❑ ❑ ❑ ✓ ✓ ✓ ✓ ✓ ▪ ▪ ▪ ▪ ▪ ▪ ▪ ▪ ➢ ➢ ➢ ➢ ➢ ➢ ➢ ➢ ➢ ➢ ✓ ✓ ✓ ✓ ✓ ✓ ✓ ✓ ✓ RATE OF VELOCITIES – DEGREE OF MIXING Low radial velocities - The extent of mixing becomes inadequate, as indicated by the loss in the spiral rope like motion of the particles. Rate at which the particles traverse the spray zone is prolonged and could potentially lead to excessive agglomeration. Caking is another serious problem encountered during powder layering at low radial velocity. High radial velocities - particle to particle and particle to wall frictional forces become intense with a very rapid pellet turnover. Generally, this condition leads to an uncontrollable, wobbly bed, resulting in severe particle attrition. Large number of fines generated, but some of the attrite particles may agglomerate to form nuclei that are subsequently layered upon. Inert starter seeds and those newly formed nuclei are different and may create content uniformity problems. ➢ ➢ ✓ ✓ ✓ ✓ ✓ Screw-feed extruders: These extruders have screws that rotate along the horizontal axis and hence transport the material horizontally; they may be axial or radial screw extruders. Axial extruders, which have a die plate that is positioned axially, consist of a feeding zone, a compression zone, and an extrusion zone. Radial extruders, the transport zone is short, and the material is extruded radially through screens mounted around the horizontal axis of the screws. Gravity-feed extruders: These extruders include the rotary cylinder and rotary gear extruders, which differ primarily in the design of the two counter-rotating cylinders. In the rotary-cylinder extruder, one of the two counter-rotating cylinders is hollow and perforated, whereas the other cylinder is solid and acts as a pressure roller. In rotary gear extruder, there are two hollow counter-rotating gear cylinders with counter bored holes. Ram extruders: In ram extruders, a piston displaces and forces the material through a die at the end. An increase of the mean pellet weight can be obtained in three different ways: 1) Fines could layer onto the pellets. 2) Pellets could coalesce. 3) Small pellets could abrade to particles fines ▪ ▪ ▪ ▪ ▪ ▪ ▪ ▪ ▪ ▪ ρ