Child Psychiatry Hum Dev (2017) 48:107–119 DOI 10.1007/s10578-016-0658-z ORIGINAL ARTICLE Antecedents of Treatment Resistant Depression in Children Victimized by Peers KL Healy1 • MR Sanders1 Published online: 8 June 2016 Ó Springer Science+Business Media New York 2016 Abstract Children victimized by peers are at increased risk of ongoing depression. This study investigates treatment resistant depression in children victimized by peers, following participation in a targeted cognitive behavioral family intervention. The sample comprised 39 children aged 6–12 years with elevated depression compared with a general sample, prior to the intervention. Six months after the intervention, 26 were no longer depressed and 13 were still depressed. This study investigated the differentiation of these two groups on the basis of parenting and child factors. Children with treatment resistant depression were discriminated from other children by lower levels of peer support and facilitative parenting immediately after the intervention. It was concluded that ongoing support from parents and peers is needed to reduce the risk of ongoing depression even if victimization has been reduced. Further research could develop a comprehensive profile of children at risk of depression following peer victimization. Keywords Peer victimization Victim Treatment resistant depression Family intervention Parenting Introduction Between 2 and 4 % of preadolescent children are formally diagnosed with depression [1], with non-diagnostic depressive symptoms at much higher levels [2]. Depressive & KL Healy k.healy@psy.uq.edu.au 1 Parenting and Family Support Centre, School of Psychology, The University of Queensland, Brisbane, QLD 4072, Australia symptoms in childhood often persist into adolescence, and beyond [3], which negatively impacts on children’s health, school performance, relationships, and may lead to suicide [4]. Victimization by peers at school is well-established as a risk factor for children’s depression; it contributes increasingly over time to depression [5, 6], which can persist months after victimization has ceased [7]. Carefully controlled studies show that peer victimization between the ages of six to eight years increases the risk of depression for many years afterwards, including well into adulthood [8, 9]. Depression is both a consequence of victimization and a risk factor for further victimization, which can result in a recursive downward spiral of internalizing and victimization over time [10, 11]. Cognitive behavior therapy is considered an effective treatment for mild to moderate childhood depression [12, 13] and pharmacological treatment is utilized in more severe cases [14]. However, treatment is not always effective. The term ‘treatment resistant’ refers to the failure of an individual to improve despite receiving treatment which is usually effective in reducing symptoms [15]. This study examines depressive symptoms in children following victimization by peers and their subsequent participation in a targeted cognitive behavioral intervention, Resilience Triple P. We examined child and family factors which discriminated those children with ongoing depressive symptoms following the intervention, from the majority of children whose depressive symptoms were successfully alleviated. Resilience Triple P is a cognitive behavioral family intervention for children victimized at school by peers. The program is designed to reduce both victimization and child distress, thus interrupting the downward spiral of ongoing internalizing problems and victimization. The program targets child and family protective factors against child distress and victimization by teaching children cognitive 123 108 behavioral skills, and involving parents in supporting their children through ‘‘facilitative parenting.’’ Facilitative parenting describes a set of parenting practices which are supportive of children’s development of peer skills and relationships. Facilitative parenting is warm and responsive, encouraging of independence (rather than over-controlling), includes coaching of social and emotional skills, and support of children’s friendships. Facilitative parenting has been found to discriminate between children reported by teachers as victimized by peers [16], and to concurrently predict children’s depression [17]. A randomized controlled trial (RCT) evaluated the effectiveness of Resilience Triple P for families of 111 children who had been victimised by peers at school [18]. Children whose families received the program had greater reductions in victimization, distress and depression, and greater improvements in peer acceptance over nine months than children in the control condition. At nine months 64 % of children in the intervention group with elevated depression at the initial assessment had moved into the normal range for depressive symptoms compared with 21 % of control children. The current study focused on a subgroup of children involved in the trial of Resilience Triple P: specifically the 39 children who were both (a) randomized to the intervention condition, and (b) had elevated depression at the initial assessment, when compared to a general sample of children of the same age. Of these 39 children, 26 no longer had elevated depression 6 months after participating in the intervention; however a minority of 13 children still had elevated depression. This study investigates child and family antecedents which discriminated those children with ongoing depressive symptoms six months after participating in the intervention, from the other children who were no longer depressed. There is no previous research which specifically investigates risk of child depression following an intervention for children victimized by peers. However there is previous research on child and family factors risk and protective factors for child depression in general. Child and Family Factors Relevant to Risk of Child Depression Previous research implicates several child and family variables relevant to risk of child depression, and therefore likely to influence the risk of ongoing depression following victimization by peers and participation in a targeted intervention. These include history of previous depression, victimization, children’s cognitive processing of peer situations, support from peers, and the