ORIGINAL ARTICLE Single-Screw Fixation Compared With Double Screw Fixation for Treatment of Medial Malleolar Fractures: A Prospective Randomized Trial Richard Buckley, MD, FRCSC,* Ernest Kwek, MBBS, FRCS, FAMS,† Paul Duffy, MD, FRCSC,* Robert Korley, MD, FRCSC,* Shannon Puloski, MD, FRCSC,* Andrew Buckley, BSc,* Ryan Martin, MD, FRCSC,* Emilia Rydberg Moller, MD,‡ and Prism Schneider, MD, FRCSC, PhD* Objectives: To determine whether single or double screw (DS) Downloaded from http://journals.lww.com/jorthotrauma by BhDMf5ePHKbH4TTImqenVBhf5K8zlU/3e4mQYkz4H4uvGcPZI6MefqDnks9SF51J on 11/05/2018 fixation of medial malleolar fractures results in better long-term health outcomes. Key Words: ankle, fracture, trauma, randomized controlled trial, medial malleolus, fixation Level of Evidence: Therapeutic Level I. See Instructions for Authors for a complete description of levels of evidence. Design: Randomized clinical trial; sealed envelope technique. Setting: Level 1 Trauma Hospital at University of Calgary, Canada. Patients: One hundred forty patients were randomized to receive (J Orthop Trauma 2018;32:548–553) INTRODUCTION Accepted for publication July 17, 2018. From the *Section of Orthopedics, Department of Surgery, University of Calgary, Calgary, AB, Canada; †Department of Orthopedic Surgery, Tan Tock Seng Hospital, Singapore; and ‡Department of Orthopedics and Trauma, Sahlgrenska University Hospital, Gothenberg, Sweden. The authors report no conflict of interest. Presented at the Annual Meeting of the Orthopaedic Trauma Association, October 13, 2017, Vancouver, Canada. Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal’s Web site (www.jorthotrauma.com). Reprints: Richard Buckley, MD, FRCSC, 3134 Hospital Dr NW, 0490 McCaig Tower, Calgary, AB, Canada T2N 5A1 (e-mail: buckclin@ ucalgary.ca). Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved. DOI: 10.1097/BOT.0000000000001311 Ankle fractures are among the most common skeletal injuries treated by orthopaedic surgeons, with an annual incidence of 187 per 100,000 in the general population.1 The mechanism of injury for malleolar fractures in young patients is typically high-energy trauma such as motor vehicle collisions or falls from height, whereas elderly patients suffer similar injuries, often with comorbidities, from low-energy trauma.2 Open reduction and internal fixation is recommended for unstable bimalleolar and trimalleolar fractures.3 Isolated medial malleolar fractures are less common, but surgery is also indicated in significantly displaced fractures with joint incongruence.4 Several techniques have been described for surgical fixation of medial malleolar fractures, including lag screws, tension band wiring, K-wiring, bioabsorbable implants, and buttress plating.1,5,6 Recent research has shown the effectiveness of tension band/k-wire fixation,7 however, screw fixation remains the most popular and reliable fixation method. A common technique uses 4.0-mm partially threaded cancellous lag screws placed perpendicular to the fracture line,8 whereas a recent research study indicates that 30-mm partially threaded screws or 45-mm fully threaded screws may provide more optimal fracture compression when placed at the physeal scar.9 Traditional teaching is to use two 4.0-mm screws instead of 1 for medial malleolar fixation to ensure rotational control. However, the medial malleolus usually fails in tension or compression, and it is questionable if significant torsional forces exist, which might require 2 screws for stable fixation.5,9 Although the results of operative stabilization of ankle fractures are generally good, patient dissatisfaction can result from implant-related pain.10 On the medial aspect of the ankle, malleolar screws can cause irritation of the posterior tibialis tendon or other soft-tissue irritation or bony impingement. A previous study has suggested that screws placed posterior to the anterior colliculus have the potential to cause posterior tibialis tendon irritation.11 Two previous studies have evaluated this subject with inconclusive results.12,13 548 J Orthop Trauma Volume 32, Number 11, November 2018 either 1 or 2 screws to reduce a medial malleolar fracture. Thirteen patients were excluded because of loss to follow-up (n = 127). Intervention: Surgical fixation of the medial malleolar fracture was performed using 1 or 2 stainless steel screws. Main Outcome Measurements: Primary outcome was comparison of physical functioning summary score on Short Form 36 questionnaires between patients in the 2 groups. Secondary objectives were to compare the Ankle Hindfoot Scale and operating room time. Clinical and radiographic assessment occurred at the time of injury and 2, 6 weeks, 3, 6, 12, and 24 months postoperatively. Results: Fourteen patients crossed over from the DS group to the single screw (SS) group based on intraoperative decisions by the surgeon (fragment too small for 