NALTREXONE Revia Vivint usedto manage alcohol ROA RO opioid antagonist opioid dependence by decreasing desire most common 50mg tablet In depot injection SC implants acute hepatitis contraindicating recent opioid use sideeffects a or liverfailure 710 days diarrhea wish at vethdrand on abdominalcramping MOA foropioiddependence foralcoholdependence blocks opioid receptors to attenuate the effects ofopioids blocking KOR blocks actionof endogenousopioid dynophir instatesdrug seehing behaviour SINCLAIR METHOD continued consumption of alcohol in combination with naltrexone naltrexone blocks action of endorphins which would provide rounding experience when driving i over time cravings brain learns to cut associate aleowd with pleasure Tanth over alcohol use ACAMPROSATE used withcounselling ROA PO psychosocial support a suicidalbehaviour majordepressive disorder anxiety Eton bindsto GABAA R I EfOH vomiting depression diarrhea i to treatalcoholdependence nausea kidney failure MOA positiveallostericmandafffter hidacy damage contraindications sideeffects NMDA R antagonist CCampral tolerance desensitised GABA R physical withdraw sincenondGABAhas no effect iGABAnormally inhibity CABA R desensitization acamprosate enhances GABAsignalling overexatation as positive allostericmodulator Etonusuallyinhibits NMDAR activity chronic Eton consumption upregulates NMDA R i HEINI canes Rautinty of excess NMDARs withdrawals withdrawal glutarde surge whitefumeaetiaks NMDARs s aeanprosate decreases glutante surge as NMDA R antagonist at DISULFIRAM used poA acetaldehyde Antabuse as secondline drugforalcoholism dehydrogenase inhibitor by Asensitivity to alcohol doesnottramings a compliance bad poor 8D implant contraindications liver problems recentalcohol use sideeffects with alcohol 02hours common severe hangover symptoms dyspnea visualdisturbance housed confusion vomiting posturalsyncope headache without alcohol to circulatory collapse headache metallicgarlictaste in mouth dlibido linerproblems Shih rush neuropathy MOA disulfiram 1 alcohol alcohol dehydrogenase acetaldehyde i Tautaldehyde acetaldehyde dehydrogenase acetyl coff hangoversymptoms DIAZEPAM Valium benzodiazepine usedfor a variety of conditions including alohdwithdrawalsyndrome ROA P O PR nasalspray M w contraindications side effects ataxia depression hyperventilation psychosis liverproblems pregnancy kidney problems sleepapnea sedation bronchitis breastfeeding copD confusion anterograde amnesia MOA myastheniagravis a ataxia benzodiazepines are positive allosteric modulator of GABA R AAAAA R are ligandgated d selective channels which when activatedby GABA i Iv activity Tirflax of Cl hypepolarisation of cortical andlimbic systems in CNS Other benzos chlordiazepoxide Clibrium alertedwithdrawal Miran diazepam lorazepam alcoholwithdnt in elderly and cirrhosis cases alprazolam'Cxanax bromazepan anxiety insomnia clonazepam Cklonopin seizures non selective opioidreceptorantagonist NALOXONE Narcan used to blockthe effects of opioids ROA endotracheal In nasalspray 10 Cerg to increasebreathing homespray take reverse OD to IV contraindications in opioidOD new available heartconditions hypersensitivity sideeffects hypotension hypertension tachycardia nausea seizures vomiting MOA sweating non selectively prevents a acute opioid withdrawal syndrome competitively binds to opioidreceptors the action ofboth endogenous and exogenous opiates BUPRENORPHINE opioid Buvidal used to treat opioid user disorder ROA subnet sublingual fun pregnant buccalinjection as well as transdermal acute chronic pain Buidal is depotinjection weekly or monthly implant subcutaneous IV contraindications sideeffects hypersensitivity nausea a vomiting a MOA acts as respiratory dry amnesia miosis perspiration orthotichypotension drowsiness dizziness mouth headache itchiness depression urinary retention a an opioid receptor modulator weakpartialagonist of MOR antagonist of KOR antagonist of Pop i binds with high affinity to mop butonly activates partially can bloch most nor agonistsand is usefulto treatdependence NALOXONE CSuboxone BUPRENORPHINE combination used to treat opioid use disorder with counselling opioid to apah giadgm.net abusedeterrent ROA sublingual a contraindications side effects a severe respiratory liner impairment create alcoholism headaches hypotension opioid withdrawal syndrome vomiting nausea pain increased sweating Mott constipation buprenorphine acts as an opioid receptor modulator weakpartialagonist of MOR antagonist of KOR antagonist of pop binds with high affinity to mop butonly activates partially can bloch most nor agonistsand is usefulto treatdependence naloxone non selectively prevents works as competitively binds to opioidreceptors the action ofboth endogenous and exogenous an opiates abusedeterrent whentaken sublingually as prescribed buprenorphine elfah dominate naloxone is negligible dueto low oral absorption if tries to misuse by naloxone acts as an injection inhalation antagonit to reduce opioideffects or even precipitate withdrawal METHADONE Dolophihelmethadose opioidagonist NMDA Rantagoni usedto treatopioid dependenceandchronicpain post a pro mostcommon II fM contraindicating i a use of anticonvulsants use side effects a a vomiting abund heat diarrhea dizziness myths due to prolonged QT nausea sleepiness a Mott ofopioidantagonists a headache a respiratory depressin sweating releases neurotransmitter invoked in paintransmission opioid agonist as inhibits action of excitatory neurotransmitter glutamate i decreases development of tolerance to opioids by disrupting memory pathways as NMDAN antagonist SERTRALINE antidepressant used to ROA selective serotoninreuptakeinhibitorcss.pe Eleven treat Po contraindications a use of depression panicdisorders OCD PTSD monoamine oxidase Moto inhibitors use of antipsychotic pineaide age of disulfiram care when prescribing elderly or patients with liver problems slower elimination sideeffects nausea diarrhea insomnia dizziness MOA dry mouth tremor decreased libido ejaculation failure serotonin transporter SERT to inhibit neuronalreuptake of serotonin and potentiate sentinergie binds to activity in the CNS THIAMINE VITAMIN Bi usedto that thiaminedeficiency in chromealcoholism alcoholmouse disorde PO ROA 1V MOA alcohol can damage stomach act lining 4 absorption of vitaminB deficiency beriberi dry a wet ACT neuropathy numbness cardiac TNR nausea cerebral vomiting tingling hyperreflexia edema dyspnea abdominal heatfailure pain Weniches encephalopathy Korsakoff'spsychosis Wernicke's Korsakoff syndrome abnormaleye movements stance and gaitataxia cognitive inpairments gabapentinoid anticonvulsant anxiolytic PREGABALIN Lupica usedto treat epilepsy neuropathicpain fibromyalgia anxiety seizures RoA Po contraindications a suicidalthought heat failure COPD kidney failure side effects a weightgain 1cg edema disturbedvision sleepiness a fatigue a dinner loss of coordination euphoria a Vertigo MOA inhibits i certain voltage dependent calcium channels fair influx VDCs