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Functional Medicine is a branch of
medicine which bases its clinical method
for the study of physiological processes.
 It 'a discipline that analyzes the
correlations between physiological
response, response and input
stressogeno dysfunctional.
Functional because it allows us to understand the
dysfunction of organs and systems before they
cause demonstrable harm to specific examinations
(predisease pathways)
 Regulatory occurs because restoring the normal
physiological conditions
F.M.R. act as an interface between conventional medicine and
complementary medicine natural to combine and/or integrate
into a global perspective, structured as transmissible science that
allows to integrate medical knowledge (science) with the herbal,
homeopathy and nutrition in a unified framework.
Functional medicine embraces the totality of the
regulatory capacities of the body:
- biophysical
- biochemical
- enzymatic
- endocrine
- immunological
- bioenergetic
trough the neurovegetative
(orthosympathetic/parasympathetic) , metabolic
(anabolism/catabolism) and cerebral regulation
Emerging perspectives of molecular
biology and neuroscience converge well
with the basic concepts of Functional
Medicine Regulatory homeodynamic on
the functioning of the body: each district,
organ, system, function is interconnected
to others and exchange them with
continuous biochemical and biophysical
information through Extra-cellular matrix
We can immagine it like a three-dimensional network
formed by big glyco proteic polymers :
› GAGs + proteins
› Structural (collagen,
› Adesive (fibronectin,
laminin ecc.)
Basal lamina
Intrafibrillar water
Composition of Extracellular Matrix: functional unit
 Assons
 Capillars
 Linfatic
Citochine and growth factors
 Nervous impulses and nerve pathways
 Electrochemical synapses
 Electromagnetic impulses
793 patients
Magnetic resonance with gadolinium to access a volume of extracellular myocardial
Increase of volume ECM is associated with increased risk of: death, cardiac
transplantation and need of mechanical cardiac assistance
Wong. Circulation 2012; 126: 1206-1216
provides specific molecular and spatial information that influences
cell proliferation, differentiation and apoptosis
 directly influence leukocyte recruitment to the inflammed tissue by
providing differential signals resulting from its spatial and molecular
composition, or indirectly by its potential to bind and present
cytokines or chemotactic factors
 mediates inflammation-induced angiogenesis and the subsequent
remodelling steps
 provides specific mechanical forces, exposes cryptic adhesion sites,
and releases biologically active fragments (matrikines) and matrixsequestered growth factors
Extreme systemic acidosis is incompatible
with life.
 Functional Medicine focuses at a slight
acidic tilt, what brings serious health
 Moderate, non-life threatening acidosis,
results in sub-optimal functioning of
uncounted cells, tissues, and organs. To
survive, the body must excrete and/or
neutralize excess acids regaining a lifesupporting acid-base balance.
Matrix with acid pH loss his capacity to compensate
 From Sol to Gel
 Loss of basic substances (Ca, K, Mg, Na)
Loss of calcium in the urine with ospetopenia and osteoporosis
Loss of potassium and magnesium stores from the body , resulting in a
tendency towards hypertension and inflammation and pain
Increased levels of blood parathyroid hormone (PTH)
Protein catabolism and depressed protein metabolism, resulting in a muscle
wasting and increased age-related muscle loss
Suppression of growth hormone, insulin-like growth factor, and other
pituitary hormones
Accelerated aging from accumulated acid waste products,
Increased production of free radicals—unstable molecules that
cause cellular damage, resulting in the worsening of pain and inflammation,
and the lowering of immune capacity, increasing risk of degenerative
disease and premature aging
Tendency for connective tissue to weaken due to increased free
Excessive acid has actually been found to be stored within the
connective tissue.
Decreased efficiency of cellular ATP energy production, causing
impaired cellular function and, eventually, impaired
organ function
Increased fluid retention, resulting in the excessive accumulation
of fluids within body tissues
Disrupted balance of intestinal bacteria
Encouragement of the growth and spread of yeast and fungi,
these potential pathogens thrive in an acid terrain
Creation of a more fertile breeding ground for many viruses, including
HIV: viruses thrive in an acidic, low-antioxidant environment
Reduced size of the brain's pool of energy reservesm, weakened
mental capacity
Decreased ability to perform exercise at a high level of intensity:
acidity creates a low-oxygen environment that is worsened by
Increased acidity of the mouth, leading to imbalanced oral bacteria
and, consequently, increased dental decay and periodontal (gum)
Creation of a mild form of hypothyroidism (low thyroid function) and a
chronic overproduction of the stress hormone cortisol
Development of low blood phosphorus levels
Detoxification and drainage of Extracellular matrix
 Maintenance of Metabolic balance
 Restoring of Intestinal Eubiosis
 Prevention of Oxidative Stress
 Evaluation of correlation between
Psyche/Brain/Organon (PNEI)
 Decrease stress (mindfulness, yoga,
breathing techniques ecc.)
Interdisciplinary Journal of Microinflammation
Related Journals
Allergy & Therapy
Microbiology &
© Avedro 2011
Interdisciplinary Journal of Microinflammation
Related Conferences
3rd International
Conference on Clinical
& Microbial
© Avedro 2011
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© Avedro 2011