2 screws), leaving the SS (n = 75) and DS groups (n = 52). There was no difference in the operating room time, SF36, or Ankle Hindfoot Scale at all follow-up time points. Conclusions: SS medial malleolar fixation provides an equally safe and effective method of fracture care as compared to DS fixation. Twenty percent of patients receiving 2 screws can be expected to crossover to receive SS fixation as a safer alternative. | www.jorthotrauma.com Copyright Ó 2018 Wolters Kluwer Health, Inc. Unauthorized reproduction of this article is prohibited. J Orthop Trauma Volume 32, Number 11, November 2018 Single Screw Fixation The incidence of implant-related complications may potentially be reduced by single-screw (SS) fixation without sacrificing joint stability. The primary goal of this study was to compare the longterm functional outcomes in 2 randomized groups after either single- or double-screw (DS) fixation of medial malleolar fractures. Secondary objectives were to compare re-operation rates between groups, rates of malunion and non-union, and time to union and complications such as implant-related pain and loss of fixation. classification method found that medial malleolus fractures could be classified with moderate interobserver reliability.16 The soft-tissue damage was described using the Tscherne classification.14 No Herscovici Type-A fractures were included in this study, and all medial malleolar fractures were randomized even if they were an anterior collicular fracture. Preoperative antibiotics were administered before skin incision (cefazolin 1 gm IV or equivalent). Operative intervention included open reduction and internal fixation of the lateral and posterior malleolar fractures as deemed necessary, with or without syndesmotic screw fixation. For the medial malleolus, a medial incision was performed. Direct visualization and reduction of the fracture fragments was achieved before the insertion of the lag screws. One or two 4.0-mm partially threaded cancellous screws were placed perpendicular to the fracture line. If an SS was used, it was placed in the center of the fragment or slightly more anterior (without the use of an antirotation wire). If 2 screws were used, an attempt was made to place them parallelly and equally spaced along the width of the fragment. The length of the unicortical screws (25–50 mm) and the use of a washer for the screws were at the discretion of the operating surgeon. After surgical intervention, application of a splint was performed, followed by a removable cast for the period of 2–6 weeks to allow early mobilization and protected weightbearing. Rehabilitation instructions and ankle mobilization exercises were provided to ensure standardized treatment. Weight-bearing was permitted based on the stability of the fracture and fixation. Patients in the 2 groups were monitored in an equivalent fashion. Critical aspects of postfracture care and rehabilitation were controlled. Clinical and radiographic assessments were performed at surgical consultation at the time of fracture, at 2, 6 weeks, 3, 6, 12, and 24 months posttreatment. We followed functional outcome results at enrollment, 6, 12, and 24 months after enrollment using outcome questionnaire Short Form 36 (SF-36) and ankle visual analog score. The SF-36 is a widely used generic measure assessing both the mental and physical aspect of a person’s well-being; 36 questions divided into 8 categories are answered.17 For this study, we focused on comparing the category of general health. Results for a joint specific outcome measure were similarly compared. The Ankle and Hindfoot Scale (AHS) produced by the American Orthopaedic Foot and Ankle Society (AOFAS) was used. The AHS is a 100-point physician administered score that evaluates different aspects of the ankle by assessing the 3 categories of pain (/40 points), function (/50 points), and ankle alignment (/10 points). In general, a higher score of 100 indicates better overall ankle health based on these categories.18 Complete surgical report forms were reviewed for accuracy and adherence to protocol by the research coordinator. Protocol deviations were reviewed to correct any problems. Any patient treated with SS fixation who demonstrated loss of reduction that required placement of an additional screw intraoperatively or on follow-up examinations was analyzed according to the “intention to treat” principle; analysis were performed in the group to which the patients were initially randomized to. This also applied to any fracture in the DS group that was not amenable to such PATIENTS AND METHODS This prospective randomized single-center trial was conducted at a level 1 trauma center. All 4 surgeons who participated were experienced trauma surgeons with previous experience in randomized control trials. Ethical and research approval was granted at the local conjoint University Ethics Board. This study was not