Essentials of Human Anatomy & Physiology
Elaine N. Marieb
Seventh Edition
Chapter 12
The Lymphatic System
and Body Defenses
Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings
Lymph Nodes
Figure 12.3
Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings
Slide
The Lymphatic System
 Two parts
 Lymphatic vessels
 Lymphoid tissues and organs
 Lymphatic system functions
 Transport fluids back to the blood
 Play essential roles in body defense and
resistance to disease
 Absorb digested fat at the intestinal villi Slide 12.1
Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings
Lymphatic Characteristics
 Lymph – excess tissue fluid carried by
lymphatic vessels
 Properties of lymphatic vessels
 One way system toward the heart
 No pump
 Lymph moves toward the heart
 Milking action of skeletal muscle
 Rhythmic contraction of smooth muscle
in vessel walls
Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings
Slide 12.2
Lymphatic Vessels
Figure 12.1
Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings
Slide
Lymphatic Vessels
 Lymphatic
collecting vessels
 Collects lymph
from lymph
capillaries
 Carries lymph to
and away from
lymph nodes
Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings
Figure 12.2
Slide
Lymphatic Vessels
 Lymphatic
collecting vessels
(continued)
 Returns fluid to
circulatory veins
near the heart
 Right lymphatic
duct
 Thoracic duct
Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings
Figure 12.2
Slide
Lymph
 Materials returned to the blood
 Water
 Blood cells
 Proteins
Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings
Slide
Lymph
 Harmful materials that enter lymph
vessels
 Bacteria
 Viruses
 Cancer cells
 Cell debris
Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings
Slide
Lymph Nodes
 Filter lymph before it is returned to the
blood
 Defense cells within lymph nodes
 Macrophages – engulf and destroy foreign
substances
 Lymphocytes – provide immune response to
antigens
Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings
Slide
Lymph Nodes
Figure 12.3
Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings
Slide
Lymph Node Structure
Figure 12.4
Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings
Slide
Other Lymphoid Organs
 Several other
organs contribute
to lymphatic
function
 Spleen
 Thymus
 Tonsils
 Peyer’s patches
Figure 12.5
Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings
Slide 12.9
The Spleen
 Located on the left side of the abdomen
 Filters blood
 Destroys worn out blood cells
 Forms blood cells in the fetus
 Acts as a blood reservoir
Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings
Slide
The Thymus
 Located low in the throat, overlying the
heart
 Functions at peak levels only during
childhood
 Produces hormones (like thymosin) to
program lymphocytes
Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings
Slide
Tonsils
 Small masses of lymphoid tissue
around the pharynx
 Trap and remove bacteria and other
foreign materials
 Tonsillitis is caused by congestion with
bacteria
Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings
Slide
Peyer’s Patches
 Found in the wall of the small intestine
 Resemble tonsils in structure
 Capture and destroy bacteria in the
intestine
Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings
Slide
Mucosa-Associated Lymphatic
Tissue (MALT)
 Includes:
 Peyer’s patches
 Tonsils
 Other small accumulations of lymphoid
tissue
 Acts as a guard to protect respiratory
and digestive tracts
Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings
Slide
Body Defenses
 The body is constantly in contact with
bacteria, fungi, and viruses (pathogens)
 The body has two defense systems for
foreign materials
 Nonspecific defense system
 Mechanisms protect against a variety of
invaders
 Responds immediately to protect body
from foreign materials
Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings
Slide
Body Defenses
Specific defense system
 Specific defense is required for each type
of invader
 Also known as the immune system
Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings
Slide
Nonspecific Body Defenses
 Body surface coverings
 Intact skin
 Mucous membranes
 Specialized human cells
 Chemicals produced by the body
Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings
Slide
Surface Membrane Barriers –
First Line of Defense
 The skin
 Physical barrier to foreign materials
 pH of the skin is acidic to inhibit bacterial
growth
 Sebum is toxic to bacteria
 Vaginal secretions are very acidic
Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings
Slide
Surface Membrane Barriers –
First Line of Defense
 Stomach mucosa
 Secretes hydrochloric acid
 Has protein-digesting enzymes
 Saliva and lacrimal fluid contain
lysozyme
 Mucus traps microogranisms in
digestive and respiratory pathways
Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings
Slide
Defensive Cells
 Phagocytes
(neutrophils and
macrophages)
 Engulfs foreign
material into a
vacuole
 Enzymes from
lysosomes digest
the material
Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings
Figure 12.6b
Slide
Macrophage attacking e-coli.
