tended by the community. By finding out more about Anavar, we will be able to decide and hopefully inform others about its negative side effects but also its positive effects. In order to do this, we as a group have decided to do an industry analysis on the medical and bodybuilding industry as Anavar is mostly used there. Bodybuilding: Anavar intake in the bodybuilding/fitness industry is greatly common for top-tier professionals in the field. Based on an article by Inside Bodybuilding, “athletes and bodybuilders now typically take 15-25mg per day. This is usually administered for 6-8 weeks.” In the sport of bodybuilding, most if not everyone competing in the highest degree is on a steroid stack which they take in cycles. Going on and off during their off-and-on seasons, it would be able to help them achieve the physique they want to bring to the stage as well as help in their training. Benefits that bodybuilders take advantage of would first of all be the enhancement of fat loss whilst a hefty increase in lean muscle mass. Despite these, strength is also increased during training which is advantageous for pushing limits and gaining more mass. Side effects on the other hand include a negative change in cholesterol levels which makes arteries clogging easier and increase one’s blood pressure. With this, testosterone is reduced greatly, lowering sex drive, and motivation and affecting important hormones. Since Anavar is broken down on the kidney instead of the liver, the kidney is very vulnerable. Lastly, hair loss is also seen with Anavar containing dihydrotestosterone which has an effect on thinning or hair fall. In terms of legality in the bodybuilding industry, it is taboo. Before the Anabolic Steroids Control Act in 1990, the substance was legal and prescriptions from doctors were easy to get. But now, buying the substance with no medical objective is illegal in most countries, and the intake or distribution of the substance has severe consequences. Despite these rules, products like Anavar is still being distributed and sold around the world legally such as Anvarol. It is approved by the FDA as it does not have the side effects of Anavar making it safer for intake. Apart from its use for fitness and enhancing athletic performance, it can be used as a medicine to treat weight loss due to medical conditions. Some of which would be burns, infections, catabolic illnesses, etc. This type of anabolic steroid promotes the growth of muscle tissue, which makes it useful for weight gain. Hence, this is why it is used to treat cases of weight loss. In addition to this, Anavar can also be used to reduce bone pain for those who suffer from osteoporosis. The reason behind this is that the drug is capable of increasing bone mineral density. HIV: HIV also known as human immunodeficiency virus is a virus that primarily attacks the immune system. There is no cure for this meaning that once you have it you’ll most likely have it for life. HIV is transmitted through sexual contact or the sharing of needles and syringes. It may seem like HIV is a lost cause but there are treatments to help control it. One of these treatments is Anavar. HIV has a big side effect on weight loss. Anavar is used to treat this, a study seen in PubMed by Carl Grunfeld, Donald P Kotler, Adrian Dobs, Marshall Glesby, and Shalender Bhasin shows how HIV patients were given 20, 40, or 80 mg of oxandrolone daily depending on their weight levels. This was in order to regain the 10%-20% body weight they lost due to the disease. The results were very pleasing as stated in the study by Carl Grunfeld , Donald P Kotler, Adrian Dobs, Marshall Glesby, and Shalender Bhasin “ Body weight increased in all groups, including the group receiving placebo, during the double-blind phase (1.1 +/2.7, 1.8 +/- 3.9, 2.8 +/- 3.3, and 2.3 +/- 2.9 kg in placebo and 20-, 40-, and 80-mg oxandrolone groups, respectively; all P < 0.014 vs. baseline). BCM increased from baseline in all groups (0.45 +/- 1.7, 0.91 +/- 2.2, 1.5 +/- 2.5, and 1.8 +/- 1.8 kg in placebo and 20-, 40-, and 80-mg oxandrolone groups, respectively). In order to regain the weight patients lost, Anavar is one of the ways that could help. It is used primarily in the medical field to help patients maintain the proper weight in order to make a fast recovery. It is not only used in the field of HIV but in many more. Cancer Cancer is the uncontrollable growth of cells in the body. When abnormal or damaged cells grow and multiply in a certain area in the body, they may form tumors. As of the present moment, there is no cure for cancer. But, there are many ways to treat the disease, and one of them would be Oxandrolone. Since weight loss is one of the symptoms of cancer, the consumption of Oxandrolone may possibly help prevent this symptom. According to an article published by Laino (n.d.), she discussed a four-month study conducted on 131 cancer patients that suffered from weight loss. All of the patients took 10 milligrams of Oxandrolone twice a day. The study shows that 81% of the patients either gained or maintained their