Review of Anatomy and Physiology Muscular System, Skeletal System, Gastrointestinal System, Special Senses and Neurological System RLE112 NGIMEPC Week 2 Session The Skeletal System Parts of the skeletal system Bones (skeleton) Joints Cartilages Ligaments Divided into two divisions Axial skeleton Appendicular skeleton Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings Functions of Bones Support of the body Protection of soft organs Movement due to attached skeletal muscles Storage of minerals (Ca and P) and fats Blood cell formation - hematopoiesis Types of Bone Cells Osteocytes Mature bone cells Osteoblasts Bone-forming cells Osteoclasts Bone-destroying cells Break down bone matrix for remodeling and release of calcium Bone remodeling is a process by both osteoblasts and osteoclasts Copyright © 2003 Pearson Education, Inc. publishing Slide 5.4 Bones of the Human Body The adult skeleton has 206 bones Two basic types of osseous - bone tissue Compact bone Dense and Homogeneous Spongy bone Small needle-like pieces of bone Many open spaces C S o l p i yd re i g5 h . t6 Classification of Bones on the Basis of Shape © 2 0 0 3 P e a r s o n Figure 5.1 C S o l p i yd re i g5 h . t7 Classification of Bones Bones are classifies according to shape into four groups: © 2 0 0 3 P e a r s o n Long bones Typically longer than wide Have a shaft with heads at both ends Contain mostly compact bone • Examples: Femur, humerus C S o l p i yd re i g5 h . t8 Classification of Bones Short bones © Generally cube-shape 2 0 0 3 Contain mostly spongy bone P e a r s o n Examples: Carpals, tarsals Sesamoid bones – form within tendons Examples: patella or kneecap C S o l p i yd re i g5 h . t9 © 2 0 0 3 P e a r s o n Classification of Bones Flat bones Thin and flattened Usually curved Thin layers of compact bone around a layer of spongy bone Examples: Skull, ribs, sternum Classification of Bones Irregular bones Irregular shape Do not fit into other bone classification categories Example: Vertebrae and hip Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings Slide 5.10 Gross Anatomy of a Long Bone Diaphysis Shaft - length Composed of compact bone Epiphysis Ends of the bone Composed mostly of spongy bone Figure 5.2a5.11 Copyright © 2003 Pearson Education, Inc. publishing Slide Structures of a Long Bone Periosteum Outside covering of the diaphysis Fibrous connective tissue membrane Sharpey’s fibers Secure periosteum to underlying bone Arteries Supply bone cells Figure 5.2c with nutrients Copyright © 2003 Pearson Education, Inc. publishing Slide 5.12 C S o l p i yd re i g5 h . t1 3 © 2 0 0 3 P e a r s o n Bone Growth Epiphyseal plates allow for growth of long bone during childhood New cartilage is continuously formed Older cartilage becomes ossified Cartilage is broken down Bone replaces cartilage Process of bone formation – ossification done by boneforming cells called osteoblasts Bone Growth Bones are remodeled and lengthened until growth stops Bones change shape somewhat Bones grow in width – appositional growth Growth due to growth hormones and sex hormones Bones are remodeled continually in response to: Calcium levels in blood and pull of gravity and © 2003 Pearson Education, Inc. Slide 5.14 muscles on theCopyright bones Bone Fractures A break in a bone Types of bone fractures Closed (simple) fracture – break that does not penetrate the skin Open (compound) fracture – broken bone penetrates through the skin Bone fractures are treated by reduction and immobilization Realignment of the bone – either by physician’s hands or surgery Common Types of Fractures Table 5.2 Copyright © 2003 Pearson Education, Inc. publishing Repair of Bone Fractures Hematoma (blood-filled swelling) is formed due to broken blood vessels Break is splinted by fibrocartilage to form a callus – cartilage matrix, bony matrix, collagen fibers – capillaries also form again Fibrocartilage callus is replaced by a bony callus made of spongy bone Bony callus is remodeled to form a Copyright © 2003 Pearson Education, Inc. publishing Slide 5.17 permanent patch C S o l p i yd re i g5 h . t1 8 © 2 0 0 3 P e a r s o n Stages in the Healing of a Bone Fracture The Axial Skeleton Copyright © 2003 Pearson Education, Inc. publishing as Slide 5.19 C S o l p i yd re i g5 h . t2 0 © 2 0 0 3 P e a r s o n The Axial Skeleton Forms the longitudinal part of the body Divided into three parts Skull Vertebral column Bony thorax The Skull Two sets of bones Cranium Facial bones Bones are joined by sutures – interlocking, immovable joints Only the mandible is attached by a freely movable joint Copyright © 2003 Pearson Education, Inc. publishing as5.21 Slide C S o l p i yd re i g5 h . t2 2 © The Skull 2 0 0 3 P e a r s o n Figure 5.7 Bones of the Skull Figure 5.11 Slide 5.23 Human Skull, Superior View Figure 5.11 Slide 5.24 Copyright © 2003 Pearson Education, Inc. publishing Structure of a Typical Vertebrae Figure 5.16 Copyright © 2003 Pearson Education, Inc. Slide 5.25 Regional Characteristics of Vertebrae Figure 5.17a, b Copyright © 2003 Pearson Education, Inc. publishing Slide 5.26 S l i d e Regional Characteristics of Vertebrae 5 . 2 7 Figure 5.17c, d The Bony Thorax Forms a cage to protect major organs Figure 5.19a Copyright © 2003 Pearson Education, Inc. publishing Slide 5.28 C S o l p i yd re i g5 h . t2 9 © 2 0 0 3 P e a r s o n The Appendicular Skeleton 126 bones of the: Limbs (appendages) Pectoral girdle Pelvic girdle The Appendicular Skeleton Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings Figure 5.6c Slide 5.30 Bones of the Shoulder Girdle Figure 5.20a, b Copyright © 2003 Pearson Education, Inc. Slide 5.31 Bones of the Upper Limb The arm is formed by a single bone Humerus Figure 5.21a, b Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings Bones of the Upper Limb • The forearm has two bones • Ulna • Radius Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings Figure 5.21c Bones of the Upper Limb The hand Carpals – wrist Metacarpals – palm Phalanges – fingers Figure 5.22 Copyright © 2003 Pearson Education, Inc. publishing Slide 5.34 Bones of the Pelvic Girdle Hip bones Composed of three pair of fused bones Ilium Ischium Pubic bone The total weight of the upper body rests on the pelvis Protects several organs Reproductive organs Urinary bladder Part of the large intestine Copyright © 2003 Pearson Education, Inc. publishing Slide 5.35 The Pelvis Figure 5.23a Copyright © 2003 Pearson Education, Inc. Slide 5.36 The Pelvis Copyright © 2003 Pearson Education, Inc. Figure 5.23b Slide 5.37 Gender Differences of the Pelvis Figure 5.23c Copyright © 2003 Pearson Education, Inc. publishing Slide 5.38 Bones of the Lower Limbs The thigh has one bone Femur – thigh bone The heaviest and strongest bone in the body Figure 5.35a, b Copyright © 2003 Pearson Education, Inc. publishing Slide 5.39 S l i d e 5 . 