General appearance Irritable bowel syndrome Pain Alleviated by defecation; diffuse; no nighttime pain Usually constant; occurs particularly in the right lower abdomen; may appear at night Healthy; no weight loss Crohn disease Weight loss; malnourishment Ulcerative colitis Weight loss only in severe cases Weight loss Colorectal carcinoma Stool habits Diarrhea or constipation, possibly alternating; no blood; no nighttime diarrhea Non-bloody, watery diarrhea; increased frequency; possible nighttime diarrhea Mostly left lower abdomen; may occur at night Bloody diarrhea with mucus Often no pain Right-sided carcinomas: melena, diarrhea Left-sided carcinomas: constipation