Diabetes Agents Parenteral agents Short duration: rapid acting Prototype: Insulin lispro (Humalog) Short duration: short acting Prototype: Regular insulin (Humulin R) Intermediate duration Prototype: Neutral protamine Hagedorn (NPH) insulin Long duration Prototype: Insulin glargine (Lantus) Ultra-Long-acting Prototype: Insulin glargine (Toujeo) Mixed Insulin Prototype: 75% insulin lispro protamine/25% insulin lispro (Humalog Mix 75/25) Oral agents Biguanides (make the body do what it does endogenously better) Metformin (Glucophage)* Thiazolidinediones (glitazones) (make the body do what it does endogenously better) Prototype: Pioglitazone (Actos) Sulfonylureas (pushes insulin out of the pancreas) Prototype: Glipizide (Gluocotrol)* Glinides (meglitinides) (pushes insulin out of the pancreas) Prototype: Repaglinide (Prandin) SGLT2 (Sodium glucose co-transporter 2) inhibitors (works on kidneys) Prototype: Canagliflozin (Invokana) DPP-4 inhibitors (Gliptins) (works on gut hormones) Prototype: Sitagliptin (Januvia) Injectable antidiabetic agents Incretin mimetic (works on gut hormones) Prototype: Exenatide (Byetta) Amylin Mimetic (works on gut hormones) Prototype: Pramlintide (Symlin) Drugs for hypoglycemia or insulin overdose Other Endocrine/Metabolism drugs Prototype: Glucagon Dextrose IV