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Future Medicine Ltd
Nanomedicine
Volume 13, Issue 17, September 2018, Pages 2121-2125
https://doi.org/10.2217/nnm-2018-0222
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Commentary
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Self-Assembling Protein
Nanoparticles: implications for HIV1 vaccine development
Christopher P Karch 1,,2, Gary R Matyas 1, Peter
Burkhard 3 & Zoltan Beck 1,,2
1 1US
Military HIV Research Program, Laboratory of Adjuvant and Antigen Research, Walter Reed Army
Institute of Research, 503 Robert Grant Ave, Silver Spring, MD 20910, USA
,2 2Henry M Jackson Foundation for the Advancement of Military Medicine, 6720A Rockledge Drive, Bethesda,
MD 20817, USA
3 3
Alpha-O
Peptides, Lörracherstrasse 50, 4125 Riehen, Switzerland
*Author for correspondence: Tel.: +1 301 319 2290: zbeck@hivresearch.org
First draft submitted: 28 June 2018; Accepted for publication: 29 June 2018; Published online: 1
October 2018.
Keywords: antigen density • conformational antibody • HIV-1 • nanoparticle • SAPN • trimeric epitope
• vaccine
Self-Assembling Protein Nanoparticles: a modern platform to increase the immunogenicity
of vaccines
Subunit vaccines are one of the major focuses of modern vaccine development. They tend
to be more tolerable than whole organism vaccines, however, they also tend to be less
immunogenic. To address this problem, different approaches such as delivery of the
antigen on a particulate carrier, displaying multiple copies of an antigen and/or use of a
modern adjuvant system can lead to stronger immune responses [1]. Nanoparticles can be
designed to combine all of these approaches allowing for the development of effective
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