Evidence Based Dentistry Overview PCC139A Dr. Kim Morita Evidence Based Decision Making • A specific set of skills for identifying, searching for and interpreting clinical and scientific evidence to be used for patient care. Scientific Evidence Experience and Judgement Patients Preferences or Values • An essential tool to improve quality of care and to reduce the gap between what we know, what is possible and what we do. Clinical/Patient Circumstances EBD Process Ask good clinical questions Conduct a computerized search Critically appraise the evidence Evaluate the outcome Apply the results in clinical practice Asking Good Questions Foreground and Background Questions Foreground 1. Specific and structured to find a precise answer 2. PICO Background 1. General knowledge 2. Broad Four Types of PICO Questions 1. Therapy/Prevention Determine the effects of treatments that avoid adverse events, improve function and are worth the effort and cost 2. Diagnosis The degree to which the test is reliable and useful 3. Harm/Etiology/Causation Causes of a disease or condition including iatrogenic forms and to determine relationship between risk factors, potentially harmful agents, and possible causes of a disease or conditions 4. Prognosis PICO Asking Good Questions P I C O The first step to develop a well-built question is to identify the patient problem or population What you plan to do for the patient • Therapy • Diagnostic test • Treatment • Alternative intervention • This should be specific and limited to one alternative choice • This specifies the results(s) of what you plan to accomplish, improve or affect • Should be measurable PICO Asking Good Questions • Allows for a direct and focused single issue and outcome • Facilitates the next step in the process, the computerized search • (P)Patient/Population “In a patient with…. • (I) Intervention will… • (C) Comparison …as compared to…” • (O) Outcome Patient/ Problem/ population Intervention Comparison Outcome Case A RCT treated anterior teeth (without crown coverage) Internal bleaching Bleaching trays Increases tooth whiteness Case B Plaque Electric toothbrush Manual toothbrush Removal of plaque Case C TMJ Hard occlusal guard Soft occlusal guard Reduce symptoms In a patient with anterior root canal treated teeth, will internal Case A bleaching as compared with external bleaching trays increase tooth whiteness? In a patient with a moderate amount of plaque, will an electric Case B toothbrush as compared to a manual toothbrush be more effective in plaque removal? In a patient with TMJ symptoms, will a hard occlusal guard as Case C compared to a soft occlusal guard be more effective in reducing TMJ symptoms? Sourcing Evidence Hierarchy of Evidence Secondary research is filtered or synthesized publications of the primary research literature. Provides evidence for cause and effect. Random assignment and can include blind or double blind strategy. Observations about the association between a particular exposure or a risk fact and the subsequent development of a disease or condition. Retrospective in that the subjects already have a certain disease and are compared with a control (disease-free) from the same population. Collections of reports on the treatment of several patients, or a report of a single patient. No statistical validity because these are observational and do not use a control group with which to compare outcomes. Image from: §https://library.triton.edu/c.php?g=433673&p=3720267 Summary • Understanding the evidence-based methodology and distinctions allows clinician to judge the validity of sources and relevance of findings. • By integrating good science with clinical judgement and patient preferences, clinicians enhance their decisionmaking ability and maximize the potential for successful patient outcomes and care. . Reference • 1. Forrest J, Miller S, Overman P, Newman M. Evidenced-Based Decision Making: A Translational Guide for Dental Professionals. Philadelphia: Lippincott Williams & Wilkins; 2009 • 2. Sackett D, Richardson W, Rosenberg W, et al. Evidenced-based Medicine: How to Practice and Teach EBM. New York: Churchill Livingston; 1997