4/18/22, 12:43 PM Docplexus Experience a virtual liver transplant surgery & an expert talk on 10 commandments in pediatric liver disease. JOURNAL WATCH date_range 02 DEC 2021 Sponsored Carboxymethylcellulose vs. Polyethylene Glycol as Tear Substitutes for Dry Eye Treatment Ophthalmology Pediatric Ophthalmology + 3 more https://www.docplexus.com/user/content/journal-watch/3fc21429-3bf9-4bf6-806e-eede90de947c FOLLOW 1/14 4/18/22, 12:43 PM Docplexus https://cdn.docplexus.com/121/11/3/863010a1-7d3a-4484-a6dd-b15d1d06e427__t.jpg Synopsis https://www.docplexus.com/user/content/journal-watch/3fc21429-3bf9-4bf6-806e-eede90de947c 2/14 4/18/22, 12:43 PM Docplexus Dry eye disease (DED) can be caused either by a lack of tear production or excessive evaporation. Multifactorial characters such as tear film, ocular surface, or neurosensory disorders result in changes in tear film osmolarity and ocular surface inflammation. The symptoms can be related to ocular pain, such as burning, irritation, grittiness, or vision-related. The severity of the condition determines the treatment, with mild cases requiring only tear replacements and severe cases requiring additional medical or surgical intervention. Artificial tears replace the aqueous layer that has become depleted and dissolves inflammatory cytokines. This “Journal Watch” discusses a prospective randomized control study from the International Journal of Medical and Health Research, entitled ‘Comparison of carboxymethylcellulose versus polyethylene glycol as tear substitutes for the treatment of dry eye,’ 2019. What was the need of the study? The most widely prescribed treatment for dry eyes is artificial tear replacement. It reduces ocular surface stress and improves tear film stability, contrast sensitivity, optical quality, and quality of life. Carboxymethylcellulose (CMC) and polyethylene glycol (PEG) are the two most commonly used tear replacements. However, the clinical efficacy of these two substitutes has remained unexplored. Study design https://www.docplexus.com/user/content/journal-watch/3fc21429-3bf9-4bf6-806e-eede90de947c 3/14 4/18/22, 12:43 PM https://www.docplexus.com/user/content/journal-watch/3fc21429-3bf9-4bf6-806e-eede90de947c Docplexus 4/14 4/18/22, 12:43 PM Docplexus What did the treatment include? Patients were randomly sampled into two groups. Patients in group I received CMC 1% QID, while group II received PEGcontaining drops QID (PEG-400 0.4%, propylene glycol 0.3 %). From each patient, one eye was selected as the study eye. If both the eyes met the inclusion criteria, the worse evaluable eye was selected. If both the eyes shared the same total ocular symptom score (TOSS) scores, the right eye was selected. On-treatment follow-up visits were conducted after 1 week and 6 weeks. What were the important findings? Significance of the study Both CMC 1% and PEG-containing eye drop effectively treated dry eye, with improvement in clinical signs and symptoms. https://www.docplexus.com/user/content/journal-watch/3fc21429-3bf9-4bf6-806e-eede90de947c 5/14 4/18/22, 12:43 PM Docplexus Patient-response to PEG-containing eye drops was faster, with a significant improvement in OSDI score from baseline to week 1 follow-up. In addition, improvement in OSDI score and corneal staining score was significantly better in the PEG group at 6 weeks, as compared to the CMC group. Improvement in other metrics such as TBUT, conjunctival staining score, and ST did not exhibit the statistical difference between the two groups. This suggests that eye drops containing PEG are better for patient satisfaction and improve ocular surface staining scores. Conclusion PEG and CMC both treatments decreased ocular surface staining, indicative of improved ocular surface health. Moreover, both alleviated objective signs and symptoms of DED. However, the study results suggested that PEG-containing eye drops provide quicker and better subjective improvement and corneal staining than CMC 1% eye drops. Reference Shilpy N, Patel DB. Comparison of carboxymethylcellulose versus polyethylene glycol as tear substitutes for the treatment of dry eye. International Journal of Medical and Health Research. 