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Biochemistry Notes

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Chapter 5: The Molecules of Life
Section 5.1
Carbon
➔ Most molecules of a cell are carbon-based
◆ Called ____________
◆ Made up of carbon atoms ___________ to one another
◆ Atoms of other elements may branch off of the _______________
➔ Can form up to ________ bonds with other atoms
◆ Can form bonds with one or more other carbon atoms producing an
endless variety of carbon skeletons
➔ Most carbon-based molecules are classified as __________________
◆ Non-carbon based molecules are classified as ________________
● Ex: _____________________
◆ ________________- organic molecules that are composed of only carbon
and hydrogen
● Many are important fuels
● Ex: ________________
◆ ___________ and __________ are frequently found in organic molecules
➔ __________________- a group of atoms within a molecule that interacts in
predictable ways with other molecules
◆ Ex: Hydroxyl groups are ____________ (attract water molecules)
➔ Some biomolecules may be composed of _____________________ of atoms
◆ Built from many similar, smaller molecular units called ______________
◆ Cells link monomers together into long chains called _____________
● May be ________________________________
● Every living cell has thousands of different kinds of polymers
● Built from fewer than _____________kinds of monomers
➔ Life’s large molecules are classified into 4 main categories:
◆ ____________________________________________
➔ Building a polymer chain
◆ Each time a monomer is added to the chain, a ________ molecule is
released
◆ _______________________
➔ Breaking a polymer chain
◆ Many molecules in _________ are polymers and must be broken down to
make their monomers available to cells
● Cells can either further break down the monomers to obtain
________ or can use them to build new ____________
◆ Cells break bonds between monomers by _______________ to them
◆ _________________
Section 5.2
Carbohydrates
➔ An organic compound made up of ____________ molecules
◆ Sugars contain the elements _________________________
◆ The molecular formula of any carbohydrate is a multiple of the basic
formula __________
◆ Most sugar molecules have a _________________ carbon backbone
➔ ______________________- simple sugars containing just one sugar unit
◆ Ex: Glucose, Fructose, Galactose
◆ Found in ____________________
◆ Sugar molecules are the main fuel supply for _______________
● Cells break down glucose molecules and extract their
_________________________
● Cells use the ________________ as raw material for making other
kinds of organic molecules (ex: ____________________________)
➔ ____________________- sugar made of 2 monosaccharides linked together
◆ The most common is ________________
● Composed of a ___________ molecule linked to a _____________
molecule
● Major carbohydrate in ____________ that nourishes all parts of the
plant
➔ __________________- long polymer chains made up of simple sugar monomers
◆ “Complex carbohydrates”
◆ Starch- a polysaccharide found in __________ cells made entirely of
____________ monomers
● Branch and coil up inside of plant cells to serve as _____________
● Humans and most other animals are able to use plant starch as
food by ______________________________________
○ Ex: ________________________ are rich in starch
◆ Glycogen- a polysaccharide found in _____________ cells made entirely
of glucose monomers
● More highly ______________ than a starch polymer
● In humans, mostly stored as granules in the __________________
◆ Cellulose- a polysaccharide in plant cells made entirely of glucose
monomers that serves as _______________________
● _________________ and _______________ to prevent falling over
● Most animals (including people) cannot ___________ cellulose
○ Commonly called ___________
○ Keeps digestive system healthy but __________________
➔ Almost all carbohydrates are ________________
◆ Due to the many ______________ groups in their sugar units
◆ Monosaccharides and disaccharides _______________________
◆ Cellulose and some forms of starch do not dissolve because
_________________________
● Cotton clothing is made up of mostly ______________ (which is
why they don’t dissolve but are very absorbent)
Section 5.3
Lipids
➔ Characterized by its inability to easily __________________________________
◆ _________________ or “water-fearing”
➔ Composed mainly of Carbon, Hydrogen and Oxygen but not in a _____________
_____________
Different Types of Lipids
➔ _______________________
➔ _______________________
➔ _______________________
What is Fat?