parenting children receive. A high level of depression immediately following the intervention is likely to be associated with increased 123 Child Psychiatry Hum Dev (2017) 48:107–119 risk of later depression. As previously identified, victimization is well-established as a risk factor for ongoing depression, so failure of an intervention to effectively reduce victimization is likely to increase the risk of ongoing depression. The relevance of cognitive interpretations, peer support, and parenting to ongoing risk of depressive is discussed below. Previous research shows that children’s cognitive interpretations of social situations mediate the impact of negative social experiences on depression. According to Hopelessness theory, strong emotional reactions are caused by inferring negative consequences and self-criticism from aversive events [19]. At least two studies have found that children’s negative cognitive interpretations mediate the relationship between negative peer behavior and depression [20, 21]. Another study [22] found that for children with higher levels of self-blaming attributions, peer victimization was linked more strongly with increases in internalizing problems over time. On the other hand, having a more optimistic cognitive style can buffer children from later depression following a stressful situation [23]. Resilience Triple P directly targets children’s cognitive interpretation of peer social behavior; however if the program has not successfully addressed a child’s cognitive negativity, this may pose a risk for ongoing depression following participation in the intervention. Children’s vulnerability to ongoing depression is also influenced by their relationships with peers and parents. Supportive relationships with peers and parents can protect against symptoms of depression in general [24, 25]. Friendships also buffer children against internalizing problems following victimization. A longitudinal study of 4th and 5th grade children [26] found that having a mutual best friend mitigated the internalizing consequences of peer victimization over time. Several cross-sectional studies of young adolescents have found that peer support at least partially mediates the relationship between victimization and depressive symptoms, as well as independently impacting depressive symptoms [27–29]. Therefore the quality of peer relationships following participation in intervention is likely to predict children’s risk of ongoing depression. Parenting also influences children’s risk of depression. There is a great deal of evidence linking supportive parenting with children’s social and emotional well-being [30, 31], regulation of negative emotions [32–34], and resilience following stressful life events [35]. A large-scale longitudinal study using a cohort of monozygotic twins disparate on victimization [36] found that warm family relationships buffered children from depression and anxiety following victimization. A mediational study [37] found that supportive parenting and peer victimization each independently predicted later depressive symptoms and Child Psychiatry Hum Dev (2017) 48:107–119 cognitions, but did not interact, and concluded that supportive parenting compensates for the negative impact of peer victimization on later depression. Negative forms of parenting have also been associated with child depression. Over-controlling parenting predicts lower capacity of young children to regulate negative emotions over time [38]. A meta-analysis of 45 studies [3] found that both parental rejection (lack of warmth) and parental control accounted for a significant amount of variance in childhood depression. Facilitative parenting is also associated with both children’s victimization and depression. Facilitative parenting draws together parenting practices which are supportive of children’s development of peer skills and relationships; it includes warm relating, encouragement of independence (rather than over-control), and incorporates explicit coaching of social and emotional skills, and support of children’s friendships. Facilitative parenting has previously been found to discriminate between children reported by teachers as bullied from those who were not [16]. Another study [17] found that, after controlling for negative parenting, facilitative parenting concurrently predicted children’s depression, and that two facilitative parenting subscales were associated with depression: child-parent communication, and less parent– child conflict. No study has previously investigated whether facilitative parenting predicts later depression in children. The current study investigated whether facilitate parenting predicts treatment resistant depression following participation in a program which specifically targeted facilitative parenting skills. Aims of this Study This study aimed to investigate if child and family factors could discriminate children with treatment resistant depression following victimization by peers, and subsequent participation in a targeted family cognitive-behavioral intervention. Treatment resistant depression was defined as ongoing elevated symptoms of depression (compared with a school community sample of the same age) 6 months after participation in Resilience Triple P. We hypothesized that children with treatment resistant depression 6 months after participating in the program would be discriminated from children who were no-longer depressed by higher levels of depression, peer victimization, and negative interpretations of peer behavior, and lower levels of peer support and facilitative parenting, immediately following program participation. On the basis of previous research on parenting practices associated with depression, we further hypothesized that children with treatment resistant depression would be identified by lower levels of parenting warmth and childparent communication, and higher levels of over-directiveness and parent–child conflict. 109 Method Participants This study tracked a sub-sample of 39 children of a total of 111 recruited between 2010 and 2012 for the RCT of the Resilience Triple P program, as described previously [18]. Families were recruited through notices in school newsletters in state and private schools in South East Queensland, Australia. The trial was open to families of children who had been bullied at school by peers, according to their parent. Bullying was defined behaviorally as ‘‘hurtful behavior which is typically repeated, and could be physical or verbal or indirect social, and carried out in person or through technology.’’ The parent needed to verify that the child had experienced either (a) ongoing bullying for at least the past month and/or (b) a recurrent problem with being bullied over more than one year. There were several other eligibility criteria: the target child needed to be (1) aged between 6 and 12 years, (2) living at home, and (3) attending a regular school. Following an initial assessment, the 111 families were randomly allocated to the control (n = 55) or the intervention condition (n = 56). Families in the intervention condition were offered an immediate start on Resilience Triple P. The current study focussed on the 39 children allocated to the intervention condition with an elevated score for depressive symptoms at the initial assessment. Elevated depression was determined by scores above the clinical cut-off on a parental depression checklist [39] calculated by comparison with a general school community sample of children from the same age-group, using methods for assessing clinical significance described by Jacobson and Truax [40]. The 39 children in the intervention condition with elevated depression at the initial assessment, included 27 boys (69 %) boys and 12 (31 %) girls ranging from 6 to 12 years with a mean age of 8.64 years (SD = 1.75 years). Of these 39 children, parents of 12 children (33 %) reported their child had a pre-existing psychiatric diagnosis including five children (13 %) with a diagnosis of autistic spectrum disorder, one child with diagnoses of both autistic spectrum and attention deficit, one child with a diagnosis of attention deficit, two children with specific learning disability, one child with sensory integration disorder, one child with an anxiety disorder, and one child with a medical condition affecting socialization. Design This study utilised a longitudinal data set which tracked children’s progress through three assessments over nine months including pre-intervention (0 months), post-intervention (3 months after recruitment), and a follow-up 123 110 assessment 6 months later (9 months after recruitment). The 39 children included in this study had clinically elevated scores on the depression checklist at the pre-intervention assessment. Apart from five families who dropped out following the first assessment, the 34 other families participated in Resilience Triple P prior to the post-intervention assessment 3 months later. We sought to discriminate children with treatment resistant depression at the 9-month follow-up (6 months after completion of intervention) on the basis of post-intervention assessment scores on depressive symptoms, peer victimisation, negative interpretations of peer social behavior, peer support and facilitative parenting. Measures Assessments were completed by children, parents and teachers at pre-intervention (0 months), post intervention (3 months), and a follow-up assessment 6 months later (9 months). Outcome Variable: Child Depression at 9 months The Preschool Feelings Checklist (PFC) [39] is a brief 16-item checklist of symptoms of depression. Parents answer ‘‘yes’’ or ‘‘no’’ for each question (e.g. ‘‘Frequently appears sad or says he/she feels sad’’). The scale correlates well with established depression measures [41], and has previously been shown to discriminate children reported by teachers to be bullied from those who are not in children aged 6–12 years [16]. This measure demonstrated acceptable internal consistency for the current sample (a = .73). Predictor Variables: Child Victimisation at 3 months The Preschool Peer Victimization Measure (PPVM) is a nine-item teacher report of peer treatment of the child [42]. All items are developmentally appropriate for children from 6 to 12 years of age. Teachers rate items from 0 (never or almost never true) to 5 (always or almost always true). Subscales include Overt Victimization comprising physical and verbal items (e.g. ‘‘This child is called a mean name’’) and Relational Victimization (e.g. ‘‘This child gets ignored by playmates when they are mad at him/her’’). Both subscales demonstrated reasonable internal consistency (a = .70, a = .74 respectively). Things Kids Do (TKD) [43] asks children to rate the frequency of specific peer behaviors in the last week at school on a 5-point scale from ‘‘not at all’’ to ‘‘heaps.’’ This is facilitated by a research assistant reading each question and pointing to a chart on which ratings are represented by coloured shapes of size corresponding to rating. The TKD Victimization scale includes 14 items about 123 Child Psychiatry Hum Dev (2017) 48:107–119 verbal, physical or relational behaviors (e.g. ‘‘Did other kids at school give you mean looks?’’). It has previously been used with this age group [16] and demonstrated acceptable internal consistency for the current sample (a = .78). After answering questions about the occurrence of peer behaviors, the child rates how upset they felt about these peer behaviors on a 5-point scale from ‘‘not upset’’ to ‘‘very upset’’, comprising the TKD Upset scale. Predictor Variables: Peer Support at 3 months Friendedness The Loneliness Questionnaire [44] includes 24 statements on friendedness (e.g. ‘‘I can find a friend when I need one’’), which children rate from 5 (always true) to 1 (not true at all). Although originally trialled with children from 3rd to 6th grade [45], a recent study [16] found it could be utilized with individual children from five years old, through use of a chart with different sized circles representing levels of agreement. The same materials produced very good internal consistency with this sample (a = .92). Peer Acceptance We used two single-item scales from the Preschool Social Behavior Scale –Teacher (PSBS-T) [46] which ask teachers to rate the child’s acceptance by peers of the same sex and opposite sex (e.g. ‘‘This child is well-liked by peers of the same sex’’). Teachers rate items from 1 (never or almost never true) to 5 (always or almost always true). Predictor Variables: Cognitive Negativity at 3 months The Sensitivity to Peer Behaviour Interview (SPBI) [47] measures children’s negative thoughts and feelings in