4 0 Bones of the Lower Limbs The leg has two bones Tibia Fibula Figure 5.35c Bones of the Lower Limbs The foot Tarsus – ankle Metatarsals – sole Phalanges – toes Copyright © 2003 Pearson Education, Inc. publishing Figure 5.25 Slide 5.41 Arches of the Foot Bones of the foot are arranged to form three strong arches Two longitudinal One transverse Figure 5.26 Copyright © 2003 Pearson Education, Inc. publishing Slide 5.42 Joints Articulations of bones Functions of joints Hold bones together Allow for mobility Ways joints are classified Functionally Structurally Copyright © 2003 Pearson Education, Inc. publishing as Slide 5.43 S l i d e 5 . 4 4 Functional Classification of Joints Synarthroses – immovable joints Amphiarthroses – slightly moveable joints Diarthroses – freely moveable joints Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings Fibrous Joints Bones united by fibrous tissue Examples Sutures in skull Syndesmoses Allows more movement than sutures because fibers are longer Example: distal end of tibia and fibula Figure 5.27d, e Copyright © 2003 Pearson Education, Inc. publishing Slide 5.45 Cartilaginous Joints Bones connected by cartilage Examples Pubic symphysis - pelvis Intervertebral joints – spinal column Figure 5.27b, c Copyright © 2003 Pearson Education, Inc. publishing Synovial Joints Articulating bones are separated by a joint cavity Synovial fluid is found in the joint cavity Copyright © 2003 Pearson Education, Inc. publishing Figure 5.27f–h Slide 5.47 The Synovial Joint Figure 5.28 Copyright © 2003 Pearson Education, Inc. publishing Slide 5.48 Types of Synovial Joints Based on Shape Figure 5.29a–c Copyright © 2003 Pearson Education, Inc. publishing as Slide 5.49 Types of Synovial Joints Based on Shape Figure 5.29d–f Slide 5.50 The Muscular System Muscles are responsible for all types of body movement Three basic muscle types are found in the body Skeletal muscle Cardiac muscle Smooth muscle Copyright © 2003 Pearson Education, Inc. Slide 6.51 Characteristics of Muscles Muscle cells are elongated (muscle cell = muscle fiber) Contraction of muscles is due to the movement of myofilaments – the muscle cell equivalent of the microfilaments of cytoskeletons All muscles share some terminology Prefix myo refers to muscle Prefix mys refers to muscle Prefix sarco refers to flesh Copyright © 2003 Pearson Education, Inc. publishing Slide 6.52 S l i d e 6 . 5 3 Skeletal Muscle Characteristics Most are attached by tendons to bones Cells are multinucleate & cigar-shaped Striated – have visible banding Voluntary – subject to conscious control Cells are surrounded and bundled by connective tissue Copyright © 2003 Pearson Education, Inc. publishing as Connective Tissue Wrappings of Skeletal Muscle Endomysium – connective tissue around single muscle fiber Perimysium – around a fascicle (bundle) of fibers Figure 6.1 Copyright © 2003 Pearson Education, Inc. Slide 6.54 Connective Tissue Wrappings of Skeletal Muscle Epimysium – covers the entire skeletal muscle Fascia – on the outside of the epimysium Figure 6.1 Copyright © 2003 Pearson Education, Inc. publishing as Skeletal Muscle Attachments Epimysium blends into a connective tissue attachment Tendon – cord-like structure Aponeuroses – sheet-like structure Sites of muscle attachment Bones Cartilages Connective tissue coverings Copyright © 2003 Pearson Education, Inc. publishing Slide 6.56 Smooth Muscle Characteristics Has no striations Spindle-shaped cells Single nucleus Involuntary – no conscious control Found mainly in the walls of hollow organs – visceral Arranged in two sheets or layers Figure 6.2a Copyright © 2003 Pearson Education, Inc. publishing Cardiac Muscle Characteristics Has striations Usually has a single nucleus Joined to another muscle cell at an intercalated disc Involuntary Found only in the heart Figure 6.2b Copyright © 2003 Pearson Education, Inc. publishing Slide 6.58 S l i d e 6 . 5 9 Function of Muscles Produce movement Maintain posture Stabilize joints Generate heat Copyright © 2003 Pearson Education, Inc. publishing as S l i d e 6 . 6 0 Properties of Skeletal Muscle Activity Irritability – ability to receive and respond to a stimulus Contractility – ability to shorten when an adequate stimulus is received Copyright © 2003 Pearson Education, Inc. publishing as Nerve Stimulus to Muscles Skeletal muscles must be stimulated by a nerve to contract Motor unit One neuron Muscle cells stimulated by that neuron Figure 6.4a Copyright © 2003 Pearson Education, Inc. publishing Slide 6.61 as Benjamin Cummings Nerve Stimulus to Muscles Neuromuscular junctions – association site of nerve and muscle Figure 6.5b Slide 6.62 Nerve Stimulus to Muscles Synaptic cleft – gap between nerve and muscle Nerve and muscle do not make contact Area between nerve and muscle is filled with interstitial fluid Figure 6.5b Copyright © 2003 Pearson Education, Inc. publishing as Slide 6.63 Contraction of a Skeletal Muscle Muscle fiber contraction is “all or none” Within a skeletal muscle, not all fibers may be stimulated during the same interval Different combinations of muscle fiber contractions may give differing responses Graded responses – different degrees of skeletal muscle shortening Changing frequency of stimulation Changing number of muscle cells stimulated Slide 6.64 Muscle Response to Strong Stimuli Muscle force depends upon the number of fibers stimulated More fibers contracting results in greater muscle tension Muscles can continue to contract unless they run out of energy Slide 6.65 Copyright © 2003 Pearson Education, Inc. publishing as Muscle Fatigue and Oxygen Debt When a muscle is fatigued, it is unable to contract even when stimulated The common reason for muscle fatigue is oxygen debt Oxygen must be “repaid” to tissue to remove oxygen debt Oxygen is required to get rid of accumulated lactic acid Increasing acidity (from lactic acid) and lack of ATP causes the muscle to contract less Slide 6.66 Types of Muscle Contractions Isotonic contractions – “same tone” or tension Myofilaments are able to slide past each other during contractions The muscle shortens Isometric contractions – “same measurement” or length Tension in the muscles increases The muscle is unable to shorten Copyright © 2003 Pearson Education, Inc. publishing as Slide 6.67 Muscle Tone Some fibers are contracted even in a relaxed muscle Different fibers contract at different times to provide muscle tone The process of stimulating various fibers is under involuntary control Copyright © 2003 Pearson Education, Inc. publishing Slide 6.68 Effects of Exercise on Muscle Results of increased muscle use Increase in muscle size Increase in muscle strength Increase in muscle efficiency Muscle becomes more fatigue resistant Copyright © 2003 Pearson Education, Inc. publishing Slide 6.69 Types of Muscles Prime