ORIGINAL ARTICLE Poor Work–Life Balance May Lead to Impaired Cognitive Function in Bus Drivers Dong-Wook Lee, MD, Yun-Chul Hong, PhD, Hwo-yeon Seo, MD, Sung-joon Cho, PhD, Soo-hyun Nam, MSc, Cham-Jin Park, MD, and Nami Lee, PhD Downloaded from https://journals.lww.com/joem by BhDMf5ePHKav1zEoum1tQfN4a+kJLhEZgbsIHo4XMi0hCywCX1AWnYQp/IlQrHD3vZhfaAjmmeMVghJEHvmwdMapeoDn+9R9ELHyRa3fnA2GAfX3OeZdfg== on 08/07/2020 Objective: This study aimed to investigate how work–life balance (WLB) corresponds to cognitive functions and which mental health conditions play a mediating role in this association among Korean bus drivers. Methods: The cognitive failures questionnaire (CFQ) was administered to 347 bus drivers in Seoul, Korea. The differences in the CFQ and WLB scores were examined by analysis of covariance, and a structural equation model (SEM) was constructed for investigating the mediating role of mental health indices between WLB and CFQ scores. Results: Compared with the highest subjective work–life balance group, the lowest group had significantly higher CFQ scores. In the SEM, anxiety was a mediating variable between subjective work–life balance and CFQ scores. Conclusions: Work–life balance is associated with cognitive failures among Korean bus drivers, and anxiety was a key mediating mental health indicator. Keywords: anxiety, cognitive function, mental health, professional drivers, work–life balance W ork–life balance (WLB) has been defined as ‘‘an individual’s ability to meet their work and family commitments, as well as other non-work responsibilities and activities.’’1 This concept encompasses a balance between family, community, work, and one’s own private life.2 WLB is the subjective perception that work and nonwork activities are compatible and harmonious according to one’s life priorities.3 It has been found that a poor WLB is negatively associated with job satisfaction and life satisfaction.4,5 Recently, several studies have reported that WLB is associated with sleep disturbances or disorders, depressive mood, sickness absence, substance abuse, and subjective health-related symptoms.6– 9 All these negative physical and psychological health outcomes could affect job performance. From the Department of Preventive Medicine, College of Medicine, Seoul National University, Seoul, Republic of Korea (Dr Lee, Dr Hong, and Dr Park); Public Health Medical Service, Seoul National University Hospital, Seoul, Republic of Korea (Dr Seo); Department of Psychiatry, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea (Dr Cho); Human Rights Center, Seoul National University Hospital, Seoul, Republic of Korea (Ms Nam and Dr Lee); and Department of Psychiatry, Seoul National University Hospital, Seoul, Republic of Korea (Dr Lee). Ethical approval: This study was approved by the Institutional Review Board (IRB) of the Seoul National University Hospital (IRB No. C-1803-077-930). This study was supported by donation funds of Seoul national university hospital from Soo-Bum Lee. The authors report no conflicts of interest. Informed consent: Informed consent was obtained from all individual participants included in the study. Clinical significance: Our study found that subjective work–life balance is associated with cognitive function measured by using cognitive failures questionnaire. We suggest that improving work–life balance among bus drivers would be an effective way to decrease traffic accidents related to cognitive function. Supplemental digital contents are available for this article. Direct URL citation appears in the printed text and is provided in the HTML and PDF versions of this article on the journal’s Web site (www.joem.org). Address correspondence to: Nami Lee, PhD, Department of Psychiatry, Seoul National University Hospital, Daehak-ro 103, Chongno-gu, Seoul 03080, Republic of Korea (nami6107@naver.com). Copyright ß 2019 American College of Occupational and Environmental Medicine DOI: 10.1097/JOM.0000000000001675 e406 Professional bus drivers have unique job requirements, which include transporting a number of unspecified persons and driving longer distances and for longer hours than other professional drivers do. These unique characteristics make them more vulnerable to accidents at work than other professions.10 In the United States, 69,000 bus accidents occurred in 2016, and 225 cases were fatal.11 In Korea, 20,074 fatal and nonfatal traffic accidents caused