Highlights: Total knee replacement (TKR) is one of the most commonly performed and lifechanging surgical procedures in the modern world, mostly in the geriatric population. Multiple regional analgesia techniques have been described for TKR surgery, but the aim is to choose a procedure-specific, opioid-sparing, and motor-sparing modality. We present a new innovative technique, “Dual Subsartorial Block”, a combination of two blocks given below the sartorius muscle to achieve optimal analgesia in TKR surgeries. A multidisciplinary approach with multimodal analgesia is the demand of time for successful surgical outcomes. “Dual Subsartorial Block” is a procedure-specific, motor-sparing, as well as opioidsparing regional analgesia technique suitable for TKR surgery with the medial parapatellar incision and other medial knee incisions. To understand the technical details of DSB, the knowledge of functional anatomy and sonoanatomy at various levels of subsartorial areas is essential. Motor-sparing and procedure-specific RA techniques are the future of RA practices, which induces the analytical thought process in applying ever-changing knowledge of anatomy, techniques, and methodologies for providing the best patient care.