mover – muscle with the major responsibility for a certain movement Antagonist – muscle that opposes or reverses a prime mover Synergist – muscle that aids a prime mover in the same movement and helps prevent rotation or unwanted movement Fixator – stabilizes the origin of a prime mover so all tension can be used to move the insertion bone Slide 6.70 Copyright © 2003 Pearson Education, Inc. publishing Naming of Skeletal Muscles Direction of muscle fibers Example: rectus (straight) or oblique (slanted) Relative size of the muscle Examples: maximus (largest), minimus (smallest), longus (long) Copyright © 2003 Pearson Education, Inc. publishing Slide 6.71 Naming of Skeletal Muscles Location of the muscle Example: many muscles are named for bones (e.g., temporalis, which is near the temporal bone) Number of origins Example: biceps, triceps, quadriceps (two, three, or four origins or heads) Slide 6.72 Copyright © 2003 Pearson Education, Inc. publishing as Naming of Skeletal Muscles Location of the muscle’s origin and insertion Example: sterno (on the sternum) cleido (clavicle) mastoid (on the mastoid process) Shape of the muscle Example: deltoid (triangular) Action of the muscle Example: flexor and extensor (flexes or extends a bone) Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings Slide 6.51 Muscles and Body Movements Movement is attained due to a muscle moving an attached bone Figure 6.12 Slide 6.74 Muscles and Body Movements Muscles are attached to at least two points Origin – attachment to an immoveable bone Insertion – attachment to a movable bone Figure 6.12 Copyright © 2003 Pearson Education, Inc. publishing Slide 6.75 Types of Ordinary Body Movements Flexion – brings 2 bones closer together Extension – increases distance between 2 bones Rotation Abduction – moving a limb away from the midline of the body Adduction – moving a limb toward the midline Circumduction – combination of all of the above except rotation Copyright © 2003 Pearson Education, Inc. publishing Special Movements Dorsiflexion – lifting the foot Plantar flexion – depressing the foot Inversion – turn foot inward Eversion – turn foot outward Supination – hand facing upward Pronation – hand facing downward Opposition – touching thumb to other fingers Copyright © 2003 Pearson Education, Inc. Slide 6.77 Head and Neck Muscles Figure 6.14 Trunk Muscles Figure 6.15 Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings Deep Trunk and Arm Muscles Figure 6.16 Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings Muscles of the Pelvis, Hip, and Thigh Figure 6.18c Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings Slide 6.55 Muscles of the Lower Leg Figure 6.19 Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings Slide 6.56 Superficial Muscles: Anterior Figure 6.20 Copyright © 2003 Pearson Education, Inc. Slide 6.57 Superficial Muscles: Posterior Figure 6.21 Copyright © 2003 Pearson Education, Inc. The Digestive System and Body Metabolism Digestion Breakdown of ingested food Absorption of nutrients into the blood Metabolism Production of cellular energy (ATP) Constructive and degradative cellular activities Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings Slide 14.1 Organs of the Digestive System Figure 14.1 Slide 14.2b Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings Organs of the Digestive System Two main groups Alimentary canal – continuous coiled hollow tube Accessory digestive organs Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings Slide 14.2a Organs of the Alimentary Canal Mouth Pharynx Esophagus Stomach Small intestine Large intestine Anus Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings Slide 14.3 Mouth (Oral Cavity) Anatomy Lips (labia) – protect the anterior opening Cheeks – form the lateral walls Hard palate – forms the anterior roof Soft palate – forms the posterior roof Uvula – fleshy projection of the soft palate Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings Figure 14.2a Slide 14.4 Mouth (Oral Cavity) Anatomy Vestibule – space between lips externally and teeth and gums internally Oral cavity – area contained by the teeth Tongue – attached at hyoid and styloid processes of the skull, and by the lingual frenulum Figure 14.2a Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings Slide 14.5 Mouth (Oral Cavity) Anatomy Tonsils Palatine tonsils Lingual tonsil Figure 14.2a Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings Slide 14.6 Processes of the Mouth Mastication (chewing) of food Mixing masticated food with saliva Initiation of swallowing by the tongue Allowing for the sense of taste Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings Slide 14.7 Pharynx Anatomy Nasopharynx – not part of the digestive system Oropharynx – posterior to oral cavity Laryngopharynx – below the oropharynx and connected to the esophagus Figure 14.2a Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings Slide 14.8 Pharynx Function Serves as a passageway for air and food Food is propelled to the esophagus by two muscle layers Longitudinal inner layer Circular outer layer Food movement is by alternating contractions of the muscle layers (peristalsis) Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings Slide 14.9 Esophagus Runs from pharynx to stomach through the diaphragm Conducts food by peristalsis (slow rhythmic squeezing) Passageway for food only (respiratory system branches off after the pharynx) Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings Slide 14.10 Layers of Alimentary Canal Organs Mucosa Submucosa Innermost layer Just beneath the mucosa Moist membrane Soft connective tissue with blood vessels, nerve endings, and lymphatics Surface epithelium Small amount of connective tissue (lamina propria) Small smooth muscle layer Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings Slide 14.11a Specialized Mucosa of the Stomach Simple columnar epithelium Mucous neck cells – produce a sticky alkaline mucus Gastric glands – secrete gastric juice Chief cells – produce protein-digesting enzymes (pepsinogens) Parietal cells – produce hydrochloric acid Endocrine cells – produce gastrin Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings Slide 14.19 Layers of Alimentary Canal Organs Muscularis externa – smooth muscle Inner circular layer Outer longitudinal layer Serosa Outermost layer – visceral peritoneum Layer of serous fluid-producing cells Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings Slide 14.11b Structure of the Stomach Mucosa Gastric pits formed by folded mucosa Glands and specialized cells are in the gastric gland region Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings Slide 14.20a Layers of Alimentary Canal Organs Figure 14.3 Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings Slide 14.13 Alimentary Canal Nerve Plexuses All are part of the autonomic