six hypothetical scenarios of negative peer behavior (e.g. ‘‘A child calls you stupid’’). A felt board and ten felt characters are used to demonstrate scenarios according to an explicit protocol. Firstly the child designs a character for themselves (i.e. chooses clothes and hair style). The research assistant then depicts scenarios in which other felt characters act towards the child’s character in a way which could be interpreted as negative (e.g. has a birthday party but does not invite the child). The child then answers specific questions about each scenario before the next scenario is introduced. Some felt characters were antagonists and others are neutral (i.e. are not described as acting one way or another).The Internalizing Cognitions scale measures children’s negative beliefs for six scenarios, including interpretations of motive (e.g. ‘‘They are trying to upset you’’), whether behavior will continue (‘‘lots of days’’ as opposed to ‘‘just today’’), and expectation that other neutral children would act similarly. Internalizing Feelings measures how upset children report they would Child Psychiatry Hum Dev (2017) 48:107–119 feel in each situation from ‘‘not upset’’, ‘‘a bit upset’’ or ‘‘very upset.’’ These two scales have previously discriminated bullied from non-bullied children [16], and produced reasonable internal consistency in this sample (a = .72; a = .70). Predictor Variables: Facilitative Parenting at 3 months The Facilitative Parenting Scale (FPS) [48] is a self-report measure of parenting which is supportive of children’s peer skills and relationships. Parents rate 58 statements from 1 (not true) to 5 (extremely true) over the last few weeks. Internal consistency for the whole scale was acceptable (a = .82). A previous study reported there are 11 subscales [16] all of which demonstrated acceptable internal consistency in the current study1: Warmth (e.g. ‘‘My child and I enjoy time together’’), (a = .82); Supports Friendships (e.g. ‘‘I arrange for my child to see friends out of school’’), (a = .76); Not Over-Protective (e.g. ‘‘I tend to baby my child’’), (a = .79); Not Conflicting (e.g. ‘‘My child and I argue a lot’’), (a = .85); Child Communicates to Parent (e.g. ‘‘My child comes to see me if s/he has a problem’’), (a = .74); Parent Coaches (e.g. ‘‘I help my child practise standing up for him/herself’’), (a = .76); Communicates with Teacher (e.g. ‘‘I can calmly discuss any concerns that might arise with my child’s teacher’’), (a = .52; mean r = .27); Not Over-Involved in School (e.g. ‘‘I talk to my child’s teacher much more than other parents do’’) (a = .76), Not Aggressively Defensive (e.g. ‘‘If another child acts meanly to my child, I might tell him/ her off’’), (a = .43; mean r = .26); Enables Independence (e.g. ‘‘I encourage my child to decorate his/her own space’’), (a = .69; mean r = .45); Not Overly Directive, (e.g. ‘‘When my child has a problem, I tell him/her what to do’’), (a = .51; mean r = .34). Procedure The assessment procedure was described comprehensively in the paper reporting the RCT [18]. Ethical clearance was first obtained from the university and educational authorities. After reading about the trial in school newsletters, families made contact with the researchers. In this initial phone call, parents were informed about the requirements of the research and screened against eligibility criteria. Eligible families were invited to visit a family clinic for an initial assessment. Formal consent was obtained from all parents, children, teachers, and school Principals. 1 As Cronbach’s alpha is sensitive to the numbers of items in scales, we calculated the mean inter-item correlation for scales with only two three items which exhibited a low alpha, as recommended [49]; the optimal range for inter-item correlation (r) is between .20 and .40. 111 Following the initial assessment, each family was randomly allocated to intervention or control conditions. Families were asked to attend subsequent assessments 3 and 9 months after the initial assessment. At each assessment, children were interviewed by research assistants with training in psychology or social work who had been trained in conducting the child assessments, according to the protocols. A research assistant read through each questionnaire with the child and utilized concrete materials provided to assist children to respond to the TKD, Loneliness Questionnaire, and SPBI. This took half an hour on each occasion. Whilst children were interviewed by research assistants, parents completed questionnaires. Questionnaires were mailed to teachers with return envelopes. The current study focuses on children allocated to the intervention condition who had elevated depressive symptoms at the initial assessment. Resilience Triple P is a manualized family intervention designed to address known modifiable risk and protective factors for children bullied at school [50]. The eight-session program includes four sessions for parents and four sessions for children with their parents present. Children learn play and friendship skills, everyday body language, how to interpret and respond to negative peer behavior and how to resolve conflicts. Parents learn facilitative parenting strategies to promote a warm parent–child relationship, support children’s friendships, address problem behavior, coach effective responses to bullying and conflict, and communicate with school staff. The program involves active skills practice and homework tasks in between sessions in which behavioral and cognitive strategies are practiced and coached. The program was delivered at a child and family clinic in groups of between three and eight families, and included between eight and 15 children aged 6–16 years (including siblings). If families missed a session they were invited to make this up in another group, or individually, resulting in mean attendance of 7.6 of eight sessions for families who commenced the program [18]. Statistical Analyses We first conducted data screening and missing data analysis. Before calculating scale scores we imputed missing data points through Expectation Maximisation, on each scale separately as recommended [51]. We used discriminant analyses through the Statistical Package for Social Sciences (SPSS) to ascertain whether children with treatment resistant depression at the follow-up