by professional bus drivers occurred in 2017, usually accompanied by passenger injury. Although efforts to improve vehicles and safety devices are necessary, more attention needs to be given to the drivers because 70% of traffic accidents are attributed to cognitive failures.12 Cognitive failures are defined as failures in perception, memory, and motor functioning in which the action does not match the intention, and are known as the most frequent cause of industrial accidents.13,14 In 2018, the Korean government introduced a 52-hour workweek rule to enhance the well-being of workers and ensure safer working conditions, which seemed essential to lessen traffic accidents and prevent road rage or violence against passengers. However, in 2019, trade unions including over 41,000 bus drivers threatened to go on strike for their income loss caused by decreased working hours.15 For bus drivers in Korea, sufficient income to support their family may be more strongly required than working less and having more private time for their WLB. Without consensus on the importance and consequence of WLB, public strategies and efforts aimed at improving the working conditions and health of ordinary workers may prove futile. In view of making the workplace safe for workers, we focused on WLB as an important factor affecting workers’ performance, especially regarding accident prevention. By focusing on WLB, we specifically sought to elucidate the relationship between professional bus drivers’ subjective well-being and safety at work. A decreased WLB has been reported as a factor accounting for the decreased performance of workers.16,17 Recently, it was reported that WLB is associated with cognitive function and driving behavior, which may be strongly related to accident-proneness in professional drivers.18 The WLB of professional drivers has been suggested as an important condition for the prevention of sickness and accidents.19 Although WLB is known to be associated with some medical and psychological conditions, which are known as plausible factors in traffic accidents, it has not been studied whether and how professional bus drivers’ WLB is associated with their cognitive function regarding accident prevention. We hypothesized that an impaired WLB causes increased cognitive errors due to anxiety, depression, sleep disorders, and substance abuse. Considering the abovementioned hypothesis, we performed a survey among professional drivers to investigate (1) the association between WLB and cognitive function measured by the cognitive failures questionnaire (CFQ), (2) the association between WLB and mental health indices, and (3) the possible pathway for the effects of WLB on cognitive functions via mental health. METHODS Study Population The target population was 16,753 city bus drivers belonging to 68 companies in Seoul, South Korea, who were members of the JOEM Volume 61, Number 10, October 2019 Copyright © 2019 American College of Occupational and Environmental Medicine. Unauthorized reproduction of this article is prohibited JOEM Volume 61, Number 10, October 2019 Work–Life Balance and Cognitive Failures labor union of bus drivers in Seoul. City bus companies in Seoul are administrated by the city transportation office of the Seoul metropolitan government, who oversee the working hours and shift patterns of bus drivers and routes of city bus lanes. Therefore, the target population, city bus drivers in Seoul, had similar weekly working hours up to 52 hours and two shifts (morning time, 8 hours between 05:00 and 15:00; afternoon time, 8 hours between 15:00 and 01:00). Distances of city bus lanes are quite different from each other, but are controlled in the range of 2 to 4 hours. With the cooperation of the labor union, we recruited participants from 38 companies from July 13 to 18, 2018. We sampled 10 participants per company whose schedules enabled them to participate in the survey. The participants voluntarily filled out a self-administered questionnaire after reading the information about the survey. Of the 377 bus drivers who participated in the study, those with incomplete answers for WLB, cognitive, or mental health indices, as well as those with missing information regarding age, sex, marital status, height, weight, smoking status, alcohol consumption, or exercise, were excluded. The final sample size used in the study was 347. This study was approved by the Institutional