Heart The hear t is a muscular organ in most animals. This organ pumps blood t hrough t he blood vessels of t he circulat ory syst em.[1] The pumped blood carries oxygen and nut rient s t o t he body, while carrying met abolic wast e such as carbon dioxide t o t he lungs.[2] In humans, t he heart is approximat ely t he size of a closed fist and is locat ed bet ween t he lungs, in t he middle compart ment of t he chest .[3] Heart The human heart Details System Circulatory Artery Aorta,[a ] pulmonary trunk and right and left pulmonary arteries,[b] right coronary artery, left main coronary artery[c] Vein Superior vena cava, inferior vena cava,[d] right and left pulmonary veins,[e] great cardiac vein, middle cardiac vein, small cardiac vein, anterior cardiac veins [f] Nerve Accelerans nerve, vagus nerve Identifiers Latin cor Greek kardía (καρδία) MeSH D006321 (https://meshb.nlm.nih.gov/record/ui? ui=D006321) TA98 A12.1.00.001 (http://www.unifr.ch/ifaa/Public/E ntryPage/TA98%20Tree/Entity%20TA98%20E N/12.1.00.001%20Entity%20TA98%20EN.htm) 3932 (https://ta2viewer.openanatomy.org/?id=3 TA2 932) Anatomical terminology In humans, ot her mammals, and birds, t he heart is divided int o four chambers: upper left and right at ria and lower left and right vent ricles.[4][5] Commonly t he right at rium and vent ricle are referred t oget her as t he right heart and t heir left count erpart s as t he left heart .[6] Fish, in cont rast , have t wo chambers, an at rium and a vent ricle, while most rept iles have t hree chambers.[5] In a healt hy heart blood flows one way t hrough t he heart due t o heart valves, which prevent backflow.[3] The heart is enclosed in a prot ect ive sac, t he pericardium, which also cont ains a small amount of fluid. The wall of t he heart is made up of t hree layers: epicardium, myocardium, and endocardium.[7] The heart pumps blood wit h a rhyt hm det ermined by a group of pacemaker cells in t he sinoat rial node. These generat e a current t hat causes t he heart t o cont ract , t raveling t hrough t he at riovent ricular node and along t he conduct ion syst em of t he heart . In humans, deoxygenat ed blood ent ers t he heart t hrough t he right at rium from t he superior and inferior venae cavae and passes it t o t he right vent ricle. From here it is pumped int o pulmonary circulat ion t o t he lungs, where it receives oxygen and gives off carbon dioxide. Oxygenat ed blood t hen ret urns t o t he left at rium, passes t hrough t he left vent ricle and is pumped out t hrough t he aort a int o syst emic circulat ion, t raveling t hrough art eries, art erioles, and capillaries—where nut rient s and ot her subst ances are exchanged bet ween blood vessels and cells, losing oxygen and gaining carbon dioxide—before being ret urned t o t he heart t hrough venules and veins.[8] The heart beat s at a rest ing rat e close t o 72 beat s per minut e.[9] Exercise t emporarily increases t he rat e, but lowers rest ing heart rat e in t he long t erm, and is good for heart healt h.[10] Cardiovascular diseases (CVD) are t he most common cause of deat h globally as of 2008, account ing for 30% of deat hs.[11][12] Of t hese more t han t hree-quart ers are a result of coronary art ery disease and st roke.[11] Risk fact ors include: smoking, being overweight , lit t le exercise, high cholest erol, high blood pressure, and poorly cont rolled diabet es, among ot hers.[13] Cardiovascular diseases frequent ly do not have sympt oms or may cause chest pain or short ness of breat h. Diagnosis of heart disease is oft en done by t he t aking of a medical hist ory, list ening t o t he heart -sounds wit h a st et hoscope, ECG, echocardiogram, and ult rasound.[3] Specialist s who focus on diseases of t he heart are called cardiologist s, alt hough many specialt ies of medicine may be involved in t reat ment .[12] Structure Development Physiology Clinical significance History Society and culture Other animals Additional images Notes References Bibliography External links Retrieved from "https://en.wikipedia.org/w/index.php? title=Heart&oldid=1117919412" Last edited 11 days ago by CactiStaccingCrane