assessment (6 months after post-assessment) could be discriminated on the basis of post-assessment scores on children’s distress and depression, peer victimisation, peer support, facilitative parenting, and cognitive negativity. We conducted an additional analysis to investigate whether treatment 123 112 resistant depression at 9 months could be predicted from facilitative parenting subscales at 3 months. For both discriminant analyses, the number of predictor variables was limited by the number of participants in the smallest group (n = 12) as recommended [52] in order to prevent overfitting of the discriminant function to the specific sample. Discriminant analysis through SPSS does not include an option to correct for cumulative alpha levels. We have therefore assessed alpha levels independently using the Bonferroni-Holm correction using both family-wise corrections and by treating each separate predictor variable as a repetition of the analysis [53]. Family-wise corrections were based on variable groups defined in this study including victimization, peer support, cognitive negativity, and parenting. For the discriminant analysis involving just facilitative parenting subscales, each subscale was conservatively treated as a repeated analysis for the purpose of calculating Bonferroni-Holm alpha cut-offs. Results Child Psychiatry Hum Dev (2017) 48:107–119 We checked if the still-depressed versus non-depressed groups were different on demographic factors. There were no significant differences between groups on the demographics tested including child age (F [1, 32] = .001, p = .981), grade (F [1, 32] = .004, p = .953), gender (v2 (1) = .54, p = .714), parent income (F [1, 32] = .007, p = .936), parent education (F [1, 32] = .029, p = .865) or whether the child had a pre-existing diagnosis v2 (7) = 710.27, p = .111). There was no significant difference between still-depressed and non-depressed groups at 9 months for attendance to the program (F [1, 32] = 1.036, p = .316). Table 1 shows the means, standard deviations, and correlations between the outcome variable of child depression at 9 months and predictor variables at 3 months. There was a significant positive correlation between child depression at 9 months and child depression at 3 months. Child depression at 9 months had significant negative associations with peer acceptance (by same and opposite sex peers), and facilitative parenting at 3 months. That is, ongoing depression at 9 months was associated with higher levels of depression, and lower levels of peer acceptance and facilitative parenting at 3 months. Preliminary Analyses Predictors of Depression at 9 Months Several variables had a significant positive skew, which is quite common for psychological measures [54], and not a strong concern in discriminant analysis [52]. Box’s M test was significant (p = .005) indicating non-normality of the variance–covariance matrix. However, Box’s M test is known to be highly sensitive to departures from normality [52], and an inspection of scatterplots revealed distributions for each group were of similar shape. Several data transformations were attempted: as these produced similar patterns to the original scores, the original scores were retained. Scores of Mahalanobis Distance showed no outliers exceeded the critical values. A missing data analysis (including that due to attrition) revealed 10.59 % of total values were missing including the five cases lost to attrition. Little’s test indicated that data points were missing completely at random, v2 (11,634) = .00, p = 1.000. The five families who dropped out after the initial assessment were compared to the 34 families who were retained. There were no differences between these groups on 19 of the 21 scales and subscales. Families who dropped out had higher ratings on child reports of Internalizing Feelings, t (37) = -2.17, p = .037 and FPS Child Communicates to Parent t (37) = -2.11, p = .042 and lower scores on FPS Not Over-Involved in School t (37) = 2.09, p = .044. When we applied Bonferroni-Holm corrections, none of these differences met the more stringent significance criteria. 123 Table 2 includes means and standard deviations of all 3-month predictor variables for children with treatment resistant depression or no depression at 9 months. One discriminant function was identified which correlated .74 with treatment resistant depression and significantly discriminated between the two groups, Wilks’ k = .45, v2 [11] = 24.98, p = .009. Table 2 shows the structure matrix and F-tests of equality of the means for the two groups for each predictor variable. The 3-month variables which best distinguished children with treatment resistant depression at 9 months and significantly correlated with the discriminant function were acceptance by opposite sex peers (r = .64), child depression (r = -.53), acceptance by same sex peers (r = .50), facilitative parenting (r = .38), and social victimization (r = -.22). When we applied Bonferroni-holm adjustments using family-wise corrections, all of these variables were significant according to the more stringent alpha levels. When we applied Bonferroni-Holm stepwise alpha criteria taking each predictor as a separate measure, social victimization failed to meet the new criteria of p \ .007, but all other variables remained significant according to the more stringent alpha levels. Classification of cases using the discriminant function resulted in 87.2 % of the total sample being correctly classified including 90.2 % of the not depressed group and 69.2 % of children still depressed at 9 months. – -.41** .31 -.14 -.44** -.42** -.11 .06 .16 .37* -.26 -.11 Parent 12. Child depression 9 months * p \ .05; ** p \ .01; *** p \ .001 .32* 9 months 3.00 (3.97) .28 .26 .11 -.26 -.26 -.41* .05 .15 Parent 3 months 11. Facilitative parenting 10. Internalizing feelings Child 3.96 (.33) -.08 .00 -.15 -.21 .03 .24 .44** .30 – 3 months .52 (.44) .01 .59*** .15 -.65*** -.02 -.14 -.48** .13 -.10 -.37* -.09 .28 .20 -.02 Child 3 months 3.01 (.92) Teacher 3 months 9. Internalizing cognitions 8. Accepted by opposite sex peers Teacher 7.Accepted by same sex peers 3 months 0.23 (.16) – .13 – -.40* -.57** -.34* .11 -.13 -.21 -.39* 4.19 (.63) Child 6. Friendedness 3 months 3.35 (.94) -.06 – .52** -.18 .04 – .27 .19 Teacher 5. Overt victimisation 3 months 1.42 (.63) -.04 -.19 – .03 .06 Teacher 4. Social victimisation 3 months 2.38 (.82) – -.18 .64*** -.18 – 2. Child distress about peer behaviour 3. Child depression at 3 months .58 (.59) Child Child Parent 3 months 3 months 3 months 1. Victimisation in previous week 1.10 (1.07) 3.81 (2.38) -.08 – .12 – 10. 