nervous system Three separate networks of nerve fibers Submucosal nerve plexus Myenteric nerve plexus Subserous plexus Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings Slide 14.14 Stomach Anatomy Located on the left side of the abdominal cavity Food enters at the cardioesophageal sphincter Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings Slide 14.15a Stomach Functions Acts as a storage tank for food Site of food breakdown Chemical breakdown of protein begins Delivers chyme (processed food) to the small intestine Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings Slide 14.18 Stomach Functions Regions of the stomach Cardiac region – near the heart Fundus Body Pylorus – funnel-shaped terminal end Food empties into the small intestine at the pyloric sphincter Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings Slide 14.18 Stomach Anatomy Rugae – internal folds of the mucosa External regions Lesser curvature Greater curvature Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings Slide 14.16a Stomach Anatomy Layers of peritoneum attached to the stomach Lesser omentum – attaches the liver to the lesser curvature Greater omentum – attaches the greater curvature to the posterior body wall Contains fat to insulate, cushion, and protect abdominal organs Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings Slide 14.16b Stomach Anatomy Figure 14.4a Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings Slide 14.17 Small Intestine The body’s major digestive organ Site of nutrient absorption into the blood Muscular tube extending form the pyloric sphincter to the ileocecal valve Suspended from the posterior abdominal wall by the mesentery Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings Slide 14.21 Subdivisions of the Small Intestine Duodenum Attached to the stomach Curves around the head of the pancreas Jejunum Attaches anteriorly to the duodenum Ileum Extends from jejunum to large intestine Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings Slide 14.22 Chemical Digestion in the Small Intestine Source of enzymes that are mixed with chyme Intestinal cells Pancreas Bile enters from the gall bladder Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings Slide 14.23a Chemical Digestion in the Small Intestine Figure 14.6 Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings Slide 14.23b Villi of the Small Intestine Fingerlike structures formed by the mucosa Give the small intestine more surface area Figure 14.7a Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings Slide 14.24 Microvilli of the Small Intestine Small projections of the plasma membrane Found on absorptive cells Figure 14.7c Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings Slide 14.25 Structures Involved in Absorption of Nutrients Absorptive cells Blood capillaries Lacteals (specialized lymphatic capillaries) Figure 14.7b Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings Slide 14.26 Folds of the Small Intestine Called circular folds or plicae circulares Deep folds of the mucosa and submucosa Do not disappear when filled with food The submucosa has Peyer’s patches (collections of lymphatic tissue) Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings Slide 14.27 Large Intestine Larger in diameter, but shorter than the small intestine Frames the internal abdomen Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings Functions of the Large Intestine Absorption of water Eliminates indigestible food from the body as feces Does not participate in digestion of food Goblet cells produce mucus to act as a lubricant Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings Slide 14.29 Structures of the Large Intestine Cecum – saclike first part of the large intestine Appendix Accumulation of lymphatic tissue that sometimes becomes inflamed (appendicitis) Hangs from the cecum Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings Slide 14.30a Structures of the Large Intestine Colon Ascending Transverse Descending S-shaped sigmoidal Rectum Anus – external body opening Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings Slide 14.30b Modifications to the Muscularis Externa in the Large Intestine Smooth muscle is reduced to three bands (teniae coli) Muscle bands have some degree of tone Walls are formed into pocketlike sacs called haustra Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings Slide 14.31 Accessory Digestive Organs Salivary glands Teeth Pancreas Liver Gall bladder Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings Slide 14.32 Salivary Glands Saliva-producing glands Parotid glands – located anterior to ears Submandibular glands Sublingual glands Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings Slide 14.33 Saliva Mixture of mucus and serous fluids Helps to form a food bolus Contains salivary amylase to begin starch digestion Dissolves chemicals so they can be tasted Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings Slide 14.34 Teeth The role is to masticate (chew) food Humans have two sets of teeth Deciduous (baby or milk) teeth 20 teeth are fully formed by age two Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings Permanent teeth Replace deciduous teeth beginning between the ages of 6 to 12 A full set is 32 teeth, but some people do not have wisdom teeth Slide 14.35a Classification of Teeth Figure 14.9 Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings Slide 14.36b Regions of a Tooth Crown – exposed part Outer enamel Dentin Pulp cavity Neck Region in contact with the gum Connects crown to root Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings Figure 14.10 Slide 14.37a Regions of a Tooth Root Periodontal membrane attached to the bone Root canal carrying blood vessels and nerves Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings Figure 14.10 Slide 14.37b Pancreas Produces a wide spectrum of digestive enzymes that break down all categories of food Enzymes are secreted into the duodenum Alkaline fluid introduced with enzymes neutralizes acidic chyme Endocrine products of pancreas Insulin Glucagons Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings Slide 14.38 Liver Largest gland in the body Located on the right side of the body under the diaphragm Consists of four lobes suspended from the diaphragm and abdominal wall by the falciform ligament Connected to the gall bladder via the common hepatic duct Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings Slide 14.39 Bile Produced by cells in the liver Composition Bile salts Bile pigment (mostly bilirubin from the breakdown of hemoglobin) Cholesterol Phospholipids Electrolytes Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings Slide 14.40 Gall Bladder Sac found in hollow fossa of liver Stores bile from the liver by way of the cystic duct Bile is introduced into the duodenum in the