2/18/2021 Pharmacology Quiz 1 Flashcards | Quizlet Pharmacokinetics is b. The study of absorption, distribution, metabolism and excretion of drugs a) The study of biological and therapeutic effects of drugs b) The study of absorption, distribution, metabolism and excretion of drugs c) The study of mechanisms of drug action d) The study of methods of new drug development What does d. Distribution of drugs in the organism "pharmacokinetics" include? a) Pharmacological effects of drugs b) Unwanted effects of drugs c) Chemical structure of a medicinal agent d) Distribution of drugs in the organism What does c. Excretion of substances "pharmacokinetics" include? a) Localization of drug https://quizlet.com/188585154/pharmacology-quiz-1-flash-cards/ 2/11 2/18/2021 Pharmacology Quiz 1 Flashcards | Quizlet action b) Mechanisms of drug action c) Excretion of substances d) Interaction of substances What does the term c. Fraction of an uncharged drug reaching "bioavailability" mean? the systemic circulation following any route administration a) Plasma protein binding degree of substance b) Permeability through the brain-blood barrier c) Fraction of an uncharged drug reaching the systemic circulation following any route administration d) Amount of a substance in urine relative to the initial dose The reasons determining c. Extent of absorption and hepatic first- bioavailability are: pass effect a) Rheological parameters of blood b) Amount of a substance obtained orally and quantity of intakes c) Extent of absorption and hepatic first-pass https://quizlet.com/188585154/pharmacology-quiz-1-flash-cards/ 3/11 2/18/2021 Pharmacology Quiz 1 Flashcards | Quizlet effect d) Glomerular filtration rate Pick out the appropriate c. Rectal alimentary route of administration when passage of drugs through liver is minimized: a) Oral b) Transdermal c) Rectal d) Intraduodenal Which route of drug b. Oral administration is most likely to lead to the firstpass effect? a) Sublingual b) Oral c) Intravenous d) Intramuscular What is characteristic of b. Absorption depends on GI tract the oral route? secretion and motor function a) Fast onset of effect b) Absorption depends on GI tract secretion and motor function c) A drug reaches the blood passing the liver https://quizlet.com/188585154/pharmacology-quiz-1-flash-cards/ 4/11 2/18/2021 Pharmacology Quiz 1 Flashcards | Quizlet d) The sterilization of medicinal forms is obligatory Pharmacodynamics b. Absorption and distribution of drugs involves the study of following EXCEPT: a) Biological and therapeutic effects of drugs b) Absorption and distribution of drugs c) Mechanisms of drug action d) Drug interactions What does "affinity" b. Measures how tightly a drug binds to a mean? receptor a) A measure of how tightly a drug binds to plasma proteins b) A measure of how tightly a drug binds to a receptor c) A measure of inhibiting potency of a drug d) A measure of bioavailability of a drug Target proteins which a d. All of the above drug molecule binds are a) Only receptors https://quizlet.com/188585154/pharmacology-quiz-1-flash-cards/ 5/11 2/18/2021 Pharmacology Quiz 1 Flashcards | Quizlet b) Only ion channels c) Only carriers d) All of the above An agonist is a b. Interacts with the receptor and initiates substance that: changes in cell function, producing various effects a) Interacts with the receptor without producing any effect b) Interacts with the receptor and initiates changes in cell function, producing various effects c) Increases concentration of another substance to produce effect d) Interacts with plasma proteins and doesn't produce any effect https://quizlet.com/188585154/pharmacology-quiz-1-flash-cards/ 6/11 2/18/2021 Pharmacology Quiz 1 Flashcards | Quizlet Upgrade to remove ads Only $2.99/month An antagonist is a d. Binds to the receptors without directly substance that: altering their functions a) Binds to the receptors and initiates changes in cell function, producing maximal effect b) Binds to the receptors and initiates changes in cell function, producing submaximal effect c) Interacts with plasma proteins and doesn't produce any effect d) Binds to the receptors without directly altering their functions 7.A competitive b) Binds to the same receptor site and antagonist is a substance progressively inhibits the agonist response that: a) Interacts with receptors and produces submaximal effect b) Binds to the same receptor site and progressively inhibits the agonist response c) Binds to the nonspecific sites of tissue d) Binds to one receptor https://quizlet.com/188585154/pharmacology-quiz-1-flash-cards/ 7/11 2/18/2021 Pharmacology Quiz 1 Flashcards | Quizlet subtype as an agonist and to another as an antagonist 8.Tick the substances d. All of the above whose mechanisms are based on interaction with ion channels a) Sodium channel blockers b) Calcium channel blockers c) Potassium channels activators d) All of the above All of the following d. The ED50 is a measure of drug's efficacy statements about efficacy and potency are true EXCEPT: a) Efficacy is usually a more important clinical consideration than potency b) Efficacy is the maximum effect of a drug c) Potency is a comparative measure, refers to the different doses of two drugs that are needed to produce the same effect https://quizlet.com/188585154/pharmacology-quiz-1-flash-cards/ 8/11 2/18/2021 Pharmacology Quiz 1 Flashcards | Quizlet d) The ED50 is a measure of drug's efficacy 10.Give the definition for c) The amount of a substance to produce a therapeutical dose: the required effect in most patients a) The amount of a substance to produce the minimal biological effect b) The amount of a substance to produce effects hazardous for an organism c) The amount of a substance to produce the required effect in most patients d) The amount of a substance to accelerate an increase of concentration of medicine in an organism 11.The types of d. Competitive antagonism are: a) Summarized b) Potentiated c) Additive d) Competitive 12.A teratogenic action is: b) Negative action on the fetus causing fetal malformation a) Toxic action on the liver https://quizlet.com/188585154/pharmacology-quiz-1-flash-cards/ 9/11 2/18/2021 Pharmacology Quiz 1 Flashcards | Quizlet b) Negative action on the fetus causing fetal malformation c) Toxic action on blood system d) Toxic action on kidneys 13.Therapeutic index (TI) a) A ratio used to evaluate the safety and is: usefulness of a drug for indication a) A ratio used to evaluate the safety and usefulness of a drug for indication b) A ratio used to evaluate the effectiveness of a drug c) A ratio used to evaluate the bioavailability of a drug d) A ratio used to evaluate the elimination of a drug THIS SET IS OFTEN IN FOLDERS WITH... Pharmacology Part 1 General Principles 1 of 2 Pharmacology Part 1 General Principles 2 of 2 43 terms 42 terms television0417 https://quizlet.com/188585154/pharmacology-quiz-1-flash-cards/ AertonHughes PLUS 10/11