to hide the left pane For Acrobat DC (Ver 2015.008.20082 for my case) & Windows 10, registry path is slightly different. HKEY_CLASSES_ROOT\Acrobat.Document.DC\shell\Open\command String to be modified is similar. "C:\Program Files (x86)\Adobe\Acrobat DC\Acrobat\Acrobat.exe" "%1" to "C:\Program Files (x86)\Adobe\Acrobat DC\Acrobat\Acrobat.exe" /A "navpanes=0" "%1"