General
1.
2.
3.
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5.
6.
7.
8.
9.
10.
11.
12.
13.
14.
15.
16.
17.
Routes of drug administration – advantages and disadvantages of each route
Factors modifying drug action – examples
Factors affecting drug absorption – enumerate and discuss
Prolongation of drug action - SN
Bioavailability
First Pass metabolism – clinical significance
Plasma Protein Binding of drugs2
Plasma half-life
Volume of distribution
Zero and first order kinetics - difference2
Drug antagonism – describe with examples
G-Protein coupled receptor
Potency and efficacy – define with examples
Enzyme induction2
Therapeutic window
Tachyphylaxis2
Idiosyncrasy
ANS
18.
19.
20.
21.
22.
23.
24.
25.
26.
27.
28.
29.
Cholinesterase inhibitors2
Pharmacotherapy of Myasthenia gravis2
Pharmacology of glaucoma
Pilocarpine in glaucoma – rationale of using
Use of anticholinergics
Atropine2
Pharmacotherapy of Atropine poisoning
Uses of sympathomimetics
Adrenaline in anaphylactic shock – rationale of using
Beta-blockers – classification, uses, S/E and c/i2
Cardioselective beta blockers – pharmacological actions and therapeutic advantages
Use of adrenaline
Autacoids
30.
31.
32.
33.
34.
35.
36.
37.
38.
Levocetrizine - SN
NSAIDS – enumerate, uses, MOA, ADR
Aspirin – Uses and S/E2
Misoprostol; why is it used in induction of labour2
Migraine - pharmacotherapy
Prophylaxis of Migraine
Acute gout – drug treatment
Colchicine in acute gout
DMARDS – describe with suitable example
CNS
39.
40.
41.
42.
43.
44.
45.
46.
47.
48.
49.
50.
51.
52.
53.
54.
55.
56.
57.
58.
59.
Benzodiazepine – MOA
Diazepam – uses and ADR
Pharmacotherapy of parkinsonism
Treatment of drug induced parkinsonism
Rationale of combining Levodopa with carbidopa3
Selegiline in Parkinsonism
Alzheimer's disease - pharmacotherapy
Atypical antipsychotics
Diphenylhydantoin – MOA and S/E
Antidepressants – classification
SSRIs; rationale of using in Depression3
Fluoxetine – MOA, adverse effects, therapeutic uses
MAO inhibitors2
Antiepileptics – classification;
Grand mal epilepsy - pharmacotherapy
Phenytoin – MOA, ADR and uses
Sodium valproate2
Disulphiram in alcohol abuse
Narcotic analgesics – classification
Morphine – uses, ADR, withdrawal symptoms
Morphine poisoning - pharmacotherapy
Anesthesia
60.
61.
62.
63.
64.
65.
66.
67.
Local anesthetics – classification
Adrenaline with Lignocaine - rationale
Lignocaine – uses and ADR
Tetracaine
Diethyl ether
D-tubocurarine and succinylcholine - difference
Rationale for ultrashort action of thiopentone sodium
Pre-anesthetic medications - SN
CVS
68.
69.
70.
71.
72.
73.
74.
75.
76.
Dopamine and dobutamine – difference
Dopamine in caridogenic shock – rationale of using
Nitrate – MOA in angina
Glyceryl trinitrate – actions, uses, ADR
Nitroglycerine – Uses and ADR
Pharmacotherapy of MI3
Digoxin – mechanism of action; rationale for giving in congestive heart failure2
Loading and maintenance dose of digoxin
Antiarrhythmic drugs – classification
77.
78.
79.
1.
1.
2.
3.
4.
2.
3.
4.
5.
Pharmacotherapy of Supraventricular tachycardia
Pharmacotherapy of Atrial flutter
Xylocaine therapy in ventricular tachycardia
Antihypertensive – classification2
Captopril – MOA, uses, ADR
ACE inhibitors in Diabetic nephropathy – rationale of using
Losartan in hypertension – rationale of using
Thiazide diuretic in hypertension – rationale of using
Amlodipine
Nifedipine
Verapamil in PSVT- rationale for using
Statins
Hematology
6. Fibrinolytics
7. Pharmacotherapy of leukemia
8. Antiplatelet drugs
Kidney
5.
6.
7.
8.
Diuretics – classification
Potassium sparing diuretics
Thiazide diuretics
Loop diuretics – SN; Furosemide – pharmacology, ADR and uses2
Endocrine
80.
81.
82.
83.
84.
85.
86.
87.
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89.
90.
91.
92.
93.
94.
95.
Types of insulin
Sulfonylurea – SN; uses and side effects2
Metformin therapy in DM
Insulin and metformin - difference
Biguanides and sulfonylurea
Diabetic ketoacidosis – drug treatment
Glucocorticoids – enumerate, pharmacological actions, therapeutic uses, ADR
Antithyroid drugs – classification
Pharmacotherapy of Thyrotoxicosis; drugs uses and their adverse effects
Propanolol in thyrotoxicosis - rationale
Radioactive Iodine
Tamoxifen
Raloxiphene
Oral contraceptives – actions, uses and ADR
Combines pill as an oral contraceptive
Methylergometrine in PPH – rationale of using
Antibiotics – General
9.
10.
11.
12.
13.
14.
15.
Penicillin
Beta-lactamase inhibitors
Amoxycillin given with clavulanic acid – rationale
Aminoglycosides – uses and side effects
Quinolones; flouroquinolone2
Pyrimethamine with sulphamethoxazole – rationale
Acute UTI - pharmacotherapy
Antibiotics – Antitubercular
96.
97.
98.
99.
DOTs regimen – advantages and disadvantages
Rifampicin – uses, s/e and c/i
Categories of tuberculous chemotherapy
Define MDR-TB
Antibiotics – Antiamoebic
16.
17.
18.
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20.
21.
Antiamoebic drugs – classification,
Metronidazole – uses and ADR3
Pharmacology of amebic hepatitis
Pharmacotherapy of amebiasis
Pharmacotherapy of amoebic colitis
Albendazole
Antibiotics - Antiviral
22. Zidovudine
Antibiotics - Antimalarial
23.
24.
25.
26.
Pharmacotherapy of malaria
Acute relapsing malaria – drug treatment
Antimalarial drugs – classification
Chloroquine – MOA, Uses, S/E4
Antibiotics – Miscellaneous
27. Drugs used in treatment of Enteric fever; discuss management of enteric fever.
Chemotherapy – Antineoplastic
100.
Methotrexate – uses, s/e and c/i; rationale of using methotrexate in malignancy2
Respiratory
101.
102.
103.
104.
105.
Bronchial Asthma – drugs and pharmacotherapy2
Acute attack of bronchial asthma – drug treatment
Pharmacological actions and uses of beta-2 agonist
Role of methylxanthines in bronchial asthma
Pharmacotherapy of Status asthmaticus2
GIT
106.
107.
108.
109.
110.
111.
Peptic ulcer – drug treatment
Pharmacotherapy of ulcerative colitis
Sulfasalazine; rationale for using in ulcerative colitis2
Osmotic purgatives
Tegaserod
Ondansetron as anti-emetic
Miscellaneous
1. Dopamine receptors
2. Penicillamine