9. 8. 7. 6. 5. 4. 3. 2. 1. Respondent Mean (SD) We investigated whether the facilitative parenting subscales at 3 months could discriminate between children with treatment resistant depression at 9 months. Table 3 shows means, standard deviations and correlations between facilitative parenting subscales at 3 months and child depression at 9 months. Two facilitative parenting subscales had significant negative correlations with children’s depression at 9 months: Not Over-Protective (r = -.39), and Not Aggressively Defensive (r = -.38). That is, children with treatment resistant depression at 9 months had parents who reported they were more over-protective and more likely to act aggressively towards others in defending their child. Table 4 includes means and standard deviations of 3month facilitative parenting subscales as predictors for children were depressed or not at 9 months. One discriminant function was identified which correlated .68 with child depression group at 9 months and significantly discriminated between the still-depressed and no-longerdepressed groups, Wilks’ k = .53, v2 [11] = 19.90, p = .047. Table 4 shows the structure matrix for the discriminant function and F-tests of equality of the means between the groups for each predictor variable. The parenting subscales which significantly distinguished treatment resistant depression at 9 months and had the highest correlations with the discriminant function were Not Conflicting (r = .41), Not Overly Directive (r = .41), Parent Coaches (r = .41), Not Aggressively Defensive (r = .38), and Not Over-Protective (r = .36). However, when we applied Bonferroni-Holm stepwise alpha criteria taking each predictor as a separate instance, none of the subscales met the more stringent cut-offs for alpha levels. Nevertheless, classification using the discriminant function resulted in 92.3 % of the total sample being correctly classified including 100.0 % of the nolonger-depressed depressed group and 76.9 % of the stilldepressed group. Timing Variable Table 1 Means, standard deviations and correlations between 3 month predictors and child depression at 9 months Facilitative Parenting Subscales as Predictors of Depression .20 113 11. Child Psychiatry Hum Dev (2017) 48:107–119 Discussion This study focused on treatment resistant depression in children following victimization by peers. We sought to identify factors which characterized children who continued to experience high levels of depressive symptomatology 6 months after participating in a targeted cognitivebehavioral family intervention. We hypothesized that children with treatment resistant depression 6 months after participating in the program would be discriminated by higher levels of depression, peer victimization and 123 114 Child Psychiatry Hum Dev (2017) 48:107–119 Table 2 Discriminant analysis using 3 month variables to predict child depression at 9 months No longer depressed at 9 months (n = 26) Still depressed at 9 months (n = 13) Mean (SD) Mean (SD) 1. Victimisation in previous week (TKD) .69 (.67) .37 (.33) .24 .94 2.53 .120 2. Child distress about peer behaviour (TKD) 1.27 (1.14) .75 (.83) .22 .94 2.18 .148 3. Child depression at 3 months 2.98 (1.93) 5.48 (2.36) -.53 .75 12.49 .001 4. Social victimisation (PPVM) 2.14 (.72) 2.86 (.82) -.22 .82 7.89 .008 5. Overt victimisation (PPVM) 1.31 (.49) 1.62 (.88) -.17 .94 2.18 .148 6. Friendedness 4.19 (.66) 4.18 (.60) .03 1.00 .00 .985 7. Accepted by same sex peers 3.67 (0.87) 2.72 (.77) .50 .79 11.16 .002 8. Accepted by opposite sex peers 3.37 (.70) 2.27 (.88) .64 .67 18.21 \.001 9. Internalizing cognitions .24 (.18) .21 (.12) .06 1.00 .18 10. Internalizing feelings .54 (.43) .47 (.48) .07 .99 .21 .647 11. Facilitative parenting 4.07 (.32) 3.75 (.25) .47 .79 9.86 .003 Predictor variable negative interpretations of peer behavior, and lower levels of peer support and facilitative parenting immediately following program participation. As hypothesized, support from peers and parents immediately following the intervention significantly distinguished children with treatment resistant depression, as did post-intervention reports of depressive symptoms and teachers’ reports of children’s social victimization. Ongoing depression in children has been well-documented following victimization. This study suggests, that following an intervention, positive, supportive relationships with parents and peers continue to play a role in determining whether depression is a longer term issue. Consistent with hypotheses, teacher reports of social victimization of children discriminated between groups; contrary to hypotheses overt victimization did not. The RCT paper [18] reported an immediate significant reduction in overt victimization in the intervention group following program participation but a more gradual reduction in social victimization over 9 months. Hence it may be that following participation in the program, overt victimization was at a reduced level for most children so did not significantly impact treatment resistant depression. However social victimization is more subtle and may have persisted for some children leading to greater risk of ongoing depressive symptoms. Social victimization is also strongly associated with lower levels of peer acceptance (See 123 Correlation with discriminant function Tests of equality of group means Wilk’s lambda F p .674 Table 1) which distinguished children with treatment resistant depression. Contrary to hypotheses, no children’s report measures discriminated children with treatment resistant depression including measures of victimization, friendedness, and negative interpretations of peer behavior at 3 months. Previous research has found that victimization, friendedness and children’s negative interpretations of peer behavior predict ongoing depression [14, 23, 28]. The current study differs from previous studies in that it reported children’s outcomes following their participation in a targeted intervention. The RCT of Resilience Triple P [18] found that post-intervention