Quadro® Comil® Quadro Comil Pharmaceutical Applications OVERVIEW DRY GRANULATION Pharmaceutical companies worldwide are successfully using the Quadro® Comil® for wet granulation mixes before drying, sizing after drying, granulating in the pre-compression stage, homogeneous mixing, conditioning, and dispersion of pigments in the manufacture of tablets. ▪ Ribbons from a roller compactor can be size reduced with a Comil® to granules with optimum particle size distribution for efficient tableting. WET GRANULATION ▪ The Comil® is designed to take wet lumpy granulations and uniformly size them at very high capacities. ▪ Sizing or de-lumping wet granulations ensure equally sized granules are introduced into driers, thus eliminating case hardening and helping granules to dry uniformly and more rapidly. ▪ Uniform particle size distributions prevent fines and potential un-even die filling or sticking at the punches during tableting. TABLET/CAPSULE RECLAIM ▪ “Off spec” tablets can be size reduced for reclaim purposes. INGREDIENT CONDITIONING ▪ Ideal for a broad range of de-lumping, mixing, finishing and milling. ▪ Lump-free homogeneous dry ingredient blending. ▪ Low heat build-up and precise screen size ensure complete dispersion, at desired particle size. COMIL BENEFITS Low dust Low noise Low heat Fewer fines Short changeover times High capacities Easy, fast cleaning ▪ “Off spec” capsules can be broken into large pieces allowing for easy separation of powder from the gelatin pieces. The overdriven Comil APPLICATION BULLETIN Chem01- metal pigment www.quadro-mpt.com