presence of fatty food Gallstones can cause blockages Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings Slide 14.41 The Senses General senses of touch (tactile) Temperature- thermoreceptors (heat) Pressure- mechanoreceptors (movement) Pain- mechanoreceptors Special senses Smell- chemoreceptors (chemicals) Taste- chemoreceptors Sight- photoreceptors (light) Hearing- mechanoreceptors Equilibrium- (balance) mechanoreceptors The Eye and Vision 70 percent of all sensory receptors are in the eyes Each eye has over a million nerve fibers Protection for the eye Most of the eye is enclosed in a bony orbit made up of the lacrimal (medial), ethmoid (posterior), sphenoid (lateral), frontal (superior), and zygomatic and maxilla (inferior) A cushion of fat surrounds most of the eye Accessory Structures of the Eye Eyelids - brush particles out of eye or cover eye Eyelashes - trap particles and keep them out of the eye Ciliary glands – modified sweat glands between the eyelashes - secrete acidic sweat to kill bacteria, lubricate eyelashes Accessory Structures of the Eye Accessory Structures of the Eye Conjunctiva Membrane that lines the eyelids Connects to the surface of the eye- forms a seal Secretes mucus to lubricate the eye http://neuromedia.neurobio.ucla.edu/campbell/eyeandear/wp_images/175_conjunctiva.gif Accessory Structures of the Eye Lacrimal apparatus Lacrimal gland – produces lacrimal fluid Lacrimal canals – drains lacrimal fluid from eyes Lacrimal sac – provides passage of lacrimal fluid towards nasal cavity Nasolacrimal duct – empties lacrimal fluid into the nasal cavity Function of the Lacrimal Apparatus Properties of lacrimal fluid Dilute salt solution (tears) Contains antibodies (fight antigens- foreign substance) and lysozyme (enzyme that destroys bacteria) Protects, moistens, and lubricates the eye Empties into the nasal cavity Extrinsic Eye Muscles Muscles attach to the outer surface of the eye Produce eye movements When Extrinsic Eye Muscles Contract Superior oblique- eyes look out and down Superior rectus- eyes looks up Lateral rectus- eyes look outward Medial rectus- eyes look inward Inferior rectus- eyes looks down Inferior oblique- eyes look in and up Structure of the Eye The wall is composed of three tunics Fibrous tunic – outside layer Choroid – middle layer Sensory tunic – inside layer The Fibrous Tunic Sclera White connective tissue layer Seen anteriorly as the “white of the eye” Semi-transparent The Fibrous Tunic Cornea Transparent, central anterior portion Allows for light to pass through (refracts, or bends, light slightly) Repairs itself easily The only human tissue that can be transplanted without fear of rejection Choroid Layer Blood-rich nutritive tunic Pigment prevents light from scattering (opaqueblocks light from getting in, has melanin) Choroid Layer Modified interiorly into two structures Cilliary body – smooth muscle (contracts to adjust the shape of the lens) Iris- pigmented layer that gives eye color (contracts to adjust the size of the pupil- regulates entry of light into the eye) Pupil – rounded opening in the iris Sensory Tunic (Retina) Contains receptor cells (photoreceptors) Rods Cones Signals leave the retina toward the brain through the optic nerve Sensory Tunic (Retina) Signals pass from photoreceptors via a two-neuron chain Bipolar neurons and Ganglion cells Neurons of the Retina and Vision Rods Most are found towards the edges of the retina Allow dim light vision and peripheral vision (more sensitive to light, do not respond in bright light) Perception is all in gray tones ROD CELLS http://webvision.med.utah.edu/imageswv/rod-GC.jpeg http://www.webvision.med.utah.edu/imageswv/PKCrodb.jpeg Neurons of the Retina and Vision Cones Allow for detailed color vision Densest in the center of the retina Fovea centralis – area of the retina with only cones Respond best in bright light No photoreceptor cells are at the optic disk, or blind spot Cone Sensitivity • There are three types of cones • Different cones are sensitive to different wavelengths - red- long - green- medium - blue- short • Color blindness is the result of lack of one or more cone type Lens Biconvex crystal-like structure Held in place by a suspensory ligament attached to the ciliary body Refracts light greatly Internal Eye Chamber Fluids Aqueous humor Watery fluid found in chamber between the lens and cornea Similar to blood plasma Helps maintain intraocular pressure Provides nutrients for the lens and cornea Reabsorbed into venous blood through the canal of Schlemm Refracts light slightly Internal Eye Chamber Fluids Vitreous humor Gel-like substance behind the lens Keeps the eye from collapsing Lasts a lifetime and is not replaced http://faculty.washington.edu/kepeter/119/images/eye3.jpg Refracts light slightly Holds lens and retina in place Lens Accommodation Light must be focused to a point on the retina for optimal vision The eye is set for distance vision (over 20 ft away) 20/20 vision- at 20 feet, you see what a normal eye would see at 20 feet (20/100- at 20, normal person would see at 100) The lens must change shape to focus for closer objects Images Formed on the Retina If the image is focused at the spot where the optic disk is located, nothing will be seen. This is known as the blind spot. There are no photoreceptors there, as nerves and blood vessels pass through this point. Visual Pathway Photoreceptors of the retina Optic nerve Optic nerve crosses at the optic chiasma Visual Pathway Optic tracts Thalamus (axons form optic radiation) Visual cortex of the occipital lobe Eye Reflexes Internal muscles are controlled by the autonomic nervous system Bright light causes pupils to constrict through action of radial (iris) and ciliary muscles Viewing close objects causes accommodation External muscles control eye movement to follow objects- voluntary, controlled at the frontal eye field Viewing close objects causes convergence (eyes moving medially) The Ear Houses two senses Hearing (interpreted in the auditory cortex of the temporal lobe) Equilibrium (balance) (interpreted in the cerebellum) Receptors are mechanoreceptors Different organs house receptors for each sense Anatomy of the Ear The ear is divided into three areas Outer (external) ear Middle ear Inner ear The External Ear Involved in hearing only Structures of the external ear Pinna (auricle)collects sound External auditory canalchannels sound inward The External Auditory Canal Narrow chamber in the temporal bone- through the external auditory meatus Lined with skin Ceruminous (wax) glands are present Ends at the tympanic membrane (eardrum) The Middle Ear or Tympanic Cavity Air-filled cavity within the temporal bone Only involved in the sense of hearing Two tubes are associated with the inner ear The opening from the auditory canal is covered by the tympanic