scores on children’s measures were no different to the comparison general sample of children (i.e. means were within the expected normal range). Therefore the failure of children’s report measures to distinguish treatment resistant depression may be due to a floor effect on children’s report measures. Another reason why children’s report measures did not distinguish children with ongoing depression may be that they focused primarily on overt rather than social victimization. As reported in the RCT of Resilience Triple P, incidents of overt victimization post-intervention were significantly reduced [18], so may have been less relevant to ongoing depression than social victimization, peer rejection, and acceptance. This is consistent with results of the current study that show that teacher reports of social Child Psychiatry Hum Dev (2017) 48:107–119 115 Table 3 Means, standard deviations and correlations between 3 month facilitative parenting subscales and child depression at 9 months Variable Timing Mean (SD) 1. 2. 3. 1. Warmth 0 months 4.22 (.45) – 2. Supports friendships 0 months 3.96 (.62) .58*** 3. Not overprotective 4. Not conflicting 0 months 3.88 (.55) .27 .17 4. 5. 6. 7. 8. 11. – 0 months 4.27 (.69) .63*** .18 .18 0 months 3.92 (.55) .62*** .51** .17 6. FP parent coaches 7. FP communicates with teacher 0 months 3.92 (.50) .34* .25 .41* 0 months 4.23 (.60) .52** .22 .12 .18 .46** .13 8. FP not overinvolved in school 0 months 3.99 (1.01) -.36* .34* .14 .09 .00 .01 9. Not aggressively defensive 0 months 4.44 (.59) .21 -.12 .59*** .21 .23 .22 .24 10. FP enables independence 0 months 3.50 (.60) .16 .09 .05 .02 .37* 11. FP not overly directive 0 months 3.27 (.81) .34* .16 .13 .26 .49** 12. Child depression 9 months 9 months 3.00 (3.97) -.28 -.26 -.20 10. – 5. FP child communicates to parent -.01 9. -.15 -.01 .48** -.39* – .23 -.02 – .30 – -.29 – – .52** – -.05 -.08 -.06 .18 -.13 .27 .09 -.26 -.38* – .27 -.16 – -.29 * p \ .05; ** p \ .01; *** p \ .001 victimization discriminated children with treatment resistant depression whereas overt victimization did not. On the basis of previous research, we made further hypotheses about facilitative parenting subscales which would discriminate children with treatment resistant depression: we predicted that children with treatment resistant depression would be identified by lower levels of parenting warmth and child-parent communication, and higher levels of over-directiveness and parent–child conflict. Five facilitative parenting subscales made a significant contribution to discriminating children with treatment resistant depression. However, when alpha criteria were adjusted using the Bonferroni-Holm method, no individual subscale met the more conservative criteria. However alpha corrections methods have been criticized for setting levels of significance which are overly stringent and which can result in important differences being overlooked (i.e. Type 2 errors) [55]. We will therefore interpret the pattern of results as reported in Table 4 cautiously and against relevant literature. As hypothesized, the parents of children with treatment resistant depression had reported higher levels of parent–child conflict and over-directive parenting than parents of children who were no longer depressed at follow-up. This is consistent with previous research showing that parent–child conflict and high levels of parental control are associated with children’s depression [3, 17]. Contrary to hypothesis, child-parent communication did not significantly discriminate children with treatment resistant depression; however this prediction was made on the basis of a previous cross-sectional study [17] and cross-sectional associations between variables do not necessarily reflect relationships over time [56]. Parental warmth was marginally significant in discriminating depression-resistant depression; previous longitudinal research shows that warm family relationships buffer children from depression and anxiety following victimization [36]. Three additional subscales helped discriminate children with treatment resistant depression: higher levels of over-protective parenting, aggressively defensive parenting and lower levels of parental coaching of the child in social and emotional skills. Although these subscales have not previously been associated with children’s depression, they have all been previously implicated as relevant to development of children’s peer relationships and risk of 123 116 Child Psychiatry Hum Dev (2017) 48:107–119 Table 4 Discriminant analysis using facilitative parenting subscales at 3 months to predict depression at 9 months Predictor variable No longer depressed at 9 months (n = 26) Still depressed at 9 months (n = 13) Correlation with discriminant function Mean (SD) Mean (SD) 1. Warmth 4.32 (.41) 4.02 (.48) .35 2. Supports friendships 4.04 (.58) 3.81 (.71) .19 3. Not over-protective 4.00 (.52) 3.63 (.53) .36 Tests of equality of group means Wilk’s lambda F p .90 3.94 .055 .97 1.18 .285 .90 4.33 .044 4. Not conflicting 4.44 (.47) 3.92 (.92) .41 .87 5.56 .024 5. Child communicates with parent 3.95 (.51) 3.87 (.64) .08 .99 .21 .650 6. Parent coaches 4.05 (.49) 3.67 (.44) .41 .87 5.60 .023 7. Communicates with teacher 4.23 (.64) 4.25 (.51) -.01 1.00 .06 .936 8. Not over-involved in school 4.19(.88) 3.58 (1.15) .32 .92 3.42 .073 9. Not aggressively defensive 4.58 (.48) 4.18 (.65) .38 .89 4.76 .036 10. Enables independence 3.60 (.62) 3.30 (.51) .26 .94 2.26 .141 11. Not overly directive 3.47 (.79) 2.87 (.70) .41 .87 5.39 .026 peer victimization. Parental coaching of children in social and emotional skills has previously been identified as a path for children’s competence with peers and peer acceptance [57]. Through participation in Resilience Triple P, parents learnt specific strategies to support their child in responding to and interpreting peer situations [18]. A previous study [58] found that parental feedback interacts with negative life events to exacerbate children’s vulnerability to depression. Parental coaching may then assist children to view events more realistically and optimistically, thereby facilitating children’s ongoing emotional regulation. Overprotective parenting has previously been associated with victimization [59]. There has been very little previous research examining the relationship