➔ Triglycerides
◆ Consists of ______________ attached to _______________________
◆ Most common type of lipid present in our ________ and in our _________
➔ Glycerol
◆ ______________________
➔ Fatty acids
◆ ______________________________
Triglycerides are found naturally in food
➔ Some triglycerides are _____________ at room temperature
◆ ____________
➔ Some triglycerides are _____________ at room temperature
◆ ____________
Saturated Fat
➔ Fat in which ___________ fatty acid chains contain _______________________
_____________ of hydrogen atoms
◆ Therefore, only has ______________ bonds
◆ _____________ at room temperature
◆ “Fat”
Unsaturated Fat
➔ Fat which contains _______________________________ of hydrogen atoms in
____________________ of its fatty acid chains
◆ Results from carbon atoms ____________________ to each other
◆ ______________ at room temperature
◆ “Oil”
Phospholipids
➔ Composed of __________________ head and _________________ tail
◆ Glycerol backbone with a _____________________ and _____________
___________________
◆ Like to line up and arrange into 2 parallel layers called _______________
_________________
Steroids
➔ Composed of
______________________ formed into _____________________
◆ Functional groups attached to the rings differ based on type and location
➔ ___________________ like triglycerides but very different structure and function
➔ Some circulate through body as chemical signals
◆ Ex: _____________________________- human sex hormones
Cholesterol
➔ ________________ molecule found in the __________________ that surround
the body’s cells
➔ Starting point from which body produces other _______________
➔ _______________________ because certain cholesterol-containing substances
in blood can cause increased risk for ____________________
Functions of Lipids
➔ ______________ Storage
➔ Circulate in the body as ________________________ to cells
➔ Structural component of ________________________
➔ ______________ for organs
➔ ________________
Energy Storage
➔ Most of our energy is provided by ___________________________________
➔ Fats are packed ____________________________________ and can store
_______________________________ in less space than Glycogen
➔ Some fat is __________________________ and good health but too much can
also be unhealthy
Chemical Signaling
➔ Help the body to produce and regulate __________________
◆ _____________________ help regulate blood clotting and control
inflammation
◆ Lipids play important roles in ________________ and ________________
Section 5.4
Proteins
➔ Polymer constructed from a set of just __________________________________
__________________________
➔ Made up of __________________________________________
➔ Responsible for the ____________________________________________
◆ Form hair and fur
◆ ________________________
◆ Provide long-term nutrient storage
◆ Circulate in body and defend body against harmful microorganisms
◆ Act as signals- convey messages from one cell to another
◆ Control the _________________________ in a cell
Amino Acids
➔ Each amino acid monomer consists of a central carbon atom bonded to 4
partners
◆ 3 of the partners are the same in every amino acid
● _______________________
● _______________________
● _______________________
◆ Different “side group” that attaches to the 4th bond of the central carbon
● Sometimes referred to as _________________
● Responsible for the __________________________________ of
each amino acid
Building a Protein
➔ Cells create proteins by linking amino acids together into a chain called a
___________________
◆ Each link is created by a ___________________________ between the
amino group of 1 amino acid and the carboxyl group of the next amino
acid in the chain
➔ Proteins are composed of ________________________________________
The body can make an enormous variety of proteins by arranging amino acids in
different orders
➔ Just like how we use 26 letters to spell all of the words in the English language!
➔ Though there’s only 20 “letters”, the “words” are much longer
◆ Most polypeptide chains are at least ________________________ in
length
➔ Very large number of possible amino acid sequences as well as polypeptides
➔ Each protein has a _______________________ of amino acids
Protein Shape
➔ A protein in the simplest form of amino acids linked together
cannot _________________ properly
➔ A functional protein consists of one or more polypeptides
__________________________________________
◆ Ex: Knitting yarn into a sweater
➔ Some ______________________________________ to each
other, which create the folds and twists
The shape is also influenced by the __________________________
➔ Usually aqueous (containing water)
➔ Water attracts hydrophilic side groups and rejects hydrophobic side groups
◆ Hydrophilic amino acids _______________________________________
__________________
◆ Hydrophobic amino acids ______________________________________
➔ Change in __________________________ can cause the protein to unravel and
lose its normal shape
◆ Called __________________ of the protein
◆ _________________________
◆ Changes the function of the protein
What happens when you fry an egg?
______________________________________________________________________
______________________________________________________________________
Section 5.5
Enzymes
Starting a chemical reaction
➔ ______________________- “start-up” energy that activates the reactants and
triggers a chemical reaction
◆ Ex: Rolling a snowball up a hill
Adding heat to molecules
➔ Provides activation energy
➔ Hotter molecules may collide with enough energy to weaken bonds
➔ Many unnecessary reactions occur at the same time
◆ Including reactions that __________________________________
Cellular reactions depend on catalysts
➔ Catalysts- compounds that _______________________________
◆ Ex: Enzymes in organisms
➔ Enzymes- ____________________ that provide a way for reactions to occur at
the cell’s normal temperature
◆ ________________________________ of the reaction
◆ Each enzyme catalyzes a specific kind of chemical reaction
◆ Affected by _________________________ just like other proteins
How do enzymes
work?
➔ __________________________- only particular reactant molecules called
substrates fit the shape of the enzyme
➔ Substrates fit into a particular region called the ____________________ on the
enzyme
◆ As the substrate enters, the active site ______________________ which
catalyzes the reaction
➔ The enzyme modifies the substrate by _________________________________,
which forms products
➔ Products are released
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