membrane (eardrum) The auditory tube connecting the middle ear with the throat (also know as the eustacian tube) Allows for equalizing pressure during yawning or swallowing This tube is otherwise collapsed Bones of the Tympanic Cavity Three bones span the cavity Malleus (hammer) Incus (anvil) Stapes (stirrup) Bones of the Tympanic Cavity Vibrations from eardrum move the malleus These bones transfer sound to the inner ear Inner Ear or Bony Labyrinth Also known as osseous labyrinthtwisted bony tubes Includes sense organs for hearing and balance Filled with perilymph Inner Ear or Bony Labyrinth • Vibrations of the stapes push and pull on the membranous oval window, moving the perilymph through the cochlea. The round window is a membrane at the opposite end to relieve pressure. Inner Ear or Bony Labryinth A maze of bony chambers within the temporal bone Cochlea Upper chamber is the scala vestibuli Lower chamber is the scala tympani Vestibule Semicircular canals Organ of Corti Located within the cochlea Receptors = hair cells on the basilar membrane Gel-like tectorial membrane is capable of bending hair cells (endolymph in the membranous labyrinth of the cochlear duct flows over it and pushes on the membrane) Cochlear nerve attached to hair cells transmits nerve impulses to auditory cortex on temporal lobe Organs of Hearing Scala vestibuli Scala tympani Mechanisms of Hearing Vibrations from sound waves move tectorial membrane (pass through the endolymph fluid filling the membranous labyrinth in the cochlear duct) Hair cells are bent by the membrane Mechanisms of Hearing An action potential starts in the cochlear nerve The signal is transmitted to the midbrain (for auditory reflexes and then directed to the auditory cortex of the temporal lobe) Continued stimulation can lead to adaptation (over stimulation to the brain makes it stop interpreting the sounds) Organs of Equilibrium Receptor cells are in two structures Vestibule Semicircular canals Equilibrium has two functional parts Static equilibrium- in the vestibule Dynamic equilibrium- in the semicircular canals Organs of Equilibrium Chemical Senses – Taste and Smell Both senses use chemoreceptors Stimulated by chemicals in solution Taste has four types of receptors Smell can differentiate a large range of chemicals Both senses complement each other and respond to many of the same stimuli Olfaction – The Sense of Smell Olfactory receptors are in the roof of the nasal cavity Neurons with long cilia Chemicals must be dissolved in mucus for detection Impulses are transmitted via the olfactory nerve Interpretation of smells is made in the cortex (olfactory area of temporal lobe) The Sense of Taste Taste buds house the receptor organs Location of taste buds Most are on the tongue Soft palate Cheeks The Tongue and Taste The tongue is covered with projections called papillae Filiform papillae – sharp with no taste buds Fungifiorm papillae – rounded with taste buds Circumvallate papillae – large papillae with taste buds Taste buds are found on the sides of papillae Structure of Taste Buds Gustatory cells are the receptors Have gustatory hairs (long microvilli) Hairs are stimulated by chemicals dissolved in saliva Impulses are carried to the gustatory complex (pareital lobe) by several cranial nerves because taste buds are found in different areas Facial nerve Glossopharyngeal nerve Vagus nerve Structure of Taste Buds Taste Sensations Sweet receptors Sugars Saccharine Some amino acids Sour receptors Acids Bitter receptors Alkaloids Salty receptors Metal ions Umami Glutamate, aspartate (MSG, meats) http://instruct1.cit.cornell.edu/courses/psych431/student2000/mle6/tonguebig.gif Developmental Aspects of the Special Senses Formed early in embryonic development Eyes are outgrowths of the brain All special senses are functional at birth The Nervous System Functions of the Nervous System Sensory input – gathering information To monitor changes occurring inside and outside the body Changes = stimuli Integration To process and interpret sensory input and decide if action is needed Motor output A response to integrated stimuli The response activates muscles or glands Slide 7.186 Copyright © 2003 Pearson Education, Inc. publishing as Structural Classification of the Nervous System Central nervous system (CNS) Brain and Spinal cord Acts as integrating and command center – interpret incoming sensory information and issue instructions based on past experiences and current conditions Peripheral nervous system (PNS) Nerves outside the brain and spinal cord Link all parts of the body by carrying impulses to the CNS and back Slide 7.187 Copyright © 2003 Pearson Education, Inc. publishing as Functional Classification of the Peripheral Nervous System Sensory (afferent) division Nerve fibers that carry information to the central nervous system Figure 7.1 Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings Slide 7.188 Functional Classification of the Peripheral Nervous System Motor (efferent) division Nerve fibers that carry impulses away from the central nervous system Figure 7.1 Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings Slide 7.189 Functional Classification of the Peripheral Nervous System Motor (efferent) division Two subdivisions Somatic nervous system = voluntary nervous system Skeletal muscle reflexes such as stretch reflex are initiated involuntarily by same fibers Autonomic nervous system = involuntary nervous system Sympathetic and parasympathetic divisions Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings Slide 7.6 Organization of the Nervous System Figure 7.2 Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Nervous Tissue: Neurons Neurons = nerve cells Cells specialized to transmit messages Major regions of neurons Cell body – nucleus and metabolic center of the cell Processes – fibers that extend from the cell body Slide 7.192 Neuron Anatomy Cell body Nissl substance – specialized rough endoplasmic reticulum Neurofibrils – intermediate cytoskeleton that maintains cell shape Figure 7.4a Copyright © 2003 Pearson Education, Inc. publishing as7.193 Slide Benjamin Cummings Neuron Anatomy Cell body Nucleus Large nucleolus Extensions outside the cell body Dendrites – conduct impulses toward the cell body Axons – conduct impulses away from the cell body Copyright © 2003 Pearson Education, Inc. publishing as Figure 7.4a Slide 7.194 Axons and Nerve Impulses Axons end in axonal terminals Axonal terminals contain vesicles with neurotransmitters Axonal terminals are separated from the next neuron by a gap Synaptic cleft – gap between adjacent neurons Synapse – junction between nerves Slide 7.195 Nerve Fiber Coverings Schwann cells – produce myelin sheaths in jelly-roll Nodes of Ranvier – gaps in myelin sheath along the axon Figure 7.5 Slide 7.196 Neuron Cell Body Location Most