between over-protective parenting and child depression, and results with been mixed [60, 61]. To our knowledge no previous research has specifically examined the relationship between parents aggressively defending the child, and child depression. It may be that both parental over-protection and aggressive defensiveness disrupt children’s peer relationships and their ability to self-regulate. This study investigated treatment resistant depression in children bullied by peers following receipt of the targeted cognitive behavioral family intervention that significantly reduced depression and victimization. Children with treatment resistant depression 6 months after participating in the intervention were characterized by lower levels of facilitative parenting and peer support immediately after intervention. The intervention, Resilience Triple P, teaches parents facilitative parenting skills. So, following an 123 intervention which targeted and increased facilitative parenting in parents, facilitative parenting still predicted child depression outcomes 6 months later. This implies that, following participation in Resilience Triple P some parents may benefit from additional support to improve their use of facilitative parenting strategies such as coaching children in social and emotional skills, resolving conflicts with their child, and supporting their child without being overly directive or overly protective. Further evaluation of Resilience Triple P using larger sample sizes would enable development of a more comprehensive profile of responders and non-responders to the treatment on the variable of child depression. This would enable early identification of families of children at-risk for ongoing depressive symptoms. This is the first study to examine antecedents of treatment resistant depression in children bullied by peers. The findings have extended previous cross-sectional research which showed associations between facilitative parenting and child depression. The strengths of this study include a longitudinal design with a specific sample of children victimized by peers who had participated in a targeted cognitive-behavioral intervention. The main limitation was the small sample size which limited the number of variables which could be included in a single discriminant analysis. Future research could extend findings of this study by using clinical diagnostic assessments to assess depression of children victimized by peers following their participation in targeted interventions. Children with treatment resistant depression in this study were characterized by lower levels of facilitative Child Psychiatry Hum Dev (2017) 48:107–119 parenting and peer support than children whose depressive symptoms were alleviated. This suggests that children who participate in Resilience Triple P and have elevated symptoms of depression immediately following participation in the program may benefit from further practitioner support promoting facilitative parenting and peer support. These findings have broader implications for schools and professionals supporting children victimized by peers. Peer victimization increases the ongoing risk of depression for children, even after victimization has been addressed. It is therefore important for parents and schools supporting children, who have been victimized by peers, to ensure that these children have ongoing warm, supportive relationships with parents and peers well after victimization has abated. Summary Children bullied by peers are at increased risk of ongoing depressive symptoms months and years after victimization has ceased. This study investigated treatment resistant depression in children victimized by peers following their participation in a targeted family cognitive-behavioral intervention. Treatment resistant depression was defined as ongoing elevated depressive symptoms compared to a general sample, 6 months after participating in the program. This study investigated whether facilitative parenting and child social and emotional variables immediately following program participation would differentiate children with treatment resistant depression 6 months later. The sample of 39 children in the current study was a subsample of children who participated in the RCT of Resilience Triple P. These children had been randomly allocated to receiving the intervention and all had elevated levels of depressive symptoms prior to participation in the program. This study sought to identify child and family factors which differentiated the minority of children with ongoing elevated depressive symptoms 6 months after participating in the program from those who were nolonger depressed. Children with treatment resistant depression were characterized by higher levels of peer support and facilitative parenting immediately following the intervention. This suggests that facilitative parenting and peer support may continue to protect children against the risk of ongoing depression following an intervention which reduces victimization and distress. Further research could identify a comprehensive profile of children at risk of depression following an intervention, who may benefit from more intensive support. Acknowledgments Thank you to the children and families who participated in this trial of Resilience Triple P, the data-base of which was used for analyses reported in this paper. We gratefully 117 acknowledge the funding of the trial by the Australian Research Council supplemented by a philanthropic donation by the Butta and Filewood families. We thank local theme-park, Dreamworld for providing discount cards for families. Compliance with Ethical Standards Conflict of interest The Triple P–Positive Parenting Program is developed and owned by The University of Queensland. The university, through its main technology transfer company Uniquest Pty Ltd, has licensed Triple P International (TPI) Pty Ltd to publish and disseminate Triple P worldwide. Royalties stemming from published Triple P resources are distributed to the Faculty of Health and Behavioural Sciences, School of Psychology, Parenting and Family Support Centre and contributory authors. Karyn L. Healy and Matthew R. Sanders are both contributory authors of Resilience Triple P and may in future receive royalties from TPI. Karyn L. 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