funded. After giving informed consent to participate in the study, patients were randomized into 1 of 2 groups, either single or double lag screw fixation of the medial malleolus as a treatment method for their fracture. All patients with closed or open ankle fractures involving the medial malleolus requiring surgery presenting to the hospital were identified through direct contact. Potentially eligible patients were assessed by an orthopaedic surgeon, a trauma fellow, or an orthopaedic resident. A physical examination and complete checklist based on study parameters were performed for eligibility. The surgeon, resident, fellow, or research coordinator conducted the informed consent discussion with the patient and obtained consent. The inclusion and exclusion criteria are shown in Supplemental Digital Content 1 (see Table, http://links.lww.com/JOT/A454) (inclusion and exclusion criteria). All skeletally mature patients who met the eligibility criteria and signed the informed consent were randomized to a fracture management strategy using the computer-generated sealed envelope technique. Independent study personnel were in charge of running the study. All participants had the option to withdraw from the trial at any point without repercussion. Neither the surgeons nor the patients were blinded to the randomization. Ankle fractures were broadly classified as isolated medial malleolar fractures, bimalleolar fractures, or trimalleolar fractures based on radiographic assessment. Both OTA/AO14 and Danis–Weber classifications15 were used. All medial malleolar fractures were included in the study except if they could not be fixed with compression lag screws [see Table, Supplemental Digital Content 1, http:// links.lww.com/JOT/A454 (inclusion and exclusion criteria)]. More specifically, medial malleolar fractures were also classified according to the Herscovici classification.4 Type-A fractures are avulsions of the tip of the malleolus, type-B occur between the tip and the level of the plafond, type-C are located at the level of the plafond [see Figure, Supplemental Digital Content 2, http://links.lww.com/JOT/A455 (typical bi-malleolar fracture)], and type-D extends vertically above this level. An evaluation of the Herscovici fracture Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved. www.jorthotrauma.com | 549 Copyright Ó 2018 Wolters Kluwer Health, Inc. Unauthorized reproduction of this article is prohibited. Buckley et al J Orthop Trauma Volume 32, Number 11, November 2018 fixation after review intraoperatively (eg, fragment too small or comminuted) and could only be fixed with an SS. This kind of crossover between groups was considered a secondary study event and included in the secondary analyses because surgical or medical intervention may contaminate results. Complications that did not require re-operation were also documented as part of the follow-up report forms. These include superficial wound infection, skin ulceration or breakdown, complex regional pain syndromes, loss of reduction not believed to require operative intervention, delayed union (failure of progression of the fracture to heal at 3 months), prominent implant not requiring removal, and ankle stiffness. Use of medications that affect bone healing and associated additional procedures were documented as part of the study. Because of the randomization process, we anticipated cointerventions to be evenly distributed between groups. Follow-up for the study continued for 24 months to allow for the secondary objectives of studying the incidence of implant-related pain and rate of implant removal, performed 6–24 months after surgery. Syndesmosis screws were removed after 6 months only if the patient demonstrated marked pain in the local area. The primary outcome measure for this study was the SF-36. The SF-36 standard deviation for patients with acute tibial fractures has been calculated to range from 8.6–11.4. The minimum clinical important difference has been identified for the SF-36 to be a 5-point difference that is roughly equal to half an SD.19 The following assumptions were used: a student t test was used to compare the mean SF-36 scores, the 2 study groups were independent, there were an equal number of patients in each group, SF-36 SD for patients with acute fractures of the ankle estimated as 10 (based on SF-36 SD for a similar group outlined above), b = 0.2 (giving each group 80% power to detect a difference of 5%, type II error = 20%), and an alpha level of 0.05 (type I error = 5%). Using these assumptions, a power calculation was performed giving a sample size of 63 patients per group. Given the loss to follow-up rate of 10% in similar trauma patient groups, the minimum sample size for this study was determined to be 70 patients per group. Statistical tests were performed using SPSS statistical software package on a personal computer (Version 11.0; SPSS, Inc, Chicago, IL). respectively. The