are found in the central nervous system in clusters called nuclei Bundles of nerve fibers in CNS = tracts Gray matter – cell bodies and unmyelinated fibers White matter – myelinated fibers Bundles of nerve fibers in PNS = nerves Ganglia – collections of cell bodies outside the central nervous system Functional Classification of Neurons Sensory (afferent) neurons Cell bodies in a ganglion outside the CNS Carry impulses from the sensory receptors to CNS Cutaneous (skin) sense organs Proprioceptors – detect stretch or tension in muscles, tendons, joints Motor (efferent) neurons Cell bodies found in the CNS Carry impulses from the central nervous system Slide 7.198 Neuron Classification Figure 7.6 Structural Classification of Neurons Multipolar neurons – many extensions from the cell body Figure 7.8a Slide 7.200 Structural Classification of Neurons Bipolar neurons – one axon and one dendrite Rare in adults – in eye and ear only Figure 7.8b Slide 7.201 Structural Classification of Neurons Unipolar neurons – have a short, single process leaving the cell body Axon conducts nerve impulses both to and from the cell body Figure 7.8c Slide 7.202 Continuation of the Nerve Impulse between Neurons Impulses are unable to cross the synapse to another nerve Neurotransmitter is released from a nerve’s axon terminal The dendrite of the next neuron has receptors that are stimulated by the neurotransmitter An action potential is started in the dendrites of the next neuron Transmission of an impulse is an electrochemical event Slide 7.203 Functional Classification of Neurons Interneurons (association neurons) Found in neural pathways in the central nervous system Cell bodies in the CNS Connect sensory and motor neurons Slide 7.204 Functional Properties of Neurons Two main functions Irritability – ability to respond to stimuli Conductivity – ability to transmit an impulse The plasma membrane at rest is polarized Fewer positive ions (usually K+) are inside the cell than outside the cell (usually Na+) Slide 7.205 The Reflex Arc Reflex – rapid, predictable, and involuntary responses to stimuli Reflex arc – direct route from a sensory neuron, to an interneuron, to an effector Copyright © 2003 Pearson Education, Inc. publishing as Figure 7.11a Slide 7.206 Simple Reflex Arc Figure 7.11b, c Slide 7.207 Types of Reflexes and Regulation Autonomic reflexes Smooth muscle regulation Size of eye pupils Heart and blood pressure regulation Regulation of glands and sweating Digestive system and elimination regulation Somatic reflexes Activation of skeletal muscles Slide 7.208 Types of Reflexes and Regulation Reflex arcs have a minimum five elements A sensory receptor – reacts to stimuli An effector receptor – muscle or gland stimulated Afferent and efferent neurons connecting the two The CNS integration center Slide 7.209 Central Nervous System (CNS) CNS develops from the embryonic neural tube – a simple tube The neural tube becomes the brain and spinal cord The opening of the neural tube becomes the ventricles Four chambers within the brain Filled with cerebrospinal fluid Slide 7.210 Regions of the Brain Cerebral hemispheres Diencephalon Brain stem Cerebellum Figure 7.12 Slide 7.211 Cerebral Hemispheres (Cerebrum) Paired (left and right) superior parts of the brain Include more than half of the brain mass Figure 7.13a Slide 7.212 Cerebral Hemispheres (Cerebrum) The surface is made of: Gyri - elevated ridges Sulci - shallow grooves Figure 7.13a Slide 7.213 Lobes of the Cerebrum Fissures (deep grooves) divide the cerebrum into lobes Surface lobes of the cerebrum – named for cranial bone over them Frontal lobe Parietal lobe Occipital lobe Temporal lobe Slide 7.214 Lobes of the Cerebrum Figure 7.15a Slide 7.215 Sensory and Motor Areas of the Cerebral Cortex Figure 7.14 Slide 7.216 Specialized Areas of the Cerebrum Somatic sensory area in parietal lobe – receives impulses from the body’s sensory receptors (except special senses) Occipital lobe – vision and temporal lobe – auditory Primary motor area – sends impulses to skeletal muscles – frontal lobe Broca’s area – involved in our ability to speak – base of the precentral gyrus Slide 7.217 Specialized Area of the Cerebrum Cerebral areas involved in special senses Gustatory area (taste) Visual area Auditory area Olfactory area Interpretation areas of the cerebrum Speech/language region Language comprehension region General interpretation area Slide 7.218 Specialized Area of the Cerebrum Figure 7.13c Layers of the Cerebrum Gray matter Outermost layer Composed mostly of neuron cell bodies Cerebral cortex Figure 7.13a Slide 7.220 Layers of the Cerebrum White matter Fiber tracts inside the gray matter Example: corpus callosum connects hemispheres Figure 7.13a Layers of the Cerebrum Basal nuclei – internal islands of gray matter Helps regulate voluntary motor activities by modifying instructions sent to the skeletal muscles Figure 7.13a Slide 7.222 Diencephalon - interbrain Sits on top of the brain stem Enclosed by the cerebral hemispheres Made of three parts Thalamus Hypothalamus Epithalamus Slide 7.223 Diencephalon Figure 7.15 Slide 7.224 Thalamus Surrounds the third ventricle of the brain The relay station for sensory impulses passing upward to the sensory cortex Transfers impulses to the correct part of the cortex for localization and interpretation Slide 7.225 Hypothalamus Under the thalamus Important autonomic nervous system center Helps regulate body temperature Controls water balance Regulates metabolism An important part of the limbic system (emotions) – emotionalvisceral brain The pituitary gland is attached to and regulated by the Slide 7.226 hypothalamus Epithalamus Forms the roof of the third ventricle Houses the pineal body (an endocrine gland) Includes the choroid plexus – forms cerebrospinal fluid Slide 7.227 Brain Stem Attaches to the spinal cord Parts of the brain stem Midbrain Pons Medulla oblongata Slide 7.228 Brain Stem Figure 7.15a Midbrain Mostly composed of tracts of nerve fibers The cerebral aqueduct – canal that connects the 3rd ventricle of the diencephalon to the 4th ventricle Has two bulging fiber tracts – cerebral peduncles – convey ascending and descending impulses Has four rounded protrusions – corpora quadrigemina – Reflex centers for vision and hearing Slide 7.230 Pons The bulging center part of the brain stem Mostly composed of fiber tracts Includes nuclei involved in the control of breathing Slide 7.231 Medulla Oblongata The lowest part of the brain stem Merges into the spinal cord Includes important fiber tracts Contains important control centers Heart rate control Blood pressure regulation Breathing Swallowing Vomiting Slide 7.232 Cerebellum Two hemispheres with convoluted surfaces Provides involuntary coordination of body movements – of skeletal muscles, balance and equilibrium