Review Board of the Seoul National University Hospital (IRB No. C-1803-077-930). problems with daytime functioning, noticeability of sleep problems by others, and distress caused by sleep difficulties. Those with ISI scores of 15 or higher can be classified as having insomnia.27 The Korean version of the ISI has been assessed for reliability and validity.28 The Korean version of the Alcohol Use Disorder Identification Test (AUDIT-K) was used to assess the severity of alcohol use, and problematic drinking was classified as an AUDIT-K score of 12 or above.29,30 Work–Life Balance The mean values and standard deviations of subjective WLB and CFQ scores were calculated according to sex, age (<40, 40 to 49, 50 to 59, and 60 years), years of bus driving experience (<10, 10 to 19, 20 to 29, and 30 years), BMI (<25 and 25), education (elementary school or below, middle school, high school, and college or above), household income (USD1300 to 2800; USD2801 to 4200; USD4201 to 6400; and USD >6400 per month), marital status (married, separated, widowed, divorced, and single), smoking status, and disease status (hypertension, diabetes, dyslipidemia, coronary heart disease, stroke, depression, and sleep disorders). We used Student t tests and analysis of variance (ANOVA) to compare the differences in WLB and CFQ scores according to demographic variables. Next, we calculated the mean and standard deviation of the CFQ scores according to quartiles of subjective WLB scores and quartiles of work–time control. Subsequently, we performed analysis of variance with covariance (ANCOVA) to compare the differences in CFQ scores after adjusting for age,sex, years of bus driving experience, and diagnosed diseases. Covariates were identified based on a review of a recent investigation of factors related to CFQ scores in industry employees.31 Next, we calculated the mean values of scores on the subjective assessment of WLB and the CFQ according to mental health indices. ANCOVA was performed to evaluate the relationship of CFQ and subjective WLB scores according to mental health indices, with adjustment for age, sex, years of bus driving experience, and diagnosed diseases. After exploring the associations between WLB, mental health concerns, and cognitive failures, we used structural equation modeling (SEM) to investigate the direct effects of the subjective assessment of WLB on cognitive failures and the indirect effects of subjective WLB on cognitive failures in relation to the mental health indices. SEM is a multivariate statistical analysis tool for estimating the relationships among multiple variables simultaneously, in a single analysis. Statistical analyses were performed using SAS PROC TTEST, SAS PROC ANOVA, and SAS PROC GLM procedures (Version 9.4; SAS Institute Inc., Cary, NC), and SPSS AMOS (Version 25.0; IBM, SPSS Inc., Chicago, IL). Statistical significance was defined as two-sided P 0.05. WLB was evaluated by the following sentence: ‘‘Please rate the current state of your WLB from 0 to 100.’’ We measured work– time control using a six-item scale developed by Ala-Mursula et al,20 which was a modification of a standard survey instrument of Statistics Finland. The participants were asked to indicate their control over the following factors of their working schedules: (1) the start and end times of a workday, (2) taking breaks during a workday, (3) opportunity for handling private matters during a workday, (4) scheduling of shift work, (5) scheduling of vacations and paid days off, and (6) the taking of unpaid leave. The responses were measured on a 10-point scale between 1 (cannot control at all) and 10 (completely control), and the mean of the six items was used in the analysis. Cognitive Failures Questionnaire The CFQ is a self-administered questionnaire for measuring the degree of usual cognitive errors in daily life.13 The CFQ consists of 25 items that assess perception, memory, and motor lapses in daily life. CFQ items are answered on a five-point Likert scale of 0 (never) to 4 (very often), and the maximum score is 100.13,21 The reliability and the validity of the Korean version of the CFQ have been established.22 Mental Health Indices The Patient Health Questionnaire (PHQ-9) was used to measure depression. The PHQ-9 was developed as a diagnostic, self-report tool for identifying depression, based on the criteria for diagnosing depression from the 4th edition of the American