weight. Additionally, the lean tissue weight increased at an average rate of 7.5% in a span of four months. Based on the study, it can be inferred that Oxandrolone is an effective drug to maintain or even gain weight despite suffering from cancer. This can be an effective method of treating this symptom of cancer. Chemical processes (how it is done) Bodybuilding HIV Cancer 15-25mg of Anavar is taken per day and is used daily throughout 6-8 weeks which is called a cycle. Instead Depending on their body weight loss of 10%-20%. HIV infected people are met with doses of 10mg of Anavar is given to the patient twice a day. The drug is ingested orally instead of being taken of it being injected to the body, it is ingested orally. Throughout the year, it is only intaked in cycles (6-8 weeks) during the off or on seasons depending on the bodybuilder’s regimen. 20-80mg of oxandrolone daily. via injection. Raw Materials 4-Androstene-3b-ol, 17-one, 1-Androstene-3b-ol, 17-one, Epiandrosterone, Androstenolone Acetate, 6-0x0-A 4-pregnene-3,20-dione, Ajuga Turkestanica Extract (Whole Plant), [(3b,5a,6a,25R)-Spirostan-3,6-diol], Microcrystaline Cellulose, Phosphatidylcholine 75%, Hydroxypropyl Beta cyclodextrin (HPBCD), Phytosterols, Magnesium Stearate, Silica, FD&C Blue #2, FD&C Red # 40. Chemical factors Molecular Weight: 306.4 Melting Point: 236.5 °C Solubility: Insoluble in water, sparingly soluble in alcohol, freely soluble in chloroform Stability: “Stable in the air but darkens when exposed to light” (Pubchem, n.d.) Economic Factors Anavar being illegal in some countries is still sold on the dark web and through illegal dealers despite it having alternatives that are similar to its effects. With it still being sold, it has a positive effect on the economy despite it being minimal. Anavar is sold through many places. Local pharmacies, specialized suppliers, online stores and more. Anavar, depending on the amount being bought by the consumer, has a price range of ₱2,200 for a pack of 50 tablets of 10mg according to shoppee. Anavar is still sold in pharmacies, whether it be through the physical store or through online pharmacies. Depending on the amount of Anavar in one package, the prices range from approximately ₱1,000-₱4,000 Environmental Factors Anavar does not have environmental factors that affect the environment negatively or positively. Health Factors Positive physical effects include: Enhancement of fat loss whilst a hefty increase in lean muscle mass, strength is also increased during training which is Positive: Weight gain, Anavar’s primary source of use in the medical field in order to help those rapidly losing weight to recover. As stated previously, there A factor would be weight gain. Since weight loss is one of the factors of cancer, Oxandrolone may be able to fix that issue. As mentioned advantageous for pushing limits and gaining more mass. Negative: negative change in cholesterol levels which makes arteries clogging easier and increases one’s blood pressure, testosterone is reduced greatly, lowering sex drive, and motivation affecting important hormones. It also leaves you vulnerable to kidney complications, hair loss, and even depression. Laws/Regulations Anabolic Steroids Control Act in 1990 makes Anavar only available to those who have prescriptions from a doctor. This makes Anavar a taboo in the bodybuilding community and industry. With this, alternatives such as Anvarol is sold and is legally approved by the FDA. are positive outcomes to the use of this drug when implemented to those sick with HIV. Negative: When taken with the wrong prescription or carelessly it may cause many changes. These are mostly related to a change in cholesterol which causes further complications when treated incorrectly. As well as kidney failure due to the drug’s natural composition. previously, around 81% of the 131 cancer patients recorded in the study either gained or maintained their weight. The Anabolic steroids act in 1990 was placed to make the consumption of the drug safer. Only making it available to those who have the proper prescriptions from a licensed professional in the industry. Based on the extensive research and analysis and compilation of it through the table, it can be seen that the three industries that use Anavar are very similar. Exactly the same substance is used and factors of the composition, chemical factors, and environmental factors are similar to each other. However, the different industries have different intentions on the product. In the bodybuilding industry, it is used for increasing physical strength and for enhancing athletic performance. On the other hand, the medical industry uses it as a method of treating conditions such as weight loss. Due to the misuse of the substance in the bodybuilding industry, a law had to be passed to prohibit the consumption of this substance unless given prescriptions by doctors. Therefore, this substance can only be used in the medical industry. IV. Results and Discussion (Group) All in all, our group would label Anavar or Oxandrolone as a positive substance