Automatic pilot – continually comparing brain’s intentions with actual body performance Slide 7.233 Cerebellum Figure 7.15a Protection of the Central Nervous System Scalp and skin Cerebrospinal fluid Skull and vertebral Blood brain barrier column Meninges Figure 7.16a Meninges Dura mater Double-layered external covering the brain Periosteum – attached to surface of the skull Meningeal layer – outer covering of the brain and continues as the dura matter of the spinal cord Folds inward in several areas that attaches the brain to cranial cavity Meninges Arachnoid layer Middle layer that is web-like Pia mater Internal layer that clings to the surface of the brain following every fold Subarachnoid space filled with cerebrospinal fluid Arachnoid villi – projections of arachnoid membrane protruding through the dura matter Slide 7.237 Cerebrospinal Fluid Similar to blood plasma composition Less protein, more vitamin C, different ions Formed by the choroid plexus Forms a watery cushion to protect the brain Circulated in arachnoid space, ventricles, and central canal of the spinal cord Ventricles and Location of the Cerebrospinal Fluid Figure 7.17a Ventricles and Location of the Cerebrospinal Fluid Figure 7.17b Blood Brain Barrier Includes the least permeable capillaries of the body – only H2O, glucose, and essential amino acids get through Excludes many potentially harmful substances Useless against some substances Fats and fat soluble molecules Respiratory gases Alcohol Nicotine Anesthesia Spinal Cord Extends from the medulla oblongata to the region of T12 Below T12 is the cauda equina (a collection of spinal nerves) Enlargements occur in the cervical and lumbar regions Figure 7.18 Slide 7.242 Spinal Cord Anatomy Internal gray matter - mostly cell bodies that surround the central canal of the cord Dorsal (posterior) horns Anterior (ventral) horns Contains motor neurons of the somatic nervous system, which send their axons out the ventral root Together they fuse to form the spinal nerves Nerves leave at the level of each vertebrae Spinal Cord Anatomy Cell bodies of sensory neurons, whose fibers enter the cord by the dorsal root, are found in an enlarged area called the dorsal root ganglion Damage to this area causes sensation from the body area served to be lost Figure 7.19 Slide 7.244 Spinal Cord Anatomy Exterior white mater – conduction tracts Posterior, lateral, and anterior columns Each contains a number of fiber tracts make up of axons with the same destination and function Figure 7.19 Copyright © 2003 Pearson Education, Inc. publishing as Spinal Cord Anatomy Central canal filled with cerebrospinal fluid Figure 7.19 Peripheral Nervous System Nerves and ganglia outside the central nervous system Nerve = bundle of neuron fibers Neuron fibers are bundled by a connective tissue sheath Cranial Nerves 12 pairs of nerves that mostly serve the head and neck Numbered in order, front to back – names reveal structures they control Most are mixed nerves, but three are sensory only Optic, olfactory, and vestibulocochlear Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings Slide 7.248 Distribution of Cranial Nerves Figure 7.21 Slide 7.249 Cranial Nerves I Olfactory nerve – sensory for smell II Optic nerve – sensory for vision III Oculomotor nerve – motor fibers to eye muscles IV Trochlear – motor fiber to eye muscles V Trigeminal nerve – sensory for the face; motor fibers to chewing muscles VI Abducens nerve – motor fibers to eye muscles VII Facial nerve – sensory for taste; motor fibers to the face VIII Vestibulocochlear nerve – sensory for balance and hearing Cranial Nerves IX Glossopharyngeal nerve – sensory for taste; motor fibers to the pharynx X Vagus nerves – sensory and motor fibers for pharynx, larynx, and viscera XI Accessory nerve – motor fibers to neck and upper back XII Hypoglossal nerve – motor fibers to tongue Slide 7.251 Spinal Nerves There is a pair of spinal nerves at the level of each vertebrae for a total of 31 pairs Spinal nerves are formed by the combination of the ventral and dorsal roots of the spinal cord Spinal nerves are named for the region from which they arise Spinal Nerves Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings Figure 7.22a Anatomy of Spinal Nerves Spinal nerves divide soon after leaving the spinal cord Dorsal rami – serve the skin and muscles of the posterior trunk Ventral rami – forms a complex of networks (plexus) for the anterior, which serve the motor and sensory needs of the limbs Figure 7.22b Slide 7.254 Examples of Nerve Distribution Figure 7.23 Copyright © 2003 Pearson Education, Inc. publishing as Slide 7.255 Autonomic Nervous System The involuntary branch of the nervous system Consists of only motor nerves Divided into two divisions Sympathetic division – mobilizes the body Parasympathetic division – allows body to unwind Anatomy of the Parasympathetic Division Originates from the brain stem and S2 – S4 Neurons in the cranial region send axons out in cranial nerves to the head and neck organs They synapse with the second motor neuron in a terminal ganglion Terminal ganglia are at the effector organs Always uses acetylcholine as a neurotransmitter Anatomy of the Sympathetic Division – thoracolumbar division Originates from T1 through L2 Preganglionic axons leave the cord in the ventral root, enter the spinal nerve, then pass through a ramus communications, to enter a sympathetic chain ganglion at the sympathetic chain (trunk) (near the spinal cord) Short pre-ganglionic neuron and long postganglionic neuron transmit impulse from CNS to the effector Norepinephrine and epinephrine are neurotransmitters to the effector organs Slide 7.258 Copyright © 2003 Pearson Education, Inc. publishing as Sympathetic Pathways Figure 7.26 Anatomy of the Autonomic Nervous System Figure 7.25 Copyright © 2003 Pearson Education, Inc. publishing as Autonomic Functioning Sympathetic – “fight-or-flight” Response to unusual stimulus Takes over to increase activities Remember as the “E” division = exercise, excitement, emergency, and embarrassment Slide 7.261 Copyright © 2003 Pearson Education, Inc. publishing as Autonomic Functioning Parasympathetic – housekeeping activites Conserves energy Maintains daily necessary body functions Remember as the “D” division - digestion, defecation, and diuresis Copyright © 2003 Pearson Education, Inc. publishing as Development Aspects of the Nervous System The nervous system is formed during the first month of embryonic development Any maternal infection can have extremely harmful effects The hypothalamus is one of the last areas of the brain to develop – contains centers for regulating body temperature No more neurons are formed after birth, but growth and maturation continues for several years largely due to myelination The brain reaches maximum weight as a young adult