Psychiatric Association’s Diagnostic and Statistical Manual of Mental Disorders. The Korean version of the PHQ-9 has been validated, and the optimal cutoff for screening for depressive disorders in Korea was suggested as a score of 5.23,24 The Beck Anxiety Inventory (BAI) consists of a 21-item questionnaire to measure the severity of anxiety symptoms. Responses are rated on a four-point (0 to 3) Likert scale, and scores can range from 0 to 63. Participants who score 10 or higher are classified as having more than minimal anxiety.25 The Korean translated version of the BAI has been validated.26 The Insomnia Severity Index (ISI), a self-report tool designed to assess the severity of insomnia, is composed of seven items, each scored on a five-point Likert scale. ISI measures the severity of problems with sleep onset, sleep maintenance, and early morning awakening, as well as sleep dissatisfaction, interference of sleep ß Other Variables Demographic variables including age, sex, education, household income, marital status, and years of bus driving experience were obtained. Anthropometric information (height in centimeters and weight in kilograms), current smoking status, and medical history (hypertension, diabetes, dyslipidemia, coronary heart disease, stroke, depression, and/or sleep disorders diagnosed by a physician) were collected through self-reported questionnaires. We calculated body mass index (BMI) based on the participants’ self-reported values. Statistical Analysis RESULTS Table 1 lists the characteristics of the study population. The mean WLB scores were significantly different according to years of bus driving experience (P ¼ 0.013) and current smoking status (P ¼ 0.006). The mean CFQ score was 18.1 (10.8), and differences 2019 American College of Occupational and Environmental Medicine e407 Copyright © 2019 American College of Occupational and Environmental Medicine. Unauthorized reproduction of this article is prohibited JOEM Volume 61, Number 10, October 2019 Lee et al TABLE 1. Characteristics and Cognitive Failures Questionnaire Scores of the Participants Subjective Work–Life Balance (0 – 100) Total Sex Male Female Age, y <40 40–49 50–59 60 Years of bus driving experience, y <10 10–19 20–29 30 BMI, kg/m2 <25 25 Education Elementary school Middle school High school College Household income (USD) 1333–2766 2767–4198 4199–6436 >6436 Civil status Married Separated Widowed Divorced Single Current smoking No Yes Hypertension Yes No Diabetes Yes No Dyslipidemia Yes No Coronary heart disease Yes No Stroke Yes No Depression Yes No Sleep disorders Yes No CFQ n (%) [or Mean SD] Mean SD 347 (100.0) 71.4 15.6 331 (95.4) 16 (4.6) 52.0 6.2 5 (1.4) 125 (36.0) 184 (53.0) 33 (9.5) 15.9 7.3 74 (21.3) 171 (49.3) 87 (25.1) 15 (4.3) 24.7 2.8 206 (59.4) 141 (40.6) 71.4 15.6 70.9 14.9 0.906 18.1 10.9 16.8 10.7 0.620 68.0 22.8 69.6 15.6 72.2 14.9 74.4 17.6 0.298 18.6 16.7 17.3 11.4 18.6 9.8 17.8 13.4 0.800 72.9 16.4 73.2 14.2 66.7 16.4 70.9 17.0 0.013 17.6 11.0 18.0 11.1 19.5 9.8 13.1 12.0 0.188 70.6 15.6 72.5 15.5 0.269 17.6 10.7 18.8 11.1 0.317 7 44 252 44 (2.0) (12.7) (72.6) (12.7) 75.7 23.2 70.0 16.2 70.9 15.4 75.0 14.4 0.307 12.3 11.3 17.8 11.9 18.1 10.6 19.2 10.9 0.474 99 164 78 6 (28.5) (47.3) (22.5) (1.7) 73.4 14.3 70.3 16.1 70.7 16.0 77.5 14.1 0.305 17.4 11.4 17.6 10.8 20.3 10.2 13.3 8.1 0.151 295 9 4 24 15 (85.0) (2.6) (1.2) (6.9) (4.3) 71.5 15.8 66.1 16.5 72.5 15.0 71.8 15.6 71.0 11.8 0.786 18.0 13.6 17.7 10.5 24.3 15.6 35.5 18.8 17.3 7.5 0.003 237 (68.3) 110 (31.7) 72.9 14.5 68.1 17.3 0.006 17.6 10.8 19.1 10.9 0.248 95 (27.4) 252 (72.6) 70.7 17.1 71.6 15.0 0.623 16.7 9.5 18.6 11.3 0.058 25 (7.2) 322 (92.8) 73.7 14.4 71.2 15.7 0.437 19.3 11.7 18.0 10.8 0.592 61 (17.6) 286 (82.4) 69.0 17.1 71.9 15.2 0.179 17.2 8.9 18.3 11.2 0.491 5 (1.4) 342 (98.6) 78.0 11.0 71.3 15.6 0.339 14.0 11.7 18.1 10.8 — 2 (0.6) 345 (99.4) 70.0 14.1 71.4 15.6 0.900 7.5 0.7 18.1 10.8 — 1 (0.3) 346 (99.7) 90.0 71.3 15.6 48 18.0 10.7 — 10 (2.9) 337 (97.1) 67.5 14.4 71.5 15.6 P Mean SD P 18.1 10.8 0.424 23.9 12.1 17.9 10.8 0.084 Significant P values (0.05) are in bold. CFQ, cognitive failures questionnaire. in CFQ scores were significant according to smoking status (P ¼ 0.024) and marital status (P ¼ 0.003). Table 2 shows the indices for WLB of the study population. Differences in CFQ scores were significant only with respect to the subjective scores of WLB and were not significantly influenced by e408 ß weekly working hours or work–time control. Compared with the lowest quartile of subjective WLB scores, the third (P ¼ 0.004) and fourth quartiles ( P < 0.001) showed significantly lower CFQ scores after adjusting for age, sex, years of bus driving experience, and diagnosed disease status. 