•
Defensive Cells
 Natural killer cells
 Can lyse and kill
cancer cells
 Can destroy virusinfected cells
Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings
Figure 12.6b
Slide
Inflammatory Response Second Line of Defense
 Triggered when body tissues are injured
 Produces four cardinal signs
 Redness
 Heat
 Swelling
 Pain
 Results in a chain of events leading to
protection and healing
Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings
Slide
Functions of the Inflammatory
Response
 Prevents spread of damaging agents
 Disposes of cell debris and pathogens
 Sets the stage for repair
Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings
Slide
Steps in the Inflammatory Response
Figure 12.7
Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings
Slide
Antimicrobial Chemicals
 Complement
 A group of at
least 20
plasma
proteins
 Activated when
they encounter
and attach to
cells
(complement
fixation)
Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings
Figure 12.8
Slide
Antimicrobial Chemicals
 Complement
(continued)
 Damage
foreign cell
surfaces
 Will rupture or
lyse the foreign
cell membrane
Figure 12.8
Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings
Slide
Antimicrobial Chemicals
 Interferon
 Secreted proteins of virus-infected cells
 Bind to healthy cell surfaces to inhibit viruses
binding
Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings
Slide
Interferons are a family species-specific proteins synthesized by
eukaryotic cells in response to viruses and a variety of natural and
synthetic stimuli. There are several different interferons commonly used
as therapeutics, termed alpha, beta, and gamma. These peptides are
used to treat hairy cell leukemia, AIDS-related Kaposi's sarcoma,
laryngeal papillomatosis, genital warts, and chronic granulomatous
disease. Side effects include black tarry stools, blood in the urine,
confusion, and loss of balance.
Fever
 Abnormally high body temperature
 Hypothalmus heat regulation can be
reset by pyrogens (secreted by white
blood cells)
 High temperatures inhibit the release of
iron and zinc from liver and spleen
needed by bacteria
 Fever also increases the speed of
tissue repair
Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings
Slide
Specific Defense: The Immune
System – Third Line of Defense
 Antigen specific – recognizes and acts
against particular foreign substances
 Systemic – not restricted to the initial
infection site
 Has memory – recognizes and mounts
a stronger attack on previously
encountered pathogens
Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings
Slide
Types of Immunity
 Humoral immunity
 Antibody-mediated immunity
 Cells produce chemicals for defense
 Cellular immunity
 Cell-mediated immunity
 Cells target virus infected cells
Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings
Slide
Antigens (Nonself)
 Any substance capable of exciting the
immune system and provoking an immune
response
 Examples of common antigens
 Foreign proteins
 Nucleic acids
 Large carbohydrates
 Some lipids
 Pollen grains
 Microorganisms
Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings
Slide
Self-Antigens
 Human cells have many surface
proteins
 Our immune cells do not attack our own
proteins
 Our cells in another person’s body can
trigger an immune response because
they are foreign
 Restricts donors for transplants
Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings
Slide
Allergies
 Many small molecules (called haptens
or incomplete antigens) are not
antigenic, but link up with our own
proteins
 The immune system may recognize and
respond to a protein-hapten
combination
 The immune response is harmful rather
than protective because it attacks our
own cells
Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings
Slide
Cells of the Immune System
 Lymphocytes
 Originate from hemocytoblasts in the red bone
marrow
 B lymphocytes become immunocompetent in
the bone marrow
 T lymphocytes become immunocompetent in
the thymus
 Macrophages
 Arise from monocytes
 Become widely distributed in lymphoid organs
Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings
Slide
Activation of Lymphocytes
Figure 12.9
Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings
Slide
Humoral (Antibody-Mediated)
Immune Response
 B lymphocytes with specific receptors
bind to a specific antigen
 The binding event activates the
lymphocyte to undergo clonal selection
 A large number of clones are produced
(primary humoral response)
Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings
Slide
Humoral (Antibody Mediated)
Immune Response
 Most B cells become plasma cells
 Produce antibodies to destroy antigens
 Activity lasts for four or five days
 Some B cells become long-lived memory
cells (secondary humoral response)
Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings
Slide
Humoral Immune Response
Figure 12.10
Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings
Slide
Active Immunity
 Your B cells
encounter
antigens and
produce
antibodies
 Active immunity
can be naturally
or artificially
acquired
Figure 12.12
Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings
Slide
Passive Immunity
 Antibodies are obtained from someone
else
 Conferred naturally from a mother to her
fetus
 Conferred artificially from immune serum or
gamma globulin
 Immunological memory does not occur
 Protection provided by “borrowed
antibodies”
Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings
Slide
Antibodies (Immunoglobulins) (Igs)
 Soluble proteins secreted by B cells
(plasma cells)
 Carried in blood plasma
 Capable of binding specifically to an
antigen
Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings
Slide
Antibody Classes
 Antibodies of each class have slightly
different roles
 Five major immunoglobulin classes –
(Do Not Need to know!)
