TOPIC 2.3 – CARBOHYDRATES & LIPIDS 2.3 – A - Carbohydrates IB BIO – 2.3 Understandings Monosaccharides are single sugar molecules. Whey two link together through condensation, they form disaccharide. These can further link to form polysaccharides. Examples of each include: U1: Monosacch. monomers are linked together by condensation reactions to form disaccharides and polysaccharide polymers. Key Terms Monnosaccharide Monosaccharide Disaccharide Polysaccharide Disaccharide Glucose Galactose Fructose Maltose Lactose Sucrose Starch Glycogen Cellulose Polysaccharide asdf 3 IB BIO – 2.3 Sucrose Guidance Formed from glucose and fructose 4 G3: Sucrose, lactose and maltose should be included as examples of disaccharides. Maltose Formed from two glucose monomers Key Terms Sucrose Maltose https://classconnection.s3.amazonaws.com/652/flashcards/729652/jpg/05_05disaccharidesynth-l1316447585157.jpg IB BIO – 2.3 Lactose Guidance Formed from glucose and fructose 5 G3: Sucrose, lactose and maltose should be included as examples of disaccharides. Key Terms Lactose https://pavansmicroscope.files.wordpress.com/2013/08/lactose_etc.png IB BIO – 2.3 Applications Mono- and disaccharides can join in many ways, which results in a wide variety of polysaccharides (aka carbohydrates). 6 A1: Structure and function of cellulose and starch in plants and glycogen in humans. Key Terms Polysaccharides Carbohydrates http://cnx.org/resources/ff24547bd43194a91783d82f3b805b5c/219_Three_Important_Polysaccharides-01.jpg IB BIO – 2.3 Applications 7 Cellulose is a polysaccharide made up of straight chains of betaglucose units. Hydrogen bonds form between the their –OH groups. A1: Structure and function of cellulose and starch in plants and glycogen in humans. Key Terms Cellulose http://bio1151.nicerweb.com/Locked/media/ch05/05_08CelluloseArrange.jpg IB BIO – 2.3 Applications A1: Structure and function of cellulose and starch in plants and glycogen in humans. Cellulose chains group together and form microfibril bundles. These 8 have high tensile strength and make up the basis of cell walls. This gives cell walls the strength to withstand high internal pressure. Key Terms Cellulose http://bio1151.nicerweb.com/Locked/media/ch05/05_08CelluloseArrange.jpg IB BIO – 2.3 Applications 9 Starch polysaccharides form when α–glucose molecules link together. Glucose units are oriented in the same way and curve into a helical structures. A1: Structure and function of cellulose and starch in plants and glycogen in humans. Key Terms Starch https://s-media-cache-ak0.pinimg.com/736x/94/0f/dd/940fddb9760db10b42f50ae0590826b0.jpg IB BIO – 2.3 Guidance G1: The structure of starch should include amylose and amylopectin. Amylose and amylopectin are two types of starch synthesized by plants. Their function is to store energy. 10 Amylopectin has branched structures which helps in store large amounts of energy Amylose consists of a long helical chain Key Terms Amylose Amylopectin http://tundra.cnx.rice.edu:8888/resources/ab0d06aaee4b01e29fa3f115bc25d92ddeb8f15e/Figure_03_02_06.jpg IB BIO – 2.3 Applications Glycogen is a polysaccharide produced in animals. It is similar to a branched form of starch, which makes it more compact. 11 A1: Structure and function of cellulose and starch in plants and glycogen in humans. Key Terms Glycogen http://www.periodni.com/gallery/glycogen.png IB BIO – 2.3 Applications Just like starch in plants, glycogen stores glucose in cells with a high12 concentration. Its many branches gives easy access to glucose. A1: Structure and function of cellulose and starch in plants and glycogen in humans. Key Terms Glycogen http://cnx.org/resources/ff24547bd43194a91783d82f3b805b5c/219_Three_Important_Polysaccharides-01.jpg IB BIO – 2.3 Skills S1: Use of molecular visualization software to compare cellulose, starch and glycogen. Key Terms Molecular Visualization 13 Computer imaging software can be used to compare the structure of polysaccharides. Go to the links below: • Cellulose - http://www.biotopics.co.uk/jsmol/cellulose.html • Amylose – http://www.biotopics.co.uk/jsmol/amylose.html • Amylopectin - http://www.biotopics.co.uk/jsmol/amylopectin.html • Glycogen - http://www.biotopics.co.uk/jsmol/glycogen.html 2.3 – B - Lipids IB BIO – 2.3 Understandings U2: Fatty acids can be saturated, monounsaturated or polyunsaturated. Key Terms Fatty acids are the building blocks of lipids, there are two different 15 kinds: saturated and unsaturated. • Saturated fatty acids - • Unsaturated - Fatty Acid asdf IB BIO – 2.3 Understandings U2: Fatty acids can be saturated, monounsaturated or polyunsaturated. Saturated fatty acids have the 16 maximum number of C-H bonds. So they only have single-covalent bonds and are relatively linear. Unsaturated fatty acids have double covalent bonds which affects their shape. • Monounsaturated – only one double bond • Polyunsaturated – multiple double bonds Key Terms Saturated Unsaturated Mono-/PolyUnsaturated http://www.periodni.com/gallery/fatty_acids.png