SS group comprised 26 men and 35 women, and the DS group had 29 men and 37 women. There were also no differences between the groups as far as additional medical complications. In the SS group, 17 patients were smokers, 14 were previous smokers, and 30 were nonsmokers. Of the patients randomized to receive DSs, 13 were smokers, 12 were previous smokers, and there were 38 nonsmokers. The 2 groups also provided similar medical histories. There were 4 patients with osteoporosis, 1 patient with diabetes, and 9 patients with cardiovascular disease in the SS group compared with 2 patients with osteoporosis and 8 with cardiovascular disease in the DS group. The most common mechanism of injury for both groups was a low-energy fall, and they presented with similar patterns of injury, including 1 open fracture in each group. The fracture patterns were identified using clinical assessment and plain radiography. There was no difference between groups regarding their injury pattern (Table 2). Between the single and DS groups, there was no significant difference in the fracture pattern using either the Herscovici or Weber classification. (see Table, Supplemental Digital Content 3, http://links.lww.com/JOT/A456 [fracture classification characteristics between groups]). All patients in this study were surgically treated within 14 days of their initial injury. There was no difference in the operating room (OR) time, time in hospital postsurgery, or need for syndesmotic fixation whether the patient received 1 or 2 screws to repair their medial malleolus (see Table, Supplemental Digital Content 4, http://links.lww.com/ JOT/A457 [Patient hospital data]) (see Figure, Supplemental Digital Content 5, http://links.lww.com/JOT/A458 [examples of fractures fixed with 1 or 2 medial malleolar screws]). Ten cases had washers used for the medial malleolar screws—7 cases in the 1 screw group and 3 cases in the 2 screw group. Using the AHS as a measure of patient well-being after surgery, there was no difference in baseline, 3-, or 24-month scores between the single and DS groups (Table 3). Similar results were found for baseline, 3-, and 24month follow-up time points for the SF-36. In the 8 measures used for this study, physical function, role physical, bodily pain, general health, vitality, social functioning, role emotional, and mental health, there was no difference in patients’ self-reported scores whether they were treated with single or DS fixation. In addition, despite the number of patients involved, there was no indication of a difference when it came to implant pain or need for removal (see Table, Supplemental Digital Content 6, http://links.lww.com/JOT/A459 [Patient complications until 24 months]). RESULTS Between August 2010 and June 2014, 140 patients with ankle fractures involving the medial malleolus requiring surgery were identified. Initially, there were 140 patients enrolled in this study, but 13 were excluded because of early loss to follow-up or withdrawal. Of the 127 remaining patients, 61 had been randomized to receive 1 screw and 66 were randomized to receive 2 screws. Intraoperative decisions by the surgeon at the time of fixation resulted in 14 patients crossing over from the DS group to the SS group [fragment too small for 2 screws (“intention to treat” still followed)], leaving SS (n = 75) and DS (n = 52) (Fig. 1). There were no significant differences between the groups as far as demographic data (Table 1). The mean age of the SS and DS groups was 44.1 (616.3) years and 45.3 (615.1) years, 550 | www.jorthotrauma.com DISCUSSION A large randomized study was necessary to determine whether DS fixation had any clinical advantage over SS fixation for medial malleolar fractures. To the best of our knowledge, this study is only the second randomized controlled trial to specifically examine the medium-term health outcomes of single versus DS fixation for medial Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved. Copyright Ó 2018 Wolters Kluwer Health, Inc. Unauthorized reproduction of this article is prohibited. J Orthop Trauma Volume 32, Number 11, November 2018 Single Screw Fixation FIGURE 1. Consort statement study schematic and design. malleolar fixation. Jones conducted a prospective randomized clinical trial with the main purpose to investigate whether single versus DS fixation could provide similar outcomes while reducing adverse results.12 Sixty consecutive patients eligible for medial malleolar surgery were randomized, of which 47 were available for follow-up at an average of 2.5 years. Their conclusion stated that medial malleolar ankle fractures can be safely and efficiently internally stabilized with SS fixation. The second study conducted by Shah et al13 was a retrospective analysis of case notes and x-rays from 76 patients having medial malleolar fracture fixation. The outcome measures were postoperative fracture