2019 American College of Occupational and Environmental Medicine Copyright © 2019 American College of Occupational and Environmental Medicine. Unauthorized reproduction of this article is prohibited JOEM Volume 61, Number 10, October 2019 Work–Life Balance and Cognitive Failures TABLE 2. Indices for Work–Life Balance and Cognitive Failures Questionnaire Scores of the Participants CFQ n (%) [or Mean SD] Subjective work–life balance Q1 (20–60) Q2 (63–70) Q3 (73–80) Q4 (85–100) Weekly working hours Q1 (40.0–49.5) Q2 (50.0–51.0) Q3 (52.0–55.0) Q4 (56.0–80.0) Work-time control Q1 (1.0–1.7) Q2 (1.8–2.7) Q3 (2.8–4.2) Q4 (4.3–9.3) 71.4 15.6 97 (28.0) 84 (24.2) 97 (28.0) 69 (19.9) 52.4 7.1 77 (22.2) 77 (22.2) 109 (31.4) 84 (24.2) 3.2 1.7 82 (23.6) 94 (27.1) 84 (24.2) 87 (25.1) Mean SD P 20.9 9.6 18.8 12.0 16.4 11.0 15.6 9.9 (Ref.) 0.154 0.004 <0.001 16.1 9.2 18.8 12.5 18.6 11.5 18.5 9.6 (Ref) 0.083 0.103 0.116 17.9 10.6 16.8 10.1 19.6 10.1 18.1 12.4 (Ref) 0.603 0.255 0.858 Significant P values (0.05) are in bold. Results of the analysis of covariance with covariates (ANCOVA) adjusting for age, sex, working duration, diagnosed disease status (eg, hypertension, diabetes, dyslipidemia, coronary vessel disease, stroke, depression, and sleep disorders). CFQ, cognitive failures questionnaire; Ref., reference; SD, standard deviation. The results of the subjective WLB scores and differences in CFQ scores according to the mental health indices are given in Table 3. Depressive status, anxiety, insomnia, and alcohol use disorder were significantly associated with higher CFQ scores. These mental health indices were also significantly associated with poorer subjective assessment of WLB. Finally, SEM analysis was performed to investigate how subjective assessment of WLB and work–time control are associated with cognitive failures (Fig. 1). In this model, mild depressive status (PHQ-9 5), mild anxiety status (BAI 10), insomnia (ISI 15), and problematic drinking (AUDIT-K 12) were considered as potential mediating variables in the association between WLB and cognitive failures. The results showed good model fit with a comparative fit index of 0.998 and a root mean square error of approximation of 0.22. The indirect effects of WLB were significant, but the direct effects were not significant (b ¼ –0.037, P ¼ 0.835). WLB was significantly and negatively associated with depression (b ¼ –0.011, P < 0.001), anxiety (b ¼ –0.006, P < 0.001), insomnia (b ¼ –0.007, P < 0.001), and alcohol use disorder (b ¼ –0.002, P < 0.001). In this model, among the mental health indices, only anxiety had significant indirect effects in the association between WLB and CFQ scores (b ¼ 8.914, P ¼ 0.004). We carried out sensitivity analyses after excluding widowed or divorced participants, as they displayed significantly higher CFQ scores than married, separated, or single participants, but the results were robust and concurrent with the main analyses (Supplementary Tables 1 to 2, http://links.lww.com/JOM/A592 and Supplementary Figure 1, http://links.lww.com/JOM/A592). The SEM analysis results were also robust, as anxiety had significant indirect effects with respect to WLB and CFQ scores (b ¼ 9.274, P ¼ 0.002). DISCUSSION Self-reported poor WLB of professional bus drivers suggests that the participants subjectively feel their lives are not sufficiently TABLE 3. Mental Health Indices, Cognitive Failures Questionnaire Scores, and Subjective Work–Life Balance of the Participants CFQ n (%) Depression (PHQ-9) <5 232 (66.9) 5 115 (33.1) Anxiety (BAI) <10 282 (81.3) 10 65 (18.7) Insomnia (ISI) <15 189 (54.5) 15 158 (45.5) Alcohol use disorder (AUDIT-K) <12 77 (22.2) 12 270 (77.8) Subjective Work–Life Balance Mean SD P Mean SD P 14.7 9.0 24.8 11.1 <0.001 75.3 13.6 63.5 16.2 <0.001 15.6 9.0 28.9 11.4 <0.001 73.0 15.1 64.5 15.7 <0.001 15.1 10.5 21.6 10.2 <0.001 75.3 14.4 66.7 15.7 <0.001 15.5 11.6 18.8 10.5 0.014 75.1 14.8 70.3 15.6 0.036 Significant P values (0.05) are in bold. Results of the analysis of covariance with covariates (ANCOVA) adjusting for age, sex, working duration, diagnosed disease status (eg, hypertension, diabetes, dyslipidemia, coronary vessel disease, stroke, depression, and sleep disorders). AUDIT-K, Korean version of the Alcohol Use Disorders Identification Test; BAI, Beck Anxiety Inventory; CFQ, cognitive failures questionnaire; ISI, Insomnia severity index; PHQ-9, Patient Health Questionnaire; SD, standard deviation. ß 2019 American College of Occupational and Environmental Medicine e409 Copyright © 2019 American College of Occupational and Environmental Medicine. Unauthorized reproduction of this article is prohibited JOEM Volume 61, Number 10, October 2019 Lee et al FIGURE 1. Structural equation model of work-life balance, cognitive failures, and mental health indices. AUDIT-K, Korean version of the Alcohol Use Disorders Identification Test; AUDIT-K, the Korean version of the alcohol use disorders identification test; BAI, Beck Anxiety Inventory; BAI, Beck anxiety inventory; ISI, Insomnia Severity Index; ISI, Insomnia severity index; PHQ-9, Patient Health Questionnaire. stable, secure, and healthy, due to the loss of balance between work and life. We found associations among WLB, depression, anxiety, insomnia, alcohol use disorder, and cognitive failures in professional bus drivers. After adjusting for possible confounding variables, higher subjective WLB scores were significantly associated with lower cognitive failures in bus drivers. We also found that anxiety is a key mediating factor in the relationship between WLB and cognitive failures. To the best of our knowledge, this is the first study of the relationship between WLB and cognitive function among bus drivers. Cognitive failures, as the major cause of driver errors and violations, could result in serious damage to passengers and pedestrians.32 In their meta-analysis, Arthur et al reported cognitive ability as one of the predictors of driving accidents.33 Larson et al studied 159 male Navy recruits in the United States and reported that participants who had experienced causing a traffic accident had significantly higher CFQ scores than participants who had not.34 A study with 160 Iranian professional drivers reported that total CFQ scores were strongly associated with driving errors.35 Previous studies support that low CFQ scores, associated with poor subjective WLB, are potential risk factors for driving accidents caused by professional bus drivers. Neurologically, chronic stress-related conditions, ‘‘allostatic load,’’ could induce structural remodeling of areas of the brain that are important for cognitive function, including the hippocampus, the amygdala, and the prefrontal cortex.36 With anxiety symptoms, the insula cortex and the right amygdala are activated, and the posterior cingulate cortex is deactivated.37 Anxiety influences the processing of the stimulus-driven attentional system and goal-directed attention; therefore, healthy cognitive function supported by goaldirected attention cannot be well sustained. Without compensatory strategies, such as enhanced effort, anxiety impairs performance effectiveness.38 Epidemiologic studies also reported that anxiety or worry has negative effects on processing efficiency for high-attentional or short-term memory demands by causing deficits in the storage and processing capacities of the working memory system.39 Anxious patients show poorly regulated attention mechanisms, inhibited performance on attentional tasks, and poor ability to utilize attentional resources.40 In this context, anxiety could play an important role regarding accident-proneness. We also found that poor WLB was associated with the onset of depression, anxiety, insomnia, and alcohol use disorders in our e410 ß sample. For testing our hypothesis, which is related to WLB, cognitive function, and mental health, we selected four disease entities that are most prevalent and significantly impair common people’s competencies. We excluded other serious psychotic and organic brain diseases that are rarely found among regularly working populations. We found that poor WLB was positively associated with depression, anxiety, insomnia, and alcohol use disorders in our sample, which confirms the findings of previous studies on the relation between WLB and mental health indices. Such findings are compatible with the studies on the similar topics of other workers. Among US nurses, work–family conflict is significantly associated with depressive symptoms.41 A cohort study with a representative national