IB BIO – 2.3 Understandings The double bonds in unsaturated fats affects their overall shape. • Cis fatty acids have H’s on the same side of the double bond. This bends the shape of the molecule. • Trans fatty acids have H’s on opposite sides of the double bond. This results in an overall linear shape. U3: Unsaturated fatty acids can be cis or trans isomers. Key Terms 17 Cis Trans http://www.nutrientsreview.com/wp-content/uploads/2014/12/Trans-cis-fatty-acid.jpg IB BIO – 2.3 Understandings 18 Triglyceride molecules are the main component of fats and oils. They are formed through condensation of 3 fatty acids and glycerol. U4: Triglycerides are formed by condensation from three fatty acids and one glycerol. Key Terms Triglyceride http://cnx.org/resources/4c57b4a7e7d8b5c8aeb90c67f774c20fed2bca54/220_Triglycerides-01.jpg IB BIO – 2.3 Understandings 19 Triglyceride molecules are the main component of fats and oils. They are formed through condensation of 3 fatty acids and glycerol. U4: Triglycerides are formed by condensation from three fatty acids and one glycerol. Key Terms Triglyceride http://cnx.org/resources/4c57b4a7e7d8b5c8aeb90c67f774c20fed2bca54/220_Triglycerides-01.jpg IB BIO – 2.3 Applications The lipids formed by fatty acids are more suitable or long-term energy storage than carbohydrates. They are able to store any more times energy in the same weight. 20 A3: Lipids are more suitable for long-term energy storage in humans than carbohydrates. Key Terms They can also aid in heat insulation, which gives them a secondary function useful for an organism. http://www.medbio.info/Horn/Time%206/muscle26.gif REVIEW IB BIO – 2.3 1. Compare the properties of saturated and unsaturated fatty acids. 2. Compare the structure of cis- and transunsaturated fatty acids. 3. Outline the formation of triglyceride. 4. Outline why lipids are more suitable for long-term energy storage. 21 2.3 – C - Health There have been many claims about the healfth effects of various 23 types of fat, especially in regards to Coronary Heart Disease (CHD). INTRO IB BIO – 2.3 http://4.bp.blogspot.com/-rivssLGQP5c/UaZHUPXYl_I/AAAAAAAABac/82k7sDAVBow/s1600/chd+awareness01.png IB BIO – 2.3 Applications A2: Scientific evidence for health risks of trans fats and saturated fatty acids. Coronary heart disease is a condition in which plaque builds up in the coronary artery. This narrows the space avaible to carry oxygenated blood to the heart’s tissues, which can result in heart attack. 24 Key Terms Coronary Heart Disease http://www.nhlbi.nih.gov/health/health-topics/topics/cad IB BIO – 2.3 Applications A2: Scientific evidence for health risks of trans fats and saturated fatty acids. Key Terms Saturated fatty acids are found in foods such as dairy and meat. A 25 strong positive correlation has been shown between intake and CHD. The correlation is strong, but a causality has not been proven. Some populations have diets rich in saturated fatty acids (Masai tribe), but almost no CHD is observed http://3.bp.blogspot.com/-QNqfLwWXGas/T0_aFtG4qKI/AAAAAAAAABs/QNXGr23iHgY/s1600/cholesterol-heart-disease.jpg IB BIO – 2.3 Applications Trans fat consumption also shows a positive correlation with CHD. 26 Other risk factors for CHD proved negative, so it is likely that this relationship is causal. Deceased patients have high trans-fat levels. A2: Scientific evidence for health risks of trans fats and saturated fatty acids. Key Terms http://sphweb.bumc.bu.edu/otlt/MPH-Modules/PH/PH709_Heart/DietaryFat-CHD.png IB BIO – 2.3 Applications A4: Evaluation of evidence and the methods used to obtain the evidence for health claims made about lipids. Evaluating Claims It is important to be able to analyze claims and the experimental methods used to gather the associated data. Questions to ask: Analysing results: • Is there correlation between lipid initake and the rate of disease? Analysing method: • How large was survey size? • How even was the sampling? • Are the differences between CHD rates and lipid intakes significant? • If the sampling was uneven, were the results adjusted to eliminate other factors? • Do statistical tests show significant differences? • • How variable is data? Were the measurements of lipid intake/CHD rates reliable? Key Terms 27 IB BIO – 2.3 Skills S2: Determination of body mass index by calculation or use of a nomogram. Key Terms A nomogram is a type of chart28 that can be used to find BMI. To use it: • Mark weight on the left • Mark height on the right • Connect the two values The individuals body mass is the indicated by the point that the line crosses. Nomogram http://web.alfredstate.edu/ammanmj/nutrition/Nutr%20Package%20Update%2007/BMI%20nomogram.jpg IB BIO – 2.3 Skills S2: Determination of body mass index by calculation or use of a nomogram. Practice 29 Using the nomogram, what is the BMI of patient who weighs 130 kg and is 65 inches tall? Answer: ~42 Key Terms Nomogram http://web.alfredstate.edu/ammanmj/nutrition/Nutr%20Package%20Update%2007/BMI%20nomogram.jpg