displacement, bony and clinical union, and patient self-assessment of return to their preinjury level of activity. Shah et al concluded that medial malleolar fractures fixed with 1 screw did not increase the risk of postoperative displacement. It has been discussed for decades in the OR worldwide that a medial malleolar fracture probably needs 2 points of fixation to minimize malrotation and failure of fixation. Our Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved. primary outcome, the SF-36, and the secondary outcome, AHS, at baseline, 3, and 24 months did not show a single point of statistical difference in any of the 8 categories between groups. This lack of difference points to SS fixation being an equivalent fracture care method in terms of the 8 general health categories of the SF-36. Our secondary objectives showed that there was no difference in the OR time, days in hospital postsurgery, or need for syndesmotic fixation between groups. Importantly, the fracture classification or complexity did not influence the overall trends in functional assessment or secondary objectives. Perhaps the most notable and important finding from the study was the patient crossover. Fourteen patients, almost 25% of those randomized to receive 2 screws, received only 1 screw. The treating surgeon had been uncomfortable with placing 2 screws in a small medial malleolar fracture fragment for fear of comminuting this small piece of bone and opted for 1 screw only. However, 2-year follow-up proved that clinical and functional outcome was no different regardless of the number of screws used. www.jorthotrauma.com | 551 Copyright Ó 2018 Wolters Kluwer Health, Inc. Unauthorized reproduction of this article is prohibited. J Orthop Trauma Volume 32, Number 11, November 2018 Buckley et al TABLE 1. Demographic Data TABLE 3. Ankle Hindfoot Scores (AHS) with P , 0.05 Mean (6SD) or Count Age SS DS Sex SS Men Women DS Men Women Smoking status SS Smoker Previous smoker Nonsmoker DS Smoker Previous smoker Nonsmoker Medical history SS Osteoporosis Diabetes (type 2) Cardiovascular disease DS Osteoporosis Diabetes (type 2) Cardiovascular disease P 0.66 44.1 (616.3) y 45.3 (615.1) y 0.88 26 35 29 37 n = 17 n = 14 n = 30 n = 13 n = 12 n = 38 .0.05 n=4 n=1 n=9 n=2 n=0 n=8 TABLE 2. Medial Malleolar Injury Patterns Mean (6SD) or Count 552 | www.jorthotrauma.com 0.88 98.5 (66.5) 98.6 (64.4) 0.74 81.1 (611.5) 81.7 (610.5) 0.30 92.3 (68.4) 94.1 (65.6) 0.22 Anterior collicular fractures are small, and treatment with 1 screw in our study proved to be satisfactory. When this study was initiated, all medial malleolar fractures were included. It is important to note, however, that the anterior colliculus represents the attachment of the superficial deltoid ligament. Because the deep deltoid is responsible for medial stability and is attached to the posterior colliculus, fixation of the anterior colliculus may in fact not be needed.20 Interestingly, there were no nonunions in either arm of our study, again suggesting that there was no advantage to using more than 1 screw in fixation of these fractures, Medical history SS Medial malleolus isolated Bimalleolar Trimalleolar DS Medial malleolus isolated Bimalleolar Trimalleolar P Mean (6SD) or Count Baseline SS (n = 54) DS (n = 60) 3 mo SS (n = 54) DS (n = 58) 24 mo SS (n = 27) DS (n = 41) P 0.88 n = 10 n = 30 n = 21 n=3 n = 38 n = 25 although CTs were not performed in this study to check for malrotation. Over the 2-year follow-up period, there was also no indication of differences in implant pain or need for implant removal in either group. As all other factors seem equal between single and DS fixation of medial malleolar fractures, the 14 patients who followed a crossover pattern suggest treatment in favor of SS fixation. The prospective randomized controlled trial study by Jones and Slabaugh12 produced very similar results to this study. Although they had a smaller sample size (n = 60) and less outcome data, they concluded that an SS was an equally safe and efficient method of fixation and offered similar patient outcomes. In addition, they found that SS fixation provided shorter operating times. The most notable difference from this study12 was the lack of crossover, as no patients were reported to have changed groups. Shah et al13 conducted analogous research in the form of a retrospective case series of 76 medial malleolar fractures (single n = 37, 2 screws n = 39). Using case notes, x-rays, and follow-up contact with patients, they concluded that there was no significant difference in clinical union, postoperative fracture displacement, or return to their preinjury level of activity between groups. There are multiple strengths with this study. This prospectively designed and powered study with a large sample size (n = 140) provides results that are applicable to a wide demographic. In addition, the crossover between groups occurred only in 1 