that should be pushed for production with its positive effects and uses outweighing the bad ones. Although there was a turn from good to bad with the abuse mostly seen in the bodybuilding and sports industry, the uses from the medical industry are too detrimental to dissolve. In accordance with this, there are strong laws held in place for minimizing oxandrolone abuse and misuse. From deaths in the sport of bodybuilding due to the side effects steroids have, the medical industry is able to save lives and cure near to incurable sicknesses. As seen in our industry analysis, it has a great impact on HIV and Cancer patients by overall improving the quality of life they have on a sickness that does not have a certain cure. Based on our research, these are the results we have gotten: The data we gathered is based on sicknesses of HIV and Cancer. In the medical field, it is shown that Anavar is used in order to gain more weight in order to achieve a faster recovery. Anavar acts as an androgen receptor to influence and increase gene expression and cellular functioning. In order to prevent any abuse of the drug, proper laws have been placed in order to limit users. Laws such as needing a proper prescription from licensed doctors and a limit to how much you can buy. Primarily the substance induces protein synthesis in the body then regulates the androgen receptor in skeletal muscle and increases IGF-1 (insulin-like growth factor). Which explains the weight gain potential. Our group decided on increasing the speed of the production of Anavar. Despite the fact that this substance is abused by many, it has its right uses. As mentioned previously, Anavar can be used as a medication to treat medical conditions such as weight loss due to diseases like HIV and cancer. We are against the idea of using this substance as a way to bulk up and enhance athletic performance as there are alternatives to that. But, we support the idea of using it as a medicine as it is an effective substance in treating patients that suffer from certain medical conditions such as weight loss. From all this, we have come to the conclusion that Anavar should be used for medical purposes. We all agree that it is used right when its intention is to treat conditions. It's just best to be aware of the side effects that may occur in one’s body and immune system. V. Reflection on Moral Consequences Yuri Sy The misuse and abuse of Anavar in certain industries have a lot of side effects and negative consequences but most of all it has moral consequences. In the medical industry, there are close to no misuses as they are diagnosed properly in that industry. In the bodybuilding industry and sports industry, on the other hand, Anavar’s misuses are commonly seen. In the bodybuilding industry, Anavar and steroid abuse are greatly normalized and pushed for by top-tier professionals. The moral consequences in the industry would be the unknowingly pushing for upping the standards of competition but increasing the risk of Anavar and steroid abuse. By normalizing steroid abuse for the enhancement of the professionals of the sport, they are misguiding leading the downward path for the younger generations. With their reach of an audience, they are able to have a great impact on the decision-making and thinking of others. With this, the abuse and misuse of Anavar for things that are not detrimental would have moral consequences tied up with it. Therefore, one must ensure they make the right decision regarding the substance of Anavar. In chemistry overall, our moral responsibilities and duties with advanced knowledge in this branch of science would be to ensure that the information we share as well as the inventions being created hopefully will not be used to harm others. The inventions and development should be done to help the development of society. An example of this is the development of Penicillin by Alexander Flemming and the use of Ammonia as plant fertilizer by Fritz Haber and Carl Bosch. Without the development of penicillin, modern-day bacterial infections would be uncurable and would make humanity vulnerable. With it being produced very well and safely it was not able to have negative uses and was used mainly for the good. Same with this, the use of ammonia by Haber and Bosch was able to combine oxygen and nitrogen in order to use it for fertilizer and help speed up and develop agriculture. This shows us that development can be done without the need for it to be used for the worse despite it inevitably happening in today’s society. After doing this research paper, I now see scientific advancements as something that not only has good connotations but also has some bad connotations. Scientists should just attempt to minimize its negative uses or effects and ensure that the positive uses outweigh the negatives before they share their invention. Now that I am more knowledgeable on the process of making harmful substances and the business that goes with them, in the future, I will definitely consider the morality involved despite the economic effects the opportunity offers. After