 IgM – can fix complement
 IgA – found mainly in mucus
 IgD – important in activation of B cell
 IgG – can cross the placental barrier
 IgE – involved in allergies
Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings
Slide
Cellular (Cell-Mediated) Immune
Response
 Antigens must be presented by
macrophages to an immunocompetent
T cell (antigen presentation)
 T cells must recognize nonself and self
(double recognition)
 After antigen binding, clones form as
with B cells, but different classes of cells
are produced
Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings
Slide
Cellular (Cell-Mediated) Immune
Response
Figure 12.15
Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings
Slide
T Cell Clones
 Cytotoxic T cells
 Specialize in killing infected cells
 Insert a toxic chemical (perforin)
 Helper T cells
 Recruit other cells to fight the invaders
 Interact directly with B cells
Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings
Slide
T Cell Clones
 Suppressor T cells
 Release chemicals to suppress the activity
of T and B cells
 Stop the immune response to prevent
uncontrolled activity
 A few members of each clone are
memory cells
Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings
Slide
Summary of the Immune Response
Figure 12.16
Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings
Slide
Organ Transplants and Rejection
 Major types of grafts
 Autografts – tissue transplanted from one
site to another on the same person
 Isografts – tissue grafts from an identical
person (identical twin)
 Allografts – tissue taken from an unrelated
person
 Xenografts – tissue taken from a different
animal species
Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings
Slide
Organ Transplants and Rejection
 Autografts and isografts are ideal
donors
 Xenografts are never successful
 Allografts are more successful with a
closer tissue match
Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings
Slide
Disorders of Immunity:
Immunodeficiencies
 Production or function of immune cells
or complement is abnormal
 May be congenital or acquired
 Includes AIDS – Acquired Immune
Deficiency Syndrome
Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings
Slide
Disorders of Immunity:
Autoimmune Diseases
 The immune system does not
distinguish between self and nonself
 The body produces antibodies and
sensitized T lymphocytes that attack its
own tissues
Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings
Slide
Disorders of Immunity:
Autoimmune Diseases
 Examples of autoimmune diseases
 Multiple sclerosis – white matter of brain
and spinal cord are destroyed
 Myasthenia gravis – impairs
communication between nerves and
skeletal muscles
 Juvenile diabetes – destroys pancreatic
beta cells that produce insulin
 Rheumatoid arthritis – destroys joints
Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings
Slide
Disorders of Immunity:
Autoimmune Diseases
 Examples of autoimmune diseases
(continued)
 Systemic lupus erythematosus (SLE) –
affects kidney, heart, lung and skin
 Glomerulonephritis – impairment of renal
function
Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings
Slide
Immune Deficiency: AIDS
• HIV targets cells
• Retrovirus attaches to CD4 receptors of
T helper cells
– Transmission: Body fluids, i.e., blood, semen,
breast milk, vaginal secretions
The Structure of HIV
Figure 9.19
Time Course of the Progression of
AIDS after HIV Infection
Figure 9.21
•AIDS progression:
–Phase I: few weeks to a few years; flu like symptoms, swollen
lymph nodes, chills, fever, fatigue, body aches. Virus is
multiplying, antibodies are made but ineffective for complete
virus removal
–Phase II: within six months to 10 years; opportunistic
infections present, Helper T cells affected, 5% may not
progress to next phase
–Phase III: Helper T cells fall below 200 per cubic millimeter
of blood AND the person has an opportunistic infection or type
of cancer. Person is now termed as having “AIDS” May
include pneumonia, meningitis, tuberculosis, encephalitis,
Kaposi’s sarcoma, and non-Hodgkin’s lumphoma….
AIDS Pandemic
• More than 36 million infected with HIV
worldwide
• Most infections in sub-Sahara of Africa
• Increasing spread in Asia and India
• Most often spread by heterosexual contact
outside U.S.