6/19/22, 3:10 PM
Quiz 3_ESC and apoptosis pathways_UTM 2022
NAME :
CLASS :
Quiz 3_ESC and apoptosis pathways_UTM 2022
13 Questions
DATE :
1.
1.What do these descriptions refer to?
*A small subpopulation within the tumor
*Possess similar properties to normal stem cells
*Overexpresses a set of stem cell genes
A
pluripotent stem cells
B
epithelial cells
C
embryonic stem cells
D
cancer stem cells
2.
what is the role of a transcription factor?
A
plays vital role in cellular proliferation,
cellular movement, establishment of cell
polarity & in stem cell maintenance
B
a defined cell population derived from the
inner cell mass of the cleavage-stage
embryo
C
differentiate into any cell lineage of the
body, and their potential for indefinite
self-renewal.
3.
Identify the major role/s of embryonic stem cell signalling pathways.
A
plays vital role in cellular proliferation
C
plays vital role in stem cell maintenance
D
essential for the regulation of gene
expression
B
plays vital role in cellular movement
D
plays vital role in establishment of cell
polarity
4.
The TWO (2) components below have important functions in the_____________signaling
pathway.
*SMO
*PATCH
A
WNT
B
GPCR
C
Notch
D
Hedgehog
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6/19/22, 3:10 PM
5.
Quiz 3_ESC and apoptosis pathways_UTM 2022
The______ and ______ are known as the genetic & epigenetic gatekeepers respectively in the
Wnt-Beta Catenin signaling pathway
A
APC complex
SFRP
B
SFRP
SMO
C
APC complex
SFRP
D
PTCH
APC complex
6.
A
The____________component in the Notch signalling pathway can induce proliferation and
angiogenesis under abnormal condition.
γ -secretase
B
CoRs
D
CSL
C
MAML
7.
Which of these are important components in the Notch signalling pathway?
I) PUMA IV) CSL
II) NICD V) MAML
III) Jag-1 VI) Destruction complex
A
II, III, IV and V
B
All the above
C
I and VI
D
I, II, III, IV and V
8.
What happens here (3rd step)???
A
nuclear collapse
B
lysis of apoptotic bodies
C
chromatin condensation
D
continued blebbing
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6/19/22, 3:10 PM
Quiz 3_ESC and apoptosis pathways_UTM 2022
9.
Highlight the main difference between both the apoptotic pathways
A
Extrinsic pathway: cytochrome C, Caspase
B
9
Intrinsic pathway: cytochrome C, Caspase
9
C
Intrinsic pathway: death receptors,
Caspase 8
Extrinsic pathway: death receptors,
Caspase 8
10.
D
In healthy matured cells, the WNT signaling pathway is turned off. What is/are responsible in
keeping the pathway turned off?
A
β -trCP
B
SFRP
C
β -catenin
D
APC complex
11.
Which of these are anti-apoptotic?
I) Bax II) Bcl-xL III) Bak IV) Bcl-2 V) PUMA
A
II, IV and V
B
I and II
C
II and IV
D
I and III
12.
Which of this/these is/are related to an apoptosome?
A
Cytochrome C
B
APaF1
C
Caspase-8
D
Caspase-9
13.
What happens during the Type IIIa Hedgehog signaling pathway?
A
HH ligand excretion by stromal cells
B
HH ligand excretion by cancer cells
C
HH signaling in cancer cells
D
HH signaling in stromal cells
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6/19/22, 3:10 PM
Quiz 3_ESC and apoptosis pathways_UTM 2022
Answer Key
1. d
2. d
3. a, b, c, d
4. d
5. c
6. c
7. a
8. a, d
9. b, d
10. a, b
11. c
12. a, b, d
13. b, d
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