Block 1 Review Pharmacology Dr.Rajni Rathore General Pharmacology • • • • • • • • • volume of distribution Half life Elimination kinetics Clearance Biotransformation : Drugs associated with acetylation Enzyme inducer and Inhibitors Types of Hypersensitivity reaction Idiosyncratic reaction Drug causing Glucose-6-phosphate dehydrogenase deficiency General Pharmacology • DRC • Redistribution • Agonist, antagonist, inverse agonist and partial agonist • Teratogenic drugs example • Transmembrane transport of drug : simple diffusion, facilitated diffusion, Active transport • Genetic polymorphisms : Phenytoin, Warfarin DRUGS FOR THE TREATMENT OF DIABETES MELLITUS • Insulin – Classification, MOA,S/E,C/I • • • • • • • Sulfonylureas : glyburide Non- Sulfonylureas : Meglitinide Metformin Pioglitazone Acarbose Glucagon -like polypeptide-1 (GLP-1) agonist Management of Hypoglycemia :IV Glucagon & Oral glucose. Endocrine Pharmacology • • • • • • Octreotide Mecasermin Bromocriptine Vasopressin Desmopressin Oxytocin Endocrine Pharmacology • • • • • • • Ketoconazole Levonorgestrel Finasteride Leuprolide Flutamide Hormonal contraceptive pills Anabolic steroids Endocrine Pharmacology • • • • • • • HRT Therapy Aromatase Inhibitors Teriparatide Calcitonin Bisphosphonate Denosumab SERM: Tamoxifen, Raloxifen MOA of all Antithyroid drugs. • • • • • Propylthiouracil Potassium iodide Methimazole Corticosteroids MOA of all antithyroid drugs