2019 Jan;5(1):196-198. IN-DEOH-2100056 Disclaimer: “For the use only of registered medical practitioners or a hospital or a laboratory” Disclaimer: “This educational information has been issued as part of awareness initiative by Alcon. In spite of best efforts, this information may become outdated over time. Alcon Laboratories (India) Pvt. Ltd. accepts no liability for the completeness for use of the information contained herewith or its update. Information, statements and photographs / recordings used here are with the permission of all and must not be replicated.” What is your opinion on using PEG over CMC to treat dry eyes? (Please comment below). NEXT ON YOUR READING favorite_border 12 chat_bubble_outline 16 visibility 1632 https://www.docplexus.com/user/content/journal-watch/3fc21429-3bf9-4bf6-806e-eede90de947c share 6/14 4/18/22, 12:43 PM Docplexus 16 Comments - 12 Like Add a comment Highly effective compared to CMC Better improvement in dry eyes Better corneal staining scores Dr. Ashok Agarwal MBBS Better improvement in dry eyes Reply Response Squad Dear doctor, thank you for sharing your thoughts with us. Stay tuned for more on Dry Eye Disease at https://www.docplexus.com/#/app/infocenters/3EA9J https://www.docplexus.com/user/content/journal-watch/3fc21429-3bf9-4bf6-806e-eede90de947c 7/14 4/18/22, 12:43 PM Docplexus Dr. Shobhit Chawla Eye care professional Useful study, justices basis of prescription Reply Response Squad Dear doctor, thank you for sharing your thoughts with us. Stay tuned for more on Dry Eye Disease at https://www.docplexus.com/#/app/infocenters/3EA9J Dr. Parmeshwaridayal Gupt... Ophthalmology Useful study Reply Response Squad Dear doctor, thank you for sharing your thoughts with us. Stay tuned for more on Dry Eye Disease at https://www.docplexus.com/#/app/infocenters/3EA9J https://www.docplexus.com/user/content/journal-watch/3fc21429-3bf9-4bf6-806e-eede90de947c 8/14 4/18/22, 12:43 PM Docplexus Dr. Kapil Sharma Works at Vision Care Eye Clinic, No... Highly effective compared to CMC Reply Response Squad Dear doctor, thank you for sharing your thoughts with us. Stay tuned for more on Dry Eye Disease at https://www.docplexus.com/#/app/infocenters/3EA9J Dr. Suhail Mohammed Radiology Good Reply Response Squad https://www.docplexus.com/user/content/journal-watch/3fc21429-3bf9-4bf6-806e-eede90de947c 9/14 4/18/22, 12:43 PM Docplexus Dear doctor, thank you for sharing your thoughts with us. Stay tuned for more on Dry Eye Disease at https://www.docplexus.com/#/app/infocenters/3EA9J Dr. Suhail Mohammed Radiology Better improvement in dry eyes Knowledge to share Reply Response Squad Dear doctor, thank you for sharing your thoughts with us. Stay tuned for more on Dry Eye Disease at https://www.docplexus.com/#/app/infocenters/3EA9J Dr. Chetankumar Prajapat... MD Medicine Highly effective compared to CMC Reply https://www.docplexus.com/user/content/journal-watch/3fc21429-3bf9-4bf6-806e-eede90de947c 10/14 4/18/22, 12:43 PM Docplexus Response Squad Dear doctor, thank you for sharing your thoughts with us. Stay tuned for more on Dry Eye Disease at https://www.docplexus.com/#/app/infocenters/3EA9J Dr. Irwan Tjandra Ophthalmology Highly effective compared to CMC Recommended Reading DED: The Effective Role of Artificial Tears date_range 14 Mar 2022 Antimony Toxicity date_range 13 Mar 2022 https://www.docplexus.com/user/content/journal-watch/3fc21429-3bf9-4bf6-806e-eede90de947c 11/14 4/18/22, 12:43 PM Docplexus Safety Aspects for Female Staff/Patients in Hospitals date_range 14 Mar 2022 Latest Updates Article date_range APR 2022 bookmark_border My First Dissection Experience General Medicine Anatomy & Physiology Article date_range APR 2022 bookmark_border Cancer Risk to Healthcare Workers from Genotoxic Agents Family Medicine + 3 more General Medicine Article date_range APR 2022 bookmark_border Pathophysiology Of COVID-19: Why Children Fare Better Than… COVID-19 + 8 more Pulmonary/Respiratory Diseases + 1 more I was wondering how exciting must be Several medications have genotoxic the first anatomy practical for doctors. characteristics. 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