finishing this paper, I can say that there are more important things than money especially in the advancements of science as morality and human safety is definitely more important. Nathan Yao Anavar is seen from different perspectives, whether it be as a medication or as a substance used for bodybuilding or sports. Although the substance's original intention was to treat medical conditions, further research revealed another possible purpose for it, to boost athletic performance. This eventually resulted in the downfall of the substance. It went so far to the point that it was misused by top-tier professional athletes, despite the various risks. It made athletic competitions demonstrate the power of Anavar, instead of the natural and authentic talents of the athletes. Furthermore, the misuse of this substance causes many side effects on one’s body. It even leads to malfunctions in certain organs and in the immune system as a whole. In certain situations like this, it is best to seek medical care. To tie things up, Anavar really depends on its intention and on one’s decisions. Using it as a medication won’t be a problem as the intention is to treat a condition. But, if one uses it with the intention of bodybuilding or enhancing athletic performance, he/she must be vigilant of the consequences to come. To me, our moral responsibilities and duties as persons that have a broad knowledge of the subject is to ensure that it is for the betterment of society. We also must make sure that the environment and its creatures are not harmed. Though every advancement should ideally fulfill these conditions, there are still those that harm the environment. An example of this would be the manufacturing of plastic. Since it is a lightweight material, it is easy to mold. This provides plastic with various possibilities when it comes to making products. Despite these opportunities, the recycling of this product results in serious damage to the environment. Another example would be the manufacturing of fuels. The manufacturing of fuels offers multiple benefits to society as it is a great source of energy. The downside to this though is the fact that tons of toxic chemicals are emitted in the air, resulting in air pollution. These are just some examples of the innovations with its benefits and consequences. But in general, every advancement or innovation, despite its benefits, has its consequences. After doing this research project, I came to realize that with great power comes great responsibility. As persons with broad knowledge on the subject, we have the power to create and to innovate. Whatever we create will affect the environment and society. So we have to be aware of how our advancements affect the environment and society as a whole. Now being more knowledgeable on the processes of producing harmful substances and the business that goes with it, what I need to keep in mind in the future should be whether that action is impacted positively or negatively. To me, I think there should be a balance between economy and morality. If I were to produce and sell a product, it must be able to sell, but at the same time, it shouldn’t cause harm to anyone or anything. By selling the product, it is my duty to ensure that no one is harmed and that no damage was dealt to the environment. Raphael Uy Anavar is used in many ways, our research showed its use in the medical industry as well as in the sports industry. Anavar helps quite the amount of people in the medical industry with its abilities. Although it helps in the medical field we see that it is also being abused in the sports industry. With people abusing its abilities in order to bodybuild, and even enhance overall performance. This has negative effects on the body like organ failure and a weaker immune system. In the end the drug has positive and negative uses, its use relies on the users intention like many other drugs. In most cases though I’d recommend using it for medication. If used to bodybuild or enhance performance there will be consequences. In most cases upon reflection I realized that people often overlook the effects of drugs like these. With them opting to consume it regardless of the side effects, in this case the drug is being consumed regardless of the liver and cholesterol side effects. All in order to gain an advantage in the sport. This is the case for many other drugs, and I believe that we as scientists have to carefully research the product we are using. In order to prevent issues and for our overall safety. VI. References (APA format) 1. Oxandrolone Oral: Uses, Side Effects, Interactions, Pictures, Warnings & Dosing WebMD. (n.d.). Retrieved September 28, 2022, from https://www.webmd.com/drugs/2/drug-8822/oxandrolone-oral/details 2. REGENX Health. (2020, August 4). Anavar (Oxandrolone). REGENX HEALTH MAIN. Retrieved September 28, 2022, from https://www.regenxhealth.com/post/anavar-oxandrolone 3. Sutherland, J. P. (2021, March 8). Oxandrolone for Management of Hypercatabolism in Severe Burns. Pharmacy Times. 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