direction, from the DS to the SS group, strengthening the notion that an SS can be as effective as 2 screws. This study will also be generalizable because it was conducted by 4 experienced trauma surgeons on a fracture that is common worldwide and treated regularly every day. The limitations of this study include potential surgeon bias toward the use of an SS, possibly explaining the one-way crossover. Most anterior collicular fractures do not need fixation, and this study did not look at this factor close enough before the study was initiated. Also, patients were only followed for 2 years postoperatively, and the late implant removal pattern is still not clear when it comes to 1 or 2 screws. Computed tomography scans were not performed to check for malrotation in those cases where 1 screw was used. A few cases had washers used to help with fixation, and these could irritate the posterior tibial tendon and confound our results. This study is too small to definitively determine that 1 screw is as satisfactory as 2 screws for all medial malleolar fracture types, but it is a starting point. Although this study was powered to detect differences in clinical outcome scores, it is Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved. Copyright Ó 2018 Wolters Kluwer Health, Inc. Unauthorized reproduction of this article is prohibited. J Orthop Trauma Volume 32, Number 11, November 2018 Single Screw Fixation not adequately powered to detect differences in the incidence of more rare complications such as nonunion or failure of fixation. A prospective study powered to show a difference in the rate of nonunion or implant failure (less than 5% in this study) would likely require over 1000 patients in each arm. In conclusion, SS fixation seems to be an efficacious treatment for most medial malleolar fractures. After medial malleolar fixation with either 1 or 2 screws, we found no significant difference with specific or general outcome scores, operating time, or complications, indicating that single screw and DS fixation provide equivalent medium-term patient outcomes. 8. Hamilton SW. Technical notes and tips: parallel screw fixation of the medial malleolus. Ann R Coll Surg Engl. 2007;89:729. 9. Parker L, Garlick N, McCarthy I, et al. Screw fixation of medial malleolar fractures; a cadaveric biomechanical study challenging the current AO philosophy. Bone Joint J. 2013;95-B:1662–1666. 10. Brown OL, Dirschl DR, Obremsky WT. Incidence of hardware-related pain and its effect on functional outcomes after open reduction and internal fixation of ankle fractures. J Orthop Trauma. 2001;15:271–274. 11. Femino JE, Gruber BF, Karunakar MA. Safe zone for the placement of medial malleolar screws. J Bone Joint Surg Am. 2007;89:133–138. 12. Jones CB, Slabaugh PB. Prospective randomized evaluation of medial malleolar fixation for ankle fractures: single versus double screw fixation. Orthop Trans 1196;21. 13. Shah Y, Syed T, Myszewski T, et al. Comparison of outcome following either one or two screws for medial malleolar fracture fixation. JBJS Br. 2010;92-B(suppl 2):255–256. 14. Marsh JL, Slongo TF, Agel J, et al. Fracture and dislocation classification compendium—2007: orthopaedic trauma association classification, database and outcomes committee. J Orthop Trauma. 2007; 21(suppl 10):S1–S163. 15. Buckley RE, Moran CG, Apivatthakakul T. AO Principles of Fracture Management. 3rd ed. Stuttgart, Germany: AO Publishing; 2017. 16. Aitken SA, Johnston I, Jennings AC, et al. An evaluation of the Herscovici classification for fractures of the medial malleolus. Foot Ankle Surg. 2016. Available at: http://dx.doi.org/10.1016/j.fas.2016.10.003. Accessed December 30, 2016. 17. Ware JE, Shelbourne CD. The MOS 36 item short form health survey (SF-36). MedCare. 1992;30:473–483. 18. Kitaoka HB, Alexander IJ, Adelaar RD, et al. Clinical rating systems for the ankle hindfoot, midfoot, hallux and lesser toes. Foot Ankle Int. 1994; 15:349–353. 19. Busse JW, Bhandari M, Guyatt GH, et al. Use of both short musculoskeletal function assessment questionnaire and short form-36 among tibial fracture patients was redundant. 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Comparison of pullout strength between 3.5-mm fully threaded, bicortical screws and 4.0-mm partially threaded, cancellous screws in the fixation of medial malleolar fractures. J Foot Ankle Surg. 2010;49:248–252. 6. Johnson BA, Fallat LM. Comparison of tension band wire and cancellous bone screw fixation for medial malleolar fractures. J Foot Ankle Surg. 1997;36:284–289. 7. Mohammed AA, Abbas KA, Mawlood AS. A comparative study in fixation methods of medial malleolus fractures between tension bands wiring and screw fixation. Springerplus 2016;5:1–6. Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved. www.jorthotrauma.com | 553 Copyright Ó 2018 Wolters Kluwer Health, Inc. Unauthorized reproduction of this article is prohibited.