sample of 2700 employed adults in the United States reported that work–family conflict is a risk factor for mood, anxiety, and substance dependence disorders.42 Another longitudinal study revealed that improvements in work–family conflict are associated with improved mental health.43 Although several studies have reported the association between WLB and patterns of safety behaviors,19,44 to our knowledge, it was not yet reported that subjective WLB itself was directly or indirectly (or both) associated with CFQ scores in relation to driving accidents. It is important to improve professional bus drivers’ WLB, which will help to prevent traffic incidents and improve the safety of transportation services. The result that anxiety is a key mediating factor between WLB and cognitive failures implies that job-stress intervention and counseling programs in the workplace to ameliorate anxiety, one of the important target symptoms, would be beneficial for preventing traffic accidents caused by bus drivers, and better service for passengers.45 Providing a psychological buffer for workers facing the dilemma between work and life commitments and lessening anxiety will be an important goal for the workplace health promotion program.46 In addition, in our study, bus drivers who smoke reported significantly lower WLB. These results suggest that promoting a smoking cessation program in the workplace could be beneficial to the WLB of bus drivers, as it has positive effects on anxiety symptoms.47 Moreover, the anxiety treatment process may be helpful to the smoking cessation process, especially for professional bus drivers. Our study has several strengths. First, to our knowledge, it is the first to investigate the association between WLB and cognitive failures in bus drivers. Second, we used validated tools to assess cognitive function in daily life (CFQ) and mental health (PHQ-9, 2019 American College of Occupational and Environmental Medicine Copyright © 2019 American College of Occupational and Environmental Medicine. Unauthorized reproduction of this article is prohibited JOEM Volume 61, Number 10, October 2019 BAI, ISI, and AUDIT-K) which offer stronger sensitivity and specificity than nonvalidated methods regarding the relation among cognition, anxiety, and other mental illness. Third, the complete survey response rate was as high as 91.3%. Both high response rate and high complete response rate help ensure minimal selection bias, as it suggests that few respondents were reluctant to finish the survey due to a specific or consistent reason. Our study has several limitations that need to be considered in the interpretation of our findings. First, we chose only one question for the subjective evaluation of WLB because grading a subjective feeling is an important index. Although WLB of an individual cannot be evaluated without considering an individual’s subjective outlook on his/her life, well-validated and widely used tools for measuring WLB will be necessary for further quantitative analysis. Second, we did not explore the specific determinants for subjective WLB. In the future, the relationship between work–family conflict and cognitive failure needs to be examined using a multidimensional measure of work–family conflict.48 Third, our study was designed as a cross-sectional study; thus, we could not conclude the directions of causality of the relationships between subjective WLB, mental health, and cognitive failures. As we have discussed, mental health indices and CFQ scores are closely correlated, and WLB may also be closely associated with mental health indices. Although the SEM results showed the best-fit results for our data, reverse causation should be considered in our cross-sectional study. Fourth, we targeted bus drivers in a metropolitan city; therefore, it is difficult to generalize our results to bus drivers in other areas, such as smaller cities or the countryside or other countries. Finally, the issue of the sex-related medical issues in work–life conflicts were not addressed because the sex ratio of the study participants was highly uneven, as most Korean bus drivers are male, although the sex difference in perceiving and experiencing WLB and mental disorders are significantly different.49 CONCLUSIONS We found associations between the WLB, mental health indices, and cognitive failures of Korean bus drivers. 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