GS441524
EFFECTIVE
TREATMENT
FOR FIP
DIAGNOSIS METHODS
AB / AG Test Kit
RT-PCR
Rivalta Test
Blood Test
Test on FCOV. The
quickest and easiest
test.
Not used widely due
to accessibility.
Accurate with right
primers.
Accurate to test
effusive form of FIP
Parameters in the
blood test are
pointers to further
confirm FIP.
GS441524
GS-441524 work by blocking viral replication. It is a
nucleoside analogues, meaning they mimic the
nucleoside building blocks—A, U, C, or G—that make
up the virus’s genetic material. Specifically, they
mimic “A,” and when the virus is tricked into
incorporating a GS-441524 molecule instead of “A”,
the replication process gets jammed up. Eventually,
no more letters can be added, and the virus cannot
replicate.
GS441524 - Half Life Drug
It takes about 3 to 4 hours for the concentration of
the drug in the plasma or the total amount in the
body to be reduced by 50%.
In other words, after one half-life, the concentration
of the drug in the body will be half of the starting
dose.
Recommendation :
12 Hours apart injection instead of 24 Hours is very
useful in severe cases of FIP. Eg. complete paralysis,
seizure, inability to eat at all (dependant on drips).
GS441524
CONCENTRATION
17mg/ml
20mg/ml
GS:20mg/ml
B12:50mcg/ml
General Rule : Above 2.5kg or Dry/ Occular/ Neuro : 20mg/ml
Above 3.5kg with Dry/ Occular/ Neuro : 30mg/ml
30mg/ml
Slow to absorb
Easy to inject
a) Please alternate the injection sites to
prevent injection site reaction
Might resist
b) Route of injection : Subcutaneous
BASE DOSAGES
WET
DRY
OCcular
Neurological
6mg/kg
8mg/kg
10mg/kg
10mg/kg
Dosages are not fix.
Increase when:
**Only 10mg/kg and above can break through the
blood-brain-barrier.
1. Blood work parameters not ideal
2. Progress is slow
3. Change of form
GS441524 CAPSULES SPECIFICATION
INGREDIENTS: GS441524 + ZEOLITE + BOSWELLIA
Active
Ingredient
Concentration
150 mg/g
= less than 2.5 kg
250 mg/g
= 2.5kg - 4 kg
400 mg/g
= greater than 4 kg
USAGE INSTRUCTIONS
Provide 1 oral capsule per day.
Adhere to a scheduled time.
Do not skip any day.
Oral capsules can be taken with supportive supplements. They do not interfere with
antibiotics or anti-inflammatory treatments your cat may be taking during FIP treatment.
When to use injections instead oral capsules?
If the cat still exhibits ocular or neurological symptoms
If the cat suffers from intermittent vomiting or diarrhea
If the cat is not eating and requires force feeding or subcutaneous (SQ) fluid
administration.
TREATMENT PERIOD
First 30 Days
1. Appetite
2. Energy Level
3. Fluid Accumulation
4. Nervous System Function
5. Litter Activity
Blood test at the end of 30 days.
-Parameters check
-Additional treatment
-Dosage Adjustments
Next 30 Days
1. Appetite
2. Energy Level
3. Fluid Accumulation
4. Nervous System Function
5. Litter Activity
Blood test at the end of 60 days.
-Parameters check
-Additional treatment
-Dosage Adjustments
Last 24 Days
1. Appetite
2. Energy Level
3. Fluid Accumulation
4. Nervous System Function
5. Litter Activity
Blood test at the end of 84 days.
-Parameters check
-Any need to continue treatment
-Dosage Adjustments
OBSERVATION PERIOD
First 30 Days
1. Appetite
2. Energy Level
3. Nervous System Function
4. Litter Activity
Next 30 Days
1. Appetite
2. Energy Level
3. Nervous System Function
4. Litter Activity
Last 24 Days
1. Appetite
2. Energy Level
3. Nervous System Function
4. Litter Activity
Blood test at the end of 30 days.
-Parameters check
Blood test at the end of 60 days.
-Parameters check
Blood test at the end of 84 days.
-Parameters check
RELAPSE - Restart Injections
RELAPSE - Restart Injections
RELAPSE - Restart
Injections
Recommended relapse injection dosage : 12mg/kg to 15mg/kg.
Shorten parameters check to 2 weeks. Not necessarily to go through full 84 days again
ANTIBIOTICS
Antibiotic cover is essential for immunosuppressing a cat, with either high dose
corticosteroids, cyclosporin A or anti-TNF-alpha antibodies
Antibiotics - No adverse reaction to be used alongside Gs441524 and should be
prescribe alongside the treatment.
Common antibiotics used by veterinarians along side GS441524
ANTIROBE - aerobic and anaerobic infections. Awaiting FIP confirmation from laboratory and
major differential diagnoses are toxoplasmosis, or bacterial peritonitis / pleurisy.
DOXYCYCLINE / OXYTETRACYCYLINE - Infectious anaemia.
AMOXICILIN / CLAVULANIC ACID - can decrease IFN gamma, which is essential for FIP survival
METRONIDAZOLE - Anaerobic organisms.
ANTIBIOTICS
DO NOT RECOMMEND:
FLUROQUINOLONE CLASS - Baytril, Zeniquin, Veraflox/ Pradofloxacin and Orbax
Based on some recent studies, fluorine is claimed to be toxic to the central nervous
system (CNS). This in turn will cause neurological symptoms to the cats.
Do note that this claim has not been supported by any independent study. However
based on our past cases, we have had FIP diagnosed cats who died after receiving
treatment with this class of antibiotics. It was approximately 8 cats in total.
Should cat still require fluoroquinolone class of antibiotics due to some class of infections, please proceed with care.
X Recommended Medicine and
Supplements
LYSINE
Arginine is necessary for a good,
healthy immune system.L-lysine
prevents arginine from being
taken up in the body.
Arginine is crucial for a healthy,
functioning immune system.
TRANSFACTOR
(IMMUNE
BOOSTER)
FIP is immune mediated. Instead of
boosting the immune system, we
need to suppress it.
Based on past cases, using TF did
not increase the survivability. Also
in some cases, it causes viral activity
to increase.
This will be study more in the
future.
FLEA
SPOT ON
Flea medication may affect the
full effect of GS441524 in the
blood.
Use powder form or flea collar
instead (external treatment)
RECOMMENDED SUPPLEMENTS
1. Vitamin B12 / Methylcobalamin
2. Royal Canine - Convalescence Support
3. Omega 3 Fatty Acids - Salmon Oil / Krill Oil
4. Liver Protection - Silymarin / Denamarin
5. Gabapentin / Lidocaine ( Ease of injection )
6. Catnip ( Ease of injection )
7. Slippery Elm Bark ( Nausea )
FOR MORE
INFORMATION
Please don't hesitate to contact us
Whatsapp
+60 11 5412 8571
Email Address
ph@basmifip.com
Website
https://www.basmifipph.com/
@Basmifipph
@basmifip.ph