tion
N on p h a r
Indomethacin,naproxen,su
lindac a
re FD
p ro
to
co
n
go
ric
aci
d nep
hritis
⬆
O
AI
D
alent
to N
Treatment
Methylprednisolon
e
ion
IM inject
rmone
Adrenocorticotropic ho
N/V & diarrh
ea
SE
ci
chi
Col
thy
yopa
Axonal neurom
>
⬇ d os e
t
men
impair
Kidney and hepatic
Re
nal d
breakdown
is e a se
Di
u ret
ic s
acid
S a li c
yl a t es > 2g
gs:
Pharm
Eth
am buto
l
Py
raz
inam id
e
lo
a co
nd
Po
Sy
mp
tom
s
N igh
t pain & infl
ammation
Fev
er & leu
kocytosis
Neutropenia
P.glycoprotein/ CYP450 inhibitors >> colchi
cine toxicit
⬆
y>
ere
xcre
tion of
uric
gic
al
nts
joi
r >2
Polyarticula
IA injection
nuc
leic
acid
d a g ra
a
Triamcinolone
⬆
yto
tox
ic drugs
nd
Gout
s
gn
Si
Prednisolone
Corticosteroids
Ora l
e
olon
Methyprednis
⬇ HGPRT
Ethanol
ne
e
of uric acid
SA
ID
s
For < 3 j o i n t s
Or IA injection
c ti o n
i n diet
P RPP
D ru
O r al
Prednison
od u
hysiology
U
Efficacy is equiv
s
tion
solu
ter re
Tapering dose af
ine
dl
2n
s
r
ibito
2 inh
Selective COX-
Pathop
v
r
e rp
r in e
C
NS
pu
⬆
lo
g
ut
Start within 24 hr for 5-8 days
nt attacks
MS
U in j
oints (Tophi)
l
ve d
ma
efi
R e c u rr e
)
ition
ic a
A ap
tion
Diet modifica
de
D
s(
c a c id
U
Local ice applica
In
clu
uri
⬆
ns
Cautio
Insteps
A nkles
He
els
& knees