General Introduction in Medical Parasitology 1st lecture for First year medical students, Faculty of Medicine Presented By Dr. Nawras Mowafy Prof. of Parasitology & Dr. Manal Zaki Prof. of Parasitology Lectures (6): Introduction to parasitology I (Definitions and Terminology) By the end of the lecture the student will be able to : 1. Define the different terms of medical parasitology. 2. State parasitism and host-parasite relationship. 3. List the different types of hosts. 4. List the different types of parasites. 5. Explain host-parasite relationship. Study Resources Garcia, Lynne Shore, and David A. Bruckner. Diagnostic Medical Parasitology. New York: Elsevier, 2016. Websites : for Microbiology, immunology and parasitology Medical Parasitology ❑ Medical Parasitology: A science which deals with the study of parasites that produce harm or disease in humans. ❑ Parasite: A living organism that lives in or upon another organism (host) driving its nutrient directly from this host and causes a certain amount of harm to it. ❑ Host: is an organism that harbours the parasite, provides the nourishment and shelter. Parasite-Host Relationship ❑ Symbiosis: Permanent association of two organisms that cannot exist independently. Both organisms living together get benefit from each other, harm or even death happen to both if they are separated. (e.g.: Flagellates live in the gut of termites. Termites feed on the woods and Flagellates digest cellulose). ❑Mutualism: (Both organisms are benefited ). Both organisms get benefit from each other. Nothing happen to them if they are separated (e.g.: Bacteria flora that form vitamin B complex in human). Parasite-Host Relationship (Cont.) ❑ Commensalism: (Eating at the same table). One organism gets benefit while the other organism is not affected (e.g.: Entamoeba coli in human intestine). ❑ Parasitism: One organism (Parasite) gets benefit and always causes injury to the other (Host) which usually suffers from the association (e.g.: Plasmodium species causing malaria). Types of Parasites 1- Ectoparasite: A type of parasite that lives on outer surface or in the superficial tissues of the host e.g. arthropods (infestation). 2- Endoparasite: This lives within the body of the host e.g. Schistosoma sp. (infection). 3- Obligate parasite: This completely dependent upon its host and can’t live far from this host (e.g.Toxoplasma gondii). 4- Facultative parasite: This can lives both free and parasitic life (e.g. Strongyloides species). Types of Parasites 5- Temporary parasite: This visits the host only at intervals for food (e.g. mosquitoes). 6- Permanent parasite: This lives in or on its host without leaving it (e.g. lice). 7- Erratic parasite (ectopic parasite): This lives in normal host but in abnormal habitat (e.g. Oxyuris in vagina & Ascaris in bile duct). Types of Parasites 8- Incidental parasite: This can establish itself in a host in which it doesn't ordinarily live (e.g. D. caninum & H. diminuta in man). 9- Accidental parasite: This inhabits an unusual host and its life cycle is expected to be incomplete within that host [e.g.Toxocara canis (a dog parasite) in man]. 10- Opportunistic parasite: This produces disease in Immunodeficient or immunocompromised patients (like AIDS and cancer patients) (e.g. Toxoplasma gondii , Strongyloides stercoralis). Types of Parasites 11- Pseudo parasite: An artifact mistaken for a parasite. 12- Coprozoic (spurious) parasite: A free-living or non-human parasite passing through the alimentary tract without infecting man, or contaminating his stool after being passed. 13- Zoonotic parasite: It is an animal parasite that is transmitted to man & producing infection. Type of Hosts 1- Definitive or Final host {D.H.}: A host that harbours the adult stages in case of helminth parasites (e.g. man in Schistosoma) or the sexual stages in case of protozoal parasites (e.g. mosquitoes in Plasmodium ). 2- Intermediate host {I.H.}: A host that harbours the larval stage of helminthes (e.g. snails in case of Schistosoma) or the asexual stage of protozoan parasite (e.g. man in Plasmodium). Type of Hosts 3- Reservoir host {R.H.}: An animal that harbours the adult parasite and acts as an important source of infection to man (e.g. cats and dogs in Heterophyes heterophyes). 4- Transport host (Paratenic host): A host that acts as a transport vehicle only (no development place to domestica). the or multiplication parasite) (e.g. takes Musca Type of Hosts (Cont.) 5- Vector: Is usually an arthropod that transmits the parasite to its host. •It can be a definitive host e.g. Female Anopheles in case of Plasmodium Or * Intermediate host (Female Culex in case of Wuchereria bancrofti. Habitat The habitat is where the parasite lives and multiplies in the body of the definitive or intermediate host, like: ▪ Small intestine ▪ Large intestine ▪ Blood vessels ▪ Organs; liver, lung, heart, brain, ….. ▪ Muscles ▪ Lymphatics ▪ Reticuloendothelial system ▪ Cells as red blood cells Nomenclature of parasites BINOMINAL SYSTEM OF NOMENCLATURE Genus + species e.g.: Ascaris lumbricoides (italics) Ascaris lumbricoides (underlined) - Genus scientific name starts with a capital letter and species name with small letter. -Binominal scientific names are written in italics or underlined. Medical Parasitology includes the study of 3 major groups of parasites. These groups are Protozoa ☺ One-celled organisms Helminths ➢ ➢ Worms: Trematodes ➢ Cestodes ➢ Nematodes Arthropods ☺ ☺ insects