ADRENERGIC AGONISTS - Chapter 30
Also called sympathomimetics that mimic the SNS. Include alpha and beta agonists, many agonists are used for pulmonary
disease, or severe shock, heart-block or in codes. Actions similar to anticholinergics. Cautious use for patients who are
tachycardic, have HTN, or CV disease. Page 504.
What your body would do being chased by a bear: increased heart rate, etc.
ine
epinephrine
Alpha and beta
agonist
"
Phenylephrine
brand name:
neosynephrine
shot
of epi
"
Phene
-
I
decongestant
isoproterenol
albuterol
¥
a
MEGA
8
¥
i¥É
is
ime
dopamine
all beta to
use
smallest dose
Possible
STIMULATOR
'
"
Beta agonist
"
agonist
Alpha
treats shock
=
•
•
•
"
BRONCHO spasms
VASOCONSTRICTION
Increases heart rate, bronchodilation, blood flow, relaxes uterus.
Adverse effects include tachycardia, restlessness, apprehension, anxiety,
fear. Use lowest possible dose.
131
Stimulates all adrenergic receptors.
p
Alpha and beta
agonist
II
SHOCK
Alpha 1 agonist, In cold and allergy products as a decongestant, and
intravenous to treat shock
Used opthalmically to dilate pupils.
Patients may develop tolerance if using as a nasal spray.
Watch for extravasation (infiltration) in tissue, causes tissue necrosis.
ing
For a nasal
ol
"
Alpha agonist and
vasoconstrictor
§
E
w/
Shock the bear
one
ine
Used for treatment of shock, anaphylaxis bronchospasm, local
vasoconstriction. Watch cardiovascular effects.
z
Common ICU medication. Used in shock and to dilate renal arteries when
perfusion is lacking (due to low blood pressure).
IBP
SHOCK
Watch for extravasation in tissue, can kill cells.
=
UBP
"
dopamine dilates
"
-
ADRENERGIC ANTAGONISTS - Chapter 31
Adverse effects if non selective (i.e., block beta 1 and 2) include problems breathing, and bradycardia (low heart rate), and
cns effects such as dizziness, depression and fatigue. If beta 1 only then bradycardia most concerning adverse effect. This
drug blocks sympathetic response so the typical symptoms of sweating, tachycardia, etc. will not be evident for patients
experiencing hypoglycemia. Do not abruptly stop these medications due to increased sensitivity of catecholimines after a
period of blockade. Used to decrease intraocular pressure with open-angle glaucoma (i.e., timolol - make sure you press on
punctal sac after administering and have pt hold head down to decrease systemic absorption).
Decreased antihypertensive effect happens with concurrent admin of NSAIDS. Sexual side effects. Actions similar to
cholinergic drugs. Page 519
Blocks sympathetic nervous system: slow BP and HR, calm, AFTER bear chase.
9
min
✗
phentolamine
192
Alpha blocker (non
selective)
Blocks all alpha
receptor sites (A1,
A2)
Used to prevent cell death with tissue extravasation due to IV
norepinephrine or dopamine. Also used for phenochromocytoma (tumor in
adrenal gland). Increases blood flow. Can be injected directly into penis
hero that prevents death
to cause an erection.
a
"
danny phantom has
so
sin
doxazosin
Alpha 1 blocker
"
DIC
✗
1
,
it's
to have
big balls
AND
not
propranolol
§
"
Blocks Beta 1 and
Beta 2 receptors
142
P
I
a
non-selective tumor
erection
Watch for CNS effects, sexual dysfunction.
Dizzy
,
fatigue
,
Decreases
WHR
+ Bp
:
di 334
florid
②
depression
Non-selective. Used in HTN.
More adverse effects than selective beta blockers (i.e., CNS effects
greater, and causes bronchospasm, this should be avoided in asthma
don't give WI tr BP
131
patients).
=
Blocks only Beta 1
,
"
HTN
NON SELECTIVE
Atenolol
metoprolol
an
Used for HTN and benign prostatic hypertrophy (BPH).
Promotes vasodilation (taking finger off hose).
Alpha-1 works more on smooth muscle.
=
-
lol
get
be able to
get hard
lol
sin
a
he can't
MORE
PROBLEMS
132
__
-
lungs
-
don't give w/ asthma !
Selective. Decreases: Used for HTN and arrhythmias.
Check HR for full minute. Bradycardia biggest concern
__
"
You're PICKY
& selective
for
a
ten ?
LOL
_
Me too !
"
swollen